Amino acid dipepetide frequency for Paraburkholderia dinghuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.949AlaAla: 16.949 ± 0.168	1.368AlaCys: 1.368 ± 0.031	6.449AlaAsp: 6.449 ± 0.055	5.721AlaGlu: 5.721 ± 0.075	4.375AlaPhe: 4.375 ± 0.052	10.339AlaGly: 10.339 ± 0.091	2.85AlaHis: 2.85 ± 0.041	5.768AlaIle: 5.768 ± 0.074	3.652AlaLys: 3.652 ± 0.06	13.938AlaLeu: 13.938 ± 0.124	3.223AlaMet: 3.223 ± 0.042	3.495AlaAsn: 3.495 ± 0.048	5.877AlaPro: 5.877 ± 0.074	5.588AlaGln: 5.588 ± 0.071	9.082AlaArg: 9.082 ± 0.11	7.566AlaSer: 7.566 ± 0.092	6.479AlaThr: 6.479 ± 0.073	8.728AlaVal: 8.728 ± 0.085	1.797AlaTrp: 1.797 ± 0.034	2.603AlaTyr: 2.603 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.294CysAla: 1.294 ± 0.031	0.145CysCys: 0.145 ± 0.008	0.57CysAsp: 0.57 ± 0.019	0.522CysGlu: 0.522 ± 0.019	0.328CysPhe: 0.328 ± 0.015	0.997CysGly: 0.997 ± 0.024	0.285CysHis: 0.285 ± 0.012	0.42CysIle: 0.42 ± 0.016	0.226CysLys: 0.226 ± 0.011	0.78CysLeu: 0.78 ± 0.023	0.206CysMet: 0.206 ± 0.011	0.266CysAsn: 0.266 ± 0.012	0.484CysPro: 0.484 ± 0.015	0.224CysGln: 0.224 ± 0.011	0.599CysArg: 0.599 ± 0.018	0.541CysSer: 0.541 ± 0.018	0.48CysThr: 0.48 ± 0.019	0.85CysVal: 0.85 ± 0.023	0.12CysTrp: 0.12 ± 0.009	0.23CysTyr: 0.23 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.844AspAla: 7.844 ± 0.081	0.498AspCys: 0.498 ± 0.018	3.178AspAsp: 3.178 ± 0.053	3.519AspGlu: 3.519 ± 0.051	1.992AspPhe: 1.992 ± 0.039	4.507AspGly: 4.507 ± 0.055	1.165AspHis: 1.165 ± 0.028	2.516AspIle: 2.516 ± 0.039	1.536AspLys: 1.536 ± 0.035	5.15AspLeu: 5.15 ± 0.06	1.164AspMet: 1.164 ± 0.028	1.339AspAsn: 1.339 ± 0.034	2.982AspPro: 2.982 ± 0.051	1.641AspGln: 1.641 ± 0.034	3.243AspArg: 3.243 ± 0.053	2.439AspSer: 2.439 ± 0.04	2.908AspThr: 2.908 ± 0.043	4.457AspVal: 4.457 ± 0.053	0.933AspTrp: 0.933 ± 0.026	1.556AspTyr: 1.556 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.577GluAla: 6.577 ± 0.084	0.409GluCys: 0.409 ± 0.018	2.124GluAsp: 2.124 ± 0.036	2.417GluGlu: 2.417 ± 0.047	1.758GluPhe: 1.758 ± 0.034	3.498GluGly: 3.498 ± 0.042	1.473GluHis: 1.473 ± 0.036	2.83GluIle: 2.83 ± 0.052	1.8GluLys: 1.8 ± 0.033	5.294GluLeu: 5.294 ± 0.075	1.258GluMet: 1.258 ± 0.029	1.469GluAsn: 1.469 ± 0.028	2.494GluPro: 2.494 ± 0.042	2.369GluGln: 2.369 ± 0.041	4.797GluArg: 4.797 ± 0.066	2.743GluSer: 2.743 ± 0.042	2.914GluThr: 2.914 ± 0.042	3.585GluVal: 3.585 ± 0.055	0.705GluTrp: 0.705 ± 0.02	1.201GluTyr: 1.201 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.792PheAla: 4.792 ± 0.06	0.413PheCys: 0.413 ± 0.016	2.616PheAsp: 2.616 ± 0.04	2.1PheGlu: 2.1 ± 0.036	1.422PhePhe: 1.422 ± 0.034	3.647PheGly: 3.647 ± 0.049	0.783PheHis: 0.783 ± 0.023	1.601PheIle: 1.601 ± 0.04	0.97PheLys: 0.97 ± 0.026	2.969PheLeu: 2.969 ± 0.045	0.783PheMet: 0.783 ± 0.023	1.18PheAsn: 1.18 ± 0.031	1.56PhePro: 1.56 ± 0.033	0.993PheGln: 0.993 ± 0.026	2.035PheArg: 2.035 ± 0.039	2.261PheSer: 2.261 ± 0.039	2.027PheThr: 2.027 ± 0.034	3.183PheVal: 3.183 ± 0.044	0.5PheTrp: 0.5 ± 0.018	0.984PheTyr: 0.984 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	9.425GlyAla: 9.425 ± 0.074	0.888GlyCys: 0.888 ± 0.026	4.064GlyAsp: 4.064 ± 0.053	4.474GlyGlu: 4.474 ± 0.054	3.349GlyPhe: 3.349 ± 0.041	6.991GlyGly: 6.991 ± 0.123	1.971GlyHis: 1.971 ± 0.034	4.253GlyIle: 4.253 ± 0.05	3.182GlyLys: 3.182 ± 0.044	7.829GlyLeu: 7.829 ± 0.083	2.175GlyMet: 2.175 ± 0.036	2.481GlyAsn: 2.481 ± 0.047	2.894GlyPro: 2.894 ± 0.041	2.836GlyGln: 2.836 ± 0.046	5.076GlyArg: 5.076 ± 0.06	4.61GlySer: 4.61 ± 0.073	4.94GlyThr: 4.94 ± 0.082	6.862GlyVal: 6.862 ± 0.064	1.345GlyTrp: 1.345 ± 0.032	2.404GlyTyr: 2.404 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	3.068HisAla: 3.068 ± 0.046	0.275HisCys: 0.275 ± 0.013	1.419HisAsp: 1.419 ± 0.028	1.254HisGlu: 1.254 ± 0.027	0.943HisPhe: 0.943 ± 0.029	2.195HisGly: 2.195 ± 0.04	0.666HisHis: 0.666 ± 0.023	0.965HisIle: 0.965 ± 0.023	0.521HisLys: 0.521 ± 0.019	2.13HisLeu: 2.13 ± 0.037	0.522HisMet: 0.522 ± 0.018	0.577HisAsn: 0.577 ± 0.019	1.439HisPro: 1.439 ± 0.031	0.678HisGln: 0.678 ± 0.017	1.535HisArg: 1.535 ± 0.034	1.07HisSer: 1.07 ± 0.026	1.13HisThr: 1.13 ± 0.025	1.763HisVal: 1.763 ± 0.024	0.426HisTrp: 0.426 ± 0.015	0.712HisTyr: 0.712 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.961IleAla: 6.961 ± 0.072	0.458IleCys: 0.458 ± 0.016	3.517IleAsp: 3.517 ± 0.047	3.305IleGlu: 3.305 ± 0.044	1.488IlePhe: 1.488 ± 0.039	4.73IleGly: 4.73 ± 0.058	0.933IleHis: 0.933 ± 0.024	1.622IleIle: 1.622 ± 0.033	1.363IleLys: 1.363 ± 0.032	3.332IleLeu: 3.332 ± 0.048	0.745IleMet: 0.745 ± 0.021	1.422IleAsn: 1.422 ± 0.03	2.117IlePro: 2.117 ± 0.039	1.259IleGln: 1.259 ± 0.028	2.789IleArg: 2.789 ± 0.045	2.58IleSer: 2.58 ± 0.046	2.484IleThr: 2.484 ± 0.038	4.409IleVal: 4.409 ± 0.055	0.541IleTrp: 0.541 ± 0.02	1.053IleTyr: 1.053 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.414LysAla: 3.414 ± 0.052	0.177LysCys: 0.177 ± 0.01	1.498LysAsp: 1.498 ± 0.039	1.429LysGlu: 1.429 ± 0.031	0.911LysPhe: 0.911 ± 0.023	2.164LysGly: 2.164 ± 0.038	0.695LysHis: 0.695 ± 0.022	1.649LysIle: 1.649 ± 0.033	1.208LysLys: 1.208 ± 0.038	3.313LysLeu: 3.313 ± 0.043	0.786LysMet: 0.786 ± 0.027	0.913LysAsn: 0.913 ± 0.026	1.958LysPro: 1.958 ± 0.035	1.208LysGln: 1.208 ± 0.032	2.341LysArg: 2.341 ± 0.042	1.778LysSer: 1.778 ± 0.032	1.839LysThr: 1.839 ± 0.039	2.246LysVal: 2.246 ± 0.04	0.377LysTrp: 0.377 ± 0.016	0.669LysTyr: 0.669 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.822LeuAla: 13.822 ± 0.102	1.019LeuCys: 1.019 ± 0.024	6.091LeuAsp: 6.091 ± 0.07	4.873LeuGlu: 4.873 ± 0.065	3.531LeuPhe: 3.531 ± 0.051	7.747LeuGly: 7.747 ± 0.08	2.234LeuHis: 2.234 ± 0.042	4.642LeuIle: 4.642 ± 0.059	3.275LeuLys: 3.275 ± 0.046	9.562LeuLeu: 9.562 ± 0.103	2.264LeuMet: 2.264 ± 0.039	2.843LeuAsn: 2.843 ± 0.043	5.605LeuPro: 5.605 ± 0.064	3.209LeuGln: 3.209 ± 0.043	7.019LeuArg: 7.019 ± 0.082	6.146LeuSer: 6.146 ± 0.12	5.59LeuThr: 5.59 ± 0.062	7.488LeuVal: 7.488 ± 0.073	1.133LeuTrp: 1.133 ± 0.028	2.239LeuTyr: 2.239 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.449MetAla: 2.449 ± 0.035	0.191MetCys: 0.191 ± 0.01	0.962MetAsp: 0.962 ± 0.025	0.954MetGlu: 0.954 ± 0.025	0.781MetPhe: 0.781 ± 0.024	1.595MetGly: 1.595 ± 0.033	0.595MetHis: 0.595 ± 0.017	1.124MetIle: 1.124 ± 0.028	1.055MetLys: 1.055 ± 0.025	2.63MetLeu: 2.63 ± 0.044	0.601MetMet: 0.601 ± 0.019	0.923MetAsn: 0.923 ± 0.023	1.458MetPro: 1.458 ± 0.031	1.005MetGln: 1.005 ± 0.025	1.779MetArg: 1.779 ± 0.032	1.714MetSer: 1.714 ± 0.033	1.597MetThr: 1.597 ± 0.03	1.507MetVal: 1.507 ± 0.033	0.236MetTrp: 0.236 ± 0.013	0.406MetTyr: 0.406 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.778AsnAla: 3.778 ± 0.049	0.267AsnCys: 0.267 ± 0.014	1.485AsnAsp: 1.485 ± 0.029	1.41AsnGlu: 1.41 ± 0.032	1.011AsnPhe: 1.011 ± 0.026	2.706AsnGly: 2.706 ± 0.047	0.579AsnHis: 0.579 ± 0.021	1.297AsnIle: 1.297 ± 0.032	0.701AsnLys: 0.701 ± 0.021	2.802AsnLeu: 2.802 ± 0.043	0.623AsnMet: 0.623 ± 0.019	0.9AsnAsn: 0.9 ± 0.031	1.881AsnPro: 1.881 ± 0.038	1.006AsnGln: 1.006 ± 0.024	1.857AsnArg: 1.857 ± 0.033	1.485AsnSer: 1.485 ± 0.048	1.604AsnThr: 1.604 ± 0.037	2.43AsnVal: 2.43 ± 0.044	0.439AsnTrp: 0.439 ± 0.017	0.75AsnTyr: 0.75 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.468ProAla: 6.468 ± 0.067	0.377ProCys: 0.377 ± 0.014	3.382ProAsp: 3.382 ± 0.056	3.062ProGlu: 3.062 ± 0.05	1.915ProPhe: 1.915 ± 0.034	4.413ProGly: 4.413 ± 0.048	1.291ProHis: 1.291 ± 0.028	1.956ProIle: 1.956 ± 0.04	1.39ProLys: 1.39 ± 0.034	5.119ProLeu: 5.119 ± 0.066	1.146ProMet: 1.146 ± 0.027	1.396ProAsn: 1.396 ± 0.029	2.462ProPro: 2.462 ± 0.049	2.039ProGln: 2.039 ± 0.041	2.893ProArg: 2.893 ± 0.049	2.69ProSer: 2.69 ± 0.048	2.531ProThr: 2.531 ± 0.046	4.473ProVal: 4.473 ± 0.057	0.67ProTrp: 0.67 ± 0.02	1.222ProTyr: 1.222 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.212GlnAla: 4.212 ± 0.06	0.293GlnCys: 0.293 ± 0.013	1.404GlnAsp: 1.404 ± 0.03	1.341GlnGlu: 1.341 ± 0.029	1.395GlnPhe: 1.395 ± 0.033	2.534GlnGly: 2.534 ± 0.047	0.935GlnHis: 0.935 ± 0.024	2.047GlnIle: 2.047 ± 0.033	1.172GlnLys: 1.172 ± 0.032	3.754GlnLeu: 3.754 ± 0.056	1.057GlnMet: 1.057 ± 0.025	1.028GlnAsn: 1.028 ± 0.029	2.095GlnPro: 2.095 ± 0.043	1.892GlnGln: 1.892 ± 0.04	2.934GlnArg: 2.934 ± 0.043	2.157GlnSer: 2.157 ± 0.04	2.093GlnThr: 2.093 ± 0.039	2.485GlnVal: 2.485 ± 0.046	0.555GlnTrp: 0.555 ± 0.021	0.997GlnTyr: 0.997 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.265ArgAla: 8.265 ± 0.087	0.609ArgCys: 0.609 ± 0.018	3.895ArgAsp: 3.895 ± 0.056	4.327ArgGlu: 4.327 ± 0.064	2.984ArgPhe: 2.984 ± 0.047	4.659ArgGly: 4.659 ± 0.059	1.86ArgHis: 1.86 ± 0.036	3.527ArgIle: 3.527 ± 0.04	2.019ArgLys: 2.019 ± 0.044	7.016ArgLeu: 7.016 ± 0.089	1.762ArgMet: 1.762 ± 0.034	1.972ArgAsn: 1.972 ± 0.035	2.992ArgPro: 2.992 ± 0.048	2.418ArgGln: 2.418 ± 0.041	5.245ArgArg: 5.245 ± 0.065	3.473ArgSer: 3.473 ± 0.047	3.49ArgThr: 3.49 ± 0.044	5.434ArgVal: 5.434 ± 0.058	1.016ArgTrp: 1.016 ± 0.027	2.042ArgTyr: 2.042 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.846SerAla: 6.846 ± 0.083	0.485SerCys: 0.485 ± 0.018	2.894SerAsp: 2.894 ± 0.035	2.582SerGlu: 2.582 ± 0.046	2.055SerPhe: 2.055 ± 0.035	5.554SerGly: 5.554 ± 0.086	1.225SerHis: 1.225 ± 0.028	2.759SerIle: 2.759 ± 0.043	1.595SerLys: 1.595 ± 0.034	5.77SerLeu: 5.77 ± 0.093	1.34SerMet: 1.34 ± 0.028	1.737SerAsn: 1.737 ± 0.039	2.9SerPro: 2.9 ± 0.044	1.886SerGln: 1.886 ± 0.036	3.717SerArg: 3.717 ± 0.045	3.641SerSer: 3.641 ± 0.101	3.533SerThr: 3.533 ± 0.15	4.511SerVal: 4.511 ± 0.066	0.738SerTrp: 0.738 ± 0.02	1.334SerTyr: 1.334 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.036ThrAla: 6.036 ± 0.067	0.475ThrCys: 0.475 ± 0.019	2.757ThrAsp: 2.757 ± 0.045	2.296ThrGlu: 2.296 ± 0.042	2.049ThrPhe: 2.049 ± 0.037	5.044ThrGly: 5.044 ± 0.072	1.269ThrHis: 1.269 ± 0.029	2.687ThrIle: 2.687 ± 0.039	1.308ThrLys: 1.308 ± 0.031	6.546ThrLeu: 6.546 ± 0.075	1.238ThrMet: 1.238 ± 0.03	1.531ThrAsn: 1.531 ± 0.042	3.596ThrPro: 3.596 ± 0.048	2.08ThrGln: 2.08 ± 0.04	3.67ThrArg: 3.67 ± 0.049	3.294ThrSer: 3.294 ± 0.096	3.133ThrThr: 3.133 ± 0.062	4.479ThrVal: 4.479 ± 0.068	0.755ThrTrp: 0.755 ± 0.021	1.254ThrTyr: 1.254 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	9.697ValAla: 9.697 ± 0.092	0.812ValCys: 0.812 ± 0.022	4.255ValAsp: 4.255 ± 0.059	4.32ValGlu: 4.32 ± 0.054	2.897ValPhe: 2.897 ± 0.044	5.583ValGly: 5.583 ± 0.073	1.556ValHis: 1.556 ± 0.029	3.838ValIle: 3.838 ± 0.05	2.526ValLys: 2.526 ± 0.043	8.021ValLeu: 8.021 ± 0.076	1.841ValMet: 1.841 ± 0.035	2.359ValAsn: 2.359 ± 0.041	4.152ValPro: 4.152 ± 0.052	2.535ValGln: 2.535 ± 0.041	5.262ValArg: 5.262 ± 0.059	4.76ValSer: 4.76 ± 0.072	4.668ValThr: 4.668 ± 0.059	6.52ValVal: 6.52 ± 0.079	1.013ValTrp: 1.013 ± 0.029	1.717ValTyr: 1.717 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.147TrpAla: 1.147 ± 0.029	0.151TrpCys: 0.151 ± 0.01	0.614TrpAsp: 0.614 ± 0.021	0.522TrpGlu: 0.522 ± 0.02	0.584TrpPhe: 0.584 ± 0.018	0.91TrpGly: 0.91 ± 0.025	0.418TrpHis: 0.418 ± 0.017	0.75TrpIle: 0.75 ± 0.021	0.422TrpLys: 0.422 ± 0.017	1.96TrpLeu: 1.96 ± 0.043	0.373TrpMet: 0.373 ± 0.015	0.485TrpAsn: 0.485 ± 0.016	0.681TrpPro: 0.681 ± 0.019	0.657TrpGln: 0.657 ± 0.02	1.215TrpArg: 1.215 ± 0.028	0.815TrpSer: 0.815 ± 0.02	0.697TrpThr: 0.697 ± 0.025	0.959TrpVal: 0.959 ± 0.023	0.236TrpTrp: 0.236 ± 0.012	0.348TrpTyr: 0.348 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.805TyrAla: 2.805 ± 0.04	0.253TyrCys: 0.253 ± 0.012	1.395TyrAsp: 1.395 ± 0.031	1.288TyrGlu: 1.288 ± 0.026	1.05TyrPhe: 1.05 ± 0.028	2.236TyrGly: 2.236 ± 0.042	0.509TyrHis: 0.509 ± 0.018	0.854TyrIle: 0.854 ± 0.025	0.653TyrLys: 0.653 ± 0.023	2.416TyrLeu: 2.416 ± 0.043	0.455TyrMet: 0.455 ± 0.014	0.696TyrAsn: 0.696 ± 0.021	1.268TyrPro: 1.268 ± 0.031	0.86TyrGln: 0.86 ± 0.022	1.914TyrArg: 1.914 ± 0.038	1.337TyrSer: 1.337 ± 0.029	1.361TyrThr: 1.361 ± 0.031	1.961TyrVal: 1.961 ± 0.033	0.409TyrTrp: 0.409 ± 0.015	0.689TyrTyr: 0.689 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5170 proteins (1685335 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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