Amino acid dipepetide frequency for Carsonella ruddii (strain PV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.581AlaAla: 0.581 ± 0.114
0.12AlaCys: 0.12 ± 0.038
0.441AlaAsp: 0.441 ± 0.106
0.621AlaGlu: 0.621 ± 0.164
0.621AlaPhe: 0.621 ± 0.101
1.162AlaGly: 1.162 ± 0.187
0.18AlaHis: 0.18 ± 0.059
2.003AlaIle: 2.003 ± 0.22
1.643AlaLys: 1.643 ± 0.165
1.502AlaLeu: 1.502 ± 0.251
0.24AlaMet: 0.24 ± 0.069
1.082AlaAsn: 1.082 ± 0.161
0.421AlaPro: 0.421 ± 0.105
0.381AlaGln: 0.381 ± 0.095
0.621AlaArg: 0.621 ± 0.121
1.102AlaSer: 1.102 ± 0.181
0.581AlaThr: 0.581 ± 0.105
0.741AlaVal: 0.741 ± 0.161
0.1AlaTrp: 0.1 ± 0.036
0.641AlaTyr: 0.641 ± 0.116
0.0AlaXaa: 0.0 ± 0.0
Cys
0.22CysAla: 0.22 ± 0.059
0.32CysCys: 0.32 ± 0.084
0.381CysAsp: 0.381 ± 0.093
0.561CysGlu: 0.561 ± 0.109
1.843CysPhe: 1.843 ± 0.182
0.761CysGly: 0.761 ± 0.126
0.16CysHis: 0.16 ± 0.052
2.123CysIle: 2.123 ± 0.232
1.943CysLys: 1.943 ± 0.2
2.043CysLeu: 2.043 ± 0.192
0.22CysMet: 0.22 ± 0.064
1.663CysAsn: 1.663 ± 0.173
0.3CysPro: 0.3 ± 0.089
0.18CysGln: 0.18 ± 0.057
0.2CysArg: 0.2 ± 0.061
1.162CysSer: 1.162 ± 0.188
0.381CysThr: 0.381 ± 0.093
0.661CysVal: 0.661 ± 0.107
0.1CysTrp: 0.1 ± 0.039
1.102CysTyr: 1.102 ± 0.16
0.0CysXaa: 0.0 ± 0.0
Asp
0.621AspAla: 0.621 ± 0.154
0.561AspCys: 0.561 ± 0.112
0.541AspAsp: 0.541 ± 0.101
0.982AspGlu: 0.982 ± 0.165
2.844AspPhe: 2.844 ± 0.205
0.881AspGly: 0.881 ± 0.149
0.22AspHis: 0.22 ± 0.07
3.726AspIle: 3.726 ± 0.311
2.905AspLys: 2.905 ± 0.233
2.945AspLeu: 2.945 ± 0.259
0.461AspMet: 0.461 ± 0.094
2.364AspAsn: 2.364 ± 0.233
0.641AspPro: 0.641 ± 0.135
0.581AspGln: 0.581 ± 0.124
0.461AspArg: 0.461 ± 0.087
1.542AspSer: 1.542 ± 0.203
0.881AspThr: 0.881 ± 0.124
1.122AspVal: 1.122 ± 0.151
0.14AspTrp: 0.14 ± 0.049
1.783AspTyr: 1.783 ± 0.186
0.0AspXaa: 0.0 ± 0.0
Glu
0.781GluAla: 0.781 ± 0.157
0.581GluCys: 0.581 ± 0.108
0.701GluAsp: 0.701 ± 0.143
1.242GluGlu: 1.242 ± 0.17
2.304GluPhe: 2.304 ± 0.194
0.941GluGly: 0.941 ± 0.173
0.401GluHis: 0.401 ± 0.094
5.388GluIle: 5.388 ± 0.404
4.427GluLys: 4.427 ± 0.298
3.826GluLeu: 3.826 ± 0.309
0.721GluMet: 0.721 ± 0.149
3.966GluAsn: 3.966 ± 0.266
0.581GluPro: 0.581 ± 0.134
0.621GluGln: 0.621 ± 0.134
0.921GluArg: 0.921 ± 0.141
1.903GluSer: 1.903 ± 0.171
1.162GluThr: 1.162 ± 0.167
1.182GluVal: 1.182 ± 0.187
0.1GluTrp: 0.1 ± 0.045
1.522GluTyr: 1.522 ± 0.203
0.0GluXaa: 0.0 ± 0.0
Phe
0.681PheAla: 0.681 ± 0.139
2.043PheCys: 2.043 ± 0.23
2.564PheAsp: 2.564 ± 0.255
2.744PheGlu: 2.744 ± 0.25
12.299PhePhe: 12.299 ± 0.801
2.504PheGly: 2.504 ± 0.189
0.761PheHis: 0.761 ± 0.122
10.436PheIle: 10.436 ± 0.55
11.939PheLys: 11.939 ± 0.522
11.778PheLeu: 11.778 ± 0.666
0.481PheMet: 0.481 ± 0.095
9.495PheAsn: 9.495 ± 0.467
1.442PhePro: 1.442 ± 0.189
1.262PheGln: 1.262 ± 0.188
1.322PheArg: 1.322 ± 0.159
5.889PheSer: 5.889 ± 0.331
2.203PheThr: 2.203 ± 0.222
2.844PheVal: 2.844 ± 0.259
0.421PheTrp: 0.421 ± 0.102
6.831PheTyr: 6.831 ± 0.399
0.0PheXaa: 0.0 ± 0.0
Gly
1.062GlyAla: 1.062 ± 0.167
0.821GlyCys: 0.821 ± 0.15
1.382GlyAsp: 1.382 ± 0.201
1.763GlyGlu: 1.763 ± 0.218
2.324GlyPhe: 2.324 ± 0.212
2.965GlyGly: 2.965 ± 0.336
0.741GlyHis: 0.741 ± 0.144
6.11GlyIle: 6.11 ± 0.402
3.445GlyLys: 3.445 ± 0.328
2.664GlyLeu: 2.664 ± 0.243
0.601GlyMet: 0.601 ± 0.136
2.444GlyAsn: 2.444 ± 0.254
0.781GlyPro: 0.781 ± 0.141
0.982GlyGln: 0.982 ± 0.146
1.162GlyArg: 1.162 ± 0.167
2.484GlySer: 2.484 ± 0.242
1.602GlyThr: 1.602 ± 0.175
1.522GlyVal: 1.522 ± 0.224
0.22GlyTrp: 0.22 ± 0.07
1.903GlyTyr: 1.903 ± 0.233
0.0GlyXaa: 0.0 ± 0.0
His
0.32HisAla: 0.32 ± 0.08
0.24HisCys: 0.24 ± 0.067
0.28HisAsp: 0.28 ± 0.072
0.22HisGlu: 0.22 ± 0.066
0.681HisPhe: 0.681 ± 0.124
0.621HisGly: 0.621 ± 0.122
0.22HisHis: 0.22 ± 0.073
1.362HisIle: 1.362 ± 0.167
0.881HisLys: 0.881 ± 0.126
1.082HisLeu: 1.082 ± 0.137
0.12HisMet: 0.12 ± 0.048
1.142HisAsn: 1.142 ± 0.185
0.28HisPro: 0.28 ± 0.075
0.2HisGln: 0.2 ± 0.061
0.24HisArg: 0.24 ± 0.067
0.841HisSer: 0.841 ± 0.121
0.621HisThr: 0.621 ± 0.104
0.501HisVal: 0.501 ± 0.12
0.04HisTrp: 0.04 ± 0.024
0.641HisTyr: 0.641 ± 0.109
0.0HisXaa: 0.0 ± 0.0
Ile
2.544IleAla: 2.544 ± 0.252
2.364IleCys: 2.364 ± 0.206
4.727IleAsp: 4.727 ± 0.318
5.388IleGlu: 5.388 ± 0.371
12.88IlePhe: 12.88 ± 0.623
6.069IleGly: 6.069 ± 0.378
1.462IleHis: 1.462 ± 0.154
22.074IleIle: 22.074 ± 0.682
23.837IleLys: 23.837 ± 0.99
16.325IleLeu: 16.325 ± 0.538
1.843IleMet: 1.843 ± 0.187
19.691IleAsn: 19.691 ± 0.696
2.684IlePro: 2.684 ± 0.211
2.003IleGln: 2.003 ± 0.181
2.784IleArg: 2.784 ± 0.236
11.258IleSer: 11.258 ± 0.492
4.647IleThr: 4.647 ± 0.297
4.767IleVal: 4.767 ± 0.276
0.561IleTrp: 0.561 ± 0.109
7.311IleTyr: 7.311 ± 0.343
0.0IleXaa: 0.0 ± 0.0
Lys
1.102LysAla: 1.102 ± 0.177
1.623LysCys: 1.623 ± 0.177
2.404LysAsp: 2.404 ± 0.293
3.345LysGlu: 3.345 ± 0.247
9.655LysPhe: 9.655 ± 0.473
2.364LysGly: 2.364 ± 0.25
1.502LysHis: 1.502 ± 0.176
28.845LysIle: 28.845 ± 1.151
34.193LysLys: 34.193 ± 1.46
10.336LysLeu: 10.336 ± 0.476
2.123LysMet: 2.123 ± 0.203
22.195LysAsn: 22.195 ± 0.932
1.643LysPro: 1.643 ± 0.172
2.264LysGln: 2.264 ± 0.2
2.264LysArg: 2.264 ± 0.225
6.089LysSer: 6.089 ± 0.334
5.028LysThr: 5.028 ± 0.318
3.566LysVal: 3.566 ± 0.298
0.561LysTrp: 0.561 ± 0.106
6.871LysTyr: 6.871 ± 0.425
0.0LysXaa: 0.0 ± 0.0
Leu
1.202LeuAla: 1.202 ± 0.185
1.362LeuCys: 1.362 ± 0.14
2.744LeuAsp: 2.744 ± 0.233
3.846LeuGlu: 3.846 ± 0.272
8.774LeuPhe: 8.774 ± 0.456
3.465LeuGly: 3.465 ± 0.286
1.102LeuHis: 1.102 ± 0.126
17.267LeuIle: 17.267 ± 0.616
15.003LeuLys: 15.003 ± 0.669
9.715LeuLeu: 9.715 ± 0.512
1.422LeuMet: 1.422 ± 0.151
13.421LeuAsn: 13.421 ± 0.63
1.943LeuPro: 1.943 ± 0.19
1.122LeuGln: 1.122 ± 0.158
1.803LeuArg: 1.803 ± 0.162
6.831LeuSer: 6.831 ± 0.413
2.864LeuThr: 2.864 ± 0.243
2.824LeuVal: 2.824 ± 0.234
0.28LeuTrp: 0.28 ± 0.072
4.347LeuTyr: 4.347 ± 0.302
0.0LeuXaa: 0.0 ± 0.0
Met
0.28MetAla: 0.28 ± 0.079
0.16MetCys: 0.16 ± 0.05
0.18MetAsp: 0.18 ± 0.054
0.401MetGlu: 0.401 ± 0.103
1.282MetPhe: 1.282 ± 0.162
0.561MetGly: 0.561 ± 0.11
0.18MetHis: 0.18 ± 0.056
2.123MetIle: 2.123 ± 0.201
1.623MetLys: 1.623 ± 0.188
1.242MetLeu: 1.242 ± 0.192
0.2MetMet: 0.2 ± 0.07
1.482MetAsn: 1.482 ± 0.15
0.22MetPro: 0.22 ± 0.086
0.18MetGln: 0.18 ± 0.06
0.14MetArg: 0.14 ± 0.055
0.721MetSer: 0.721 ± 0.127
0.381MetThr: 0.381 ± 0.087
0.26MetVal: 0.26 ± 0.077
0.06MetTrp: 0.06 ± 0.035
0.701MetTyr: 0.701 ± 0.102
0.0MetXaa: 0.0 ± 0.0
Asn
1.002AsnAla: 1.002 ± 0.145
2.103AsnCys: 2.103 ± 0.198
2.884AsnAsp: 2.884 ± 0.284
3.626AsnGlu: 3.626 ± 0.246
14.062AsnPhe: 14.062 ± 0.674
2.624AsnGly: 2.624 ± 0.285
0.982AsnHis: 0.982 ± 0.163
18.148AsnIle: 18.148 ± 0.737
16.366AsnLys: 16.366 ± 0.633
12.7AsnLeu: 12.7 ± 0.68
1.082AsnMet: 1.082 ± 0.114
14.202AsnAsn: 14.202 ± 0.708
1.182AsnPro: 1.182 ± 0.167
1.442AsnGln: 1.442 ± 0.167
1.763AsnArg: 1.763 ± 0.194
7.452AsnSer: 7.452 ± 0.423
2.744AsnThr: 2.744 ± 0.219
3.906AsnVal: 3.906 ± 0.241
0.761AsnTrp: 0.761 ± 0.135
8.734AsnTyr: 8.734 ± 0.54
0.0AsnXaa: 0.0 ± 0.0
Pro
0.421ProAla: 0.421 ± 0.123
0.441ProCys: 0.441 ± 0.081
0.421ProAsp: 0.421 ± 0.08
0.661ProGlu: 0.661 ± 0.127
1.082ProPhe: 1.082 ± 0.152
1.062ProGly: 1.062 ± 0.173
0.24ProHis: 0.24 ± 0.065
2.965ProIle: 2.965 ± 0.303
1.602ProLys: 1.602 ± 0.151
1.442ProLeu: 1.442 ± 0.179
0.22ProMet: 0.22 ± 0.064
1.242ProAsn: 1.242 ± 0.124
0.26ProPro: 0.26 ± 0.065
0.361ProGln: 0.361 ± 0.107
0.341ProArg: 0.341 ± 0.096
1.102ProSer: 1.102 ± 0.172
0.781ProThr: 0.781 ± 0.113
0.621ProVal: 0.621 ± 0.123
0.16ProTrp: 0.16 ± 0.058
0.781ProTyr: 0.781 ± 0.114
0.0ProXaa: 0.0 ± 0.0
Gln
0.381GlnAla: 0.381 ± 0.087
0.18GlnCys: 0.18 ± 0.062
0.341GlnAsp: 0.341 ± 0.083
0.621GlnGlu: 0.621 ± 0.149
0.841GlnPhe: 0.841 ± 0.127
0.541GlnGly: 0.541 ± 0.096
0.12GlnHis: 0.12 ± 0.047
2.764GlnIle: 2.764 ± 0.225
1.803GlnLys: 1.803 ± 0.181
1.242GlnLeu: 1.242 ± 0.183
0.28GlnMet: 0.28 ± 0.082
1.643GlnAsn: 1.643 ± 0.157
0.28GlnPro: 0.28 ± 0.094
0.32GlnGln: 0.32 ± 0.09
0.401GlnArg: 0.401 ± 0.093
0.941GlnSer: 0.941 ± 0.121
0.721GlnThr: 0.721 ± 0.14
0.621GlnVal: 0.621 ± 0.1
0.08GlnTrp: 0.08 ± 0.044
0.641GlnTyr: 0.641 ± 0.123
0.0GlnXaa: 0.0 ± 0.0
Arg
0.341ArgAla: 0.341 ± 0.08
0.28ArgCys: 0.28 ± 0.074
0.381ArgAsp: 0.381 ± 0.083
0.941ArgGlu: 0.941 ± 0.181
1.342ArgPhe: 1.342 ± 0.186
0.982ArgGly: 0.982 ± 0.174
0.22ArgHis: 0.22 ± 0.06
2.905ArgIle: 2.905 ± 0.237
2.604ArgLys: 2.604 ± 0.221
1.763ArgLeu: 1.763 ± 0.199
0.3ArgMet: 0.3 ± 0.077
1.582ArgAsn: 1.582 ± 0.146
0.381ArgPro: 0.381 ± 0.087
0.461ArgGln: 0.461 ± 0.106
0.381ArgArg: 0.381 ± 0.085
1.342ArgSer: 1.342 ± 0.147
0.681ArgThr: 0.681 ± 0.122
0.861ArgVal: 0.861 ± 0.134
0.04ArgTrp: 0.04 ± 0.03
0.781ArgTyr: 0.781 ± 0.134
0.0ArgXaa: 0.0 ± 0.0
Ser
1.142SerAla: 1.142 ± 0.186
1.182SerCys: 1.182 ± 0.165
2.003SerAsp: 2.003 ± 0.184
1.783SerGlu: 1.783 ± 0.213
5.128SerPhe: 5.128 ± 0.355
3.505SerGly: 3.505 ± 0.32
0.881SerHis: 0.881 ± 0.121
10.436SerIle: 10.436 ± 0.496
7.191SerLys: 7.191 ± 0.397
6.53SerLeu: 6.53 ± 0.365
0.721SerMet: 0.721 ± 0.115
6.37SerAsn: 6.37 ± 0.356
1.122SerPro: 1.122 ± 0.17
0.881SerGln: 0.881 ± 0.124
1.442SerArg: 1.442 ± 0.185
4.367SerSer: 4.367 ± 0.335
2.604SerThr: 2.604 ± 0.252
2.324SerVal: 2.324 ± 0.213
0.24SerTrp: 0.24 ± 0.073
3.586SerTyr: 3.586 ± 0.283
0.0SerXaa: 0.0 ± 0.0
Thr
0.661ThrAla: 0.661 ± 0.135
0.341ThrCys: 0.341 ± 0.09
1.022ThrAsp: 1.022 ± 0.133
0.982ThrGlu: 0.982 ± 0.162
2.444ThrPhe: 2.444 ± 0.227
2.324ThrGly: 2.324 ± 0.241
0.481ThrHis: 0.481 ± 0.114
5.108ThrIle: 5.108 ± 0.35
3.886ThrLys: 3.886 ± 0.236
2.804ThrLeu: 2.804 ± 0.235
0.421ThrMet: 0.421 ± 0.094
3.245ThrAsn: 3.245 ± 0.301
0.661ThrPro: 0.661 ± 0.117
0.621ThrGln: 0.621 ± 0.12
0.761ThrArg: 0.761 ± 0.106
1.943ThrSer: 1.943 ± 0.228
1.442ThrThr: 1.442 ± 0.187
1.042ThrVal: 1.042 ± 0.131
0.18ThrTrp: 0.18 ± 0.061
1.402ThrTyr: 1.402 ± 0.171
0.0ThrXaa: 0.0 ± 0.0
Val
0.781ValAla: 0.781 ± 0.145
0.541ValCys: 0.541 ± 0.104
0.982ValAsp: 0.982 ± 0.186
1.502ValGlu: 1.502 ± 0.238
3.045ValPhe: 3.045 ± 0.238
1.683ValGly: 1.683 ± 0.257
0.381ValHis: 0.381 ± 0.079
3.586ValIle: 3.586 ± 0.253
4.387ValLys: 4.387 ± 0.268
4.026ValLeu: 4.026 ± 0.287
0.381ValMet: 0.381 ± 0.095
3.165ValAsn: 3.165 ± 0.263
0.601ValPro: 0.601 ± 0.116
0.401ValGln: 0.401 ± 0.106
0.601ValArg: 0.601 ± 0.106
2.223ValSer: 2.223 ± 0.234
0.861ValThr: 0.861 ± 0.145
1.082ValVal: 1.082 ± 0.172
0.22ValTrp: 0.22 ± 0.059
1.743ValTyr: 1.743 ± 0.191
0.0ValXaa: 0.0 ± 0.0
Trp
0.08TrpAla: 0.08 ± 0.037
0.06TrpCys: 0.06 ± 0.034
0.12TrpAsp: 0.12 ± 0.053
0.14TrpGlu: 0.14 ± 0.056
0.341TrpPhe: 0.341 ± 0.09
0.2TrpGly: 0.2 ± 0.056
0.04TrpHis: 0.04 ± 0.027
0.641TrpIle: 0.641 ± 0.133
0.601TrpLys: 0.601 ± 0.106
0.561TrpLeu: 0.561 ± 0.121
0.08TrpMet: 0.08 ± 0.043
0.621TrpAsn: 0.621 ± 0.11
0.02TrpPro: 0.02 ± 0.02
0.04TrpGln: 0.04 ± 0.031
0.14TrpArg: 0.14 ± 0.055
0.28TrpSer: 0.28 ± 0.077
0.14TrpThr: 0.14 ± 0.05
0.12TrpVal: 0.12 ± 0.048
0.04TrpTrp: 0.04 ± 0.032
0.361TrpTyr: 0.361 ± 0.074
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.581TyrAla: 0.581 ± 0.107
1.002TyrCys: 1.002 ± 0.119
1.703TyrAsp: 1.703 ± 0.183
1.903TyrGlu: 1.903 ± 0.191
6.15TyrPhe: 6.15 ± 0.436
1.763TyrGly: 1.763 ± 0.198
0.26TyrHis: 0.26 ± 0.063
7.211TyrIle: 7.211 ± 0.387
7.712TyrLys: 7.712 ± 0.393
6.811TyrLeu: 6.811 ± 0.333
0.441TyrMet: 0.441 ± 0.093
6.751TyrAsn: 6.751 ± 0.41
0.761TyrPro: 0.761 ± 0.125
0.461TyrGln: 0.461 ± 0.095
0.821TyrArg: 0.821 ± 0.118
3.966TyrSer: 3.966 ± 0.295
1.442TyrThr: 1.442 ± 0.16
1.623TyrVal: 1.623 ± 0.145
0.32TyrTrp: 0.32 ± 0.089
4.046TyrTyr: 4.046 ± 0.28
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 182 proteins (49923 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski