Amino acid dipepetide frequency for Eremothecium cymbalariae (strain CBS 270.75 / DBVPG 7215 / KCTC 17166 / NRRL Y-17582) (Yeast)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.866AlaAla: 4.866 ± 0.075
0.745AlaCys: 0.745 ± 0.02
2.905AlaAsp: 2.905 ± 0.045
3.409AlaGlu: 3.409 ± 0.048
2.194AlaPhe: 2.194 ± 0.036
3.368AlaGly: 3.368 ± 0.05
1.163AlaHis: 1.163 ± 0.022
3.671AlaIle: 3.671 ± 0.043
3.833AlaLys: 3.833 ± 0.049
5.563AlaLeu: 5.563 ± 0.058
1.291AlaMet: 1.291 ± 0.027
2.771AlaAsn: 2.771 ± 0.036
2.369AlaPro: 2.369 ± 0.053
2.256AlaGln: 2.256 ± 0.044
2.612AlaArg: 2.612 ± 0.041
5.033AlaSer: 5.033 ± 0.057
3.669AlaThr: 3.669 ± 0.051
3.902AlaVal: 3.902 ± 0.051
0.509AlaTrp: 0.509 ± 0.016
1.746AlaTyr: 1.746 ± 0.029
0.0AlaXaa: 0.0 ± 0.0
Cys
0.672CysAla: 0.672 ± 0.018
0.276CysCys: 0.276 ± 0.011
0.739CysAsp: 0.739 ± 0.021
0.692CysGlu: 0.692 ± 0.018
0.65CysPhe: 0.65 ± 0.018
0.973CysGly: 0.973 ± 0.024
0.353CysHis: 0.353 ± 0.013
0.955CysIle: 0.955 ± 0.022
0.8CysLys: 0.8 ± 0.021
1.295CysLeu: 1.295 ± 0.025
0.317CysMet: 0.317 ± 0.013
0.685CysAsn: 0.685 ± 0.018
0.524CysPro: 0.524 ± 0.017
0.496CysGln: 0.496 ± 0.015
0.596CysArg: 0.596 ± 0.014
1.188CysSer: 1.188 ± 0.026
0.665CysThr: 0.665 ± 0.018
0.874CysVal: 0.874 ± 0.021
0.167CysTrp: 0.167 ± 0.009
0.522CysTyr: 0.522 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.217AspAla: 3.217 ± 0.042
0.675AspCys: 0.675 ± 0.015
4.328AspAsp: 4.328 ± 0.068
4.739AspGlu: 4.739 ± 0.063
2.476AspPhe: 2.476 ± 0.032
3.277AspGly: 3.277 ± 0.049
1.137AspHis: 1.137 ± 0.021
4.137AspIle: 4.137 ± 0.044
3.302AspLys: 3.302 ± 0.047
5.442AspLeu: 5.442 ± 0.053
1.223AspMet: 1.223 ± 0.023
2.755AspAsn: 2.755 ± 0.032
2.495AspPro: 2.495 ± 0.036
1.858AspGln: 1.858 ± 0.031
2.343AspArg: 2.343 ± 0.036
4.772AspSer: 4.772 ± 0.052
2.873AspThr: 2.873 ± 0.043
3.737AspVal: 3.737 ± 0.04
0.684AspTrp: 0.684 ± 0.018
2.101AspTyr: 2.101 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
3.559GluAla: 3.559 ± 0.047
0.724GluCys: 0.724 ± 0.02
4.279GluAsp: 4.279 ± 0.048
5.733GluGlu: 5.733 ± 0.081
2.84GluPhe: 2.84 ± 0.034
2.956GluGly: 2.956 ± 0.042
1.533GluHis: 1.533 ± 0.027
3.809GluIle: 3.809 ± 0.044
4.474GluLys: 4.474 ± 0.058
7.012GluLeu: 7.012 ± 0.084
1.378GluMet: 1.378 ± 0.027
3.449GluAsn: 3.449 ± 0.045
2.127GluPro: 2.127 ± 0.035
2.971GluGln: 2.971 ± 0.037
3.272GluArg: 3.272 ± 0.043
4.852GluSer: 4.852 ± 0.052
3.237GluThr: 3.237 ± 0.04
3.865GluVal: 3.865 ± 0.047
0.663GluTrp: 0.663 ± 0.019
2.399GluTyr: 2.399 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
2.262PheAla: 2.262 ± 0.037
0.566PheCys: 0.566 ± 0.018
2.511PheAsp: 2.511 ± 0.034
2.752PheGlu: 2.752 ± 0.039
1.75PhePhe: 1.75 ± 0.035
2.607PheGly: 2.607 ± 0.047
1.016PheHis: 1.016 ± 0.021
2.678PheIle: 2.678 ± 0.039
2.892PheLys: 2.892 ± 0.037
3.932PheLeu: 3.932 ± 0.05
0.948PheMet: 0.948 ± 0.02
2.287PheAsn: 2.287 ± 0.035
1.73PhePro: 1.73 ± 0.027
1.895PheGln: 1.895 ± 0.029
1.82PheArg: 1.82 ± 0.032
3.495PheSer: 3.495 ± 0.044
2.37PheThr: 2.37 ± 0.035
2.627PheVal: 2.627 ± 0.041
0.518PheTrp: 0.518 ± 0.016
1.536PheTyr: 1.536 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
3.245GlyAla: 3.245 ± 0.053
0.826GlyCys: 0.826 ± 0.019
3.096GlyAsp: 3.096 ± 0.042
3.032GlyGlu: 3.032 ± 0.038
2.459GlyPhe: 2.459 ± 0.035
4.164GlyGly: 4.164 ± 0.079
1.269GlyHis: 1.269 ± 0.026
3.647GlyIle: 3.647 ± 0.042
3.608GlyLys: 3.608 ± 0.045
4.827GlyLeu: 4.827 ± 0.059
1.128GlyMet: 1.128 ± 0.023
2.871GlyAsn: 2.871 ± 0.04
1.767GlyPro: 1.767 ± 0.04
1.818GlyGln: 1.818 ± 0.035
2.533GlyArg: 2.533 ± 0.038
5.342GlySer: 5.342 ± 0.068
3.203GlyThr: 3.203 ± 0.048
3.618GlyVal: 3.618 ± 0.051
0.624GlyTrp: 0.624 ± 0.02
2.0GlyTyr: 2.0 ± 0.033
0.0GlyXaa: 0.0 ± 0.0
His
1.124HisAla: 1.124 ± 0.025
0.332HisCys: 0.332 ± 0.012
1.227HisAsp: 1.227 ± 0.024
1.385HisGlu: 1.385 ± 0.025
0.941HisPhe: 0.941 ± 0.02
1.349HisGly: 1.349 ± 0.028
0.799HisHis: 0.799 ± 0.028
1.468HisIle: 1.468 ± 0.025
1.343HisLys: 1.343 ± 0.024
2.18HisLeu: 2.18 ± 0.03
0.525HisMet: 0.525 ± 0.016
1.119HisAsn: 1.119 ± 0.023
1.147HisPro: 1.147 ± 0.026
1.03HisGln: 1.03 ± 0.03
1.19HisArg: 1.19 ± 0.027
1.925HisSer: 1.925 ± 0.034
1.146HisThr: 1.146 ± 0.023
1.345HisVal: 1.345 ± 0.026
0.26HisTrp: 0.26 ± 0.01
0.849HisTyr: 0.849 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
3.538IleAla: 3.538 ± 0.042
0.937IleCys: 0.937 ± 0.021
3.706IleAsp: 3.706 ± 0.041
3.845IleGlu: 3.845 ± 0.049
2.539IlePhe: 2.539 ± 0.041
3.151IleGly: 3.151 ± 0.042
1.403IleHis: 1.403 ± 0.023
3.723IleIle: 3.723 ± 0.047
4.104IleLys: 4.104 ± 0.049
5.915IleLeu: 5.915 ± 0.061
1.275IleMet: 1.275 ± 0.026
3.221IleAsn: 3.221 ± 0.045
3.224IlePro: 3.224 ± 0.041
2.399IleGln: 2.399 ± 0.036
2.879IleArg: 2.879 ± 0.04
5.684IleSer: 5.684 ± 0.062
3.464IleThr: 3.464 ± 0.041
3.741IleVal: 3.741 ± 0.04
0.733IleTrp: 0.733 ± 0.021
2.101IleTyr: 2.101 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
3.591LysAla: 3.591 ± 0.053
0.847LysCys: 0.847 ± 0.023
3.792LysAsp: 3.792 ± 0.049
4.52LysGlu: 4.52 ± 0.064
2.964LysPhe: 2.964 ± 0.039
2.977LysGly: 2.977 ± 0.036
1.517LysHis: 1.517 ± 0.025
3.996LysIle: 3.996 ± 0.047
5.356LysLys: 5.356 ± 0.073
7.13LysLeu: 7.13 ± 0.061
1.467LysMet: 1.467 ± 0.029
3.568LysAsn: 3.568 ± 0.041
2.785LysPro: 2.785 ± 0.044
2.938LysGln: 2.938 ± 0.047
3.983LysArg: 3.983 ± 0.047
5.145LysSer: 5.145 ± 0.059
3.383LysThr: 3.383 ± 0.043
4.081LysVal: 4.081 ± 0.042
0.786LysTrp: 0.786 ± 0.019
2.592LysTyr: 2.592 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
5.595LeuAla: 5.595 ± 0.054
1.401LeuCys: 1.401 ± 0.03
5.569LeuAsp: 5.569 ± 0.056
6.48LeuGlu: 6.48 ± 0.062
4.129LeuPhe: 4.129 ± 0.055
4.874LeuGly: 4.874 ± 0.054
2.248LeuHis: 2.248 ± 0.04
5.466LeuIle: 5.466 ± 0.062
7.33LeuLys: 7.33 ± 0.073
9.889LeuLeu: 9.889 ± 0.098
2.06LeuMet: 2.06 ± 0.029
5.21LeuAsn: 5.21 ± 0.059
4.714LeuPro: 4.714 ± 0.055
4.584LeuGln: 4.584 ± 0.045
4.745LeuArg: 4.745 ± 0.049
8.447LeuSer: 8.447 ± 0.076
5.104LeuThr: 5.104 ± 0.053
5.791LeuVal: 5.791 ± 0.059
0.953LeuTrp: 0.953 ± 0.023
3.192LeuTyr: 3.192 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
1.396MetAla: 1.396 ± 0.026
0.301MetCys: 0.301 ± 0.012
1.396MetAsp: 1.396 ± 0.024
1.396MetGlu: 1.396 ± 0.028
0.912MetPhe: 0.912 ± 0.023
1.176MetGly: 1.176 ± 0.021
0.429MetHis: 0.429 ± 0.012
1.223MetIle: 1.223 ± 0.02
1.519MetLys: 1.519 ± 0.028
2.143MetLeu: 2.143 ± 0.034
0.518MetMet: 0.518 ± 0.018
1.182MetAsn: 1.182 ± 0.026
0.856MetPro: 0.856 ± 0.021
0.774MetGln: 0.774 ± 0.021
0.927MetArg: 0.927 ± 0.021
2.059MetSer: 2.059 ± 0.028
1.114MetThr: 1.114 ± 0.024
1.417MetVal: 1.417 ± 0.025
0.193MetTrp: 0.193 ± 0.01
0.616MetTyr: 0.616 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.877AsnAla: 2.877 ± 0.038
0.693AsnCys: 0.693 ± 0.017
3.091AsnAsp: 3.091 ± 0.038
3.37AsnGlu: 3.37 ± 0.043
2.136AsnPhe: 2.136 ± 0.035
3.17AsnGly: 3.17 ± 0.042
1.136AsnHis: 1.136 ± 0.022
3.52AsnIle: 3.52 ± 0.04
3.467AsnLys: 3.467 ± 0.044
4.695AsnLeu: 4.695 ± 0.046
1.212AsnMet: 1.212 ± 0.021
3.423AsnAsn: 3.423 ± 0.073
2.327AsnPro: 2.327 ± 0.035
1.871AsnGln: 1.871 ± 0.034
2.218AsnArg: 2.218 ± 0.029
4.853AsnSer: 4.853 ± 0.053
2.996AsnThr: 2.996 ± 0.041
3.197AsnVal: 3.197 ± 0.035
0.611AsnTrp: 0.611 ± 0.017
1.841AsnTyr: 1.841 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
2.463ProAla: 2.463 ± 0.045
0.421ProCys: 0.421 ± 0.017
2.223ProAsp: 2.223 ± 0.032
2.903ProGlu: 2.903 ± 0.043
1.791ProPhe: 1.791 ± 0.031
2.21ProGly: 2.21 ± 0.04
0.963ProHis: 0.963 ± 0.023
2.661ProIle: 2.661 ± 0.038
2.758ProLys: 2.758 ± 0.046
4.222ProLeu: 4.222 ± 0.045
0.864ProMet: 0.864 ± 0.023
2.199ProAsn: 2.199 ± 0.033
2.63ProPro: 2.63 ± 0.068
2.016ProGln: 2.016 ± 0.052
1.89ProArg: 1.89 ± 0.031
4.196ProSer: 4.196 ± 0.07
2.75ProThr: 2.75 ± 0.04
2.847ProVal: 2.847 ± 0.038
0.425ProTrp: 0.425 ± 0.014
1.418ProTyr: 1.418 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
2.121GlnAla: 2.121 ± 0.043
0.532GlnCys: 0.532 ± 0.015
2.155GlnAsp: 2.155 ± 0.034
2.938GlnGlu: 2.938 ± 0.044
1.767GlnPhe: 1.767 ± 0.032
1.958GlnGly: 1.958 ± 0.033
1.118GlnHis: 1.118 ± 0.029
2.331GlnIle: 2.331 ± 0.037
2.59GlnLys: 2.59 ± 0.041
4.729GlnLeu: 4.729 ± 0.05
0.849GlnMet: 0.849 ± 0.019
2.017GlnAsn: 2.017 ± 0.032
1.812GlnPro: 1.812 ± 0.041
3.912GlnGln: 3.912 ± 0.198
2.257GlnArg: 2.257 ± 0.037
3.111GlnSer: 3.111 ± 0.043
1.957GlnThr: 1.957 ± 0.034
2.354GlnVal: 2.354 ± 0.037
0.462GlnTrp: 0.462 ± 0.014
1.414GlnTyr: 1.414 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
2.615ArgAla: 2.615 ± 0.04
0.736ArgCys: 0.736 ± 0.02
2.613ArgAsp: 2.613 ± 0.038
3.038ArgGlu: 3.038 ± 0.04
2.079ArgPhe: 2.079 ± 0.032
2.462ArgGly: 2.462 ± 0.047
1.14ArgHis: 1.14 ± 0.022
3.028ArgIle: 3.028 ± 0.037
3.603ArgLys: 3.603 ± 0.048
4.652ArgLeu: 4.652 ± 0.047
1.032ArgMet: 1.032 ± 0.023
2.522ArgAsn: 2.522 ± 0.04
1.815ArgPro: 1.815 ± 0.031
2.0ArgGln: 2.0 ± 0.037
3.207ArgArg: 3.207 ± 0.046
4.007ArgSer: 4.007 ± 0.047
2.461ArgThr: 2.461 ± 0.039
2.664ArgVal: 2.664 ± 0.035
0.539ArgTrp: 0.539 ± 0.018
1.811ArgTyr: 1.811 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
4.921SerAla: 4.921 ± 0.064
1.082SerCys: 1.082 ± 0.022
4.554SerAsp: 4.554 ± 0.052
4.889SerGlu: 4.889 ± 0.049
3.567SerPhe: 3.567 ± 0.041
5.118SerGly: 5.118 ± 0.071
1.88SerHis: 1.88 ± 0.033
5.36SerIle: 5.36 ± 0.05
5.983SerLys: 5.983 ± 0.062
8.268SerLeu: 8.268 ± 0.066
1.965SerMet: 1.965 ± 0.03
4.981SerAsn: 4.981 ± 0.056
3.873SerPro: 3.873 ± 0.076
3.436SerGln: 3.436 ± 0.052
4.117SerArg: 4.117 ± 0.047
9.905SerSer: 9.905 ± 0.158
5.518SerThr: 5.518 ± 0.091
5.272SerVal: 5.272 ± 0.052
0.861SerTrp: 0.861 ± 0.021
2.675SerTyr: 2.675 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
3.571ThrAla: 3.571 ± 0.048
0.679ThrCys: 0.679 ± 0.02
2.787ThrAsp: 2.787 ± 0.037
3.127ThrGlu: 3.127 ± 0.042
2.246ThrPhe: 2.246 ± 0.036
3.289ThrGly: 3.289 ± 0.046
1.161ThrHis: 1.161 ± 0.023
3.462ThrIle: 3.462 ± 0.04
3.566ThrLys: 3.566 ± 0.041
5.289ThrLeu: 5.289 ± 0.056
1.185ThrMet: 1.185 ± 0.024
2.904ThrAsn: 2.904 ± 0.042
2.959ThrPro: 2.959 ± 0.062
1.927ThrGln: 1.927 ± 0.033
2.407ThrArg: 2.407 ± 0.033
5.126ThrSer: 5.126 ± 0.074
3.801ThrThr: 3.801 ± 0.077
3.725ThrVal: 3.725 ± 0.056
0.574ThrTrp: 0.574 ± 0.017
1.638ThrTyr: 1.638 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
3.906ValAla: 3.906 ± 0.046
0.87ValCys: 0.87 ± 0.022
3.806ValAsp: 3.806 ± 0.046
4.081ValGlu: 4.081 ± 0.044
2.612ValPhe: 2.612 ± 0.037
3.451ValGly: 3.451 ± 0.046
1.299ValHis: 1.299 ± 0.025
3.753ValIle: 3.753 ± 0.043
3.932ValLys: 3.932 ± 0.044
6.014ValLeu: 6.014 ± 0.054
1.274ValMet: 1.274 ± 0.03
3.058ValAsn: 3.058 ± 0.039
2.982ValPro: 2.982 ± 0.045
2.348ValGln: 2.348 ± 0.033
2.813ValArg: 2.813 ± 0.033
5.465ValSer: 5.465 ± 0.047
3.482ValThr: 3.482 ± 0.043
4.287ValVal: 4.287 ± 0.049
0.61ValTrp: 0.61 ± 0.019
1.984ValTyr: 1.984 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
0.541TrpAla: 0.541 ± 0.017
0.25TrpCys: 0.25 ± 0.01
0.707TrpAsp: 0.707 ± 0.024
0.648TrpGlu: 0.648 ± 0.019
0.519TrpPhe: 0.519 ± 0.018
0.555TrpGly: 0.555 ± 0.018
0.242TrpHis: 0.242 ± 0.011
0.616TrpIle: 0.616 ± 0.018
0.837TrpLys: 0.837 ± 0.021
1.077TrpLeu: 1.077 ± 0.026
0.253TrpMet: 0.253 ± 0.011
0.643TrpAsn: 0.643 ± 0.016
0.327TrpPro: 0.327 ± 0.012
0.383TrpGln: 0.383 ± 0.012
0.57TrpArg: 0.57 ± 0.018
0.868TrpSer: 0.868 ± 0.021
0.534TrpThr: 0.534 ± 0.018
0.588TrpVal: 0.588 ± 0.016
0.165TrpTrp: 0.165 ± 0.009
0.427TrpTyr: 0.427 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.798TyrAla: 1.798 ± 0.035
0.545TyrCys: 0.545 ± 0.017
2.085TyrAsp: 2.085 ± 0.034
2.152TyrGlu: 2.152 ± 0.036
1.623TyrPhe: 1.623 ± 0.033
1.992TyrGly: 1.992 ± 0.034
0.88TyrHis: 0.88 ± 0.019
2.078TyrIle: 2.078 ± 0.033
2.12TyrLys: 2.12 ± 0.032
3.506TyrLeu: 3.506 ± 0.046
0.784TyrMet: 0.784 ± 0.021
1.841TyrAsn: 1.841 ± 0.034
1.39TyrPro: 1.39 ± 0.027
1.473TyrGln: 1.473 ± 0.027
1.646TyrArg: 1.646 ± 0.028
2.752TyrSer: 2.752 ± 0.047
1.695TyrThr: 1.695 ± 0.03
2.094TyrVal: 2.094 ± 0.033
0.41TyrTrp: 0.41 ± 0.013
1.444TyrTyr: 1.444 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.002XaaXaa: 0.002 ± 0.002
Statistics based on 4429 proteins (2154228 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski