Amino acid dipepetide frequency for Acinetobacter nectaris CIP 110549

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.003AlaAla: 6.003 ± 0.117	0.818AlaCys: 0.818 ± 0.033	3.899AlaAsp: 3.899 ± 0.08	4.72AlaGlu: 4.72 ± 0.1	3.309AlaPhe: 3.309 ± 0.063	5.151AlaGly: 5.151 ± 0.097	1.755AlaHis: 1.755 ± 0.053	5.82AlaIle: 5.82 ± 0.093	4.803AlaLys: 4.803 ± 0.082	8.914AlaLeu: 8.914 ± 0.119	2.162AlaMet: 2.162 ± 0.058	3.387AlaAsn: 3.387 ± 0.084	2.601AlaPro: 2.601 ± 0.073	4.114AlaGln: 4.114 ± 0.084	3.176AlaArg: 3.176 ± 0.067	4.957AlaSer: 4.957 ± 0.076	4.472AlaThr: 4.472 ± 0.095	5.477AlaVal: 5.477 ± 0.089	1.03AlaTrp: 1.03 ± 0.038	2.615AlaTyr: 2.615 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.691CysAla: 0.691 ± 0.029	0.123CysCys: 0.123 ± 0.013	0.467CysAsp: 0.467 ± 0.03	0.516CysGlu: 0.516 ± 0.025	0.495CysPhe: 0.495 ± 0.025	0.75CysGly: 0.75 ± 0.035	0.299CysHis: 0.299 ± 0.019	0.777CysIle: 0.777 ± 0.037	0.43CysLys: 0.43 ± 0.023	1.035CysLeu: 1.035 ± 0.039	0.196CysMet: 0.196 ± 0.017	0.351CysAsn: 0.351 ± 0.023	0.381CysPro: 0.381 ± 0.024	0.404CysGln: 0.404 ± 0.022	0.379CysArg: 0.379 ± 0.02	0.676CysSer: 0.676 ± 0.031	0.471CysThr: 0.471 ± 0.029	0.606CysVal: 0.606 ± 0.026	0.092CysTrp: 0.092 ± 0.01	0.325CysTyr: 0.325 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.267AspAla: 4.267 ± 0.093	0.392AspCys: 0.392 ± 0.023	2.609AspAsp: 2.609 ± 0.072	3.369AspGlu: 3.369 ± 0.082	2.372AspPhe: 2.372 ± 0.056	3.263AspGly: 3.263 ± 0.076	1.359AspHis: 1.359 ± 0.042	4.222AspIle: 4.222 ± 0.072	2.656AspLys: 2.656 ± 0.067	5.463AspLeu: 5.463 ± 0.09	1.194AspMet: 1.194 ± 0.041	2.07AspAsn: 2.07 ± 0.06	1.901AspPro: 1.901 ± 0.054	2.613AspGln: 2.613 ± 0.058	2.197AspArg: 2.197 ± 0.063	2.645AspSer: 2.645 ± 0.066	2.682AspThr: 2.682 ± 0.062	3.655AspVal: 3.655 ± 0.07	0.765AspTrp: 0.765 ± 0.036	1.837AspTyr: 1.837 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.481GluAla: 4.481 ± 0.089	0.466GluCys: 0.466 ± 0.027	2.761GluAsp: 2.761 ± 0.065	3.241GluGlu: 3.241 ± 0.085	2.07GluPhe: 2.07 ± 0.053	3.018GluGly: 3.018 ± 0.074	1.572GluHis: 1.572 ± 0.047	4.386GluIle: 4.386 ± 0.069	4.761GluLys: 4.761 ± 0.09	5.504GluLeu: 5.504 ± 0.089	1.457GluMet: 1.457 ± 0.046	3.139GluAsn: 3.139 ± 0.069	1.674GluPro: 1.674 ± 0.044	3.75GluGln: 3.75 ± 0.078	2.738GluArg: 2.738 ± 0.07	3.251GluSer: 3.251 ± 0.077	3.112GluThr: 3.112 ± 0.065	3.833GluVal: 3.833 ± 0.079	0.679GluTrp: 0.679 ± 0.032	1.917GluTyr: 1.917 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.415PheAla: 3.415 ± 0.076	0.493PheCys: 0.493 ± 0.026	2.583PheAsp: 2.583 ± 0.049	2.459PheGlu: 2.459 ± 0.056	1.956PhePhe: 1.956 ± 0.067	3.127PheGly: 3.127 ± 0.069	0.85PheHis: 0.85 ± 0.028	3.59PheIle: 3.59 ± 0.093	2.597PheLys: 2.597 ± 0.07	4.053PheLeu: 4.053 ± 0.098	1.038PheMet: 1.038 ± 0.04	2.261PheAsn: 2.261 ± 0.054	1.441PhePro: 1.441 ± 0.043	1.553PheGln: 1.553 ± 0.047	1.441PheArg: 1.441 ± 0.044	3.401PheSer: 3.401 ± 0.077	2.269PheThr: 2.269 ± 0.063	2.531PheVal: 2.531 ± 0.068	0.542PheTrp: 0.542 ± 0.03	1.564PheTyr: 1.564 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.671GlyAla: 4.671 ± 0.081	0.783GlyCys: 0.783 ± 0.034	2.794GlyAsp: 2.794 ± 0.066	3.484GlyGlu: 3.484 ± 0.072	3.155GlyPhe: 3.155 ± 0.07	4.288GlyGly: 4.288 ± 0.097	1.616GlyHis: 1.616 ± 0.051	4.954GlyIle: 4.954 ± 0.103	3.829GlyLys: 3.829 ± 0.072	6.789GlyLeu: 6.789 ± 0.095	1.68GlyMet: 1.68 ± 0.053	2.641GlyAsn: 2.641 ± 0.098	1.404GlyPro: 1.404 ± 0.042	2.949GlyGln: 2.949 ± 0.075	2.714GlyArg: 2.714 ± 0.064	3.904GlySer: 3.904 ± 0.089	3.666GlyThr: 3.666 ± 0.095	4.653GlyVal: 4.653 ± 0.087	0.814GlyTrp: 0.814 ± 0.034	2.419GlyTyr: 2.419 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.973HisAla: 1.973 ± 0.057	0.269HisCys: 0.269 ± 0.019	1.235HisAsp: 1.235 ± 0.036	1.292HisGlu: 1.292 ± 0.045	1.201HisPhe: 1.201 ± 0.039	1.589HisGly: 1.589 ± 0.053	0.865HisHis: 0.865 ± 0.037	1.932HisIle: 1.932 ± 0.054	1.149HisLys: 1.149 ± 0.04	2.715HisLeu: 2.715 ± 0.064	0.548HisMet: 0.548 ± 0.027	0.888HisAsn: 0.888 ± 0.033	1.227HisPro: 1.227 ± 0.042	1.337HisGln: 1.337 ± 0.046	0.986HisArg: 0.986 ± 0.037	1.354HisSer: 1.354 ± 0.044	1.358HisThr: 1.358 ± 0.045	1.583HisVal: 1.583 ± 0.055	0.372HisTrp: 0.372 ± 0.023	0.966HisTyr: 0.966 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.612IleAla: 6.612 ± 0.116	0.85IleCys: 0.85 ± 0.036	4.27IleAsp: 4.27 ± 0.069	4.655IleGlu: 4.655 ± 0.081	3.246IlePhe: 3.246 ± 0.092	5.0IleGly: 5.0 ± 0.098	1.791IleHis: 1.791 ± 0.044	4.766IleIle: 4.766 ± 0.102	3.762IleLys: 3.762 ± 0.076	7.059IleLeu: 7.059 ± 0.117	1.466IleMet: 1.466 ± 0.042	3.233IleAsn: 3.233 ± 0.072	3.162IlePro: 3.162 ± 0.071	3.769IleGln: 3.769 ± 0.073	3.04IleArg: 3.04 ± 0.063	5.128IleSer: 5.128 ± 0.097	4.027IleThr: 4.027 ± 0.075	4.464IleVal: 4.464 ± 0.093	0.769IleTrp: 0.769 ± 0.03	2.32IleTyr: 2.32 ± 0.06	0.0IleXaa: 0.0 ± 0.0
Lys	4.606LysAla: 4.606 ± 0.083	0.335LysCys: 0.335 ± 0.019	3.447LysAsp: 3.447 ± 0.075	3.673LysGlu: 3.673 ± 0.083	2.068LysPhe: 2.068 ± 0.067	3.159LysGly: 3.159 ± 0.069	1.466LysHis: 1.466 ± 0.048	4.275LysIle: 4.275 ± 0.075	4.337LysLys: 4.337 ± 0.091	5.38LysLeu: 5.38 ± 0.079	1.575LysMet: 1.575 ± 0.041	3.548LysAsn: 3.548 ± 0.079	2.317LysPro: 2.317 ± 0.057	3.476LysGln: 3.476 ± 0.071	2.652LysArg: 2.652 ± 0.061	3.613LysSer: 3.613 ± 0.069	3.607LysThr: 3.607 ± 0.084	3.975LysVal: 3.975 ± 0.079	0.64LysTrp: 0.64 ± 0.027	2.047LysTyr: 2.047 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	8.364LeuAla: 8.364 ± 0.107	1.095LeuCys: 1.095 ± 0.041	5.823LeuAsp: 5.823 ± 0.094	5.959LeuGlu: 5.959 ± 0.103	4.286LeuPhe: 4.286 ± 0.103	6.89LeuGly: 6.89 ± 0.104	2.212LeuHis: 2.212 ± 0.06	7.124LeuIle: 7.124 ± 0.123	6.786LeuLys: 6.786 ± 0.109	9.761LeuLeu: 9.761 ± 0.144	2.409LeuMet: 2.409 ± 0.063	5.548LeuAsn: 5.548 ± 0.094	4.418LeuPro: 4.418 ± 0.071	4.337LeuGln: 4.337 ± 0.083	3.932LeuArg: 3.932 ± 0.073	7.638LeuSer: 7.638 ± 0.097	5.992LeuThr: 5.992 ± 0.1	6.025LeuVal: 6.025 ± 0.088	1.157LeuTrp: 1.157 ± 0.045	2.858LeuTyr: 2.858 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	1.91MetAla: 1.91 ± 0.05	0.226MetCys: 0.226 ± 0.017	0.957MetAsp: 0.957 ± 0.042	0.929MetGlu: 0.929 ± 0.032	0.804MetPhe: 0.804 ± 0.035	1.642MetGly: 1.642 ± 0.05	0.573MetHis: 0.573 ± 0.029	1.571MetIle: 1.571 ± 0.048	1.47MetLys: 1.47 ± 0.045	2.382MetLeu: 2.382 ± 0.062	0.664MetMet: 0.664 ± 0.035	1.354MetAsn: 1.354 ± 0.041	1.089MetPro: 1.089 ± 0.039	1.314MetGln: 1.314 ± 0.047	1.045MetArg: 1.045 ± 0.035	1.906MetSer: 1.906 ± 0.049	1.511MetThr: 1.511 ± 0.04	1.585MetVal: 1.585 ± 0.053	0.174MetTrp: 0.174 ± 0.016	0.582MetTyr: 0.582 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.695AsnAla: 3.695 ± 0.081	0.377AsnCys: 0.377 ± 0.023	2.476AsnAsp: 2.476 ± 0.051	2.51AsnGlu: 2.51 ± 0.054	1.993AsnPhe: 1.993 ± 0.052	2.942AsnGly: 2.942 ± 0.09	1.228AsnHis: 1.228 ± 0.043	4.009AsnIle: 4.009 ± 0.074	2.815AsnLys: 2.815 ± 0.063	4.666AsnLeu: 4.666 ± 0.084	1.077AsnMet: 1.077 ± 0.033	2.532AsnAsn: 2.532 ± 0.094	2.144AsnPro: 2.144 ± 0.052	2.372AsnGln: 2.372 ± 0.069	1.872AsnArg: 1.872 ± 0.055	2.88AsnSer: 2.88 ± 0.088	3.261AsnThr: 3.261 ± 0.101	2.872AsnVal: 2.872 ± 0.078	0.569AsnTrp: 0.569 ± 0.027	1.767AsnTyr: 1.767 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.601ProAla: 2.601 ± 0.067	0.281ProCys: 0.281 ± 0.021	1.849ProAsp: 1.849 ± 0.053	2.957ProGlu: 2.957 ± 0.071	1.75ProPhe: 1.75 ± 0.053	1.5ProGly: 1.5 ± 0.049	0.976ProHis: 0.976 ± 0.033	2.915ProIle: 2.915 ± 0.066	2.583ProLys: 2.583 ± 0.063	3.937ProLeu: 3.937 ± 0.07	0.961ProMet: 0.961 ± 0.033	2.16ProAsn: 2.16 ± 0.06	1.134ProPro: 1.134 ± 0.041	1.895ProGln: 1.895 ± 0.057	1.31ProArg: 1.31 ± 0.044	2.499ProSer: 2.499 ± 0.06	2.385ProThr: 2.385 ± 0.059	2.556ProVal: 2.556 ± 0.068	0.443ProTrp: 0.443 ± 0.026	1.398ProTyr: 1.398 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.401GlnAla: 4.401 ± 0.089	0.357GlnCys: 0.357 ± 0.022	2.338GlnAsp: 2.338 ± 0.06	2.673GlnGlu: 2.673 ± 0.059	2.046GlnPhe: 2.046 ± 0.051	2.847GlnGly: 2.847 ± 0.064	1.576GlnHis: 1.576 ± 0.05	3.313GlnIle: 3.313 ± 0.065	3.232GlnLys: 3.232 ± 0.071	5.197GlnLeu: 5.197 ± 0.102	1.111GlnMet: 1.111 ± 0.032	2.419GlnAsn: 2.419 ± 0.066	2.046GlnPro: 2.046 ± 0.061	3.481GlnGln: 3.481 ± 0.107	2.303GlnArg: 2.303 ± 0.057	3.107GlnSer: 3.107 ± 0.07	2.66GlnThr: 2.66 ± 0.059	3.351GlnVal: 3.351 ± 0.069	0.644GlnTrp: 0.644 ± 0.036	1.877GlnTyr: 1.877 ± 0.049	0.0GlnXaa: 0.0 ± 0.0
Arg	3.027ArgAla: 3.027 ± 0.064	0.351ArgCys: 0.351 ± 0.02	2.059ArgAsp: 2.059 ± 0.059	2.592ArgGlu: 2.592 ± 0.073	1.997ArgPhe: 1.997 ± 0.056	2.318ArgGly: 2.318 ± 0.065	1.089ArgHis: 1.089 ± 0.037	3.076ArgIle: 3.076 ± 0.063	2.313ArgLys: 2.313 ± 0.06	4.598ArgLeu: 4.598 ± 0.094	1.006ArgMet: 1.006 ± 0.034	1.784ArgAsn: 1.784 ± 0.046	1.597ArgPro: 1.597 ± 0.051	2.205ArgGln: 2.205 ± 0.06	2.08ArgArg: 2.08 ± 0.06	2.208ArgSer: 2.208 ± 0.057	2.077ArgThr: 2.077 ± 0.049	2.739ArgVal: 2.739 ± 0.064	0.472ArgTrp: 0.472 ± 0.024	1.745ArgTyr: 1.745 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.847SerAla: 4.847 ± 0.091	0.577SerCys: 0.577 ± 0.027	3.205SerAsp: 3.205 ± 0.073	3.568SerGlu: 3.568 ± 0.073	3.104SerPhe: 3.104 ± 0.071	4.394SerGly: 4.394 ± 0.095	1.64SerHis: 1.64 ± 0.045	4.854SerIle: 4.854 ± 0.088	3.577SerLys: 3.577 ± 0.08	6.731SerLeu: 6.731 ± 0.091	1.5SerMet: 1.5 ± 0.049	3.122SerAsn: 3.122 ± 0.082	2.443SerPro: 2.443 ± 0.054	3.118SerGln: 3.118 ± 0.061	2.508SerArg: 2.508 ± 0.064	4.561SerSer: 4.561 ± 0.102	3.845SerThr: 3.845 ± 0.097	3.849SerVal: 3.849 ± 0.07	0.764SerTrp: 0.764 ± 0.032	2.294SerTyr: 2.294 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	4.853ThrAla: 4.853 ± 0.101	0.468ThrCys: 0.468 ± 0.026	2.91ThrAsp: 2.91 ± 0.078	2.944ThrGlu: 2.944 ± 0.06	2.306ThrPhe: 2.306 ± 0.052	4.078ThrGly: 4.078 ± 0.098	1.456ThrHis: 1.456 ± 0.046	3.856ThrIle: 3.856 ± 0.072	2.881ThrLys: 2.881 ± 0.064	6.428ThrLeu: 6.428 ± 0.106	1.039ThrMet: 1.039 ± 0.035	2.504ThrAsn: 2.504 ± 0.091	2.816ThrPro: 2.816 ± 0.065	2.884ThrGln: 2.884 ± 0.066	2.221ThrArg: 2.221 ± 0.051	3.551ThrSer: 3.551 ± 0.079	3.668ThrThr: 3.668 ± 0.12	3.934ThrVal: 3.934 ± 0.085	0.665ThrTrp: 0.665 ± 0.031	1.832ThrTyr: 1.832 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	5.33ValAla: 5.33 ± 0.09	0.693ValCys: 0.693 ± 0.03	3.65ValAsp: 3.65 ± 0.069	3.964ValGlu: 3.964 ± 0.077	2.78ValPhe: 2.78 ± 0.067	4.401ValGly: 4.401 ± 0.077	1.311ValHis: 1.311 ± 0.044	4.744ValIle: 4.744 ± 0.094	3.704ValLys: 3.704 ± 0.088	6.689ValLeu: 6.689 ± 0.094	1.645ValMet: 1.645 ± 0.05	2.991ValAsn: 2.991 ± 0.074	2.527ValPro: 2.527 ± 0.058	2.727ValGln: 2.727 ± 0.05	2.546ValArg: 2.546 ± 0.063	4.353ValSer: 4.353 ± 0.074	3.786ValThr: 3.786 ± 0.088	4.536ValVal: 4.536 ± 0.095	0.715ValTrp: 0.715 ± 0.031	1.877ValTyr: 1.877 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.759TrpAla: 0.759 ± 0.033	0.134TrpCys: 0.134 ± 0.015	0.521TrpAsp: 0.521 ± 0.026	0.499TrpGlu: 0.499 ± 0.029	0.617TrpPhe: 0.617 ± 0.032	0.677TrpGly: 0.677 ± 0.03	0.356TrpHis: 0.356 ± 0.024	0.807TrpIle: 0.807 ± 0.037	0.681TrpLys: 0.681 ± 0.031	1.535TrpLeu: 1.535 ± 0.054	0.33TrpMet: 0.33 ± 0.019	0.592TrpAsn: 0.592 ± 0.029	0.334TrpPro: 0.334 ± 0.023	0.814TrpGln: 0.814 ± 0.035	0.568TrpArg: 0.568 ± 0.027	0.773TrpSer: 0.773 ± 0.031	0.553TrpThr: 0.553 ± 0.026	0.823TrpVal: 0.823 ± 0.035	0.159TrpTrp: 0.159 ± 0.014	0.398TrpTyr: 0.398 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.675TyrAla: 2.675 ± 0.057	0.375TyrCys: 0.375 ± 0.021	1.68TyrAsp: 1.68 ± 0.052	1.807TyrGlu: 1.807 ± 0.053	1.607TyrPhe: 1.607 ± 0.05	2.175TyrGly: 2.175 ± 0.056	0.846TyrHis: 0.846 ± 0.041	2.396TyrIle: 2.396 ± 0.068	1.831TyrLys: 1.831 ± 0.052	3.776TyrLeu: 3.776 ± 0.076	0.631TyrMet: 0.631 ± 0.028	1.537TyrAsn: 1.537 ± 0.049	1.436TyrPro: 1.436 ± 0.041	1.865TyrGln: 1.865 ± 0.048	1.625TyrArg: 1.625 ± 0.044	2.097TyrSer: 2.097 ± 0.061	1.896TyrThr: 1.896 ± 0.049	1.922TyrVal: 1.922 ± 0.054	0.463TyrTrp: 0.463 ± 0.027	1.116TyrTyr: 1.116 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2541 proteins (781571 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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