Amino acid dipepetide frequency for Algoriphagus aquimarinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.082AlaAla: 5.082 ± 0.075	0.549AlaCys: 0.549 ± 0.017	3.837AlaAsp: 3.837 ± 0.054	4.727AlaGlu: 4.727 ± 0.063	3.556AlaPhe: 3.556 ± 0.048	5.296AlaGly: 5.296 ± 0.074	1.196AlaHis: 1.196 ± 0.024	5.202AlaIle: 5.202 ± 0.065	4.552AlaLys: 4.552 ± 0.064	6.364AlaLeu: 6.364 ± 0.078	1.845AlaMet: 1.845 ± 0.041	3.279AlaAsn: 3.279 ± 0.048	2.306AlaPro: 2.306 ± 0.052	2.569AlaGln: 2.569 ± 0.039	2.289AlaArg: 2.289 ± 0.042	4.642AlaSer: 4.642 ± 0.064	3.509AlaThr: 3.509 ± 0.057	4.223AlaVal: 4.223 ± 0.063	0.8AlaTrp: 0.8 ± 0.025	2.513AlaTyr: 2.513 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.46CysAla: 0.46 ± 0.017	0.075CysCys: 0.075 ± 0.007	0.383CysAsp: 0.383 ± 0.021	0.42CysGlu: 0.42 ± 0.02	0.354CysPhe: 0.354 ± 0.013	0.548CysGly: 0.548 ± 0.024	0.177CysHis: 0.177 ± 0.015	0.44CysIle: 0.44 ± 0.016	0.36CysLys: 0.36 ± 0.016	0.584CysLeu: 0.584 ± 0.021	0.139CysMet: 0.139 ± 0.009	0.272CysAsn: 0.272 ± 0.015	0.292CysPro: 0.292 ± 0.017	0.245CysGln: 0.245 ± 0.013	0.214CysArg: 0.214 ± 0.011	0.533CysSer: 0.533 ± 0.019	0.37CysThr: 0.37 ± 0.014	0.391CysVal: 0.391 ± 0.016	0.071CysTrp: 0.071 ± 0.008	0.248CysTyr: 0.248 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.464AspAla: 3.464 ± 0.047	0.348AspCys: 0.348 ± 0.017	2.567AspAsp: 2.567 ± 0.05	3.907AspGlu: 3.907 ± 0.059	3.699AspPhe: 3.699 ± 0.054	4.131AspGly: 4.131 ± 0.071	1.024AspHis: 1.024 ± 0.027	3.694AspIle: 3.694 ± 0.044	3.55AspLys: 3.55 ± 0.048	5.932AspLeu: 5.932 ± 0.062	1.288AspMet: 1.288 ± 0.033	2.377AspAsn: 2.377 ± 0.047	2.575AspPro: 2.575 ± 0.046	2.3AspGln: 2.3 ± 0.042	2.305AspArg: 2.305 ± 0.046	3.467AspSer: 3.467 ± 0.05	2.305AspThr: 2.305 ± 0.034	3.166AspVal: 3.166 ± 0.05	0.935AspTrp: 0.935 ± 0.024	2.553AspTyr: 2.553 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	4.687GluAla: 4.687 ± 0.065	0.284GluCys: 0.284 ± 0.014	3.544GluAsp: 3.544 ± 0.048	5.302GluGlu: 5.302 ± 0.075	3.268GluPhe: 3.268 ± 0.047	4.309GluGly: 4.309 ± 0.055	1.003GluHis: 1.003 ± 0.027	5.568GluIle: 5.568 ± 0.071	5.698GluLys: 5.698 ± 0.082	6.922GluLeu: 6.922 ± 0.071	1.902GluMet: 1.902 ± 0.037	4.102GluAsn: 4.102 ± 0.056	1.747GluPro: 1.747 ± 0.04	2.286GluGln: 2.286 ± 0.041	2.625GluArg: 2.625 ± 0.039	4.09GluSer: 4.09 ± 0.057	3.272GluThr: 3.272 ± 0.057	4.885GluVal: 4.885 ± 0.065	0.789GluTrp: 0.789 ± 0.023	2.307GluTyr: 2.307 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.431PheAla: 3.431 ± 0.048	0.381PheCys: 0.381 ± 0.017	3.247PheAsp: 3.247 ± 0.044	3.519PheGlu: 3.519 ± 0.051	2.776PhePhe: 2.776 ± 0.047	3.844PheGly: 3.844 ± 0.061	0.912PheHis: 0.912 ± 0.027	3.375PheIle: 3.375 ± 0.053	2.994PheLys: 2.994 ± 0.046	5.033PheLeu: 5.033 ± 0.072	1.144PheMet: 1.144 ± 0.026	2.608PheAsn: 2.608 ± 0.042	2.015PhePro: 2.015 ± 0.039	1.908PheGln: 1.908 ± 0.035	1.96PheArg: 1.96 ± 0.038	4.127PheSer: 4.127 ± 0.058	3.097PheThr: 3.097 ± 0.058	2.921PheVal: 2.921 ± 0.045	0.717PheTrp: 0.717 ± 0.024	2.042PheTyr: 2.042 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	4.625GlyAla: 4.625 ± 0.065	0.502GlyCys: 0.502 ± 0.022	3.752GlyAsp: 3.752 ± 0.063	4.47GlyGlu: 4.47 ± 0.06	3.928GlyPhe: 3.928 ± 0.057	5.033GlyGly: 5.033 ± 0.091	1.205GlyHis: 1.205 ± 0.034	5.571GlyIle: 5.571 ± 0.065	5.334GlyLys: 5.334 ± 0.065	6.664GlyLeu: 6.664 ± 0.07	1.992GlyMet: 1.992 ± 0.041	3.696GlyAsn: 3.696 ± 0.063	1.713GlyPro: 1.713 ± 0.036	2.263GlyGln: 2.263 ± 0.039	2.567GlyArg: 2.567 ± 0.052	4.465GlySer: 4.465 ± 0.073	3.935GlyThr: 3.935 ± 0.073	4.817GlyVal: 4.817 ± 0.069	0.933GlyTrp: 0.933 ± 0.025	2.949GlyTyr: 2.949 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	1.114HisAla: 1.114 ± 0.032	0.156HisCys: 0.156 ± 0.01	0.818HisAsp: 0.818 ± 0.023	1.114HisGlu: 1.114 ± 0.027	1.097HisPhe: 1.097 ± 0.031	1.218HisGly: 1.218 ± 0.029	0.467HisHis: 0.467 ± 0.018	1.154HisIle: 1.154 ± 0.029	0.918HisLys: 0.918 ± 0.026	1.882HisLeu: 1.882 ± 0.039	0.399HisMet: 0.399 ± 0.015	0.719HisAsn: 0.719 ± 0.021	1.005HisPro: 1.005 ± 0.028	0.74HisGln: 0.74 ± 0.021	0.715HisArg: 0.715 ± 0.019	1.128HisSer: 1.128 ± 0.028	0.899HisThr: 0.899 ± 0.025	0.973HisVal: 0.973 ± 0.028	0.263HisTrp: 0.263 ± 0.015	0.728HisTyr: 0.728 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.261IleAla: 5.261 ± 0.063	0.594IleCys: 0.594 ± 0.023	4.113IleAsp: 4.113 ± 0.049	4.679IleGlu: 4.679 ± 0.063	3.438IlePhe: 3.438 ± 0.061	5.077IleGly: 5.077 ± 0.074	1.386IleHis: 1.386 ± 0.034	4.611IleIle: 4.611 ± 0.063	4.523IleLys: 4.523 ± 0.061	7.101IleLeu: 7.101 ± 0.087	1.37IleMet: 1.37 ± 0.033	3.689IleAsn: 3.689 ± 0.058	3.419IlePro: 3.419 ± 0.049	2.866IleGln: 2.866 ± 0.047	2.957IleArg: 2.957 ± 0.044	5.739IleSer: 5.739 ± 0.065	4.145IleThr: 4.145 ± 0.059	4.114IleVal: 4.114 ± 0.059	0.838IleTrp: 0.838 ± 0.025	2.573IleTyr: 2.573 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.853LysAla: 4.853 ± 0.064	0.266LysCys: 0.266 ± 0.013	3.848LysAsp: 3.848 ± 0.06	5.124LysGlu: 5.124 ± 0.072	2.696LysPhe: 2.696 ± 0.044	4.484LysGly: 4.484 ± 0.056	1.101LysHis: 1.101 ± 0.026	5.063LysIle: 5.063 ± 0.065	5.056LysLys: 5.056 ± 0.074	6.195LysLeu: 6.195 ± 0.074	1.916LysMet: 1.916 ± 0.04	3.75LysAsn: 3.75 ± 0.05	2.524LysPro: 2.524 ± 0.042	2.036LysGln: 2.036 ± 0.037	2.511LysArg: 2.511 ± 0.047	4.709LysSer: 4.709 ± 0.063	3.614LysThr: 3.614 ± 0.048	4.58LysVal: 4.58 ± 0.055	0.801LysTrp: 0.801 ± 0.023	2.522LysTyr: 2.522 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	7.087LeuAla: 7.087 ± 0.082	0.678LeuCys: 0.678 ± 0.025	5.795LeuAsp: 5.795 ± 0.067	6.715LeuGlu: 6.715 ± 0.075	4.804LeuPhe: 4.804 ± 0.068	6.715LeuGly: 6.715 ± 0.067	1.557LeuHis: 1.557 ± 0.036	7.242LeuIle: 7.242 ± 0.086	6.713LeuLys: 6.713 ± 0.075	9.251LeuLeu: 9.251 ± 0.105	2.322LeuMet: 2.322 ± 0.044	4.935LeuAsn: 4.935 ± 0.064	4.045LeuPro: 4.045 ± 0.059	3.206LeuGln: 3.206 ± 0.048	3.572LeuArg: 3.572 ± 0.052	7.031LeuSer: 7.031 ± 0.064	5.352LeuThr: 5.352 ± 0.075	6.149LeuVal: 6.149 ± 0.07	0.972LeuTrp: 0.972 ± 0.027	3.063LeuTyr: 3.063 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.886MetAla: 1.886 ± 0.041	0.123MetCys: 0.123 ± 0.01	1.488MetAsp: 1.488 ± 0.03	1.715MetGlu: 1.715 ± 0.037	0.761MetPhe: 0.761 ± 0.024	1.75MetGly: 1.75 ± 0.034	0.417MetHis: 0.417 ± 0.016	1.824MetIle: 1.824 ± 0.036	2.161MetLys: 2.161 ± 0.038	2.177MetLeu: 2.177 ± 0.042	0.688MetMet: 0.688 ± 0.021	1.413MetAsn: 1.413 ± 0.029	1.042MetPro: 1.042 ± 0.024	0.84MetGln: 0.84 ± 0.027	0.972MetArg: 0.972 ± 0.024	1.514MetSer: 1.514 ± 0.029	1.291MetThr: 1.291 ± 0.029	1.523MetVal: 1.523 ± 0.033	0.195MetTrp: 0.195 ± 0.011	0.647MetTyr: 0.647 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.254AsnAla: 3.254 ± 0.042	0.327AsnCys: 0.327 ± 0.016	2.439AsnAsp: 2.439 ± 0.046	3.097AsnGlu: 3.097 ± 0.046	2.739AsnPhe: 2.739 ± 0.043	3.645AsnGly: 3.645 ± 0.059	0.919AsnHis: 0.919 ± 0.026	3.317AsnIle: 3.317 ± 0.051	2.76AsnLys: 2.76 ± 0.044	5.21AsnLeu: 5.21 ± 0.064	1.173AsnMet: 1.173 ± 0.026	2.308AsnAsn: 2.308 ± 0.051	2.95AsnPro: 2.95 ± 0.046	2.271AsnGln: 2.271 ± 0.047	2.102AsnArg: 2.102 ± 0.04	3.821AsnSer: 3.821 ± 0.051	2.766AsnThr: 2.766 ± 0.046	2.819AsnVal: 2.819 ± 0.047	0.819AsnTrp: 0.819 ± 0.026	2.34AsnTyr: 2.34 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	2.828ProAla: 2.828 ± 0.048	0.176ProCys: 0.176 ± 0.01	2.558ProAsp: 2.558 ± 0.041	3.488ProGlu: 3.488 ± 0.052	2.093ProPhe: 2.093 ± 0.035	2.671ProGly: 2.671 ± 0.045	0.676ProHis: 0.676 ± 0.021	2.792ProIle: 2.792 ± 0.049	2.449ProLys: 2.449 ± 0.047	3.328ProLeu: 3.328 ± 0.046	0.913ProMet: 0.913 ± 0.025	2.088ProAsn: 2.088 ± 0.041	0.94ProPro: 0.94 ± 0.026	1.204ProGln: 1.204 ± 0.028	1.136ProArg: 1.136 ± 0.029	2.55ProSer: 2.55 ± 0.041	2.161ProThr: 2.161 ± 0.045	2.694ProVal: 2.694 ± 0.041	0.465ProTrp: 0.465 ± 0.019	1.426ProTyr: 1.426 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.477GlnAla: 2.477 ± 0.045	0.167GlnCys: 0.167 ± 0.01	1.85GlnAsp: 1.85 ± 0.031	2.616GlnGlu: 2.616 ± 0.044	1.672GlnPhe: 1.672 ± 0.036	2.156GlnGly: 2.156 ± 0.042	0.598GlnHis: 0.598 ± 0.025	2.769GlnIle: 2.769 ± 0.045	2.664GlnLys: 2.664 ± 0.045	3.689GlnLeu: 3.689 ± 0.061	0.89GlnMet: 0.89 ± 0.025	2.025GlnAsn: 2.025 ± 0.039	1.193GlnPro: 1.193 ± 0.027	1.313GlnGln: 1.313 ± 0.033	1.409GlnArg: 1.409 ± 0.031	2.356GlnSer: 2.356 ± 0.041	1.934GlnThr: 1.934 ± 0.037	2.575GlnVal: 2.575 ± 0.041	0.377GlnTrp: 0.377 ± 0.016	1.201GlnTyr: 1.201 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.323ArgAla: 2.323 ± 0.043	0.173ArgCys: 0.173 ± 0.011	2.021ArgAsp: 2.021 ± 0.038	2.663ArgGlu: 2.663 ± 0.044	2.079ArgPhe: 2.079 ± 0.037	2.287ArgGly: 2.287 ± 0.039	0.588ArgHis: 0.588 ± 0.022	3.041ArgIle: 3.041 ± 0.048	2.902ArgLys: 2.902 ± 0.044	3.603ArgLeu: 3.603 ± 0.052	1.122ArgMet: 1.122 ± 0.032	2.097ArgAsn: 2.097 ± 0.044	1.333ArgPro: 1.333 ± 0.028	1.229ArgGln: 1.229 ± 0.03	1.492ArgArg: 1.492 ± 0.035	2.294ArgSer: 2.294 ± 0.043	2.006ArgThr: 2.006 ± 0.036	2.436ArgVal: 2.436 ± 0.039	0.481ArgTrp: 0.481 ± 0.017	1.541ArgTyr: 1.541 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.26SerAla: 4.26 ± 0.059	0.64SerCys: 0.64 ± 0.02	3.778SerAsp: 3.778 ± 0.053	4.46SerGlu: 4.46 ± 0.057	3.91SerPhe: 3.91 ± 0.058	5.313SerGly: 5.313 ± 0.075	1.191SerHis: 1.191 ± 0.03	5.114SerIle: 5.114 ± 0.063	4.627SerLys: 4.627 ± 0.059	6.828SerLeu: 6.828 ± 0.073	1.565SerMet: 1.565 ± 0.031	3.39SerAsn: 3.39 ± 0.051	2.683SerPro: 2.683 ± 0.048	2.572SerGln: 2.572 ± 0.044	2.61SerArg: 2.61 ± 0.046	4.994SerSer: 4.994 ± 0.067	3.683SerThr: 3.683 ± 0.048	4.108SerVal: 4.108 ± 0.061	0.862SerTrp: 0.862 ± 0.026	2.715SerTyr: 2.715 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	3.742ThrAla: 3.742 ± 0.064	0.348ThrCys: 0.348 ± 0.018	3.04ThrAsp: 3.04 ± 0.058	3.333ThrGlu: 3.333 ± 0.047	2.868ThrPhe: 2.868 ± 0.054	4.264ThrGly: 4.264 ± 0.072	0.972ThrHis: 0.972 ± 0.022	3.974ThrIle: 3.974 ± 0.05	3.022ThrLys: 3.022 ± 0.045	5.221ThrLeu: 5.221 ± 0.063	1.031ThrMet: 1.031 ± 0.028	2.502ThrAsn: 2.502 ± 0.049	2.468ThrPro: 2.468 ± 0.046	1.907ThrGln: 1.907 ± 0.034	1.744ThrArg: 1.744 ± 0.036	3.716ThrSer: 3.716 ± 0.052	2.905ThrThr: 2.905 ± 0.058	3.497ThrVal: 3.497 ± 0.073	0.73ThrTrp: 0.73 ± 0.024	2.185ThrTyr: 2.185 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	4.352ValAla: 4.352 ± 0.062	0.465ValCys: 0.465 ± 0.021	3.572ValAsp: 3.572 ± 0.057	4.07ValGlu: 4.07 ± 0.06	3.335ValPhe: 3.335 ± 0.054	4.23ValGly: 4.23 ± 0.068	1.048ValHis: 1.048 ± 0.029	4.687ValIle: 4.687 ± 0.062	4.234ValLys: 4.234 ± 0.059	6.116ValLeu: 6.116 ± 0.07	1.54ValMet: 1.54 ± 0.031	3.293ValAsn: 3.293 ± 0.057	2.367ValPro: 2.367 ± 0.04	2.025ValGln: 2.025 ± 0.039	2.331ValArg: 2.331 ± 0.044	4.572ValSer: 4.572 ± 0.058	3.469ValThr: 3.469 ± 0.068	4.0ValVal: 4.0 ± 0.06	0.732ValTrp: 0.732 ± 0.021	2.23ValTyr: 2.23 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.786TrpAla: 0.786 ± 0.025	0.075TrpCys: 0.075 ± 0.007	0.771TrpAsp: 0.771 ± 0.023	0.853TrpGlu: 0.853 ± 0.026	0.629TrpPhe: 0.629 ± 0.022	0.826TrpGly: 0.826 ± 0.026	0.256TrpHis: 0.256 ± 0.014	0.903TrpIle: 0.903 ± 0.025	0.957TrpLys: 0.957 ± 0.025	1.115TrpLeu: 1.115 ± 0.029	0.432TrpMet: 0.432 ± 0.018	0.67TrpAsn: 0.67 ± 0.022	0.403TrpPro: 0.403 ± 0.02	0.44TrpGln: 0.44 ± 0.016	0.508TrpArg: 0.508 ± 0.019	0.762TrpSer: 0.762 ± 0.023	0.666TrpThr: 0.666 ± 0.023	0.802TrpVal: 0.802 ± 0.025	0.187TrpTrp: 0.187 ± 0.013	0.449TrpTyr: 0.449 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.366TyrAla: 2.366 ± 0.042	0.251TyrCys: 0.251 ± 0.013	2.169TyrAsp: 2.169 ± 0.043	2.316TyrGlu: 2.316 ± 0.042	2.35TyrPhe: 2.35 ± 0.04	2.616TyrGly: 2.616 ± 0.043	0.813TyrHis: 0.813 ± 0.025	2.15TyrIle: 2.15 ± 0.04	2.175TyrLys: 2.175 ± 0.034	3.989TyrLeu: 3.989 ± 0.058	0.756TyrMet: 0.756 ± 0.024	1.862TyrAsn: 1.862 ± 0.038	1.616TyrPro: 1.616 ± 0.036	1.709TyrGln: 1.709 ± 0.035	1.692TyrArg: 1.692 ± 0.033	2.797TyrSer: 2.797 ± 0.048	2.088TyrThr: 2.088 ± 0.044	1.994TyrVal: 1.994 ± 0.037	0.524TyrTrp: 0.524 ± 0.017	1.654TyrTyr: 1.654 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4362 proteins (1512798 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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