Amino acid dipepetide frequency for Candidatus Marinimicrobia bacterium MT.SAG.3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.823AlaAla: 5.823 ± 0.146
0.431AlaCys: 0.431 ± 0.029
3.786AlaAsp: 3.786 ± 0.078
5.063AlaGlu: 5.063 ± 0.122
2.777AlaPhe: 2.777 ± 0.079
5.424AlaGly: 5.424 ± 0.124
1.075AlaHis: 1.075 ± 0.049
5.324AlaIle: 5.324 ± 0.127
4.047AlaLys: 4.047 ± 0.091
6.951AlaLeu: 6.951 ± 0.115
1.802AlaMet: 1.802 ± 0.1
2.648AlaAsn: 2.648 ± 0.087
1.966AlaPro: 1.966 ± 0.071
1.814AlaGln: 1.814 ± 0.058
2.719AlaArg: 2.719 ± 0.075
4.323AlaSer: 4.323 ± 0.09
3.249AlaThr: 3.249 ± 0.085
5.21AlaVal: 5.21 ± 0.111
0.568AlaTrp: 0.568 ± 0.033
2.106AlaTyr: 2.106 ± 0.081
0.0AlaXaa: 0.0 ± 0.0
Cys
0.411CysAla: 0.411 ± 0.027
0.084CysCys: 0.084 ± 0.013
0.329CysAsp: 0.329 ± 0.026
0.392CysGlu: 0.392 ± 0.036
0.192CysPhe: 0.192 ± 0.016
0.713CysGly: 0.713 ± 0.045
0.208CysHis: 0.208 ± 0.032
0.415CysIle: 0.415 ± 0.027
0.36CysLys: 0.36 ± 0.029
0.452CysLeu: 0.452 ± 0.03
0.116CysMet: 0.116 ± 0.014
0.225CysAsn: 0.225 ± 0.019
0.304CysPro: 0.304 ± 0.028
0.125CysGln: 0.125 ± 0.015
0.298CysArg: 0.298 ± 0.023
0.478CysSer: 0.478 ± 0.034
0.288CysThr: 0.288 ± 0.025
0.456CysVal: 0.456 ± 0.032
0.035CysTrp: 0.035 ± 0.009
0.213CysTyr: 0.213 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.704AspAla: 3.704 ± 0.097
0.339AspCys: 0.339 ± 0.027
3.577AspAsp: 3.577 ± 0.101
4.722AspGlu: 4.722 ± 0.112
2.867AspPhe: 2.867 ± 0.084
4.448AspGly: 4.448 ± 0.118
0.954AspHis: 0.954 ± 0.044
4.814AspIle: 4.814 ± 0.099
3.821AspLys: 3.821 ± 0.089
5.802AspLeu: 5.802 ± 0.107
1.481AspMet: 1.481 ± 0.059
2.474AspAsn: 2.474 ± 0.078
2.346AspPro: 2.346 ± 0.076
1.259AspGln: 1.259 ± 0.051
2.67AspArg: 2.67 ± 0.077
4.548AspSer: 4.548 ± 0.118
2.627AspThr: 2.627 ± 0.081
3.641AspVal: 3.641 ± 0.077
0.695AspTrp: 0.695 ± 0.039
2.184AspTyr: 2.184 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
4.64GluAla: 4.64 ± 0.117
0.394GluCys: 0.394 ± 0.031
3.733GluAsp: 3.733 ± 0.089
6.215GluGlu: 6.215 ± 0.16
3.077GluPhe: 3.077 ± 0.095
4.669GluGly: 4.669 ± 0.114
1.109GluHis: 1.109 ± 0.047
6.27GluIle: 6.27 ± 0.129
5.788GluLys: 5.788 ± 0.127
7.425GluLeu: 7.425 ± 0.141
2.072GluMet: 2.072 ± 0.067
3.68GluAsn: 3.68 ± 0.082
2.251GluPro: 2.251 ± 0.077
1.8GluGln: 1.8 ± 0.068
3.674GluArg: 3.674 ± 0.088
4.946GluSer: 4.946 ± 0.111
3.383GluThr: 3.383 ± 0.093
4.658GluVal: 4.658 ± 0.108
0.815GluTrp: 0.815 ± 0.041
2.562GluTyr: 2.562 ± 0.077
0.0GluXaa: 0.0 ± 0.0
Phe
3.048PheAla: 3.048 ± 0.103
0.286PheCys: 0.286 ± 0.024
3.079PheAsp: 3.079 ± 0.098
2.991PheGlu: 2.991 ± 0.074
2.104PhePhe: 2.104 ± 0.084
3.741PheGly: 3.741 ± 0.092
0.782PheHis: 0.782 ± 0.037
3.416PheIle: 3.416 ± 0.089
2.652PheLys: 2.652 ± 0.084
4.356PheLeu: 4.356 ± 0.127
1.126PheMet: 1.126 ± 0.048
2.221PheAsn: 2.221 ± 0.072
1.635PhePro: 1.635 ± 0.063
1.113PheGln: 1.113 ± 0.049
2.015PheArg: 2.015 ± 0.066
3.921PheSer: 3.921 ± 0.111
2.448PheThr: 2.448 ± 0.079
2.699PheVal: 2.699 ± 0.075
0.513PheTrp: 0.513 ± 0.038
1.594PheTyr: 1.594 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
4.928GlyAla: 4.928 ± 0.129
0.541GlyCys: 0.541 ± 0.032
4.466GlyAsp: 4.466 ± 0.12
5.108GlyGlu: 5.108 ± 0.12
3.639GlyPhe: 3.639 ± 0.1
5.676GlyGly: 5.676 ± 0.131
1.283GlyHis: 1.283 ± 0.056
6.546GlyIle: 6.546 ± 0.117
5.047GlyLys: 5.047 ± 0.12
6.444GlyLeu: 6.444 ± 0.111
2.01GlyMet: 2.01 ± 0.064
3.269GlyAsn: 3.269 ± 0.095
1.704GlyPro: 1.704 ± 0.062
1.616GlyGln: 1.616 ± 0.062
3.216GlyArg: 3.216 ± 0.077
5.153GlySer: 5.153 ± 0.124
4.127GlyThr: 4.127 ± 0.111
5.016GlyVal: 5.016 ± 0.11
0.983GlyTrp: 0.983 ± 0.059
2.905GlyTyr: 2.905 ± 0.089
0.0GlyXaa: 0.0 ± 0.0
His
0.989HisAla: 0.989 ± 0.049
0.133HisCys: 0.133 ± 0.016
0.94HisAsp: 0.94 ± 0.039
1.103HisGlu: 1.103 ± 0.05
0.821HisPhe: 0.821 ± 0.041
1.265HisGly: 1.265 ± 0.052
0.356HisHis: 0.356 ± 0.027
1.189HisIle: 1.189 ± 0.046
0.921HisLys: 0.921 ± 0.041
1.78HisLeu: 1.78 ± 0.059
0.37HisMet: 0.37 ± 0.027
0.672HisAsn: 0.672 ± 0.031
0.971HisPro: 0.971 ± 0.048
0.494HisGln: 0.494 ± 0.03
0.721HisArg: 0.721 ± 0.038
1.256HisSer: 1.256 ± 0.046
0.924HisThr: 0.924 ± 0.044
0.93HisVal: 0.93 ± 0.047
0.2HisTrp: 0.2 ± 0.019
0.656HisTyr: 0.656 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
5.856IleAla: 5.856 ± 0.124
0.59IleCys: 0.59 ± 0.034
5.069IleAsp: 5.069 ± 0.102
5.911IleGlu: 5.911 ± 0.115
3.449IlePhe: 3.449 ± 0.08
6.17IleGly: 6.17 ± 0.107
1.338IleHis: 1.338 ± 0.059
6.258IleIle: 6.258 ± 0.122
5.187IleLys: 5.187 ± 0.102
7.478IleLeu: 7.478 ± 0.142
1.594IleMet: 1.594 ± 0.064
3.483IleAsn: 3.483 ± 0.092
3.455IlePro: 3.455 ± 0.085
2.01IleGln: 2.01 ± 0.068
3.767IleArg: 3.767 ± 0.094
6.767IleSer: 6.767 ± 0.129
4.317IleThr: 4.317 ± 0.103
5.089IleVal: 5.089 ± 0.103
0.795IleTrp: 0.795 ± 0.046
2.756IleTyr: 2.756 ± 0.08
0.0IleXaa: 0.0 ± 0.0
Lys
4.094LysAla: 4.094 ± 0.114
0.337LysCys: 0.337 ± 0.025
3.426LysAsp: 3.426 ± 0.087
5.441LysGlu: 5.441 ± 0.128
2.762LysPhe: 2.762 ± 0.069
4.051LysGly: 4.051 ± 0.117
1.087LysHis: 1.087 ± 0.04
6.048LysIle: 6.048 ± 0.12
5.271LysLys: 5.271 ± 0.153
6.091LysLeu: 6.091 ± 0.112
1.902LysMet: 1.902 ± 0.064
3.275LysAsn: 3.275 ± 0.083
2.309LysPro: 2.309 ± 0.068
1.618LysGln: 1.618 ± 0.056
3.294LysArg: 3.294 ± 0.083
4.799LysSer: 4.799 ± 0.11
3.157LysThr: 3.157 ± 0.07
4.021LysVal: 4.021 ± 0.097
0.607LysTrp: 0.607 ± 0.037
2.464LysTyr: 2.464 ± 0.078
0.0LysXaa: 0.0 ± 0.0
Leu
6.405LeuAla: 6.405 ± 0.14
0.484LeuCys: 0.484 ± 0.035
5.13LeuAsp: 5.13 ± 0.105
6.387LeuGlu: 6.387 ± 0.127
4.716LeuPhe: 4.716 ± 0.125
6.515LeuGly: 6.515 ± 0.12
1.504LeuHis: 1.504 ± 0.049
7.905LeuIle: 7.905 ± 0.138
6.94LeuLys: 6.94 ± 0.15
9.88LeuLeu: 9.88 ± 0.19
2.431LeuMet: 2.431 ± 0.071
4.946LeuAsn: 4.946 ± 0.102
3.945LeuPro: 3.945 ± 0.095
2.599LeuGln: 2.599 ± 0.077
4.619LeuArg: 4.619 ± 0.091
8.344LeuSer: 8.344 ± 0.144
5.678LeuThr: 5.678 ± 0.112
5.316LeuVal: 5.316 ± 0.107
0.876LeuTrp: 0.876 ± 0.051
2.971LeuTyr: 2.971 ± 0.085
0.0LeuXaa: 0.0 ± 0.0
Met
1.749MetAla: 1.749 ± 0.068
0.127MetCys: 0.127 ± 0.019
1.263MetAsp: 1.263 ± 0.055
1.706MetGlu: 1.706 ± 0.053
0.932MetPhe: 0.932 ± 0.05
1.908MetGly: 1.908 ± 0.065
0.374MetHis: 0.374 ± 0.027
1.982MetIle: 1.982 ± 0.068
2.029MetLys: 2.029 ± 0.066
2.392MetLeu: 2.392 ± 0.098
0.738MetMet: 0.738 ± 0.05
1.477MetAsn: 1.477 ± 0.051
1.015MetPro: 1.015 ± 0.043
0.611MetGln: 0.611 ± 0.034
1.205MetArg: 1.205 ± 0.047
1.694MetSer: 1.694 ± 0.062
1.467MetThr: 1.467 ± 0.056
1.543MetVal: 1.543 ± 0.057
0.194MetTrp: 0.194 ± 0.016
0.562MetTyr: 0.562 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
2.597AsnAla: 2.597 ± 0.08
0.302AsnCys: 0.302 ± 0.027
2.605AsnAsp: 2.605 ± 0.084
3.069AsnGlu: 3.069 ± 0.084
2.17AsnPhe: 2.17 ± 0.072
3.242AsnGly: 3.242 ± 0.095
0.746AsnHis: 0.746 ± 0.037
4.047AsnIle: 4.047 ± 0.099
2.666AsnLys: 2.666 ± 0.079
4.818AsnLeu: 4.818 ± 0.097
1.185AsnMet: 1.185 ± 0.042
2.082AsnAsn: 2.082 ± 0.075
2.278AsnPro: 2.278 ± 0.071
1.081AsnGln: 1.081 ± 0.051
2.352AsnArg: 2.352 ± 0.079
3.575AsnSer: 3.575 ± 0.106
1.941AsnThr: 1.941 ± 0.064
2.954AsnVal: 2.954 ± 0.074
0.558AsnTrp: 0.558 ± 0.037
1.71AsnTyr: 1.71 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
2.27ProAla: 2.27 ± 0.073
0.168ProCys: 0.168 ± 0.017
2.591ProAsp: 2.591 ± 0.073
3.402ProGlu: 3.402 ± 0.082
1.845ProPhe: 1.845 ± 0.065
2.672ProGly: 2.672 ± 0.082
0.64ProHis: 0.64 ± 0.04
2.762ProIle: 2.762 ± 0.086
1.914ProLys: 1.914 ± 0.055
3.541ProLeu: 3.541 ± 0.088
0.864ProMet: 0.864 ± 0.038
1.702ProAsn: 1.702 ± 0.056
1.299ProPro: 1.299 ± 0.059
0.879ProGln: 0.879 ± 0.039
1.351ProArg: 1.351 ± 0.057
2.401ProSer: 2.401 ± 0.074
1.833ProThr: 1.833 ± 0.063
2.719ProVal: 2.719 ± 0.075
0.356ProTrp: 0.356 ± 0.025
1.175ProTyr: 1.175 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
1.628GlnAla: 1.628 ± 0.055
0.121GlnCys: 0.121 ± 0.016
1.136GlnAsp: 1.136 ± 0.04
1.686GlnGlu: 1.686 ± 0.053
1.222GlnPhe: 1.222 ± 0.052
1.504GlnGly: 1.504 ± 0.057
0.341GlnHis: 0.341 ± 0.023
2.066GlnIle: 2.066 ± 0.066
1.761GlnLys: 1.761 ± 0.053
2.632GlnLeu: 2.632 ± 0.072
0.713GlnMet: 0.713 ± 0.04
1.365GlnAsn: 1.365 ± 0.05
0.877GlnPro: 0.877 ± 0.044
0.733GlnGln: 0.733 ± 0.049
1.228GlnArg: 1.228 ± 0.052
1.737GlnSer: 1.737 ± 0.056
1.393GlnThr: 1.393 ± 0.06
1.508GlnVal: 1.508 ± 0.06
0.27GlnTrp: 0.27 ± 0.025
0.881GlnTyr: 0.881 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
2.948ArgAla: 2.948 ± 0.076
0.251ArgCys: 0.251 ± 0.023
2.472ArgAsp: 2.472 ± 0.077
3.463ArgGlu: 3.463 ± 0.094
2.215ArgPhe: 2.215 ± 0.07
3.024ArgGly: 3.024 ± 0.084
0.803ArgHis: 0.803 ± 0.045
3.876ArgIle: 3.876 ± 0.079
3.293ArgLys: 3.293 ± 0.081
4.624ArgLeu: 4.624 ± 0.108
1.257ArgMet: 1.257 ± 0.051
2.104ArgAsn: 2.104 ± 0.065
1.22ArgPro: 1.22 ± 0.054
1.214ArgGln: 1.214 ± 0.047
2.468ArgArg: 2.468 ± 0.087
3.057ArgSer: 3.057 ± 0.075
2.288ArgThr: 2.288 ± 0.068
2.997ArgVal: 2.997 ± 0.081
0.533ArgTrp: 0.533 ± 0.031
1.765ArgTyr: 1.765 ± 0.071
0.0ArgXaa: 0.0 ± 0.0
Ser
5.134SerAla: 5.134 ± 0.087
0.447SerCys: 0.447 ± 0.03
4.785SerAsp: 4.785 ± 0.102
5.59SerGlu: 5.59 ± 0.112
3.396SerPhe: 3.396 ± 0.096
6.088SerGly: 6.088 ± 0.127
1.138SerHis: 1.138 ± 0.048
5.766SerIle: 5.766 ± 0.108
4.581SerLys: 4.581 ± 0.113
7.184SerLeu: 7.184 ± 0.114
1.735SerMet: 1.735 ± 0.062
3.226SerAsn: 3.226 ± 0.089
2.644SerPro: 2.644 ± 0.087
1.757SerGln: 1.757 ± 0.054
3.036SerArg: 3.036 ± 0.079
5.635SerSer: 5.635 ± 0.117
3.645SerThr: 3.645 ± 0.089
5.034SerVal: 5.034 ± 0.112
0.881SerTrp: 0.881 ± 0.047
2.476SerTyr: 2.476 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
3.639ThrAla: 3.639 ± 0.081
0.311ThrCys: 0.311 ± 0.025
3.486ThrAsp: 3.486 ± 0.105
3.383ThrGlu: 3.383 ± 0.094
2.466ThrPhe: 2.466 ± 0.071
4.601ThrGly: 4.601 ± 0.106
0.889ThrHis: 0.889 ± 0.05
4.113ThrIle: 4.113 ± 0.095
2.783ThrLys: 2.783 ± 0.076
5.408ThrLeu: 5.408 ± 0.103
1.091ThrMet: 1.091 ± 0.047
2.119ThrAsn: 2.119 ± 0.061
2.192ThrPro: 2.192 ± 0.07
1.271ThrGln: 1.271 ± 0.044
1.992ThrArg: 1.992 ± 0.063
3.218ThrSer: 3.218 ± 0.093
2.985ThrThr: 2.985 ± 0.094
3.612ThrVal: 3.612 ± 0.082
0.515ThrTrp: 0.515 ± 0.037
1.653ThrTyr: 1.653 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
4.382ValAla: 4.382 ± 0.1
0.464ValCys: 0.464 ± 0.034
4.035ValAsp: 4.035 ± 0.101
4.583ValGlu: 4.583 ± 0.092
2.648ValPhe: 2.648 ± 0.079
4.691ValGly: 4.691 ± 0.104
1.054ValHis: 1.054 ± 0.052
5.469ValIle: 5.469 ± 0.125
4.186ValLys: 4.186 ± 0.089
5.664ValLeu: 5.664 ± 0.125
1.455ValMet: 1.455 ± 0.052
2.897ValAsn: 2.897 ± 0.077
2.327ValPro: 2.327 ± 0.067
1.618ValGln: 1.618 ± 0.054
3.036ValArg: 3.036 ± 0.076
4.728ValSer: 4.728 ± 0.103
3.77ValThr: 3.77 ± 0.087
4.456ValVal: 4.456 ± 0.119
0.66ValTrp: 0.66 ± 0.042
2.213ValTyr: 2.213 ± 0.068
0.0ValXaa: 0.0 ± 0.0
Trp
0.695TrpAla: 0.695 ± 0.041
0.071TrpCys: 0.071 ± 0.013
0.687TrpAsp: 0.687 ± 0.043
0.721TrpGlu: 0.721 ± 0.037
0.527TrpPhe: 0.527 ± 0.036
0.793TrpGly: 0.793 ± 0.052
0.262TrpHis: 0.262 ± 0.025
0.799TrpIle: 0.799 ± 0.041
0.707TrpLys: 0.707 ± 0.041
0.985TrpLeu: 0.985 ± 0.05
0.311TrpMet: 0.311 ± 0.023
0.662TrpAsn: 0.662 ± 0.035
0.235TrpPro: 0.235 ± 0.027
0.255TrpGln: 0.255 ± 0.022
0.494TrpArg: 0.494 ± 0.033
0.754TrpSer: 0.754 ± 0.046
0.564TrpThr: 0.564 ± 0.036
0.65TrpVal: 0.65 ± 0.039
0.145TrpTrp: 0.145 ± 0.017
0.335TrpTyr: 0.335 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.166TyrAla: 2.166 ± 0.068
0.215TyrCys: 0.215 ± 0.021
2.378TyrAsp: 2.378 ± 0.077
2.223TyrGlu: 2.223 ± 0.076
1.914TyrPhe: 1.914 ± 0.062
2.484TyrGly: 2.484 ± 0.086
0.748TyrHis: 0.748 ± 0.041
2.272TyrIle: 2.272 ± 0.062
2.102TyrLys: 2.102 ± 0.069
3.678TyrLeu: 3.678 ± 0.099
0.713TyrMet: 0.713 ± 0.036
1.451TyrAsn: 1.451 ± 0.065
1.412TyrPro: 1.412 ± 0.048
0.938TyrGln: 0.938 ± 0.04
1.718TyrArg: 1.718 ± 0.062
2.844TyrSer: 2.844 ± 0.073
1.645TyrThr: 1.645 ± 0.058
1.827TyrVal: 1.827 ± 0.06
0.452TyrTrp: 0.452 ± 0.032
1.489TyrTyr: 1.489 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1570 proteins (510553 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski