Amino acid dipepetide frequency for Legionella geestiana

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.676AlaAla: 9.676 ± 0.165	1.62AlaCys: 1.62 ± 0.055	4.388AlaAsp: 4.388 ± 0.084	5.619AlaGlu: 5.619 ± 0.094	4.597AlaPhe: 4.597 ± 0.08	7.231AlaGly: 7.231 ± 0.116	2.718AlaHis: 2.718 ± 0.064	5.822AlaIle: 5.822 ± 0.095	3.636AlaLys: 3.636 ± 0.073	13.454AlaLeu: 13.454 ± 0.185	2.81AlaMet: 2.81 ± 0.057	3.045AlaAsn: 3.045 ± 0.067	4.212AlaPro: 4.212 ± 0.086	3.402AlaGln: 3.402 ± 0.078	7.073AlaArg: 7.073 ± 0.114	6.336AlaSer: 6.336 ± 0.091	4.558AlaThr: 4.558 ± 0.081	6.133AlaVal: 6.133 ± 0.089	1.344AlaTrp: 1.344 ± 0.041	2.102AlaTyr: 2.102 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.225CysAla: 1.225 ± 0.036	0.176CysCys: 0.176 ± 0.016	0.621CysAsp: 0.621 ± 0.031	0.842CysGlu: 0.842 ± 0.037	0.644CysPhe: 0.644 ± 0.028	1.048CysGly: 1.048 ± 0.044	0.361CysHis: 0.361 ± 0.021	0.767CysIle: 0.767 ± 0.037	0.484CysLys: 0.484 ± 0.03	1.471CysLeu: 1.471 ± 0.044	0.396CysMet: 0.396 ± 0.022	0.457CysAsn: 0.457 ± 0.027	0.599CysPro: 0.599 ± 0.031	0.477CysGln: 0.477 ± 0.027	0.808CysArg: 0.808 ± 0.036	0.806CysSer: 0.806 ± 0.037	0.679CysThr: 0.679 ± 0.031	0.887CysVal: 0.887 ± 0.034	0.135CysTrp: 0.135 ± 0.013	0.379CysTyr: 0.379 ± 0.022	0.001CysXaa: 0.001 ± 0.001
Asp	6.065AspAla: 6.065 ± 0.108	0.639AspCys: 0.639 ± 0.029	2.409AspAsp: 2.409 ± 0.067	3.204AspGlu: 3.204 ± 0.075	2.478AspPhe: 2.478 ± 0.06	3.147AspGly: 3.147 ± 0.065	0.71AspHis: 0.71 ± 0.029	3.353AspIle: 3.353 ± 0.074	2.37AspLys: 2.37 ± 0.064	3.881AspLeu: 3.881 ± 0.082	1.312AspMet: 1.312 ± 0.043	2.035AspAsn: 2.035 ± 0.053	1.772AspPro: 1.772 ± 0.05	0.825AspGln: 0.825 ± 0.041	2.234AspArg: 2.234 ± 0.056	2.923AspSer: 2.923 ± 0.064	3.168AspThr: 3.168 ± 0.065	3.372AspVal: 3.372 ± 0.076	0.777AspTrp: 0.777 ± 0.035	1.72AspTyr: 1.72 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	6.954GluAla: 6.954 ± 0.116	0.706GluCys: 0.706 ± 0.031	2.758GluAsp: 2.758 ± 0.067	3.566GluGlu: 3.566 ± 0.087	1.768GluPhe: 1.768 ± 0.054	3.978GluGly: 3.978 ± 0.08	1.775GluHis: 1.775 ± 0.059	3.217GluIle: 3.217 ± 0.072	3.65GluLys: 3.65 ± 0.085	5.511GluLeu: 5.511 ± 0.093	1.551GluMet: 1.551 ± 0.049	2.586GluAsn: 2.586 ± 0.051	2.257GluPro: 2.257 ± 0.059	2.585GluGln: 2.585 ± 0.06	4.265GluArg: 4.265 ± 0.08	3.753GluSer: 3.753 ± 0.071	3.709GluThr: 3.709 ± 0.072	3.733GluVal: 3.733 ± 0.083	0.733GluTrp: 0.733 ± 0.035	1.622GluTyr: 1.622 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	4.177PheAla: 4.177 ± 0.08	0.669PheCys: 0.669 ± 0.032	2.361PheAsp: 2.361 ± 0.058	2.526PheGlu: 2.526 ± 0.067	2.189PhePhe: 2.189 ± 0.069	2.922PheGly: 2.922 ± 0.067	0.933PheHis: 0.933 ± 0.039	2.339PheIle: 2.339 ± 0.052	1.537PheLys: 1.537 ± 0.044	4.38PheLeu: 4.38 ± 0.088	0.997PheMet: 0.997 ± 0.036	1.698PheAsn: 1.698 ± 0.053	1.793PhePro: 1.793 ± 0.054	1.387PheGln: 1.387 ± 0.038	2.171PheArg: 2.171 ± 0.056	3.321PheSer: 3.321 ± 0.075	2.411PheThr: 2.411 ± 0.067	2.671PheVal: 2.671 ± 0.065	0.565PheTrp: 0.565 ± 0.031	1.361PheTyr: 1.361 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	5.786GlyAla: 5.786 ± 0.091	1.0GlyCys: 1.0 ± 0.04	2.885GlyAsp: 2.885 ± 0.062	3.994GlyGlu: 3.994 ± 0.08	3.596GlyPhe: 3.596 ± 0.089	4.414GlyGly: 4.414 ± 0.092	1.754GlyHis: 1.754 ± 0.047	4.568GlyIle: 4.568 ± 0.094	3.335GlyLys: 3.335 ± 0.073	7.421GlyLeu: 7.421 ± 0.104	2.213GlyMet: 2.213 ± 0.056	2.379GlyAsn: 2.379 ± 0.069	1.772GlyPro: 1.772 ± 0.058	2.273GlyGln: 2.273 ± 0.063	3.786GlyArg: 3.786 ± 0.079	3.728GlySer: 3.728 ± 0.076	3.421GlyThr: 3.421 ± 0.068	5.209GlyVal: 5.209 ± 0.093	0.854GlyTrp: 0.854 ± 0.032	2.233GlyTyr: 2.233 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	3.053HisAla: 3.053 ± 0.066	0.453HisCys: 0.453 ± 0.022	1.176HisAsp: 1.176 ± 0.04	1.538HisGlu: 1.538 ± 0.046	1.375HisPhe: 1.375 ± 0.046	1.87HisGly: 1.87 ± 0.049	0.969HisHis: 0.969 ± 0.035	1.388HisIle: 1.388 ± 0.043	0.816HisLys: 0.816 ± 0.034	2.975HisLeu: 2.975 ± 0.064	0.556HisMet: 0.556 ± 0.028	0.783HisAsn: 0.783 ± 0.034	1.656HisPro: 1.656 ± 0.051	1.092HisGln: 1.092 ± 0.044	1.517HisArg: 1.517 ± 0.05	1.257HisSer: 1.257 ± 0.037	1.486HisThr: 1.486 ± 0.045	1.529HisVal: 1.529 ± 0.044	0.392HisTrp: 0.392 ± 0.023	0.995HisTyr: 0.995 ± 0.039	0.0HisXaa: 0.0 ± 0.0
Ile	6.029IleAla: 6.029 ± 0.097	0.652IleCys: 0.652 ± 0.028	3.265IleAsp: 3.265 ± 0.075	3.522IleGlu: 3.522 ± 0.08	1.947IlePhe: 1.947 ± 0.059	3.798IleGly: 3.798 ± 0.083	1.432IleHis: 1.432 ± 0.051	3.0IleIle: 3.0 ± 0.078	2.193IleLys: 2.193 ± 0.056	5.415IleLeu: 5.415 ± 0.097	1.18IleMet: 1.18 ± 0.044	2.449IleAsn: 2.449 ± 0.059	2.916IlePro: 2.916 ± 0.051	1.87IleGln: 1.87 ± 0.048	3.405IleArg: 3.405 ± 0.071	3.397IleSer: 3.397 ± 0.077	3.328IleThr: 3.328 ± 0.08	3.266IleVal: 3.266 ± 0.075	0.476IleTrp: 0.476 ± 0.025	1.319IleTyr: 1.319 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.507LysAla: 4.507 ± 0.088	0.352LysCys: 0.352 ± 0.024	2.107LysAsp: 2.107 ± 0.052	2.279LysGlu: 2.279 ± 0.065	1.026LysPhe: 1.026 ± 0.035	2.568LysGly: 2.568 ± 0.059	1.076LysHis: 1.076 ± 0.04	2.462LysIle: 2.462 ± 0.062	2.493LysLys: 2.493 ± 0.061	3.833LysLeu: 3.833 ± 0.068	0.992LysMet: 0.992 ± 0.034	2.116LysAsn: 2.116 ± 0.059	2.506LysPro: 2.506 ± 0.061	1.519LysGln: 1.519 ± 0.057	2.722LysArg: 2.722 ± 0.06	2.86LysSer: 2.86 ± 0.059	3.142LysThr: 3.142 ± 0.069	2.379LysVal: 2.379 ± 0.055	0.389LysTrp: 0.389 ± 0.022	0.993LysTyr: 0.993 ± 0.038	0.001LysXaa: 0.001 ± 0.001
Leu	11.145LeuAla: 11.145 ± 0.156	1.582LeuCys: 1.582 ± 0.048	5.217LeuAsp: 5.217 ± 0.085	6.926LeuGlu: 6.926 ± 0.12	4.715LeuPhe: 4.715 ± 0.106	6.535LeuGly: 6.535 ± 0.115	3.015LeuHis: 3.015 ± 0.071	5.377LeuIle: 5.377 ± 0.091	5.358LeuLys: 5.358 ± 0.099	13.007LeuLeu: 13.007 ± 0.232	2.949LeuMet: 2.949 ± 0.074	4.147LeuAsn: 4.147 ± 0.084	6.029LeuPro: 6.029 ± 0.106	5.207LeuGln: 5.207 ± 0.103	6.452LeuArg: 6.452 ± 0.107	8.003LeuSer: 8.003 ± 0.117	6.28LeuThr: 6.28 ± 0.093	6.878LeuVal: 6.878 ± 0.109	1.238LeuTrp: 1.238 ± 0.042	2.982LeuTyr: 2.982 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.508MetAla: 2.508 ± 0.059	0.243MetCys: 0.243 ± 0.018	1.273MetAsp: 1.273 ± 0.039	1.446MetGlu: 1.446 ± 0.04	0.724MetPhe: 0.724 ± 0.03	1.67MetGly: 1.67 ± 0.051	0.748MetHis: 0.748 ± 0.03	1.04MetIle: 1.04 ± 0.042	1.235MetLys: 1.235 ± 0.043	3.163MetLeu: 3.163 ± 0.082	0.737MetMet: 0.737 ± 0.034	1.023MetAsn: 1.023 ± 0.043	1.524MetPro: 1.524 ± 0.05	1.404MetGln: 1.404 ± 0.05	1.792MetArg: 1.792 ± 0.044	1.585MetSer: 1.585 ± 0.047	1.482MetThr: 1.482 ± 0.043	1.739MetVal: 1.739 ± 0.051	0.159MetTrp: 0.159 ± 0.014	0.515MetTyr: 0.515 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	4.106AsnAla: 4.106 ± 0.081	0.431AsnCys: 0.431 ± 0.027	1.767AsnAsp: 1.767 ± 0.048	1.851AsnGlu: 1.851 ± 0.058	1.23AsnPhe: 1.23 ± 0.045	2.542AsnGly: 2.542 ± 0.061	1.097AsnHis: 1.097 ± 0.037	2.178AsnIle: 2.178 ± 0.057	1.288AsnLys: 1.288 ± 0.046	3.914AsnLeu: 3.914 ± 0.091	0.774AsnMet: 0.774 ± 0.03	1.497AsnAsn: 1.497 ± 0.054	2.742AsnPro: 2.742 ± 0.074	1.425AsnGln: 1.425 ± 0.042	2.251AsnArg: 2.251 ± 0.054	1.777AsnSer: 1.777 ± 0.051	2.299AsnThr: 2.299 ± 0.068	2.156AsnVal: 2.156 ± 0.059	0.477AsnTrp: 0.477 ± 0.026	1.021AsnTyr: 1.021 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.733ProAla: 4.733 ± 0.086	0.576ProCys: 0.576 ± 0.027	2.944ProAsp: 2.944 ± 0.062	4.189ProGlu: 4.189 ± 0.077	1.975ProPhe: 1.975 ± 0.051	3.566ProGly: 3.566 ± 0.078	1.172ProHis: 1.172 ± 0.037	1.799ProIle: 1.799 ± 0.046	1.786ProLys: 1.786 ± 0.051	5.582ProLeu: 5.582 ± 0.096	1.203ProMet: 1.203 ± 0.04	1.464ProAsn: 1.464 ± 0.046	2.075ProPro: 2.075 ± 0.068	1.737ProGln: 1.737 ± 0.046	2.22ProArg: 2.22 ± 0.054	2.66ProSer: 2.66 ± 0.055	1.77ProThr: 1.77 ± 0.049	4.192ProVal: 4.192 ± 0.081	0.744ProTrp: 0.744 ± 0.033	1.0ProTyr: 1.0 ± 0.039	0.003ProXaa: 0.003 ± 0.002
Gln	3.828GlnAla: 3.828 ± 0.076	0.461GlnCys: 0.461 ± 0.024	1.528GlnAsp: 1.528 ± 0.044	2.225GlnGlu: 2.225 ± 0.062	1.586GlnPhe: 1.586 ± 0.05	2.405GlnGly: 2.405 ± 0.062	1.053GlnHis: 1.053 ± 0.037	1.841GlnIle: 1.841 ± 0.05	2.266GlnLys: 2.266 ± 0.059	3.643GlnLeu: 3.643 ± 0.075	0.968GlnMet: 0.968 ± 0.035	1.6GlnAsn: 1.6 ± 0.05	1.574GlnPro: 1.574 ± 0.053	1.989GlnGln: 1.989 ± 0.074	2.257GlnArg: 2.257 ± 0.055	2.764GlnSer: 2.764 ± 0.068	2.249GlnThr: 2.249 ± 0.051	2.387GlnVal: 2.387 ± 0.062	0.559GlnTrp: 0.559 ± 0.028	1.164GlnTyr: 1.164 ± 0.042	0.001GlnXaa: 0.001 ± 0.001
Arg	5.921ArgAla: 5.921 ± 0.099	0.612ArgCys: 0.612 ± 0.031	3.037ArgAsp: 3.037 ± 0.062	4.712ArgGlu: 4.712 ± 0.098	3.116ArgPhe: 3.116 ± 0.064	3.565ArgGly: 3.565 ± 0.06	1.876ArgHis: 1.876 ± 0.062	3.679ArgIle: 3.679 ± 0.078	2.259ArgLys: 2.259 ± 0.051	7.582ArgLeu: 7.582 ± 0.115	1.744ArgMet: 1.744 ± 0.042	2.009ArgAsn: 2.009 ± 0.046	2.288ArgPro: 2.288 ± 0.057	2.596ArgGln: 2.596 ± 0.063	3.709ArgArg: 3.709 ± 0.073	2.636ArgSer: 2.636 ± 0.058	2.87ArgThr: 2.87 ± 0.062	4.174ArgVal: 4.174 ± 0.082	0.794ArgTrp: 0.794 ± 0.038	1.982ArgTyr: 1.982 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	6.082SerAla: 6.082 ± 0.104	0.771SerCys: 0.771 ± 0.034	2.918SerAsp: 2.918 ± 0.067	3.553SerGlu: 3.553 ± 0.073	2.437SerPhe: 2.437 ± 0.063	5.018SerGly: 5.018 ± 0.087	1.647SerHis: 1.647 ± 0.05	3.302SerIle: 3.302 ± 0.081	2.07SerLys: 2.07 ± 0.056	7.452SerLeu: 7.452 ± 0.111	1.854SerMet: 1.854 ± 0.052	1.951SerAsn: 1.951 ± 0.054	3.156SerPro: 3.156 ± 0.078	2.303SerGln: 2.303 ± 0.055	3.881SerArg: 3.881 ± 0.074	4.425SerSer: 4.425 ± 0.131	3.191SerThr: 3.191 ± 0.068	4.134SerVal: 4.134 ± 0.09	0.771SerTrp: 0.771 ± 0.032	1.306SerTyr: 1.306 ± 0.041	0.004SerXaa: 0.004 ± 0.002
Thr	4.918ThrAla: 4.918 ± 0.084	0.7ThrCys: 0.7 ± 0.035	2.625ThrAsp: 2.625 ± 0.058	2.857ThrGlu: 2.857 ± 0.062	2.094ThrPhe: 2.094 ± 0.058	4.252ThrGly: 4.252 ± 0.077	1.608ThrHis: 1.608 ± 0.046	2.753ThrIle: 2.753 ± 0.055	1.447ThrLys: 1.447 ± 0.046	7.803ThrLeu: 7.803 ± 0.123	1.072ThrMet: 1.072 ± 0.035	1.475ThrAsn: 1.475 ± 0.042	3.67ThrPro: 3.67 ± 0.08	1.868ThrGln: 1.868 ± 0.054	3.618ThrArg: 3.618 ± 0.075	3.005ThrSer: 3.005 ± 0.066	2.735ThrThr: 2.735 ± 0.061	3.932ThrVal: 3.932 ± 0.072	0.759ThrTrp: 0.759 ± 0.032	1.102ThrTyr: 1.102 ± 0.045	0.001ThrXaa: 0.001 ± 0.001
Val	5.789ValAla: 5.789 ± 0.093	0.977ValCys: 0.977 ± 0.034	3.354ValAsp: 3.354 ± 0.071	3.85ValGlu: 3.85 ± 0.081	3.107ValPhe: 3.107 ± 0.074	3.659ValGly: 3.659 ± 0.078	1.678ValHis: 1.678 ± 0.047	4.037ValIle: 4.037 ± 0.071	2.657ValLys: 2.657 ± 0.067	7.509ValLeu: 7.509 ± 0.117	1.79ValMet: 1.79 ± 0.057	2.654ValAsn: 2.654 ± 0.054	2.883ValPro: 2.883 ± 0.066	2.176ValGln: 2.176 ± 0.053	4.185ValArg: 4.185 ± 0.083	4.702ValSer: 4.702 ± 0.091	3.504ValThr: 3.504 ± 0.079	4.622ValVal: 4.622 ± 0.091	0.767ValTrp: 0.767 ± 0.034	1.887ValTyr: 1.887 ± 0.056	0.001ValXaa: 0.001 ± 0.001
Trp	0.806TrpAla: 0.806 ± 0.031	0.199TrpCys: 0.199 ± 0.014	0.493TrpAsp: 0.493 ± 0.026	0.608TrpGlu: 0.608 ± 0.026	0.572TrpPhe: 0.572 ± 0.03	0.647TrpGly: 0.647 ± 0.03	0.449TrpHis: 0.449 ± 0.029	0.678TrpIle: 0.678 ± 0.03	0.529TrpLys: 0.529 ± 0.028	1.834TrpLeu: 1.834 ± 0.052	0.388TrpMet: 0.388 ± 0.021	0.515TrpAsn: 0.515 ± 0.024	0.523TrpPro: 0.523 ± 0.029	0.816TrpGln: 0.816 ± 0.034	0.833TrpArg: 0.833 ± 0.036	0.678TrpSer: 0.678 ± 0.034	0.554TrpThr: 0.554 ± 0.027	0.796TrpVal: 0.796 ± 0.033	0.22TrpTrp: 0.22 ± 0.017	0.445TrpTyr: 0.445 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.469TyrAla: 2.469 ± 0.054	0.446TyrCys: 0.446 ± 0.024	1.272TyrAsp: 1.272 ± 0.071	1.367TyrGlu: 1.367 ± 0.046	1.228TyrPhe: 1.228 ± 0.048	1.784TyrGly: 1.784 ± 0.052	0.806TyrHis: 0.806 ± 0.031	1.259TyrIle: 1.259 ± 0.042	0.911TyrLys: 0.911 ± 0.038	3.213TyrLeu: 3.213 ± 0.065	0.521TyrMet: 0.521 ± 0.027	0.942TyrAsn: 0.942 ± 0.04	1.442TyrPro: 1.442 ± 0.048	1.396TyrGln: 1.396 ± 0.039	1.982TyrArg: 1.982 ± 0.054	1.61TyrSer: 1.61 ± 0.051	1.455TyrThr: 1.455 ± 0.044	1.598TyrVal: 1.598 ± 0.047	0.427TyrTrp: 0.427 ± 0.024	0.957TyrTyr: 0.957 ± 0.032	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.003XaaGly: 0.003 ± 0.002	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.041XaaXaa: 0.041 ± 0.012

Statistics based on 2282 proteins (773064 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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