Amino acid dipepetide frequency for Streptococcus phage CHPC875

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.25AlaAla: 3.25 ± 0.934
0.271AlaCys: 0.271 ± 0.165
4.514AlaAsp: 4.514 ± 0.644
4.604AlaGlu: 4.604 ± 0.657
2.799AlaPhe: 2.799 ± 0.787
4.153AlaGly: 4.153 ± 0.772
0.632AlaHis: 0.632 ± 0.17
3.882AlaIle: 3.882 ± 0.695
6.41AlaLys: 6.41 ± 1.077
6.681AlaLeu: 6.681 ± 0.697
1.444AlaMet: 1.444 ± 0.311
3.972AlaAsn: 3.972 ± 0.729
1.354AlaPro: 1.354 ± 0.357
2.799AlaGln: 2.799 ± 0.503
2.167AlaArg: 2.167 ± 0.44
4.785AlaSer: 4.785 ± 0.585
4.062AlaThr: 4.062 ± 0.774
4.604AlaVal: 4.604 ± 0.686
0.993AlaTrp: 0.993 ± 0.261
2.618AlaTyr: 2.618 ± 0.538
0.0AlaXaa: 0.0 ± 0.0
Cys
0.09CysAla: 0.09 ± 0.077
0.0CysCys: 0.0 ± 0.0
0.722CysAsp: 0.722 ± 0.287
0.271CysGlu: 0.271 ± 0.172
0.271CysPhe: 0.271 ± 0.219
0.09CysGly: 0.09 ± 0.106
0.09CysHis: 0.09 ± 0.098
0.09CysIle: 0.09 ± 0.086
0.542CysLys: 0.542 ± 0.239
0.451CysLeu: 0.451 ± 0.222
0.09CysMet: 0.09 ± 0.103
0.181CysAsn: 0.181 ± 0.109
0.181CysPro: 0.181 ± 0.141
0.09CysGln: 0.09 ± 0.086
0.181CysArg: 0.181 ± 0.171
0.632CysSer: 0.632 ± 0.27
0.361CysThr: 0.361 ± 0.182
0.271CysVal: 0.271 ± 0.148
0.181CysTrp: 0.181 ± 0.128
0.181CysTyr: 0.181 ± 0.121
0.0CysXaa: 0.0 ± 0.0
Asp
4.333AspAla: 4.333 ± 0.657
0.361AspCys: 0.361 ± 0.196
4.333AspAsp: 4.333 ± 0.587
4.243AspGlu: 4.243 ± 0.588
3.701AspPhe: 3.701 ± 0.561
6.5AspGly: 6.5 ± 1.078
1.174AspHis: 1.174 ± 0.351
5.417AspIle: 5.417 ± 0.6
5.236AspLys: 5.236 ± 0.633
4.243AspLeu: 4.243 ± 0.687
2.167AspMet: 2.167 ± 0.468
3.16AspAsn: 3.16 ± 0.784
1.986AspPro: 1.986 ± 0.479
1.354AspGln: 1.354 ± 0.299
3.25AspArg: 3.25 ± 0.613
3.521AspSer: 3.521 ± 0.743
3.972AspThr: 3.972 ± 0.65
2.708AspVal: 2.708 ± 0.474
0.632AspTrp: 0.632 ± 0.244
2.618AspTyr: 2.618 ± 0.397
0.0AspXaa: 0.0 ± 0.0
Glu
4.514GluAla: 4.514 ± 0.621
0.181GluCys: 0.181 ± 0.124
3.972GluAsp: 3.972 ± 0.656
5.146GluGlu: 5.146 ± 1.221
2.257GluPhe: 2.257 ± 0.526
2.708GluGly: 2.708 ± 0.348
1.174GluHis: 1.174 ± 0.353
6.41GluIle: 6.41 ± 0.889
4.333GluLys: 4.333 ± 1.129
6.771GluLeu: 6.771 ± 1.102
2.347GluMet: 2.347 ± 0.588
4.424GluAsn: 4.424 ± 0.734
2.076GluPro: 2.076 ± 0.528
3.701GluGln: 3.701 ± 0.651
3.25GluArg: 3.25 ± 0.544
3.069GluSer: 3.069 ± 0.588
3.972GluThr: 3.972 ± 0.542
4.604GluVal: 4.604 ± 0.769
1.083GluTrp: 1.083 ± 0.292
3.16GluTyr: 3.16 ± 0.543
0.0GluXaa: 0.0 ± 0.0
Phe
3.34PheAla: 3.34 ± 0.554
0.0PheCys: 0.0 ± 0.0
3.069PheAsp: 3.069 ± 0.548
2.257PheGlu: 2.257 ± 0.592
1.715PhePhe: 1.715 ± 0.337
3.34PheGly: 3.34 ± 0.645
0.451PheHis: 0.451 ± 0.203
2.708PheIle: 2.708 ± 0.446
4.333PheLys: 4.333 ± 0.689
2.347PheLeu: 2.347 ± 0.491
0.812PheMet: 0.812 ± 0.254
3.611PheAsn: 3.611 ± 0.45
0.632PhePro: 0.632 ± 0.242
1.083PheGln: 1.083 ± 0.268
1.264PheArg: 1.264 ± 0.279
2.437PheSer: 2.437 ± 0.372
2.618PheThr: 2.618 ± 0.683
2.708PheVal: 2.708 ± 0.519
0.632PheTrp: 0.632 ± 0.225
2.257PheTyr: 2.257 ± 0.469
0.0PheXaa: 0.0 ± 0.0
Gly
3.16GlyAla: 3.16 ± 0.732
0.271GlyCys: 0.271 ± 0.132
3.792GlyAsp: 3.792 ± 0.708
4.333GlyGlu: 4.333 ± 0.624
2.889GlyPhe: 2.889 ± 0.502
4.153GlyGly: 4.153 ± 0.843
0.632GlyHis: 0.632 ± 0.247
5.326GlyIle: 5.326 ± 0.694
6.139GlyLys: 6.139 ± 0.907
5.958GlyLeu: 5.958 ± 0.977
1.444GlyMet: 1.444 ± 0.334
3.882GlyAsn: 3.882 ± 0.747
1.354GlyPro: 1.354 ± 0.432
3.069GlyGln: 3.069 ± 0.596
3.16GlyArg: 3.16 ± 0.516
4.062GlySer: 4.062 ± 0.668
5.056GlyThr: 5.056 ± 0.587
3.882GlyVal: 3.882 ± 0.614
1.354GlyTrp: 1.354 ± 0.373
2.799GlyTyr: 2.799 ± 0.407
0.0GlyXaa: 0.0 ± 0.0
His
0.542HisAla: 0.542 ± 0.212
0.0HisCys: 0.0 ± 0.0
1.083HisAsp: 1.083 ± 0.317
0.632HisGlu: 0.632 ± 0.269
0.542HisPhe: 0.542 ± 0.204
0.542HisGly: 0.542 ± 0.189
0.451HisHis: 0.451 ± 0.178
1.174HisIle: 1.174 ± 0.361
1.264HisLys: 1.264 ± 0.337
0.993HisLeu: 0.993 ± 0.253
0.542HisMet: 0.542 ± 0.227
0.812HisAsn: 0.812 ± 0.333
0.542HisPro: 0.542 ± 0.182
0.812HisGln: 0.812 ± 0.258
0.903HisArg: 0.903 ± 0.273
0.993HisSer: 0.993 ± 0.259
0.632HisThr: 0.632 ± 0.229
1.264HisVal: 1.264 ± 0.232
0.181HisTrp: 0.181 ± 0.124
1.083HisTyr: 1.083 ± 0.359
0.0HisXaa: 0.0 ± 0.0
Ile
5.417IleAla: 5.417 ± 0.806
0.361IleCys: 0.361 ± 0.192
5.056IleAsp: 5.056 ± 0.73
5.146IleGlu: 5.146 ± 0.949
1.625IlePhe: 1.625 ± 0.338
4.694IleGly: 4.694 ± 0.695
0.993IleHis: 0.993 ± 0.272
3.431IleIle: 3.431 ± 0.432
6.951IleLys: 6.951 ± 0.619
3.521IleLeu: 3.521 ± 0.653
1.896IleMet: 1.896 ± 0.492
3.972IleAsn: 3.972 ± 0.632
3.069IlePro: 3.069 ± 0.473
3.16IleGln: 3.16 ± 0.416
2.528IleArg: 2.528 ± 0.424
4.062IleSer: 4.062 ± 0.514
3.431IleThr: 3.431 ± 0.43
3.16IleVal: 3.16 ± 0.755
0.632IleTrp: 0.632 ± 0.184
2.167IleTyr: 2.167 ± 0.412
0.0IleXaa: 0.0 ± 0.0
Lys
6.049LysAla: 6.049 ± 0.809
0.361LysCys: 0.361 ± 0.239
5.417LysAsp: 5.417 ± 0.89
7.944LysGlu: 7.944 ± 1.092
3.972LysPhe: 3.972 ± 0.742
5.236LysGly: 5.236 ± 0.887
1.535LysHis: 1.535 ± 0.44
5.146LysIle: 5.146 ± 0.581
6.951LysLys: 6.951 ± 0.994
7.132LysLeu: 7.132 ± 0.834
2.979LysMet: 2.979 ± 0.54
4.875LysAsn: 4.875 ± 0.634
2.889LysPro: 2.889 ± 0.451
4.333LysGln: 4.333 ± 0.633
3.701LysArg: 3.701 ± 0.535
4.153LysSer: 4.153 ± 0.489
4.965LysThr: 4.965 ± 0.779
4.153LysVal: 4.153 ± 0.482
1.625LysTrp: 1.625 ± 0.327
3.431LysTyr: 3.431 ± 0.603
0.0LysXaa: 0.0 ± 0.0
Leu
6.139LeuAla: 6.139 ± 0.788
0.451LeuCys: 0.451 ± 0.198
5.326LeuAsp: 5.326 ± 0.79
7.042LeuGlu: 7.042 ± 1.048
3.069LeuPhe: 3.069 ± 0.397
5.687LeuGly: 5.687 ± 0.865
0.903LeuHis: 0.903 ± 0.27
4.062LeuIle: 4.062 ± 0.601
7.764LeuLys: 7.764 ± 0.877
5.326LeuLeu: 5.326 ± 0.682
2.437LeuMet: 2.437 ± 0.469
4.604LeuAsn: 4.604 ± 0.612
2.528LeuPro: 2.528 ± 0.427
2.618LeuGln: 2.618 ± 0.429
3.611LeuArg: 3.611 ± 0.862
5.146LeuSer: 5.146 ± 0.839
6.319LeuThr: 6.319 ± 1.058
3.611LeuVal: 3.611 ± 0.57
0.632LeuTrp: 0.632 ± 0.21
2.437LeuTyr: 2.437 ± 0.527
0.0LeuXaa: 0.0 ± 0.0
Met
1.535MetAla: 1.535 ± 0.352
0.0MetCys: 0.0 ± 0.0
0.993MetAsp: 0.993 ± 0.28
1.444MetGlu: 1.444 ± 0.383
1.083MetPhe: 1.083 ± 0.247
1.083MetGly: 1.083 ± 0.294
0.361MetHis: 0.361 ± 0.2
1.896MetIle: 1.896 ± 0.325
3.16MetLys: 3.16 ± 0.576
2.257MetLeu: 2.257 ± 0.421
0.451MetMet: 0.451 ± 0.229
1.174MetAsn: 1.174 ± 0.258
0.903MetPro: 0.903 ± 0.261
0.903MetGln: 0.903 ± 0.294
0.993MetArg: 0.993 ± 0.258
1.806MetSer: 1.806 ± 0.454
1.625MetThr: 1.625 ± 0.316
1.715MetVal: 1.715 ± 0.381
0.09MetTrp: 0.09 ± 0.073
1.264MetTyr: 1.264 ± 0.431
0.0MetXaa: 0.0 ± 0.0
Asn
5.146AsnAla: 5.146 ± 1.126
0.361AsnCys: 0.361 ± 0.217
3.25AsnAsp: 3.25 ± 0.459
4.514AsnGlu: 4.514 ± 0.926
2.799AsnPhe: 2.799 ± 0.443
6.5AsnGly: 6.5 ± 1.065
0.903AsnHis: 0.903 ± 0.27
3.701AsnIle: 3.701 ± 0.54
4.514AsnLys: 4.514 ± 0.643
5.236AsnLeu: 5.236 ± 0.484
0.903AsnMet: 0.903 ± 0.246
4.062AsnAsn: 4.062 ± 0.563
2.708AsnPro: 2.708 ± 0.604
2.799AsnGln: 2.799 ± 0.495
2.257AsnArg: 2.257 ± 0.566
4.243AsnSer: 4.243 ± 0.689
3.16AsnThr: 3.16 ± 0.567
2.979AsnVal: 2.979 ± 0.471
0.903AsnTrp: 0.903 ± 0.247
2.257AsnTyr: 2.257 ± 0.477
0.0AsnXaa: 0.0 ± 0.0
Pro
1.896ProAla: 1.896 ± 0.385
0.0ProCys: 0.0 ± 0.0
1.444ProAsp: 1.444 ± 0.326
1.806ProGlu: 1.806 ± 0.489
1.174ProPhe: 1.174 ± 0.352
1.264ProGly: 1.264 ± 0.424
0.451ProHis: 0.451 ± 0.194
1.264ProIle: 1.264 ± 0.314
3.701ProLys: 3.701 ± 0.623
2.528ProLeu: 2.528 ± 0.44
0.271ProMet: 0.271 ± 0.138
2.799ProAsn: 2.799 ± 0.417
0.451ProPro: 0.451 ± 0.23
1.806ProGln: 1.806 ± 0.357
0.812ProArg: 0.812 ± 0.332
2.347ProSer: 2.347 ± 0.418
1.896ProThr: 1.896 ± 0.428
1.444ProVal: 1.444 ± 0.328
0.451ProTrp: 0.451 ± 0.152
1.083ProTyr: 1.083 ± 0.291
0.0ProXaa: 0.0 ± 0.0
Gln
3.882GlnAla: 3.882 ± 0.612
0.181GlnCys: 0.181 ± 0.122
2.437GlnAsp: 2.437 ± 0.517
2.799GlnGlu: 2.799 ± 0.642
1.444GlnPhe: 1.444 ± 0.302
3.792GlnGly: 3.792 ± 0.721
0.451GlnHis: 0.451 ± 0.243
2.076GlnIle: 2.076 ± 0.474
2.979GlnLys: 2.979 ± 0.492
3.792GlnLeu: 3.792 ± 0.55
1.625GlnMet: 1.625 ± 0.31
2.437GlnAsn: 2.437 ± 0.419
0.812GlnPro: 0.812 ± 0.276
3.701GlnGln: 3.701 ± 0.692
1.896GlnArg: 1.896 ± 0.369
2.528GlnSer: 2.528 ± 0.365
2.979GlnThr: 2.979 ± 0.394
2.167GlnVal: 2.167 ± 0.427
0.812GlnTrp: 0.812 ± 0.215
2.167GlnTyr: 2.167 ± 0.388
0.0GlnXaa: 0.0 ± 0.0
Arg
1.896ArgAla: 1.896 ± 0.456
0.181ArgCys: 0.181 ± 0.131
2.347ArgAsp: 2.347 ± 0.436
2.437ArgGlu: 2.437 ± 0.577
2.076ArgPhe: 2.076 ± 0.332
2.708ArgGly: 2.708 ± 0.537
0.812ArgHis: 0.812 ± 0.306
3.16ArgIle: 3.16 ± 0.475
3.069ArgLys: 3.069 ± 0.642
4.243ArgLeu: 4.243 ± 0.754
0.993ArgMet: 0.993 ± 0.363
2.437ArgAsn: 2.437 ± 0.419
0.993ArgPro: 0.993 ± 0.263
2.347ArgGln: 2.347 ± 0.396
1.444ArgArg: 1.444 ± 0.344
1.625ArgSer: 1.625 ± 0.417
2.528ArgThr: 2.528 ± 0.698
2.167ArgVal: 2.167 ± 0.355
0.993ArgTrp: 0.993 ± 0.318
2.257ArgTyr: 2.257 ± 0.44
0.0ArgXaa: 0.0 ± 0.0
Ser
3.431SerAla: 3.431 ± 0.506
0.722SerCys: 0.722 ± 0.301
4.604SerAsp: 4.604 ± 0.609
3.792SerGlu: 3.792 ± 0.629
2.528SerPhe: 2.528 ± 0.5
4.243SerGly: 4.243 ± 0.55
0.632SerHis: 0.632 ± 0.178
4.875SerIle: 4.875 ± 0.525
4.875SerLys: 4.875 ± 0.8
4.153SerLeu: 4.153 ± 0.526
1.444SerMet: 1.444 ± 0.288
4.965SerAsn: 4.965 ± 0.776
1.986SerPro: 1.986 ± 0.299
3.16SerGln: 3.16 ± 0.601
3.25SerArg: 3.25 ± 0.738
3.34SerSer: 3.34 ± 0.596
3.16SerThr: 3.16 ± 0.555
4.604SerVal: 4.604 ± 0.509
0.632SerTrp: 0.632 ± 0.179
2.528SerTyr: 2.528 ± 0.565
0.0SerXaa: 0.0 ± 0.0
Thr
4.153ThrAla: 4.153 ± 0.668
0.181ThrCys: 0.181 ± 0.116
3.972ThrAsp: 3.972 ± 0.634
3.792ThrGlu: 3.792 ± 0.543
2.708ThrPhe: 2.708 ± 0.489
3.882ThrGly: 3.882 ± 0.518
1.354ThrHis: 1.354 ± 0.235
3.882ThrIle: 3.882 ± 0.683
5.507ThrLys: 5.507 ± 0.578
6.41ThrLeu: 6.41 ± 0.729
0.632ThrMet: 0.632 ± 0.23
4.785ThrAsn: 4.785 ± 0.794
1.715ThrPro: 1.715 ± 0.376
2.437ThrGln: 2.437 ± 0.468
1.625ThrArg: 1.625 ± 0.337
4.153ThrSer: 4.153 ± 0.628
3.431ThrThr: 3.431 ± 0.725
3.611ThrVal: 3.611 ± 0.587
0.993ThrTrp: 0.993 ± 0.288
3.16ThrTyr: 3.16 ± 0.699
0.0ThrXaa: 0.0 ± 0.0
Val
4.153ValAla: 4.153 ± 0.615
0.451ValCys: 0.451 ± 0.189
4.604ValAsp: 4.604 ± 0.416
3.521ValGlu: 3.521 ± 0.636
2.437ValPhe: 2.437 ± 0.446
3.611ValGly: 3.611 ± 0.468
0.722ValHis: 0.722 ± 0.206
2.979ValIle: 2.979 ± 0.386
4.965ValLys: 4.965 ± 0.64
3.16ValLeu: 3.16 ± 0.543
0.903ValMet: 0.903 ± 0.298
3.972ValAsn: 3.972 ± 0.615
1.535ValPro: 1.535 ± 0.358
1.986ValGln: 1.986 ± 0.541
1.715ValArg: 1.715 ± 0.433
4.965ValSer: 4.965 ± 0.811
5.056ValThr: 5.056 ± 0.763
2.528ValVal: 2.528 ± 0.49
0.993ValTrp: 0.993 ± 0.269
1.625ValTyr: 1.625 ± 0.409
0.0ValXaa: 0.0 ± 0.0
Trp
0.451TrpAla: 0.451 ± 0.215
0.0TrpCys: 0.0 ± 0.0
0.903TrpAsp: 0.903 ± 0.342
0.632TrpGlu: 0.632 ± 0.211
0.451TrpPhe: 0.451 ± 0.161
0.542TrpGly: 0.542 ± 0.176
0.451TrpHis: 0.451 ± 0.207
0.903TrpIle: 0.903 ± 0.262
0.903TrpLys: 0.903 ± 0.332
1.444TrpLeu: 1.444 ± 0.371
0.09TrpMet: 0.09 ± 0.101
0.903TrpAsn: 0.903 ± 0.274
0.09TrpPro: 0.09 ± 0.079
0.722TrpGln: 0.722 ± 0.185
0.812TrpArg: 0.812 ± 0.237
1.896TrpSer: 1.896 ± 0.649
1.083TrpThr: 1.083 ± 0.38
1.535TrpVal: 1.535 ± 0.321
0.271TrpTrp: 0.271 ± 0.181
0.181TrpTyr: 0.181 ± 0.124
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.618TyrAla: 2.618 ± 0.489
0.632TyrCys: 0.632 ± 0.265
3.069TyrAsp: 3.069 ± 0.582
2.799TyrGlu: 2.799 ± 0.532
2.076TyrPhe: 2.076 ± 0.429
1.986TyrGly: 1.986 ± 0.371
0.812TyrHis: 0.812 ± 0.232
2.889TyrIle: 2.889 ± 0.521
3.25TyrLys: 3.25 ± 0.507
3.16TyrLeu: 3.16 ± 0.502
1.174TyrMet: 1.174 ± 0.429
2.167TyrAsn: 2.167 ± 0.432
1.083TyrPro: 1.083 ± 0.318
2.076TyrGln: 2.076 ± 0.396
1.896TyrArg: 1.896 ± 0.326
3.16TyrSer: 3.16 ± 0.662
2.076TyrThr: 2.076 ± 0.49
2.167TyrVal: 2.167 ± 0.357
0.181TyrTrp: 0.181 ± 0.133
2.618TyrTyr: 2.618 ± 0.763
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (11078 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski