Amino acid dipepetide frequency for Chitinophaga japonensis (Flexibacter japonensis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.446AlaAla: 10.446 ± 0.11	0.975AlaCys: 0.975 ± 0.022	4.87AlaAsp: 4.87 ± 0.048	4.296AlaGlu: 4.296 ± 0.055	3.821AlaPhe: 3.821 ± 0.049	7.919AlaGly: 7.919 ± 0.088	1.638AlaHis: 1.638 ± 0.03	5.101AlaIle: 5.101 ± 0.054	3.275AlaLys: 3.275 ± 0.045	8.598AlaLeu: 8.598 ± 0.075	2.031AlaMet: 2.031 ± 0.032	3.294AlaAsn: 3.294 ± 0.06	3.649AlaPro: 3.649 ± 0.05	3.653AlaGln: 3.653 ± 0.044	4.471AlaArg: 4.471 ± 0.05	4.507AlaSer: 4.507 ± 0.051	4.872AlaThr: 4.872 ± 0.099	5.854AlaVal: 5.854 ± 0.061	1.203AlaTrp: 1.203 ± 0.025	3.463AlaTyr: 3.463 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.659CysAla: 0.659 ± 0.021	0.205CysCys: 0.205 ± 0.009	0.38CysAsp: 0.38 ± 0.013	0.406CysGlu: 0.406 ± 0.014	0.455CysPhe: 0.455 ± 0.016	0.716CysGly: 0.716 ± 0.021	0.227CysHis: 0.227 ± 0.011	0.613CysIle: 0.613 ± 0.018	0.373CysLys: 0.373 ± 0.013	0.951CysLeu: 0.951 ± 0.024	0.253CysMet: 0.253 ± 0.01	0.4CysAsn: 0.4 ± 0.016	0.4CysPro: 0.4 ± 0.017	0.28CysGln: 0.28 ± 0.012	0.53CysArg: 0.53 ± 0.017	0.597CysSer: 0.597 ± 0.019	0.542CysThr: 0.542 ± 0.02	0.469CysVal: 0.469 ± 0.016	0.146CysTrp: 0.146 ± 0.01	0.429CysTyr: 0.429 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.489AspAla: 4.489 ± 0.054	0.4AspCys: 0.4 ± 0.014	2.39AspAsp: 2.39 ± 0.048	2.844AspGlu: 2.844 ± 0.042	2.551AspPhe: 2.551 ± 0.037	3.982AspGly: 3.982 ± 0.07	1.161AspHis: 1.161 ± 0.023	3.707AspIle: 3.707 ± 0.046	2.932AspLys: 2.932 ± 0.041	4.608AspLeu: 4.608 ± 0.055	1.272AspMet: 1.272 ± 0.025	2.559AspAsn: 2.559 ± 0.049	2.537AspPro: 2.537 ± 0.039	1.749AspGln: 1.749 ± 0.031	2.608AspArg: 2.608 ± 0.033	2.865AspSer: 2.865 ± 0.043	3.016AspThr: 3.016 ± 0.05	3.213AspVal: 3.213 ± 0.046	0.813AspTrp: 0.813 ± 0.021	2.453AspTyr: 2.453 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	4.747GluAla: 4.747 ± 0.059	0.37GluCys: 0.37 ± 0.014	2.735GluAsp: 2.735 ± 0.036	3.621GluGlu: 3.621 ± 0.051	1.831GluPhe: 1.831 ± 0.032	3.602GluGly: 3.602 ± 0.052	1.283GluHis: 1.283 ± 0.031	3.359GluIle: 3.359 ± 0.049	4.173GluLys: 4.173 ± 0.051	5.44GluLeu: 5.44 ± 0.061	1.504GluMet: 1.504 ± 0.029	2.483GluAsn: 2.483 ± 0.038	1.762GluPro: 1.762 ± 0.03	3.076GluGln: 3.076 ± 0.044	2.988GluArg: 2.988 ± 0.045	2.314GluSer: 2.314 ± 0.034	2.679GluThr: 2.679 ± 0.044	3.726GluVal: 3.726 ± 0.046	0.765GluTrp: 0.765 ± 0.019	1.928GluTyr: 1.928 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.197PheAla: 3.197 ± 0.043	0.449PheCys: 0.449 ± 0.014	2.555PheAsp: 2.555 ± 0.039	2.267PheGlu: 2.267 ± 0.035	2.181PhePhe: 2.181 ± 0.036	2.956PheGly: 2.956 ± 0.039	0.913PheHis: 0.913 ± 0.025	2.871PheIle: 2.871 ± 0.042	1.994PheLys: 1.994 ± 0.033	4.097PheLeu: 4.097 ± 0.061	1.091PheMet: 1.091 ± 0.023	2.434PheAsn: 2.434 ± 0.039	1.819PhePro: 1.819 ± 0.028	1.28PheGln: 1.28 ± 0.026	2.721PheArg: 2.721 ± 0.035	3.254PheSer: 3.254 ± 0.042	3.14PheThr: 3.14 ± 0.048	2.451PheVal: 2.451 ± 0.038	0.546PheTrp: 0.546 ± 0.018	1.898PheTyr: 1.898 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	6.022GlyAla: 6.022 ± 0.074	0.746GlyCys: 0.746 ± 0.023	3.513GlyAsp: 3.513 ± 0.054	3.548GlyGlu: 3.548 ± 0.047	3.395GlyPhe: 3.395 ± 0.048	5.523GlyGly: 5.523 ± 0.076	1.539GlyHis: 1.539 ± 0.028	5.286GlyIle: 5.286 ± 0.053	4.421GlyLys: 4.421 ± 0.05	6.482GlyLeu: 6.482 ± 0.062	2.035GlyMet: 2.035 ± 0.032	3.756GlyAsn: 3.756 ± 0.058	2.089GlyPro: 2.089 ± 0.042	2.84GlyGln: 2.84 ± 0.041	3.977GlyArg: 3.977 ± 0.046	4.475GlySer: 4.475 ± 0.055	4.418GlyThr: 4.418 ± 0.075	4.728GlyVal: 4.728 ± 0.051	1.22GlyTrp: 1.22 ± 0.029	3.369GlyTyr: 3.369 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.705HisAla: 1.705 ± 0.03	0.271HisCys: 0.271 ± 0.011	0.929HisAsp: 0.929 ± 0.021	1.04HisGlu: 1.04 ± 0.024	1.235HisPhe: 1.235 ± 0.024	1.295HisGly: 1.295 ± 0.031	0.69HisHis: 0.69 ± 0.019	1.488HisIle: 1.488 ± 0.03	0.927HisLys: 0.927 ± 0.026	2.279HisLeu: 2.279 ± 0.038	0.472HisMet: 0.472 ± 0.016	0.964HisAsn: 0.964 ± 0.021	1.283HisPro: 1.283 ± 0.028	0.806HisGln: 0.806 ± 0.022	1.161HisArg: 1.161 ± 0.024	1.101HisSer: 1.101 ± 0.021	1.408HisThr: 1.408 ± 0.028	1.131HisVal: 1.131 ± 0.021	0.342HisTrp: 0.342 ± 0.014	1.096HisTyr: 1.096 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.543IleAla: 5.543 ± 0.059	0.63IleCys: 0.63 ± 0.019	3.251IleAsp: 3.251 ± 0.045	2.9IleGlu: 2.9 ± 0.045	2.483IlePhe: 2.483 ± 0.044	4.178IleGly: 4.178 ± 0.049	1.262IleHis: 1.262 ± 0.028	3.793IleIle: 3.793 ± 0.058	2.989IleLys: 2.989 ± 0.043	5.144IleLeu: 5.144 ± 0.055	1.291IleMet: 1.291 ± 0.03	2.954IleAsn: 2.954 ± 0.039	3.027IlePro: 3.027 ± 0.039	2.147IleGln: 2.147 ± 0.031	3.748IleArg: 3.748 ± 0.042	4.077IleSer: 4.077 ± 0.051	4.261IleThr: 4.261 ± 0.069	3.62IleVal: 3.62 ± 0.047	0.702IleTrp: 0.702 ± 0.02	2.432IleTyr: 2.432 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.605LysAla: 4.605 ± 0.063	0.293LysCys: 0.293 ± 0.014	3.156LysAsp: 3.156 ± 0.044	3.565LysGlu: 3.565 ± 0.054	1.576LysPhe: 1.576 ± 0.03	4.004LysGly: 4.004 ± 0.048	1.052LysHis: 1.052 ± 0.022	3.121LysIle: 3.121 ± 0.042	3.571LysLys: 3.571 ± 0.06	4.418LysLeu: 4.418 ± 0.047	1.478LysMet: 1.478 ± 0.034	2.195LysAsn: 2.195 ± 0.039	2.121LysPro: 2.121 ± 0.036	2.35LysGln: 2.35 ± 0.037	2.564LysArg: 2.564 ± 0.039	2.371LysSer: 2.371 ± 0.036	2.941LysThr: 2.941 ± 0.038	3.601LysVal: 3.601 ± 0.048	0.702LysTrp: 0.702 ± 0.018	2.014LysTyr: 2.014 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	8.004LeuAla: 8.004 ± 0.08	1.008LeuCys: 1.008 ± 0.026	4.968LeuAsp: 4.968 ± 0.052	5.465LeuGlu: 5.465 ± 0.058	4.378LeuPhe: 4.378 ± 0.065	6.153LeuGly: 6.153 ± 0.059	2.297LeuHis: 2.297 ± 0.037	4.662LeuIle: 4.662 ± 0.054	5.239LeuLys: 5.239 ± 0.067	11.462LeuLeu: 11.462 ± 0.141	2.088LeuMet: 2.088 ± 0.035	4.251LeuAsn: 4.251 ± 0.058	5.106LeuPro: 5.106 ± 0.054	5.866LeuGln: 5.866 ± 0.075	5.027LeuArg: 5.027 ± 0.052	6.388LeuSer: 6.388 ± 0.055	5.184LeuThr: 5.184 ± 0.055	6.254LeuVal: 6.254 ± 0.065	1.083LeuTrp: 1.083 ± 0.028	3.661LeuTyr: 3.661 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.065MetAla: 2.065 ± 0.036	0.147MetCys: 0.147 ± 0.008	1.318MetAsp: 1.318 ± 0.027	1.6MetGlu: 1.6 ± 0.031	0.714MetPhe: 0.714 ± 0.018	1.547MetGly: 1.547 ± 0.03	0.548MetHis: 0.548 ± 0.015	1.357MetIle: 1.357 ± 0.027	1.638MetLys: 1.638 ± 0.029	2.458MetLeu: 2.458 ± 0.041	0.615MetMet: 0.615 ± 0.018	1.155MetAsn: 1.155 ± 0.028	1.252MetPro: 1.252 ± 0.027	1.382MetGln: 1.382 ± 0.025	1.182MetArg: 1.182 ± 0.025	1.192MetSer: 1.192 ± 0.024	1.118MetThr: 1.118 ± 0.025	1.474MetVal: 1.474 ± 0.029	0.215MetTrp: 0.215 ± 0.012	0.699MetTyr: 0.699 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.757AsnAla: 3.757 ± 0.052	0.373AsnCys: 0.373 ± 0.016	2.366AsnAsp: 2.366 ± 0.04	2.309AsnGlu: 2.309 ± 0.037	1.929AsnPhe: 1.929 ± 0.032	4.117AsnGly: 4.117 ± 0.066	0.792AsnHis: 0.792 ± 0.019	3.273AsnIle: 3.273 ± 0.043	2.33AsnLys: 2.33 ± 0.04	3.874AsnLeu: 3.874 ± 0.056	1.091AsnMet: 1.091 ± 0.026	2.578AsnAsn: 2.578 ± 0.058	2.369AsnPro: 2.369 ± 0.042	1.485AsnGln: 1.485 ± 0.031	2.53AsnArg: 2.53 ± 0.038	2.467AsnSer: 2.467 ± 0.046	2.951AsnThr: 2.951 ± 0.061	2.824AsnVal: 2.824 ± 0.046	0.703AsnTrp: 0.703 ± 0.021	2.045AsnTyr: 2.045 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	5.382ProAla: 5.382 ± 0.063	0.293ProCys: 0.293 ± 0.012	3.083ProAsp: 3.083 ± 0.043	3.059ProGlu: 3.059 ± 0.042	2.074ProPhe: 2.074 ± 0.031	4.159ProGly: 4.159 ± 0.049	0.902ProHis: 0.902 ± 0.024	1.776ProIle: 1.776 ± 0.03	1.448ProLys: 1.448 ± 0.024	4.216ProLeu: 4.216 ± 0.047	0.813ProMet: 0.813 ± 0.021	1.652ProAsn: 1.652 ± 0.035	1.814ProPro: 1.814 ± 0.039	1.693ProGln: 1.693 ± 0.029	1.76ProArg: 1.76 ± 0.034	2.134ProSer: 2.134 ± 0.037	1.762ProThr: 1.762 ± 0.035	4.289ProVal: 4.289 ± 0.056	0.558ProTrp: 0.558 ± 0.018	1.765ProTyr: 1.765 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.788GlnAla: 3.788 ± 0.049	0.277GlnCys: 0.277 ± 0.011	2.024GlnAsp: 2.024 ± 0.033	2.897GlnGlu: 2.897 ± 0.038	1.688GlnPhe: 1.688 ± 0.031	2.585GlnGly: 2.585 ± 0.036	1.353GlnHis: 1.353 ± 0.029	1.787GlnIle: 1.787 ± 0.031	1.946GlnLys: 1.946 ± 0.032	5.069GlnLeu: 5.069 ± 0.061	0.957GlnMet: 0.957 ± 0.024	1.458GlnAsn: 1.458 ± 0.033	2.372GlnPro: 2.372 ± 0.034	3.594GlnGln: 3.594 ± 0.053	2.401GlnArg: 2.401 ± 0.038	2.034GlnSer: 2.034 ± 0.032	2.045GlnThr: 2.045 ± 0.035	3.326GlnVal: 3.326 ± 0.045	0.654GlnTrp: 0.654 ± 0.016	1.966GlnTyr: 1.966 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.427ArgAla: 3.427 ± 0.043	0.358ArgCys: 0.358 ± 0.015	2.489ArgAsp: 2.489 ± 0.036	3.377ArgGlu: 3.377 ± 0.046	2.665ArgPhe: 2.665 ± 0.042	2.714ArgGly: 2.714 ± 0.04	1.348ArgHis: 1.348 ± 0.031	3.652ArgIle: 3.652 ± 0.044	3.121ArgLys: 3.121 ± 0.047	5.537ArgLeu: 5.537 ± 0.056	1.422ArgMet: 1.422 ± 0.029	2.797ArgAsn: 2.797 ± 0.04	2.113ArgPro: 2.113 ± 0.031	2.881ArgGln: 2.881 ± 0.043	2.773ArgArg: 2.773 ± 0.041	2.935ArgSer: 2.935 ± 0.03	2.614ArgThr: 2.614 ± 0.04	3.112ArgVal: 3.112 ± 0.04	0.84ArgTrp: 0.84 ± 0.02	2.599ArgTyr: 2.599 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.758SerAla: 4.758 ± 0.052	0.567SerCys: 0.567 ± 0.018	2.578SerAsp: 2.578 ± 0.039	2.363SerGlu: 2.363 ± 0.036	3.027SerPhe: 3.027 ± 0.045	5.005SerGly: 5.005 ± 0.055	1.01SerHis: 1.01 ± 0.024	3.615SerIle: 3.615 ± 0.04	2.443SerLys: 2.443 ± 0.042	5.974SerLeu: 5.974 ± 0.055	1.295SerMet: 1.295 ± 0.027	2.539SerAsn: 2.539 ± 0.043	2.399SerPro: 2.399 ± 0.041	1.865SerGln: 1.865 ± 0.03	3.195SerArg: 3.195 ± 0.04	3.482SerSer: 3.482 ± 0.056	3.226SerThr: 3.226 ± 0.056	3.648SerVal: 3.648 ± 0.046	0.829SerTrp: 0.829 ± 0.021	2.582SerTyr: 2.582 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.839ThrAla: 5.839 ± 0.101	0.472ThrCys: 0.472 ± 0.016	3.317ThrAsp: 3.317 ± 0.054	2.661ThrGlu: 2.661 ± 0.037	2.565ThrPhe: 2.565 ± 0.035	5.499ThrGly: 5.499 ± 0.073	1.039ThrHis: 1.039 ± 0.022	3.566ThrIle: 3.566 ± 0.073	2.005ThrLys: 2.005 ± 0.033	5.691ThrLeu: 5.691 ± 0.055	1.026ThrMet: 1.026 ± 0.021	2.215ThrAsn: 2.215 ± 0.047	3.055ThrPro: 3.055 ± 0.044	1.866ThrGln: 1.866 ± 0.035	2.743ThrArg: 2.743 ± 0.038	2.976ThrSer: 2.976 ± 0.055	3.43ThrThr: 3.43 ± 0.068	4.408ThrVal: 4.408 ± 0.091	0.813ThrTrp: 0.813 ± 0.024	2.293ThrTyr: 2.293 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	5.268ValAla: 5.268 ± 0.06	0.651ValCys: 0.651 ± 0.019	3.159ValAsp: 3.159 ± 0.044	3.195ValGlu: 3.195 ± 0.04	2.898ValPhe: 2.898 ± 0.042	3.501ValGly: 3.501 ± 0.044	1.32ValHis: 1.32 ± 0.028	4.333ValIle: 4.333 ± 0.051	3.962ValLys: 3.962 ± 0.056	6.69ValLeu: 6.69 ± 0.068	1.645ValMet: 1.645 ± 0.03	3.428ValAsn: 3.428 ± 0.053	3.114ValPro: 3.114 ± 0.045	2.907ValGln: 2.907 ± 0.038	3.075ValArg: 3.075 ± 0.043	4.193ValSer: 4.193 ± 0.046	4.396ValThr: 4.396 ± 0.096	4.298ValVal: 4.298 ± 0.057	0.799ValTrp: 0.799 ± 0.02	2.67ValTyr: 2.67 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	0.935TrpAla: 0.935 ± 0.023	0.138TrpCys: 0.138 ± 0.007	0.732TrpAsp: 0.732 ± 0.023	0.844TrpGlu: 0.844 ± 0.019	0.573TrpPhe: 0.573 ± 0.017	0.976TrpGly: 0.976 ± 0.023	0.321TrpHis: 0.321 ± 0.012	0.802TrpIle: 0.802 ± 0.023	0.819TrpLys: 0.819 ± 0.021	1.511TrpLeu: 1.511 ± 0.034	0.41TrpMet: 0.41 ± 0.013	0.711TrpAsn: 0.711 ± 0.019	0.449TrpPro: 0.449 ± 0.017	0.835TrpGln: 0.835 ± 0.02	0.68TrpArg: 0.68 ± 0.016	0.722TrpSer: 0.722 ± 0.02	0.75TrpThr: 0.75 ± 0.024	0.753TrpVal: 0.753 ± 0.022	0.299TrpTrp: 0.299 ± 0.013	0.587TrpTyr: 0.587 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.299TyrAla: 3.299 ± 0.042	0.407TyrCys: 0.407 ± 0.016	2.339TyrAsp: 2.339 ± 0.037	2.126TyrGlu: 2.126 ± 0.03	2.076TyrPhe: 2.076 ± 0.031	2.953TyrGly: 2.953 ± 0.046	0.929TyrHis: 0.929 ± 0.024	2.268TyrIle: 2.268 ± 0.035	2.091TyrLys: 2.091 ± 0.032	4.046TyrLeu: 4.046 ± 0.057	0.888TyrMet: 0.888 ± 0.02	2.338TyrAsn: 2.338 ± 0.037	1.904TyrPro: 1.904 ± 0.035	1.666TyrGln: 1.666 ± 0.032	2.643TyrArg: 2.643 ± 0.038	2.316TyrSer: 2.316 ± 0.038	2.724TyrThr: 2.724 ± 0.046	2.32TyrVal: 2.32 ± 0.034	0.615TyrTrp: 0.615 ± 0.018	2.063TyrTyr: 2.063 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5570 proteins (2127033 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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