Amino acid dipepetide frequency for Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.43AlaAla: 10.43 ± 0.108	1.406AlaCys: 1.406 ± 0.046	4.618AlaAsp: 4.618 ± 0.054	5.929AlaGlu: 5.929 ± 0.068	3.834AlaPhe: 3.834 ± 0.051	8.779AlaGly: 8.779 ± 0.095	1.804AlaHis: 1.804 ± 0.035	4.619AlaIle: 4.619 ± 0.07	3.268AlaLys: 3.268 ± 0.06	9.812AlaLeu: 9.812 ± 0.093	2.484AlaMet: 2.484 ± 0.048	2.319AlaAsn: 2.319 ± 0.048	3.68AlaPro: 3.68 ± 0.06	2.668AlaGln: 2.668 ± 0.051	7.113AlaArg: 7.113 ± 0.084	5.039AlaSer: 5.039 ± 0.058	3.843AlaThr: 3.843 ± 0.061	8.255AlaVal: 8.255 ± 0.091	1.079AlaTrp: 1.079 ± 0.03	2.288AlaTyr: 2.288 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.225CysAla: 1.225 ± 0.035	0.274CysCys: 0.274 ± 0.013	0.616CysAsp: 0.616 ± 0.021	0.708CysGlu: 0.708 ± 0.023	0.535CysPhe: 0.535 ± 0.021	1.577CysGly: 1.577 ± 0.041	0.361CysHis: 0.361 ± 0.02	0.634CysIle: 0.634 ± 0.02	0.374CysLys: 0.374 ± 0.017	1.329CysLeu: 1.329 ± 0.031	0.323CysMet: 0.323 ± 0.017	0.374CysAsn: 0.374 ± 0.016	0.921CysPro: 0.921 ± 0.03	0.294CysGln: 0.294 ± 0.017	1.306CysArg: 1.306 ± 0.03	0.885CysSer: 0.885 ± 0.033	0.625CysThr: 0.625 ± 0.024	0.91CysVal: 0.91 ± 0.03	0.166CysTrp: 0.166 ± 0.011	0.339CysTyr: 0.339 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.717AspAla: 4.717 ± 0.063	0.668AspCys: 0.668 ± 0.022	2.441AspAsp: 2.441 ± 0.05	3.498AspGlu: 3.498 ± 0.065	2.438AspPhe: 2.438 ± 0.043	4.251AspGly: 4.251 ± 0.071	1.209AspHis: 1.209 ± 0.031	2.936AspIle: 2.936 ± 0.053	1.863AspLys: 1.863 ± 0.038	5.629AspLeu: 5.629 ± 0.065	1.176AspMet: 1.176 ± 0.029	1.225AspAsn: 1.225 ± 0.032	3.188AspPro: 3.188 ± 0.055	1.363AspGln: 1.363 ± 0.034	4.414AspArg: 4.414 ± 0.058	2.608AspSer: 2.608 ± 0.043	2.254AspThr: 2.254 ± 0.042	3.703AspVal: 3.703 ± 0.052	0.731AspTrp: 0.731 ± 0.026	1.613AspTyr: 1.613 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.374GluAla: 6.374 ± 0.08	0.749GluCys: 0.749 ± 0.026	3.245GluAsp: 3.245 ± 0.051	4.898GluGlu: 4.898 ± 0.069	2.325GluPhe: 2.325 ± 0.041	4.472GluGly: 4.472 ± 0.062	1.374GluHis: 1.374 ± 0.035	4.245GluIle: 4.245 ± 0.063	3.795GluLys: 3.795 ± 0.068	6.455GluLeu: 6.455 ± 0.077	1.868GluMet: 1.868 ± 0.039	2.159GluAsn: 2.159 ± 0.033	2.723GluPro: 2.723 ± 0.052	2.19GluGln: 2.19 ± 0.041	5.245GluArg: 5.245 ± 0.083	3.607GluSer: 3.607 ± 0.059	3.406GluThr: 3.406 ± 0.044	4.609GluVal: 4.609 ± 0.063	0.755GluTrp: 0.755 ± 0.026	1.682GluTyr: 1.682 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.395PheAla: 3.395 ± 0.054	0.677PheCys: 0.677 ± 0.023	2.421PheAsp: 2.421 ± 0.044	2.472PheGlu: 2.472 ± 0.046	2.02PhePhe: 2.02 ± 0.043	3.385PheGly: 3.385 ± 0.054	1.065PheHis: 1.065 ± 0.027	2.114PheIle: 2.114 ± 0.045	1.523PheLys: 1.523 ± 0.034	4.455PheLeu: 4.455 ± 0.066	0.928PheMet: 0.928 ± 0.024	1.222PheAsn: 1.222 ± 0.028	2.133PhePro: 2.133 ± 0.044	1.279PheGln: 1.279 ± 0.033	2.951PheArg: 2.951 ± 0.049	2.645PheSer: 2.645 ± 0.05	2.073PheThr: 2.073 ± 0.04	2.854PheVal: 2.854 ± 0.052	0.558PheTrp: 0.558 ± 0.022	1.221PheTyr: 1.221 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	7.095GlyAla: 7.095 ± 0.092	1.296GlyCys: 1.296 ± 0.036	3.782GlyAsp: 3.782 ± 0.057	4.903GlyGlu: 4.903 ± 0.074	3.625GlyPhe: 3.625 ± 0.053	6.814GlyGly: 6.814 ± 0.107	1.683GlyHis: 1.683 ± 0.034	5.435GlyIle: 5.435 ± 0.069	4.423GlyLys: 4.423 ± 0.059	7.962GlyLeu: 7.962 ± 0.086	2.46GlyMet: 2.46 ± 0.042	2.549GlyAsn: 2.549 ± 0.058	3.129GlyPro: 3.129 ± 0.051	2.285GlyGln: 2.285 ± 0.047	6.045GlyArg: 6.045 ± 0.077	4.845GlySer: 4.845 ± 0.062	4.784GlyThr: 4.784 ± 0.078	5.994GlyVal: 5.994 ± 0.084	1.056GlyTrp: 1.056 ± 0.034	2.534GlyTyr: 2.534 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.807HisAla: 1.807 ± 0.036	0.361HisCys: 0.361 ± 0.016	1.047HisAsp: 1.047 ± 0.03	1.274HisGlu: 1.274 ± 0.032	1.011HisPhe: 1.011 ± 0.024	1.895HisGly: 1.895 ± 0.038	0.601HisHis: 0.601 ± 0.023	1.07HisIle: 1.07 ± 0.032	0.661HisLys: 0.661 ± 0.022	2.251HisLeu: 2.251 ± 0.046	0.468HisMet: 0.468 ± 0.018	0.567HisAsn: 0.567 ± 0.019	1.475HisPro: 1.475 ± 0.032	0.59HisGln: 0.59 ± 0.022	1.704HisArg: 1.704 ± 0.037	1.166HisSer: 1.166 ± 0.027	0.918HisThr: 0.918 ± 0.024	1.466HisVal: 1.466 ± 0.032	0.289HisTrp: 0.289 ± 0.014	0.709HisTyr: 0.709 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.26IleAla: 5.26 ± 0.064	0.705IleCys: 0.705 ± 0.025	3.111IleAsp: 3.111 ± 0.047	3.771IleGlu: 3.771 ± 0.061	2.036IlePhe: 2.036 ± 0.046	4.429IleGly: 4.429 ± 0.066	1.251IleHis: 1.251 ± 0.031	2.693IleIle: 2.693 ± 0.052	2.107IleLys: 2.107 ± 0.045	5.716IleLeu: 5.716 ± 0.064	1.171IleMet: 1.171 ± 0.031	1.568IleAsn: 1.568 ± 0.035	3.121IlePro: 3.121 ± 0.052	1.614IleGln: 1.614 ± 0.037	4.352IleArg: 4.352 ± 0.057	3.172IleSer: 3.172 ± 0.052	2.66IleThr: 2.66 ± 0.047	4.395IleVal: 4.395 ± 0.053	0.495IleTrp: 0.495 ± 0.02	1.422IleTyr: 1.422 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.067LysAla: 4.067 ± 0.052	0.453LysCys: 0.453 ± 0.021	2.333LysAsp: 2.333 ± 0.047	3.119LysGlu: 3.119 ± 0.053	1.2LysPhe: 1.2 ± 0.031	3.351LysGly: 3.351 ± 0.051	0.862LysHis: 0.862 ± 0.024	2.508LysIle: 2.508 ± 0.047	2.367LysLys: 2.367 ± 0.05	3.722LysLeu: 3.722 ± 0.06	1.143LysMet: 1.143 ± 0.034	1.368LysAsn: 1.368 ± 0.03	2.311LysPro: 2.311 ± 0.048	1.252LysGln: 1.252 ± 0.039	2.906LysArg: 2.906 ± 0.049	2.392LysSer: 2.392 ± 0.045	2.507LysThr: 2.507 ± 0.039	3.204LysVal: 3.204 ± 0.063	0.538LysTrp: 0.538 ± 0.021	1.17LysTyr: 1.17 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	10.056LeuAla: 10.056 ± 0.098	1.371LeuCys: 1.371 ± 0.035	5.745LeuAsp: 5.745 ± 0.067	6.934LeuGlu: 6.934 ± 0.093	4.219LeuPhe: 4.219 ± 0.073	7.76LeuGly: 7.76 ± 0.076	2.061LeuHis: 2.061 ± 0.043	5.237LeuIle: 5.237 ± 0.075	4.805LeuLys: 4.805 ± 0.067	10.413LeuLeu: 10.413 ± 0.11	2.245LeuMet: 2.245 ± 0.045	2.936LeuAsn: 2.936 ± 0.046	5.239LeuPro: 5.239 ± 0.067	3.104LeuGln: 3.104 ± 0.054	7.397LeuArg: 7.397 ± 0.084	6.505LeuSer: 6.505 ± 0.078	4.917LeuThr: 4.917 ± 0.07	7.305LeuVal: 7.305 ± 0.087	1.058LeuTrp: 1.058 ± 0.029	2.424LeuTyr: 2.424 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.499MetAla: 2.499 ± 0.045	0.243MetCys: 0.243 ± 0.013	1.383MetAsp: 1.383 ± 0.032	1.823MetGlu: 1.823 ± 0.041	0.702MetPhe: 0.702 ± 0.024	2.023MetGly: 2.023 ± 0.042	0.463MetHis: 0.463 ± 0.02	1.386MetIle: 1.386 ± 0.032	1.497MetLys: 1.497 ± 0.035	2.225MetLeu: 2.225 ± 0.037	0.63MetMet: 0.63 ± 0.023	0.923MetAsn: 0.923 ± 0.025	1.231MetPro: 1.231 ± 0.034	0.768MetGln: 0.768 ± 0.025	1.685MetArg: 1.685 ± 0.035	1.53MetSer: 1.53 ± 0.031	1.42MetThr: 1.42 ± 0.034	1.86MetVal: 1.86 ± 0.043	0.191MetTrp: 0.191 ± 0.012	0.437MetTyr: 0.437 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.647AsnAla: 2.647 ± 0.051	0.427AsnCys: 0.427 ± 0.02	1.373AsnAsp: 1.373 ± 0.038	1.553AsnGlu: 1.553 ± 0.033	1.05AsnPhe: 1.05 ± 0.03	2.389AsnGly: 2.389 ± 0.051	0.639AsnHis: 0.639 ± 0.021	1.705AsnIle: 1.705 ± 0.041	0.929AsnLys: 0.929 ± 0.03	3.185AsnLeu: 3.185 ± 0.049	0.669AsnMet: 0.669 ± 0.021	0.841AsnAsn: 0.841 ± 0.033	2.09AsnPro: 2.09 ± 0.042	0.803AsnGln: 0.803 ± 0.026	2.401AsnArg: 2.401 ± 0.046	1.33AsnSer: 1.33 ± 0.037	1.289AsnThr: 1.289 ± 0.038	2.319AsnVal: 2.319 ± 0.049	0.398AsnTrp: 0.398 ± 0.016	0.815AsnTyr: 0.815 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	4.957ProAla: 4.957 ± 0.07	0.628ProCys: 0.628 ± 0.021	3.245ProAsp: 3.245 ± 0.049	4.242ProGlu: 4.242 ± 0.058	2.182ProPhe: 2.182 ± 0.039	4.989ProGly: 4.989 ± 0.064	1.039ProHis: 1.039 ± 0.026	2.151ProIle: 2.151 ± 0.045	1.751ProLys: 1.751 ± 0.035	4.543ProLeu: 4.543 ± 0.056	1.167ProMet: 1.167 ± 0.028	1.257ProAsn: 1.257 ± 0.031	2.745ProPro: 2.745 ± 0.056	1.413ProGln: 1.413 ± 0.036	3.139ProArg: 3.139 ± 0.05	2.828ProSer: 2.828 ± 0.046	2.088ProThr: 2.088 ± 0.041	4.332ProVal: 4.332 ± 0.061	0.677ProTrp: 0.677 ± 0.026	1.342ProTyr: 1.342 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.058GlnAla: 3.058 ± 0.057	0.384GlnCys: 0.384 ± 0.019	1.375GlnAsp: 1.375 ± 0.032	1.993GlnGlu: 1.993 ± 0.047	1.036GlnPhe: 1.036 ± 0.029	2.271GlnGly: 2.271 ± 0.038	0.515GlnHis: 0.515 ± 0.02	1.587GlnIle: 1.587 ± 0.035	1.495GlnLys: 1.495 ± 0.036	2.715GlnLeu: 2.715 ± 0.045	0.823GlnMet: 0.823 ± 0.026	0.884GlnAsn: 0.884 ± 0.026	1.384GlnPro: 1.384 ± 0.036	1.144GlnGln: 1.144 ± 0.109	2.032GlnArg: 2.032 ± 0.052	1.614GlnSer: 1.614 ± 0.037	1.438GlnThr: 1.438 ± 0.035	2.395GlnVal: 2.395 ± 0.045	0.427GlnTrp: 0.427 ± 0.022	0.752GlnTyr: 0.752 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	5.925ArgAla: 5.925 ± 0.071	0.997ArgCys: 0.997 ± 0.03	3.866ArgAsp: 3.866 ± 0.049	5.698ArgGlu: 5.698 ± 0.077	3.432ArgPhe: 3.432 ± 0.052	4.995ArgGly: 4.995 ± 0.064	1.712ArgHis: 1.712 ± 0.037	4.819ArgIle: 4.819 ± 0.062	3.747ArgLys: 3.747 ± 0.054	7.953ArgLeu: 7.953 ± 0.088	2.086ArgMet: 2.086 ± 0.035	2.418ArgAsn: 2.418 ± 0.041	3.267ArgPro: 3.267 ± 0.052	2.501ArgGln: 2.501 ± 0.058	5.783ArgArg: 5.783 ± 0.083	4.128ArgSer: 4.128 ± 0.066	3.495ArgThr: 3.495 ± 0.052	5.141ArgVal: 5.141 ± 0.068	0.928ArgTrp: 0.928 ± 0.027	2.105ArgTyr: 2.105 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.116SerAla: 5.116 ± 0.071	0.81SerCys: 0.81 ± 0.031	2.742SerAsp: 2.742 ± 0.052	3.314SerGlu: 3.314 ± 0.055	2.607SerPhe: 2.607 ± 0.048	5.701SerGly: 5.701 ± 0.067	1.199SerHis: 1.199 ± 0.03	3.122SerIle: 3.122 ± 0.054	1.961SerLys: 1.961 ± 0.043	5.892SerLeu: 5.892 ± 0.067	1.591SerMet: 1.591 ± 0.036	1.389SerAsn: 1.389 ± 0.036	3.222SerPro: 3.222 ± 0.053	1.485SerGln: 1.485 ± 0.034	4.534SerArg: 4.534 ± 0.06	3.413SerSer: 3.413 ± 0.05	2.787SerThr: 2.787 ± 0.053	4.071SerVal: 4.071 ± 0.056	0.772SerTrp: 0.772 ± 0.026	1.547SerTyr: 1.547 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	4.725ThrAla: 4.725 ± 0.056	0.596ThrCys: 0.596 ± 0.022	2.382ThrAsp: 2.382 ± 0.045	2.648ThrGlu: 2.648 ± 0.048	1.995ThrPhe: 1.995 ± 0.046	5.015ThrGly: 5.015 ± 0.073	1.004ThrHis: 1.004 ± 0.028	2.746ThrIle: 2.746 ± 0.053	1.507ThrLys: 1.507 ± 0.035	5.107ThrLeu: 5.107 ± 0.059	1.102ThrMet: 1.102 ± 0.03	1.291ThrAsn: 1.291 ± 0.035	2.815ThrPro: 2.815 ± 0.045	1.218ThrGln: 1.218 ± 0.031	3.24ThrArg: 3.24 ± 0.047	2.583ThrSer: 2.583 ± 0.058	2.426ThrThr: 2.426 ± 0.056	4.296ThrVal: 4.296 ± 0.072	0.598ThrTrp: 0.598 ± 0.024	1.364ThrTyr: 1.364 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	6.723ValAla: 6.723 ± 0.081	1.145ValCys: 1.145 ± 0.034	4.072ValAsp: 4.072 ± 0.057	5.072ValGlu: 5.072 ± 0.07	3.427ValPhe: 3.427 ± 0.048	5.389ValGly: 5.389 ± 0.067	1.567ValHis: 1.567 ± 0.034	4.234ValIle: 4.234 ± 0.058	3.197ValLys: 3.197 ± 0.054	8.167ValLeu: 8.167 ± 0.088	1.778ValMet: 1.778 ± 0.04	2.286ValAsn: 2.286 ± 0.043	3.991ValPro: 3.991 ± 0.06	2.07ValGln: 2.07 ± 0.044	5.428ValArg: 5.428 ± 0.073	4.697ValSer: 4.697 ± 0.063	3.826ValThr: 3.826 ± 0.06	6.173ValVal: 6.173 ± 0.08	0.827ValTrp: 0.827 ± 0.022	1.995ValTyr: 1.995 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.945TrpAla: 0.945 ± 0.029	0.149TrpCys: 0.149 ± 0.01	0.604TrpAsp: 0.604 ± 0.025	0.78TrpGlu: 0.78 ± 0.026	0.49TrpPhe: 0.49 ± 0.021	0.878TrpGly: 0.878 ± 0.031	0.286TrpHis: 0.286 ± 0.015	0.674TrpIle: 0.674 ± 0.022	0.621TrpLys: 0.621 ± 0.022	1.28TrpLeu: 1.28 ± 0.037	0.316TrpMet: 0.316 ± 0.015	0.498TrpAsn: 0.498 ± 0.022	0.562TrpPro: 0.562 ± 0.022	0.404TrpGln: 0.404 ± 0.019	0.909TrpArg: 0.909 ± 0.027	0.699TrpSer: 0.699 ± 0.024	0.631TrpThr: 0.631 ± 0.03	0.891TrpVal: 0.891 ± 0.029	0.173TrpTrp: 0.173 ± 0.011	0.315TrpTyr: 0.315 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.248TyrAla: 2.248 ± 0.04	0.438TyrCys: 0.438 ± 0.019	1.522TyrAsp: 1.522 ± 0.042	1.549TyrGlu: 1.549 ± 0.04	1.23TyrPhe: 1.23 ± 0.032	2.337TyrGly: 2.337 ± 0.05	0.638TyrHis: 0.638 ± 0.021	1.133TyrIle: 1.133 ± 0.031	0.883TyrLys: 0.883 ± 0.03	2.921TyrLeu: 2.921 ± 0.043	0.49TyrMet: 0.49 ± 0.02	0.778TyrAsn: 0.778 ± 0.025	1.486TyrPro: 1.486 ± 0.033	0.875TyrGln: 0.875 ± 0.028	2.41TyrArg: 2.41 ± 0.037	1.59TyrSer: 1.59 ± 0.04	1.272TyrThr: 1.272 ± 0.037	1.89TyrVal: 1.89 ± 0.043	0.386TyrTrp: 0.386 ± 0.017	0.901TyrTyr: 0.901 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4012 proteins (1348052 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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