Amino acid dipepetide frequency for Daphnis nerii cypovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.202AlaAla: 3.202 ± 1.219
0.711AlaCys: 0.711 ± 0.338
3.735AlaAsp: 3.735 ± 0.736
3.202AlaGlu: 3.202 ± 0.562
3.202AlaPhe: 3.202 ± 1.05
2.49AlaGly: 2.49 ± 0.881
0.711AlaHis: 0.711 ± 0.373
5.158AlaIle: 5.158 ± 0.827
2.846AlaLys: 2.846 ± 0.728
6.403AlaLeu: 6.403 ± 1.033
2.846AlaMet: 2.846 ± 0.584
4.269AlaAsn: 4.269 ± 0.544
2.312AlaPro: 2.312 ± 1.051
1.067AlaGln: 1.067 ± 0.699
4.269AlaArg: 4.269 ± 0.726
6.226AlaSer: 6.226 ± 1.149
4.98AlaThr: 4.98 ± 1.035
4.091AlaVal: 4.091 ± 0.802
0.534AlaTrp: 0.534 ± 0.357
2.134AlaTyr: 2.134 ± 0.541
0.0AlaXaa: 0.0 ± 0.0
Cys
0.356CysAla: 0.356 ± 0.23
0.178CysCys: 0.178 ± 0.241
0.178CysAsp: 0.178 ± 0.241
1.779CysGlu: 1.779 ± 0.547
0.534CysPhe: 0.534 ± 0.301
0.534CysGly: 0.534 ± 0.504
0.178CysHis: 0.178 ± 0.151
0.178CysIle: 0.178 ± 0.164
0.178CysLys: 0.178 ± 0.195
0.356CysLeu: 0.356 ± 0.229
0.534CysMet: 0.534 ± 0.314
0.534CysAsn: 0.534 ± 0.249
0.356CysPro: 0.356 ± 0.201
0.356CysGln: 0.356 ± 0.261
0.178CysArg: 0.178 ± 0.241
0.534CysSer: 0.534 ± 0.344
0.534CysThr: 0.534 ± 0.37
0.889CysVal: 0.889 ± 0.242
0.0CysTrp: 0.0 ± 0.0
1.245CysTyr: 1.245 ± 0.396
0.0CysXaa: 0.0 ± 0.0
Asp
4.447AspAla: 4.447 ± 1.278
0.534AspCys: 0.534 ± 0.339
4.091AspAsp: 4.091 ± 0.896
4.803AspGlu: 4.803 ± 1.053
2.134AspPhe: 2.134 ± 0.603
4.091AspGly: 4.091 ± 0.946
1.245AspHis: 1.245 ± 0.465
3.913AspIle: 3.913 ± 0.536
2.49AspLys: 2.49 ± 0.713
3.913AspLeu: 3.913 ± 0.897
1.067AspMet: 1.067 ± 0.333
1.957AspAsn: 1.957 ± 0.645
1.601AspPro: 1.601 ± 0.259
2.134AspGln: 2.134 ± 0.23
2.49AspArg: 2.49 ± 0.534
4.091AspSer: 4.091 ± 0.561
3.024AspThr: 3.024 ± 0.981
5.514AspVal: 5.514 ± 0.495
0.889AspTrp: 0.889 ± 0.324
2.312AspTyr: 2.312 ± 0.673
0.0AspXaa: 0.0 ± 0.0
Glu
3.735GluAla: 3.735 ± 0.93
0.711GluCys: 0.711 ± 0.467
3.024GluAsp: 3.024 ± 0.618
5.158GluGlu: 5.158 ± 0.957
2.49GluPhe: 2.49 ± 0.477
3.024GluGly: 3.024 ± 0.637
1.779GluHis: 1.779 ± 0.634
5.692GluIle: 5.692 ± 0.85
3.38GluLys: 3.38 ± 1.094
7.293GluLeu: 7.293 ± 0.882
2.846GluMet: 2.846 ± 0.724
4.091GluAsn: 4.091 ± 0.751
1.423GluPro: 1.423 ± 0.482
3.38GluGln: 3.38 ± 1.019
5.336GluArg: 5.336 ± 0.941
5.158GluSer: 5.158 ± 1.407
3.557GluThr: 3.557 ± 1.117
3.557GluVal: 3.557 ± 1.234
0.356GluTrp: 0.356 ± 0.199
3.735GluTyr: 3.735 ± 0.556
0.0GluXaa: 0.0 ± 0.0
Phe
2.134PheAla: 2.134 ± 0.595
0.356PheCys: 0.356 ± 0.403
2.312PheAsp: 2.312 ± 0.432
3.913PheGlu: 3.913 ± 0.818
1.067PhePhe: 1.067 ± 0.448
2.668PheGly: 2.668 ± 0.736
0.0PheHis: 0.0 ± 0.0
2.312PheIle: 2.312 ± 0.784
2.49PheLys: 2.49 ± 0.464
2.49PheLeu: 2.49 ± 0.67
1.067PheMet: 1.067 ± 0.368
3.202PheAsn: 3.202 ± 0.51
1.067PhePro: 1.067 ± 0.595
1.245PheGln: 1.245 ± 0.424
1.423PheArg: 1.423 ± 0.364
2.312PheSer: 2.312 ± 0.617
2.846PheThr: 2.846 ± 0.503
2.134PheVal: 2.134 ± 0.848
0.0PheTrp: 0.0 ± 0.0
0.711PheTyr: 0.711 ± 0.232
0.0PheXaa: 0.0 ± 0.0
Gly
3.202GlyAla: 3.202 ± 0.943
0.534GlyCys: 0.534 ± 0.209
3.913GlyAsp: 3.913 ± 0.726
3.913GlyGlu: 3.913 ± 1.102
0.889GlyPhe: 0.889 ± 0.384
2.49GlyGly: 2.49 ± 0.688
1.067GlyHis: 1.067 ± 0.787
3.557GlyIle: 3.557 ± 1.1
3.024GlyLys: 3.024 ± 0.718
3.913GlyLeu: 3.913 ± 0.832
0.889GlyMet: 0.889 ± 0.403
2.49GlyAsn: 2.49 ± 0.622
1.423GlyPro: 1.423 ± 0.49
1.779GlyGln: 1.779 ± 0.324
2.49GlyArg: 2.49 ± 0.584
1.957GlySer: 1.957 ± 0.682
4.447GlyThr: 4.447 ± 0.513
3.38GlyVal: 3.38 ± 1.04
0.534GlyTrp: 0.534 ± 0.371
0.711GlyTyr: 0.711 ± 0.26
0.0GlyXaa: 0.0 ± 0.0
His
1.779HisAla: 1.779 ± 0.372
0.0HisCys: 0.0 ± 0.0
1.245HisAsp: 1.245 ± 0.513
2.49HisGlu: 2.49 ± 0.551
1.423HisPhe: 1.423 ± 0.385
0.356HisGly: 0.356 ± 0.171
1.067HisHis: 1.067 ± 0.677
0.711HisIle: 0.711 ± 0.3
1.245HisLys: 1.245 ± 0.228
3.557HisLeu: 3.557 ± 0.627
0.711HisMet: 0.711 ± 0.352
0.534HisAsn: 0.534 ± 0.309
0.889HisPro: 0.889 ± 0.481
0.0HisGln: 0.0 ± 0.0
1.245HisArg: 1.245 ± 0.25
1.423HisSer: 1.423 ± 0.423
1.423HisThr: 1.423 ± 0.424
1.423HisVal: 1.423 ± 0.368
0.356HisTrp: 0.356 ± 0.264
1.067HisTyr: 1.067 ± 0.7
0.0HisXaa: 0.0 ± 0.0
Ile
3.557IleAla: 3.557 ± 0.874
0.889IleCys: 0.889 ± 0.337
5.692IleAsp: 5.692 ± 0.882
5.692IleGlu: 5.692 ± 0.802
1.601IlePhe: 1.601 ± 0.335
3.557IleGly: 3.557 ± 1.372
1.423IleHis: 1.423 ± 0.386
4.803IleIle: 4.803 ± 1.267
4.269IleLys: 4.269 ± 1.23
7.293IleLeu: 7.293 ± 1.634
1.601IleMet: 1.601 ± 0.738
6.226IleAsn: 6.226 ± 0.918
2.846IlePro: 2.846 ± 0.397
2.668IleGln: 2.668 ± 0.634
4.447IleArg: 4.447 ± 0.877
5.514IleSer: 5.514 ± 0.613
4.803IleThr: 4.803 ± 0.848
2.846IleVal: 2.846 ± 0.863
0.889IleTrp: 0.889 ± 0.44
3.913IleTyr: 3.913 ± 0.826
0.0IleXaa: 0.0 ± 0.0
Lys
2.846LysAla: 2.846 ± 0.865
0.356LysCys: 0.356 ± 0.206
2.846LysAsp: 2.846 ± 0.348
2.668LysGlu: 2.668 ± 1.074
1.779LysPhe: 1.779 ± 0.587
1.957LysGly: 1.957 ± 0.571
0.534LysHis: 0.534 ± 0.265
3.913LysIle: 3.913 ± 0.961
1.779LysLys: 1.779 ± 0.75
5.336LysLeu: 5.336 ± 1.134
1.245LysMet: 1.245 ± 0.557
2.312LysAsn: 2.312 ± 0.709
1.245LysPro: 1.245 ± 0.592
1.423LysGln: 1.423 ± 0.595
4.447LysArg: 4.447 ± 1.254
2.49LysSer: 2.49 ± 0.853
4.447LysThr: 4.447 ± 1.266
3.38LysVal: 3.38 ± 1.051
0.178LysTrp: 0.178 ± 0.195
2.846LysTyr: 2.846 ± 0.641
0.0LysXaa: 0.0 ± 0.0
Leu
6.048LeuAla: 6.048 ± 0.942
1.245LeuCys: 1.245 ± 0.527
4.447LeuAsp: 4.447 ± 0.806
4.803LeuGlu: 4.803 ± 0.955
3.38LeuPhe: 3.38 ± 0.897
3.735LeuGly: 3.735 ± 0.768
2.312LeuHis: 2.312 ± 0.426
6.403LeuIle: 6.403 ± 0.953
3.557LeuLys: 3.557 ± 0.837
7.649LeuLeu: 7.649 ± 1.075
2.846LeuMet: 2.846 ± 0.575
6.403LeuAsn: 6.403 ± 0.872
2.846LeuPro: 2.846 ± 0.728
5.336LeuGln: 5.336 ± 0.935
6.759LeuArg: 6.759 ± 0.868
9.783LeuSer: 9.783 ± 1.378
6.937LeuThr: 6.937 ± 1.3
4.625LeuVal: 4.625 ± 0.951
0.711LeuTrp: 0.711 ± 0.338
3.38LeuTyr: 3.38 ± 0.929
0.0LeuXaa: 0.0 ± 0.0
Met
1.601MetAla: 1.601 ± 0.27
0.178MetCys: 0.178 ± 0.201
0.534MetAsp: 0.534 ± 0.451
0.534MetGlu: 0.534 ± 0.343
1.245MetPhe: 1.245 ± 0.352
1.067MetGly: 1.067 ± 0.228
0.889MetHis: 0.889 ± 0.385
2.49MetIle: 2.49 ± 0.881
0.889MetLys: 0.889 ± 0.461
2.312MetLeu: 2.312 ± 0.645
1.245MetMet: 1.245 ± 0.593
1.245MetAsn: 1.245 ± 0.499
0.711MetPro: 0.711 ± 0.325
1.423MetGln: 1.423 ± 0.682
3.024MetArg: 3.024 ± 0.824
2.49MetSer: 2.49 ± 0.761
3.735MetThr: 3.735 ± 0.857
1.423MetVal: 1.423 ± 0.469
0.178MetTrp: 0.178 ± 0.151
2.134MetTyr: 2.134 ± 0.704
0.0MetXaa: 0.0 ± 0.0
Asn
5.158AsnAla: 5.158 ± 1.277
0.534AsnCys: 0.534 ± 0.196
3.38AsnAsp: 3.38 ± 0.686
7.471AsnGlu: 7.471 ± 0.997
2.134AsnPhe: 2.134 ± 0.571
3.024AsnGly: 3.024 ± 0.735
0.889AsnHis: 0.889 ± 0.469
4.803AsnIle: 4.803 ± 0.874
3.735AsnLys: 3.735 ± 0.634
4.269AsnLeu: 4.269 ± 0.782
2.312AsnMet: 2.312 ± 0.452
4.625AsnAsn: 4.625 ± 0.678
1.067AsnPro: 1.067 ± 0.724
2.668AsnGln: 2.668 ± 0.566
2.846AsnArg: 2.846 ± 0.8
2.49AsnSer: 2.49 ± 0.436
3.38AsnThr: 3.38 ± 0.482
5.692AsnVal: 5.692 ± 0.62
0.889AsnTrp: 0.889 ± 0.415
2.49AsnTyr: 2.49 ± 0.819
0.0AsnXaa: 0.0 ± 0.0
Pro
1.601ProAla: 1.601 ± 0.483
0.534ProCys: 0.534 ± 0.301
1.245ProAsp: 1.245 ± 0.357
2.49ProGlu: 2.49 ± 0.918
1.067ProPhe: 1.067 ± 0.365
1.601ProGly: 1.601 ± 0.747
0.534ProHis: 0.534 ± 0.26
2.134ProIle: 2.134 ± 0.5
1.423ProLys: 1.423 ± 0.398
3.024ProLeu: 3.024 ± 0.954
0.889ProMet: 0.889 ± 0.188
1.779ProAsn: 1.779 ± 0.294
1.423ProPro: 1.423 ± 0.482
0.889ProGln: 0.889 ± 0.284
1.779ProArg: 1.779 ± 0.647
3.202ProSer: 3.202 ± 0.769
2.49ProThr: 2.49 ± 0.577
1.601ProVal: 1.601 ± 0.259
0.711ProTrp: 0.711 ± 0.348
2.134ProTyr: 2.134 ± 0.601
0.0ProXaa: 0.0 ± 0.0
Gln
1.423GlnAla: 1.423 ± 0.378
0.534GlnCys: 0.534 ± 0.25
1.423GlnAsp: 1.423 ± 0.471
1.779GlnGlu: 1.779 ± 0.497
1.245GlnPhe: 1.245 ± 0.501
1.601GlnGly: 1.601 ± 0.802
1.423GlnHis: 1.423 ± 0.386
2.49GlnIle: 2.49 ± 0.528
1.245GlnLys: 1.245 ± 0.557
3.024GlnLeu: 3.024 ± 0.874
0.534GlnMet: 0.534 ± 0.256
2.312GlnAsn: 2.312 ± 0.56
1.067GlnPro: 1.067 ± 0.389
2.134GlnGln: 2.134 ± 0.602
2.49GlnArg: 2.49 ± 0.591
2.49GlnSer: 2.49 ± 0.799
3.024GlnThr: 3.024 ± 0.798
1.957GlnVal: 1.957 ± 0.456
0.356GlnTrp: 0.356 ± 0.229
1.245GlnTyr: 1.245 ± 0.318
0.0GlnXaa: 0.0 ± 0.0
Arg
4.091ArgAla: 4.091 ± 0.795
0.0ArgCys: 0.0 ± 0.0
3.202ArgAsp: 3.202 ± 0.837
3.024ArgGlu: 3.024 ± 0.662
1.601ArgPhe: 1.601 ± 0.62
2.668ArgGly: 2.668 ± 0.967
1.245ArgHis: 1.245 ± 0.486
5.514ArgIle: 5.514 ± 0.742
1.779ArgLys: 1.779 ± 0.353
6.937ArgLeu: 6.937 ± 0.764
1.245ArgMet: 1.245 ± 0.345
4.625ArgAsn: 4.625 ± 0.759
2.312ArgPro: 2.312 ± 0.591
1.601ArgGln: 1.601 ± 0.848
3.913ArgArg: 3.913 ± 0.961
4.98ArgSer: 4.98 ± 0.603
2.134ArgThr: 2.134 ± 0.324
5.692ArgVal: 5.692 ± 0.601
0.711ArgTrp: 0.711 ± 0.382
3.024ArgTyr: 3.024 ± 0.804
0.0ArgXaa: 0.0 ± 0.0
Ser
5.514SerAla: 5.514 ± 0.562
0.356SerCys: 0.356 ± 0.327
4.98SerAsp: 4.98 ± 0.68
5.158SerGlu: 5.158 ± 0.93
3.557SerPhe: 3.557 ± 0.914
3.735SerGly: 3.735 ± 1.086
1.779SerHis: 1.779 ± 0.384
5.158SerIle: 5.158 ± 0.84
3.38SerLys: 3.38 ± 1.096
6.759SerLeu: 6.759 ± 1.143
2.312SerMet: 2.312 ± 0.271
4.625SerAsn: 4.625 ± 0.984
1.779SerPro: 1.779 ± 0.652
1.601SerGln: 1.601 ± 0.593
5.692SerArg: 5.692 ± 0.99
5.87SerSer: 5.87 ± 1.387
4.803SerThr: 4.803 ± 0.814
5.514SerVal: 5.514 ± 0.721
0.534SerTrp: 0.534 ± 0.254
1.957SerTyr: 1.957 ± 0.828
0.0SerXaa: 0.0 ± 0.0
Thr
5.158ThrAla: 5.158 ± 1.357
0.534ThrCys: 0.534 ± 0.361
3.735ThrAsp: 3.735 ± 0.857
3.38ThrGlu: 3.38 ± 0.668
2.668ThrPhe: 2.668 ± 0.636
3.024ThrGly: 3.024 ± 0.4
2.312ThrHis: 2.312 ± 0.717
5.692ThrIle: 5.692 ± 1.168
4.625ThrLys: 4.625 ± 1.011
7.115ThrLeu: 7.115 ± 0.889
1.423ThrMet: 1.423 ± 0.356
4.091ThrAsn: 4.091 ± 0.794
2.49ThrPro: 2.49 ± 0.519
1.423ThrGln: 1.423 ± 0.529
2.846ThrArg: 2.846 ± 0.675
6.403ThrSer: 6.403 ± 1.052
3.557ThrThr: 3.557 ± 0.752
3.735ThrVal: 3.735 ± 0.904
0.889ThrTrp: 0.889 ± 0.336
2.49ThrTyr: 2.49 ± 0.531
0.0ThrXaa: 0.0 ± 0.0
Val
3.38ValAla: 3.38 ± 0.596
0.711ValCys: 0.711 ± 0.506
3.557ValAsp: 3.557 ± 0.855
4.091ValGlu: 4.091 ± 0.678
3.024ValPhe: 3.024 ± 0.435
2.312ValGly: 2.312 ± 0.529
1.779ValHis: 1.779 ± 0.482
6.581ValIle: 6.581 ± 0.703
3.024ValLys: 3.024 ± 0.406
6.403ValLeu: 6.403 ± 0.973
1.779ValMet: 1.779 ± 0.426
5.336ValAsn: 5.336 ± 1.1
3.202ValPro: 3.202 ± 0.468
1.245ValGln: 1.245 ± 0.537
2.312ValArg: 2.312 ± 0.599
3.38ValSer: 3.38 ± 0.7
4.98ValThr: 4.98 ± 0.783
3.38ValVal: 3.38 ± 0.648
0.889ValTrp: 0.889 ± 0.59
2.312ValTyr: 2.312 ± 0.444
0.0ValXaa: 0.0 ± 0.0
Trp
1.067TrpAla: 1.067 ± 0.516
0.178TrpCys: 0.178 ± 0.164
0.356TrpAsp: 0.356 ± 0.233
0.534TrpGlu: 0.534 ± 0.393
0.356TrpPhe: 0.356 ± 0.171
0.178TrpGly: 0.178 ± 0.164
0.534TrpHis: 0.534 ± 0.258
0.178TrpIle: 0.178 ± 0.147
0.711TrpLys: 0.711 ± 0.362
0.889TrpLeu: 0.889 ± 0.397
0.356TrpMet: 0.356 ± 0.267
0.711TrpAsn: 0.711 ± 0.513
0.711TrpPro: 0.711 ± 0.305
0.178TrpGln: 0.178 ± 0.151
0.711TrpArg: 0.711 ± 0.292
0.889TrpSer: 0.889 ± 0.422
0.356TrpThr: 0.356 ± 0.199
0.356TrpVal: 0.356 ± 0.233
0.178TrpTrp: 0.178 ± 0.195
0.711TrpTyr: 0.711 ± 0.325
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.091TyrAla: 4.091 ± 0.617
0.534TyrCys: 0.534 ± 0.198
3.024TyrAsp: 3.024 ± 0.76
2.846TyrGlu: 2.846 ± 0.474
0.356TyrPhe: 0.356 ± 0.302
2.49TyrGly: 2.49 ± 0.631
1.245TyrHis: 1.245 ± 0.685
2.846TyrIle: 2.846 ± 0.55
1.957TyrLys: 1.957 ± 0.632
4.269TyrLeu: 4.269 ± 1.099
1.423TyrMet: 1.423 ± 0.599
2.49TyrAsn: 2.49 ± 0.622
1.779TyrPro: 1.779 ± 0.614
1.245TyrGln: 1.245 ± 0.512
1.601TyrArg: 1.601 ± 0.519
3.38TyrSer: 3.38 ± 0.89
2.134TyrThr: 2.134 ± 0.708
2.49TyrVal: 2.49 ± 0.713
0.356TyrTrp: 0.356 ± 0.295
1.601TyrTyr: 1.601 ± 0.42
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (5623 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski