Amino acid dipepetide frequency for Enterococcus phage Entf1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.44AlaAla: 6.44 ± 1.402
0.65AlaCys: 0.65 ± 0.227
4.254AlaAsp: 4.254 ± 0.526
5.731AlaGlu: 5.731 ± 0.487
2.836AlaPhe: 2.836 ± 0.375
4.549AlaGly: 4.549 ± 0.66
0.591AlaHis: 0.591 ± 0.254
5.199AlaIle: 5.199 ± 0.551
5.258AlaLys: 5.258 ± 0.713
6.736AlaLeu: 6.736 ± 0.618
2.6AlaMet: 2.6 ± 0.417
3.545AlaAsn: 3.545 ± 0.489
2.068AlaPro: 2.068 ± 0.382
2.068AlaGln: 2.068 ± 0.389
3.25AlaArg: 3.25 ± 0.452
4.549AlaSer: 4.549 ± 0.615
4.018AlaThr: 4.018 ± 0.626
4.431AlaVal: 4.431 ± 0.661
0.414AlaTrp: 0.414 ± 0.163
3.131AlaTyr: 3.131 ± 0.591
0.0AlaXaa: 0.0 ± 0.0
Cys
0.355CysAla: 0.355 ± 0.135
0.532CysCys: 0.532 ± 0.22
0.473CysAsp: 0.473 ± 0.162
0.65CysGlu: 0.65 ± 0.175
0.295CysPhe: 0.295 ± 0.117
0.768CysGly: 0.768 ± 0.265
0.059CysHis: 0.059 ± 0.055
0.532CysIle: 0.532 ± 0.19
0.591CysLys: 0.591 ± 0.259
0.65CysLeu: 0.65 ± 0.178
0.414CysMet: 0.414 ± 0.145
0.236CysAsn: 0.236 ± 0.115
0.118CysPro: 0.118 ± 0.13
0.414CysGln: 0.414 ± 0.144
0.236CysArg: 0.236 ± 0.119
0.355CysSer: 0.355 ± 0.149
0.473CysThr: 0.473 ± 0.188
0.355CysVal: 0.355 ± 0.156
0.059CysTrp: 0.059 ± 0.062
0.295CysTyr: 0.295 ± 0.142
0.0CysXaa: 0.0 ± 0.0
Asp
3.9AspAla: 3.9 ± 0.56
0.65AspCys: 0.65 ± 0.212
2.836AspAsp: 2.836 ± 0.754
4.549AspGlu: 4.549 ± 0.489
3.427AspPhe: 3.427 ± 0.586
3.781AspGly: 3.781 ± 0.56
0.355AspHis: 0.355 ± 0.148
4.018AspIle: 4.018 ± 0.466
3.722AspLys: 3.722 ± 0.413
5.436AspLeu: 5.436 ± 0.527
2.541AspMet: 2.541 ± 0.514
2.836AspAsn: 2.836 ± 0.501
1.241AspPro: 1.241 ± 0.253
0.768AspGln: 0.768 ± 0.255
1.95AspArg: 1.95 ± 0.371
3.191AspSer: 3.191 ± 0.376
4.313AspThr: 4.313 ± 0.802
3.781AspVal: 3.781 ± 0.49
0.768AspTrp: 0.768 ± 0.281
3.191AspTyr: 3.191 ± 0.364
0.0AspXaa: 0.0 ± 0.0
Glu
8.508GluAla: 8.508 ± 0.683
0.591GluCys: 0.591 ± 0.23
5.495GluAsp: 5.495 ± 0.601
10.103GluGlu: 10.103 ± 0.932
3.604GluPhe: 3.604 ± 0.534
6.499GluGly: 6.499 ± 0.702
1.004GluHis: 1.004 ± 0.252
4.254GluIle: 4.254 ± 0.502
5.554GluLys: 5.554 ± 0.734
7.326GluLeu: 7.326 ± 0.9
2.482GluMet: 2.482 ± 0.35
4.136GluAsn: 4.136 ± 0.605
2.009GluPro: 2.009 ± 0.375
3.309GluGln: 3.309 ± 0.465
4.431GluArg: 4.431 ± 0.496
5.731GluSer: 5.731 ± 0.643
4.254GluThr: 4.254 ± 0.639
6.677GluVal: 6.677 ± 0.531
1.773GluTrp: 1.773 ± 0.356
3.604GluTyr: 3.604 ± 0.517
0.0GluXaa: 0.0 ± 0.0
Phe
2.304PheAla: 2.304 ± 0.389
0.295PheCys: 0.295 ± 0.13
2.718PheAsp: 2.718 ± 0.502
3.309PheGlu: 3.309 ± 0.445
1.418PhePhe: 1.418 ± 0.286
2.836PheGly: 2.836 ± 0.486
0.768PheHis: 0.768 ± 0.212
3.368PheIle: 3.368 ± 0.501
3.309PheLys: 3.309 ± 0.352
3.309PheLeu: 3.309 ± 0.466
1.064PheMet: 1.064 ± 0.296
2.186PheAsn: 2.186 ± 0.319
1.418PhePro: 1.418 ± 0.318
1.123PheGln: 1.123 ± 0.28
1.477PheArg: 1.477 ± 0.249
2.6PheSer: 2.6 ± 0.482
3.25PheThr: 3.25 ± 0.381
2.895PheVal: 2.895 ± 0.435
0.473PheTrp: 0.473 ± 0.21
1.536PheTyr: 1.536 ± 0.43
0.0PheXaa: 0.0 ± 0.0
Gly
3.486GlyAla: 3.486 ± 0.452
0.532GlyCys: 0.532 ± 0.22
3.25GlyAsp: 3.25 ± 0.477
4.431GlyGlu: 4.431 ± 0.441
3.604GlyPhe: 3.604 ± 0.527
3.663GlyGly: 3.663 ± 0.973
1.182GlyHis: 1.182 ± 0.236
4.786GlyIle: 4.786 ± 0.698
5.613GlyLys: 5.613 ± 0.734
4.431GlyLeu: 4.431 ± 0.565
1.713GlyMet: 1.713 ± 0.224
3.545GlyAsn: 3.545 ± 0.451
0.059GlyPro: 0.059 ± 0.059
1.95GlyGln: 1.95 ± 0.376
3.131GlyArg: 3.131 ± 0.42
3.545GlySer: 3.545 ± 0.441
5.022GlyThr: 5.022 ± 0.728
3.84GlyVal: 3.84 ± 0.535
1.241GlyTrp: 1.241 ± 0.371
3.486GlyTyr: 3.486 ± 0.413
0.0GlyXaa: 0.0 ± 0.0
His
1.004HisAla: 1.004 ± 0.249
0.295HisCys: 0.295 ± 0.128
0.414HisAsp: 0.414 ± 0.179
1.477HisGlu: 1.477 ± 0.3
1.123HisPhe: 1.123 ± 0.245
1.182HisGly: 1.182 ± 0.206
0.414HisHis: 0.414 ± 0.167
1.595HisIle: 1.595 ± 0.32
1.359HisLys: 1.359 ± 0.359
1.3HisLeu: 1.3 ± 0.269
0.118HisMet: 0.118 ± 0.09
0.886HisAsn: 0.886 ± 0.209
0.591HisPro: 0.591 ± 0.193
0.532HisGln: 0.532 ± 0.188
1.064HisArg: 1.064 ± 0.22
0.768HisSer: 0.768 ± 0.224
0.473HisThr: 0.473 ± 0.185
0.945HisVal: 0.945 ± 0.202
0.118HisTrp: 0.118 ± 0.073
0.65HisTyr: 0.65 ± 0.216
0.0HisXaa: 0.0 ± 0.0
Ile
4.904IleAla: 4.904 ± 0.482
0.65IleCys: 0.65 ± 0.234
4.136IleAsp: 4.136 ± 0.47
5.554IleGlu: 5.554 ± 0.591
2.245IlePhe: 2.245 ± 0.432
3.309IleGly: 3.309 ± 0.436
1.477IleHis: 1.477 ± 0.289
3.072IleIle: 3.072 ± 0.549
5.14IleLys: 5.14 ± 0.593
3.9IleLeu: 3.9 ± 0.63
1.654IleMet: 1.654 ± 0.327
4.668IleAsn: 4.668 ± 0.477
1.832IlePro: 1.832 ± 0.289
2.954IleGln: 2.954 ± 0.647
2.541IleArg: 2.541 ± 0.463
3.545IleSer: 3.545 ± 0.406
3.84IleThr: 3.84 ± 0.818
3.663IleVal: 3.663 ± 0.473
0.65IleTrp: 0.65 ± 0.238
2.659IleTyr: 2.659 ± 0.35
0.0IleXaa: 0.0 ± 0.0
Lys
8.035LysAla: 8.035 ± 0.629
0.355LysCys: 0.355 ± 0.148
4.727LysAsp: 4.727 ± 0.479
7.74LysGlu: 7.74 ± 0.875
2.363LysPhe: 2.363 ± 0.454
5.14LysGly: 5.14 ± 0.566
1.713LysHis: 1.713 ± 0.346
3.663LysIle: 3.663 ± 0.42
6.322LysLys: 6.322 ± 0.689
6.027LysLeu: 6.027 ± 0.536
2.541LysMet: 2.541 ± 0.483
2.836LysAsn: 2.836 ± 0.389
3.427LysPro: 3.427 ± 0.468
2.836LysGln: 2.836 ± 0.46
3.427LysArg: 3.427 ± 0.507
4.136LysSer: 4.136 ± 0.592
3.84LysThr: 3.84 ± 0.472
5.258LysVal: 5.258 ± 0.519
1.064LysTrp: 1.064 ± 0.222
2.718LysTyr: 2.718 ± 0.45
0.0LysXaa: 0.0 ± 0.0
Leu
4.904LeuAla: 4.904 ± 0.584
0.473LeuCys: 0.473 ± 0.188
4.904LeuAsp: 4.904 ± 0.483
9.69LeuGlu: 9.69 ± 0.967
2.718LeuPhe: 2.718 ± 0.337
4.963LeuGly: 4.963 ± 0.774
0.945LeuHis: 0.945 ± 0.194
4.904LeuIle: 4.904 ± 0.641
6.617LeuLys: 6.617 ± 0.631
5.849LeuLeu: 5.849 ± 0.662
2.009LeuMet: 2.009 ± 0.295
3.9LeuAsn: 3.9 ± 0.442
3.013LeuPro: 3.013 ± 0.364
3.191LeuGln: 3.191 ± 0.564
3.486LeuArg: 3.486 ± 0.393
5.731LeuSer: 5.731 ± 0.585
6.44LeuThr: 6.44 ± 0.641
5.436LeuVal: 5.436 ± 0.718
0.709LeuTrp: 0.709 ± 0.203
2.836LeuTyr: 2.836 ± 0.447
0.0LeuXaa: 0.0 ± 0.0
Met
2.777MetAla: 2.777 ± 0.542
0.059MetCys: 0.059 ± 0.069
1.595MetAsp: 1.595 ± 0.303
3.663MetGlu: 3.663 ± 0.448
0.827MetPhe: 0.827 ± 0.28
0.827MetGly: 0.827 ± 0.255
0.295MetHis: 0.295 ± 0.12
1.477MetIle: 1.477 ± 0.259
2.127MetLys: 2.127 ± 0.334
2.304MetLeu: 2.304 ± 0.374
0.591MetMet: 0.591 ± 0.194
1.3MetAsn: 1.3 ± 0.262
1.064MetPro: 1.064 ± 0.235
0.768MetGln: 0.768 ± 0.2
1.477MetArg: 1.477 ± 0.286
1.95MetSer: 1.95 ± 0.332
1.418MetThr: 1.418 ± 0.302
1.418MetVal: 1.418 ± 0.236
0.236MetTrp: 0.236 ± 0.135
1.123MetTyr: 1.123 ± 0.253
0.0MetXaa: 0.0 ± 0.0
Asn
2.895AsnAla: 2.895 ± 0.433
0.295AsnCys: 0.295 ± 0.151
2.482AsnAsp: 2.482 ± 0.366
3.781AsnGlu: 3.781 ± 0.463
1.95AsnPhe: 1.95 ± 0.3
4.077AsnGly: 4.077 ± 0.496
1.654AsnHis: 1.654 ± 0.456
3.368AsnIle: 3.368 ± 0.425
4.727AsnLys: 4.727 ± 0.515
4.077AsnLeu: 4.077 ± 0.559
1.3AsnMet: 1.3 ± 0.256
2.541AsnAsn: 2.541 ± 0.501
2.836AsnPro: 2.836 ± 0.494
1.595AsnGln: 1.595 ± 0.296
1.95AsnArg: 1.95 ± 0.284
3.427AsnSer: 3.427 ± 0.479
3.309AsnThr: 3.309 ± 0.386
2.895AsnVal: 2.895 ± 0.43
0.591AsnTrp: 0.591 ± 0.24
2.009AsnTyr: 2.009 ± 0.423
0.0AsnXaa: 0.0 ± 0.0
Pro
1.95ProAla: 1.95 ± 0.444
0.177ProCys: 0.177 ± 0.099
1.418ProAsp: 1.418 ± 0.313
3.604ProGlu: 3.604 ± 0.517
1.477ProPhe: 1.477 ± 0.333
0.236ProGly: 0.236 ± 0.136
0.65ProHis: 0.65 ± 0.19
2.245ProIle: 2.245 ± 0.302
2.895ProLys: 2.895 ± 0.392
2.422ProLeu: 2.422 ± 0.369
1.004ProMet: 1.004 ± 0.23
1.891ProAsn: 1.891 ± 0.435
0.768ProPro: 0.768 ± 0.215
0.768ProGln: 0.768 ± 0.209
1.123ProArg: 1.123 ± 0.309
2.422ProSer: 2.422 ± 0.481
1.654ProThr: 1.654 ± 0.268
1.773ProVal: 1.773 ± 0.331
0.355ProTrp: 0.355 ± 0.143
1.418ProTyr: 1.418 ± 0.32
0.0ProXaa: 0.0 ± 0.0
Gln
2.659GlnAla: 2.659 ± 0.422
0.059GlnCys: 0.059 ± 0.06
1.654GlnAsp: 1.654 ± 0.327
2.895GlnGlu: 2.895 ± 0.476
1.182GlnPhe: 1.182 ± 0.289
2.363GlnGly: 2.363 ± 0.486
0.591GlnHis: 0.591 ± 0.179
1.595GlnIle: 1.595 ± 0.321
2.127GlnLys: 2.127 ± 0.389
2.954GlnLeu: 2.954 ± 0.412
0.827GlnMet: 0.827 ± 0.305
1.064GlnAsn: 1.064 ± 0.275
1.004GlnPro: 1.004 ± 0.234
1.595GlnGln: 1.595 ± 0.539
1.536GlnArg: 1.536 ± 0.268
2.009GlnSer: 2.009 ± 0.352
2.304GlnThr: 2.304 ± 0.342
2.541GlnVal: 2.541 ± 0.417
0.591GlnTrp: 0.591 ± 0.172
1.713GlnTyr: 1.713 ± 0.336
0.0GlnXaa: 0.0 ± 0.0
Arg
2.6ArgAla: 2.6 ± 0.436
0.473ArgCys: 0.473 ± 0.151
1.891ArgAsp: 1.891 ± 0.257
3.131ArgGlu: 3.131 ± 0.334
2.541ArgPhe: 2.541 ± 0.326
3.25ArgGly: 3.25 ± 0.373
0.827ArgHis: 0.827 ± 0.249
3.486ArgIle: 3.486 ± 0.506
3.013ArgLys: 3.013 ± 0.482
4.077ArgLeu: 4.077 ± 0.522
0.65ArgMet: 0.65 ± 0.199
2.186ArgAsn: 2.186 ± 0.416
1.418ArgPro: 1.418 ± 0.325
1.477ArgGln: 1.477 ± 0.269
1.95ArgArg: 1.95 ± 0.365
2.068ArgSer: 2.068 ± 0.404
2.009ArgThr: 2.009 ± 0.344
3.013ArgVal: 3.013 ± 0.501
0.473ArgTrp: 0.473 ± 0.186
2.068ArgTyr: 2.068 ± 0.305
0.0ArgXaa: 0.0 ± 0.0
Ser
3.309SerAla: 3.309 ± 0.404
0.295SerCys: 0.295 ± 0.145
3.191SerAsp: 3.191 ± 0.4
4.963SerGlu: 4.963 ± 0.482
2.541SerPhe: 2.541 ± 0.319
4.018SerGly: 4.018 ± 0.471
0.945SerHis: 0.945 ± 0.275
4.431SerIle: 4.431 ± 0.696
5.968SerLys: 5.968 ± 0.526
5.554SerLeu: 5.554 ± 0.564
1.3SerMet: 1.3 ± 0.234
3.545SerAsn: 3.545 ± 0.375
1.832SerPro: 1.832 ± 0.271
1.891SerGln: 1.891 ± 0.349
2.777SerArg: 2.777 ± 0.393
2.895SerSer: 2.895 ± 0.432
3.545SerThr: 3.545 ± 0.446
3.545SerVal: 3.545 ± 0.615
0.532SerTrp: 0.532 ± 0.176
3.072SerTyr: 3.072 ± 0.386
0.0SerXaa: 0.0 ± 0.0
Thr
5.14ThrAla: 5.14 ± 0.791
0.591ThrCys: 0.591 ± 0.18
3.781ThrAsp: 3.781 ± 0.47
3.9ThrGlu: 3.9 ± 0.441
3.191ThrPhe: 3.191 ± 0.462
3.25ThrGly: 3.25 ± 0.469
1.004ThrHis: 1.004 ± 0.269
3.368ThrIle: 3.368 ± 0.501
3.663ThrLys: 3.663 ± 0.423
6.086ThrLeu: 6.086 ± 0.604
1.477ThrMet: 1.477 ± 0.315
3.368ThrAsn: 3.368 ± 0.581
2.6ThrPro: 2.6 ± 0.494
1.595ThrGln: 1.595 ± 0.36
1.891ThrArg: 1.891 ± 0.381
4.136ThrSer: 4.136 ± 0.536
2.836ThrThr: 2.836 ± 0.488
5.14ThrVal: 5.14 ± 0.741
0.827ThrTrp: 0.827 ± 0.184
2.541ThrTyr: 2.541 ± 0.384
0.0ThrXaa: 0.0 ± 0.0
Val
4.313ValAla: 4.313 ± 0.671
0.532ValCys: 0.532 ± 0.182
4.49ValAsp: 4.49 ± 0.525
5.318ValGlu: 5.318 ± 0.664
2.659ValPhe: 2.659 ± 0.344
4.136ValGly: 4.136 ± 0.555
1.064ValHis: 1.064 ± 0.237
3.9ValIle: 3.9 ± 0.488
5.968ValLys: 5.968 ± 0.629
5.377ValLeu: 5.377 ± 0.65
1.418ValMet: 1.418 ± 0.291
3.84ValAsn: 3.84 ± 0.453
1.654ValPro: 1.654 ± 0.342
2.304ValGln: 2.304 ± 0.372
2.659ValArg: 2.659 ± 0.52
3.722ValSer: 3.722 ± 0.536
3.84ValThr: 3.84 ± 0.529
4.313ValVal: 4.313 ± 0.571
1.418ValTrp: 1.418 ± 0.298
2.482ValTyr: 2.482 ± 0.48
0.0ValXaa: 0.0 ± 0.0
Trp
0.827TrpAla: 0.827 ± 0.228
0.059TrpCys: 0.059 ± 0.059
0.768TrpAsp: 0.768 ± 0.206
1.713TrpGlu: 1.713 ± 0.258
0.473TrpPhe: 0.473 ± 0.175
1.004TrpGly: 1.004 ± 0.308
0.236TrpHis: 0.236 ± 0.094
1.004TrpIle: 1.004 ± 0.221
1.004TrpLys: 1.004 ± 0.266
0.65TrpLeu: 0.65 ± 0.176
0.059TrpMet: 0.059 ± 0.059
1.064TrpAsn: 1.064 ± 0.195
0.0TrpPro: 0.0 ± 0.0
0.532TrpGln: 0.532 ± 0.206
0.414TrpArg: 0.414 ± 0.148
0.945TrpSer: 0.945 ± 0.237
0.709TrpThr: 0.709 ± 0.263
0.65TrpVal: 0.65 ± 0.225
0.118TrpTrp: 0.118 ± 0.077
0.65TrpTyr: 0.65 ± 0.199
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.009TyrAla: 2.009 ± 0.309
0.295TyrCys: 0.295 ± 0.149
2.777TyrAsp: 2.777 ± 0.432
5.14TyrGlu: 5.14 ± 0.624
1.241TyrPhe: 1.241 ± 0.308
2.659TyrGly: 2.659 ± 0.426
0.532TyrHis: 0.532 ± 0.182
2.127TyrIle: 2.127 ± 0.371
3.191TyrLys: 3.191 ± 0.39
4.254TyrLeu: 4.254 ± 0.521
1.477TyrMet: 1.477 ± 0.324
2.186TyrAsn: 2.186 ± 0.38
1.3TyrPro: 1.3 ± 0.235
1.595TyrGln: 1.595 ± 0.301
1.832TyrArg: 1.832 ± 0.335
2.422TyrSer: 2.422 ± 0.296
2.836TyrThr: 2.836 ± 0.466
2.836TyrVal: 2.836 ± 0.398
0.473TyrTrp: 0.473 ± 0.188
2.304TyrTyr: 2.304 ± 0.365
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 96 proteins (16926 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski