Amino acid dipepetide frequency for Ruegeria phage vB_RpoP-V13

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.567AlaAla: 8.567 ± 0.861
0.471AlaCys: 0.471 ± 0.137
5.954AlaAsp: 5.954 ± 0.569
6.04AlaGlu: 6.04 ± 0.545
2.699AlaPhe: 2.699 ± 0.313
6.811AlaGly: 6.811 ± 0.633
1.328AlaHis: 1.328 ± 0.233
4.198AlaIle: 4.198 ± 0.391
5.054AlaLys: 5.054 ± 0.57
7.025AlaLeu: 7.025 ± 0.763
2.913AlaMet: 2.913 ± 0.321
4.412AlaAsn: 4.412 ± 0.581
3.041AlaPro: 3.041 ± 0.341
4.198AlaGln: 4.198 ± 0.534
3.255AlaArg: 3.255 ± 0.393
4.412AlaSer: 4.412 ± 0.511
4.583AlaThr: 4.583 ± 0.546
6.768AlaVal: 6.768 ± 0.839
1.199AlaTrp: 1.199 ± 0.215
2.827AlaTyr: 2.827 ± 0.318
0.0AlaXaa: 0.0 ± 0.0
Cys
0.514CysAla: 0.514 ± 0.172
0.043CysCys: 0.043 ± 0.051
0.386CysAsp: 0.386 ± 0.127
0.514CysGlu: 0.514 ± 0.147
0.3CysPhe: 0.3 ± 0.104
0.728CysGly: 0.728 ± 0.265
0.086CysHis: 0.086 ± 0.057
0.214CysIle: 0.214 ± 0.091
0.643CysLys: 0.643 ± 0.174
0.6CysLeu: 0.6 ± 0.153
0.171CysMet: 0.171 ± 0.075
0.214CysAsn: 0.214 ± 0.106
0.557CysPro: 0.557 ± 0.211
0.3CysGln: 0.3 ± 0.113
0.257CysArg: 0.257 ± 0.094
0.6CysSer: 0.6 ± 0.195
0.257CysThr: 0.257 ± 0.114
0.643CysVal: 0.643 ± 0.213
0.129CysTrp: 0.129 ± 0.083
0.214CysTyr: 0.214 ± 0.091
0.0CysXaa: 0.0 ± 0.0
Asp
5.568AspAla: 5.568 ± 0.573
0.343AspCys: 0.343 ± 0.106
4.84AspAsp: 4.84 ± 0.373
5.054AspGlu: 5.054 ± 0.571
2.484AspPhe: 2.484 ± 0.302
5.183AspGly: 5.183 ± 0.571
1.285AspHis: 1.285 ± 0.231
3.812AspIle: 3.812 ± 0.432
3.512AspLys: 3.512 ± 0.467
5.611AspLeu: 5.611 ± 0.537
1.799AspMet: 1.799 ± 0.22
2.57AspAsn: 2.57 ± 0.34
3.898AspPro: 3.898 ± 0.353
2.613AspGln: 2.613 ± 0.296
3.255AspArg: 3.255 ± 0.295
3.769AspSer: 3.769 ± 0.32
3.684AspThr: 3.684 ± 0.414
4.626AspVal: 4.626 ± 0.469
1.114AspTrp: 1.114 ± 0.223
2.699AspTyr: 2.699 ± 0.405
0.0AspXaa: 0.0 ± 0.0
Glu
5.825GluAla: 5.825 ± 0.582
0.386GluCys: 0.386 ± 0.13
5.183GluAsp: 5.183 ± 0.571
6.596GluGlu: 6.596 ± 0.601
3.384GluPhe: 3.384 ± 0.339
4.283GluGly: 4.283 ± 0.423
1.242GluHis: 1.242 ± 0.299
4.583GluIle: 4.583 ± 0.332
4.241GluLys: 4.241 ± 0.519
5.354GluLeu: 5.354 ± 0.506
2.699GluMet: 2.699 ± 0.363
2.784GluAsn: 2.784 ± 0.295
1.885GluPro: 1.885 ± 0.303
3.641GluGln: 3.641 ± 0.355
3.213GluArg: 3.213 ± 0.357
3.17GluSer: 3.17 ± 0.328
5.012GluThr: 5.012 ± 0.591
4.669GluVal: 4.669 ± 0.415
0.728GluTrp: 0.728 ± 0.187
1.671GluTyr: 1.671 ± 0.266
0.0GluXaa: 0.0 ± 0.0
Phe
2.741PheAla: 2.741 ± 0.315
0.3PheCys: 0.3 ± 0.126
2.527PheAsp: 2.527 ± 0.244
2.27PheGlu: 2.27 ± 0.26
1.542PhePhe: 1.542 ± 0.345
2.699PheGly: 2.699 ± 0.351
0.428PheHis: 0.428 ± 0.122
2.613PheIle: 2.613 ± 0.338
2.142PheLys: 2.142 ± 0.344
2.784PheLeu: 2.784 ± 0.375
1.499PheMet: 1.499 ± 0.289
2.27PheAsn: 2.27 ± 0.34
1.456PhePro: 1.456 ± 0.21
1.328PheGln: 1.328 ± 0.214
1.885PheArg: 1.885 ± 0.267
2.356PheSer: 2.356 ± 0.327
2.527PheThr: 2.527 ± 0.339
2.484PheVal: 2.484 ± 0.279
0.514PheTrp: 0.514 ± 0.143
1.585PheTyr: 1.585 ± 0.268
0.0PheXaa: 0.0 ± 0.0
Gly
5.697GlyAla: 5.697 ± 0.615
0.6GlyCys: 0.6 ± 0.236
4.069GlyAsp: 4.069 ± 0.459
3.941GlyGlu: 3.941 ± 0.354
3.298GlyPhe: 3.298 ± 0.342
5.354GlyGly: 5.354 ± 0.607
0.985GlyHis: 0.985 ± 0.254
3.855GlyIle: 3.855 ± 0.385
4.241GlyLys: 4.241 ± 0.469
5.311GlyLeu: 5.311 ± 0.504
2.142GlyMet: 2.142 ± 0.367
4.369GlyAsn: 4.369 ± 0.419
2.185GlyPro: 2.185 ± 0.31
2.784GlyGln: 2.784 ± 0.373
3.041GlyArg: 3.041 ± 0.391
5.183GlySer: 5.183 ± 0.474
5.354GlyThr: 5.354 ± 0.54
5.097GlyVal: 5.097 ± 0.452
1.371GlyTrp: 1.371 ± 0.279
2.442GlyTyr: 2.442 ± 0.267
0.0GlyXaa: 0.0 ± 0.0
His
1.028HisAla: 1.028 ± 0.203
0.086HisCys: 0.086 ± 0.058
1.071HisAsp: 1.071 ± 0.243
1.114HisGlu: 1.114 ± 0.285
0.685HisPhe: 0.685 ± 0.173
0.942HisGly: 0.942 ± 0.252
0.3HisHis: 0.3 ± 0.136
1.114HisIle: 1.114 ± 0.288
1.157HisLys: 1.157 ± 0.271
1.456HisLeu: 1.456 ± 0.324
0.471HisMet: 0.471 ± 0.143
0.514HisAsn: 0.514 ± 0.13
0.985HisPro: 0.985 ± 0.165
0.557HisGln: 0.557 ± 0.157
0.942HisArg: 0.942 ± 0.266
0.857HisSer: 0.857 ± 0.212
0.643HisThr: 0.643 ± 0.169
1.157HisVal: 1.157 ± 0.233
0.3HisTrp: 0.3 ± 0.097
1.157HisTyr: 1.157 ± 0.244
0.0HisXaa: 0.0 ± 0.0
Ile
4.883IleAla: 4.883 ± 0.512
0.257IleCys: 0.257 ± 0.097
3.812IleAsp: 3.812 ± 0.39
3.255IleGlu: 3.255 ± 0.377
2.099IlePhe: 2.099 ± 0.31
2.998IleGly: 2.998 ± 0.301
1.157IleHis: 1.157 ± 0.262
3.084IleIle: 3.084 ± 0.391
2.484IleLys: 2.484 ± 0.37
4.198IleLeu: 4.198 ± 0.313
1.542IleMet: 1.542 ± 0.282
2.784IleAsn: 2.784 ± 0.285
2.741IlePro: 2.741 ± 0.38
2.313IleGln: 2.313 ± 0.279
2.913IleArg: 2.913 ± 0.39
3.727IleSer: 3.727 ± 0.35
3.512IleThr: 3.512 ± 0.422
3.084IleVal: 3.084 ± 0.412
1.028IleTrp: 1.028 ± 0.254
2.142IleTyr: 2.142 ± 0.334
0.0IleXaa: 0.0 ± 0.0
Lys
5.226LysAla: 5.226 ± 0.518
0.428LysCys: 0.428 ± 0.138
3.255LysAsp: 3.255 ± 0.4
5.183LysGlu: 5.183 ± 0.51
1.713LysPhe: 1.713 ± 0.294
3.427LysGly: 3.427 ± 0.309
1.242LysHis: 1.242 ± 0.324
2.741LysIle: 2.741 ± 0.331
3.984LysLys: 3.984 ± 0.653
5.183LysLeu: 5.183 ± 0.652
1.585LysMet: 1.585 ± 0.292
2.956LysAsn: 2.956 ± 0.366
2.056LysPro: 2.056 ± 0.35
2.527LysGln: 2.527 ± 0.385
2.57LysArg: 2.57 ± 0.307
3.684LysSer: 3.684 ± 0.432
3.255LysThr: 3.255 ± 0.35
3.855LysVal: 3.855 ± 0.432
0.985LysTrp: 0.985 ± 0.197
1.842LysTyr: 1.842 ± 0.229
0.0LysXaa: 0.0 ± 0.0
Leu
6.682LeuAla: 6.682 ± 0.89
0.728LeuCys: 0.728 ± 0.169
5.74LeuAsp: 5.74 ± 0.701
5.526LeuGlu: 5.526 ± 0.423
2.656LeuPhe: 2.656 ± 0.331
4.498LeuGly: 4.498 ± 0.383
1.157LeuHis: 1.157 ± 0.22
3.898LeuIle: 3.898 ± 0.424
4.412LeuLys: 4.412 ± 0.556
4.797LeuLeu: 4.797 ± 0.471
2.27LeuMet: 2.27 ± 0.359
4.926LeuAsn: 4.926 ± 0.451
3.512LeuPro: 3.512 ± 0.528
3.855LeuGln: 3.855 ± 0.395
4.369LeuArg: 4.369 ± 0.4
5.397LeuSer: 5.397 ± 0.461
5.611LeuThr: 5.611 ± 0.427
4.583LeuVal: 4.583 ± 0.341
1.157LeuTrp: 1.157 ± 0.176
2.27LeuTyr: 2.27 ± 0.375
0.0LeuXaa: 0.0 ± 0.0
Met
3.384MetAla: 3.384 ± 0.357
0.386MetCys: 0.386 ± 0.154
2.484MetAsp: 2.484 ± 0.314
1.628MetGlu: 1.628 ± 0.298
1.028MetPhe: 1.028 ± 0.198
2.227MetGly: 2.227 ± 0.279
0.214MetHis: 0.214 ± 0.096
2.313MetIle: 2.313 ± 0.293
1.928MetLys: 1.928 ± 0.272
2.056MetLeu: 2.056 ± 0.367
0.814MetMet: 0.814 ± 0.182
2.056MetAsn: 2.056 ± 0.281
1.499MetPro: 1.499 ± 0.265
1.713MetGln: 1.713 ± 0.363
1.199MetArg: 1.199 ± 0.186
1.97MetSer: 1.97 ± 0.31
1.885MetThr: 1.885 ± 0.249
1.928MetVal: 1.928 ± 0.262
0.428MetTrp: 0.428 ± 0.153
0.728MetTyr: 0.728 ± 0.169
0.0MetXaa: 0.0 ± 0.0
Asn
4.155AsnAla: 4.155 ± 0.488
0.471AsnCys: 0.471 ± 0.168
3.47AsnAsp: 3.47 ± 0.413
3.127AsnGlu: 3.127 ± 0.296
1.97AsnPhe: 1.97 ± 0.216
3.812AsnGly: 3.812 ± 0.383
0.771AsnHis: 0.771 ± 0.164
2.356AsnIle: 2.356 ± 0.359
2.741AsnLys: 2.741 ± 0.463
4.498AsnLeu: 4.498 ± 0.409
1.456AsnMet: 1.456 ± 0.219
2.399AsnAsn: 2.399 ± 0.315
2.827AsnPro: 2.827 ± 0.397
2.956AsnGln: 2.956 ± 0.295
2.356AsnArg: 2.356 ± 0.339
2.656AsnSer: 2.656 ± 0.226
3.598AsnThr: 3.598 ± 0.345
2.656AsnVal: 2.656 ± 0.319
0.643AsnTrp: 0.643 ± 0.176
2.27AsnTyr: 2.27 ± 0.294
0.0AsnXaa: 0.0 ± 0.0
Pro
3.127ProAla: 3.127 ± 0.346
0.257ProCys: 0.257 ± 0.108
3.17ProAsp: 3.17 ± 0.405
4.198ProGlu: 4.198 ± 0.405
1.756ProPhe: 1.756 ± 0.253
2.784ProGly: 2.784 ± 0.264
0.514ProHis: 0.514 ± 0.178
2.099ProIle: 2.099 ± 0.308
2.356ProLys: 2.356 ± 0.387
2.827ProLeu: 2.827 ± 0.275
1.285ProMet: 1.285 ± 0.257
2.227ProAsn: 2.227 ± 0.288
1.285ProPro: 1.285 ± 0.296
1.671ProGln: 1.671 ± 0.304
1.585ProArg: 1.585 ± 0.205
2.87ProSer: 2.87 ± 0.445
2.784ProThr: 2.784 ± 0.385
3.127ProVal: 3.127 ± 0.351
0.428ProTrp: 0.428 ± 0.109
0.9ProTyr: 0.9 ± 0.225
0.0ProXaa: 0.0 ± 0.0
Gln
4.198GlnAla: 4.198 ± 0.604
0.257GlnCys: 0.257 ± 0.109
2.442GlnAsp: 2.442 ± 0.353
3.812GlnGlu: 3.812 ± 0.308
1.499GlnPhe: 1.499 ± 0.303
2.527GlnGly: 2.527 ± 0.323
0.6GlnHis: 0.6 ± 0.158
2.356GlnIle: 2.356 ± 0.313
3.127GlnLys: 3.127 ± 0.411
3.255GlnLeu: 3.255 ± 0.483
1.885GlnMet: 1.885 ± 0.281
2.227GlnAsn: 2.227 ± 0.367
1.97GlnPro: 1.97 ± 0.365
1.97GlnGln: 1.97 ± 0.296
2.27GlnArg: 2.27 ± 0.268
2.013GlnSer: 2.013 ± 0.264
2.827GlnThr: 2.827 ± 0.41
3.041GlnVal: 3.041 ± 0.361
0.9GlnTrp: 0.9 ± 0.255
1.456GlnTyr: 1.456 ± 0.194
0.0GlnXaa: 0.0 ± 0.0
Arg
3.727ArgAla: 3.727 ± 0.385
0.471ArgCys: 0.471 ± 0.138
2.741ArgAsp: 2.741 ± 0.315
3.084ArgGlu: 3.084 ± 0.394
1.842ArgPhe: 1.842 ± 0.245
3.213ArgGly: 3.213 ± 0.279
0.857ArgHis: 0.857 ± 0.19
2.356ArgIle: 2.356 ± 0.337
2.613ArgLys: 2.613 ± 0.356
4.369ArgLeu: 4.369 ± 0.416
1.97ArgMet: 1.97 ± 0.254
2.142ArgAsn: 2.142 ± 0.34
1.499ArgPro: 1.499 ± 0.211
2.613ArgGln: 2.613 ± 0.346
2.142ArgArg: 2.142 ± 0.245
2.484ArgSer: 2.484 ± 0.321
2.613ArgThr: 2.613 ± 0.268
3.255ArgVal: 3.255 ± 0.336
0.771ArgTrp: 0.771 ± 0.224
1.799ArgTyr: 1.799 ± 0.296
0.0ArgXaa: 0.0 ± 0.0
Ser
4.283SerAla: 4.283 ± 0.398
0.471SerCys: 0.471 ± 0.152
3.941SerAsp: 3.941 ± 0.541
3.598SerGlu: 3.598 ± 0.326
2.484SerPhe: 2.484 ± 0.258
5.654SerGly: 5.654 ± 0.396
1.157SerHis: 1.157 ± 0.223
3.17SerIle: 3.17 ± 0.336
3.298SerLys: 3.298 ± 0.302
4.54SerLeu: 4.54 ± 0.402
2.27SerMet: 2.27 ± 0.313
2.699SerAsn: 2.699 ± 0.293
2.527SerPro: 2.527 ± 0.293
1.885SerGln: 1.885 ± 0.343
2.527SerArg: 2.527 ± 0.306
3.555SerSer: 3.555 ± 0.37
3.727SerThr: 3.727 ± 0.405
4.112SerVal: 4.112 ± 0.454
0.685SerTrp: 0.685 ± 0.15
1.585SerTyr: 1.585 ± 0.223
0.0SerXaa: 0.0 ± 0.0
Thr
5.654ThrAla: 5.654 ± 0.487
0.257ThrCys: 0.257 ± 0.142
3.941ThrAsp: 3.941 ± 0.333
3.598ThrGlu: 3.598 ± 0.273
2.27ThrPhe: 2.27 ± 0.274
5.868ThrGly: 5.868 ± 0.519
1.285ThrHis: 1.285 ± 0.254
3.341ThrIle: 3.341 ± 0.29
3.812ThrLys: 3.812 ± 0.44
5.311ThrLeu: 5.311 ± 0.529
1.628ThrMet: 1.628 ± 0.253
3.512ThrAsn: 3.512 ± 0.338
2.956ThrPro: 2.956 ± 0.336
2.527ThrGln: 2.527 ± 0.28
2.913ThrArg: 2.913 ± 0.265
2.784ThrSer: 2.784 ± 0.367
4.54ThrThr: 4.54 ± 0.636
4.583ThrVal: 4.583 ± 0.486
0.643ThrTrp: 0.643 ± 0.145
2.356ThrTyr: 2.356 ± 0.33
0.0ThrXaa: 0.0 ± 0.0
Val
6.082ValAla: 6.082 ± 0.736
0.728ValCys: 0.728 ± 0.186
4.712ValAsp: 4.712 ± 0.458
4.626ValGlu: 4.626 ± 0.365
2.227ValPhe: 2.227 ± 0.251
4.969ValGly: 4.969 ± 0.514
0.857ValHis: 0.857 ± 0.209
3.427ValIle: 3.427 ± 0.379
4.069ValLys: 4.069 ± 0.64
4.969ValLeu: 4.969 ± 0.506
2.399ValMet: 2.399 ± 0.293
3.641ValAsn: 3.641 ± 0.649
2.784ValPro: 2.784 ± 0.311
2.87ValGln: 2.87 ± 0.442
3.298ValArg: 3.298 ± 0.328
4.283ValSer: 4.283 ± 0.477
4.283ValThr: 4.283 ± 0.566
4.455ValVal: 4.455 ± 0.457
0.643ValTrp: 0.643 ± 0.186
2.056ValTyr: 2.056 ± 0.255
0.0ValXaa: 0.0 ± 0.0
Trp
1.242TrpAla: 1.242 ± 0.235
0.043TrpCys: 0.043 ± 0.037
1.157TrpAsp: 1.157 ± 0.211
1.071TrpGlu: 1.071 ± 0.206
0.6TrpPhe: 0.6 ± 0.158
1.071TrpGly: 1.071 ± 0.283
0.386TrpHis: 0.386 ± 0.158
0.857TrpIle: 0.857 ± 0.219
0.643TrpLys: 0.643 ± 0.174
1.114TrpLeu: 1.114 ± 0.21
0.386TrpMet: 0.386 ± 0.117
0.685TrpAsn: 0.685 ± 0.182
0.257TrpPro: 0.257 ± 0.117
0.557TrpGln: 0.557 ± 0.13
0.942TrpArg: 0.942 ± 0.23
0.6TrpSer: 0.6 ± 0.162
1.199TrpThr: 1.199 ± 0.252
1.028TrpVal: 1.028 ± 0.175
0.343TrpTrp: 0.343 ± 0.135
0.557TrpTyr: 0.557 ± 0.156
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.17TyrAla: 3.17 ± 0.3
0.386TyrCys: 0.386 ± 0.125
2.827TyrAsp: 2.827 ± 0.428
2.313TyrGlu: 2.313 ± 0.318
1.414TyrPhe: 1.414 ± 0.267
2.27TyrGly: 2.27 ± 0.362
0.685TyrHis: 0.685 ± 0.19
1.628TyrIle: 1.628 ± 0.321
1.242TyrLys: 1.242 ± 0.184
2.827TyrLeu: 2.827 ± 0.38
0.643TyrMet: 0.643 ± 0.167
1.799TyrAsn: 1.799 ± 0.313
1.328TyrPro: 1.328 ± 0.222
1.756TyrGln: 1.756 ± 0.225
1.628TyrArg: 1.628 ± 0.245
1.799TyrSer: 1.799 ± 0.298
1.885TyrThr: 1.885 ± 0.343
2.227TyrVal: 2.227 ± 0.387
0.728TyrTrp: 0.728 ± 0.149
0.942TyrTyr: 0.942 ± 0.155
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 79 proteins (23347 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski