Amino acid dipepetide frequency for Brazilian marseillevirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.28AlaAla: 3.28 ± 0.25
1.233AlaCys: 1.233 ± 0.095
2.278AlaAsp: 2.278 ± 0.134
3.596AlaGlu: 3.596 ± 0.174
2.937AlaPhe: 2.937 ± 0.151
2.346AlaGly: 2.346 ± 0.172
0.873AlaHis: 0.873 ± 0.088
2.629AlaIle: 2.629 ± 0.165
4.573AlaLys: 4.573 ± 0.251
4.864AlaLeu: 4.864 ± 0.226
1.319AlaMet: 1.319 ± 0.1
2.201AlaAsn: 2.201 ± 0.144
1.901AlaPro: 1.901 ± 0.141
1.841AlaGln: 1.841 ± 0.126
2.697AlaArg: 2.697 ± 0.161
4.264AlaSer: 4.264 ± 0.203
3.245AlaThr: 3.245 ± 0.221
3.477AlaVal: 3.477 ± 0.196
0.574AlaTrp: 0.574 ± 0.073
1.627AlaTyr: 1.627 ± 0.128
0.0AlaXaa: 0.0 ± 0.0
Cys
1.293CysAla: 1.293 ± 0.121
0.702CysCys: 0.702 ± 0.072
1.344CysAsp: 1.344 ± 0.111
1.593CysGlu: 1.593 ± 0.141
1.558CysPhe: 1.558 ± 0.129
1.824CysGly: 1.824 ± 0.145
0.42CysHis: 0.42 ± 0.054
1.319CysIle: 1.319 ± 0.118
1.704CysLys: 1.704 ± 0.129
2.158CysLeu: 2.158 ± 0.137
0.445CysMet: 0.445 ± 0.068
0.916CysAsn: 0.916 ± 0.092
1.507CysPro: 1.507 ± 0.148
0.702CysGln: 0.702 ± 0.087
1.087CysArg: 1.087 ± 0.084
2.047CysSer: 2.047 ± 0.14
1.13CysThr: 1.13 ± 0.105
1.43CysVal: 1.43 ± 0.11
0.377CysTrp: 0.377 ± 0.051
0.796CysTyr: 0.796 ± 0.085
0.0CysXaa: 0.0 ± 0.0
Asp
2.672AspAla: 2.672 ± 0.166
1.259AspCys: 1.259 ± 0.124
2.372AspAsp: 2.372 ± 0.178
4.547AspGlu: 4.547 ± 0.27
3.031AspPhe: 3.031 ± 0.154
4.461AspGly: 4.461 ± 0.226
0.625AspHis: 0.625 ± 0.078
3.751AspIle: 3.751 ± 0.223
3.708AspLys: 3.708 ± 0.187
3.579AspLeu: 3.579 ± 0.187
1.028AspMet: 1.028 ± 0.097
1.541AspAsn: 1.541 ± 0.114
1.832AspPro: 1.832 ± 0.142
1.173AspGln: 1.173 ± 0.104
2.226AspArg: 2.226 ± 0.139
3.348AspSer: 3.348 ± 0.196
2.038AspThr: 2.038 ± 0.145
3.811AspVal: 3.811 ± 0.198
0.754AspTrp: 0.754 ± 0.086
1.593AspTyr: 1.593 ± 0.108
0.0AspXaa: 0.0 ± 0.0
Glu
3.87GluAla: 3.87 ± 0.188
1.55GluCys: 1.55 ± 0.133
4.281GluAsp: 4.281 ± 0.243
8.743GluGlu: 8.743 ± 0.473
4.581GluPhe: 4.581 ± 0.169
4.067GluGly: 4.067 ± 0.189
1.456GluHis: 1.456 ± 0.119
3.999GluIle: 3.999 ± 0.175
9.359GluLys: 9.359 ± 0.374
6.294GluLeu: 6.294 ± 0.254
2.278GluMet: 2.278 ± 0.13
4.384GluAsn: 4.384 ± 0.2
2.047GluPro: 2.047 ± 0.156
2.492GluGln: 2.492 ± 0.16
5.489GluArg: 5.489 ± 0.268
4.213GluSer: 4.213 ± 0.228
4.812GluThr: 4.812 ± 0.206
3.939GluVal: 3.939 ± 0.179
1.113GluTrp: 1.113 ± 0.1
2.646GluTyr: 2.646 ± 0.164
0.0GluXaa: 0.0 ± 0.0
Phe
3.785PheAla: 3.785 ± 0.185
1.944PheCys: 1.944 ± 0.134
3.083PheAsp: 3.083 ± 0.169
4.333PheGlu: 4.333 ± 0.217
3.322PhePhe: 3.322 ± 0.198
4.076PheGly: 4.076 ± 0.175
1.062PheHis: 1.062 ± 0.097
2.106PheIle: 2.106 ± 0.133
2.132PheLys: 2.132 ± 0.126
6.593PheLeu: 6.593 ± 0.292
1.113PheMet: 1.113 ± 0.1
1.147PheAsn: 1.147 ± 0.096
2.449PhePro: 2.449 ± 0.14
1.807PheGln: 1.807 ± 0.132
3.066PheArg: 3.066 ± 0.169
5.275PheSer: 5.275 ± 0.219
2.029PheThr: 2.029 ± 0.158
5.095PheVal: 5.095 ± 0.199
1.199PheTrp: 1.199 ± 0.089
1.747PheTyr: 1.747 ± 0.121
0.0PheXaa: 0.0 ± 0.0
Gly
2.749GlyAla: 2.749 ± 0.194
1.507GlyCys: 1.507 ± 0.116
3.031GlyAsp: 3.031 ± 0.155
4.761GlyGlu: 4.761 ± 0.225
2.595GlyPhe: 2.595 ± 0.147
3.194GlyGly: 3.194 ± 0.219
1.053GlyHis: 1.053 ± 0.095
3.733GlyIle: 3.733 ± 0.201
6.645GlyLys: 6.645 ± 0.291
4.17GlyLeu: 4.17 ± 0.185
1.447GlyMet: 1.447 ± 0.108
3.117GlyAsn: 3.117 ± 0.19
1.447GlyPro: 1.447 ± 0.115
2.192GlyGln: 2.192 ± 0.174
3.305GlyArg: 3.305 ± 0.188
4.384GlySer: 4.384 ± 0.262
4.513GlyThr: 4.513 ± 0.283
4.299GlyVal: 4.299 ± 0.19
0.822GlyTrp: 0.822 ± 0.088
2.252GlyTyr: 2.252 ± 0.155
0.0GlyXaa: 0.0 ± 0.0
His
0.728HisAla: 0.728 ± 0.084
0.522HisCys: 0.522 ± 0.069
0.539HisAsp: 0.539 ± 0.072
1.207HisGlu: 1.207 ± 0.111
1.019HisPhe: 1.019 ± 0.095
1.841HisGly: 1.841 ± 0.158
0.42HisHis: 0.42 ± 0.067
1.456HisIle: 1.456 ± 0.118
1.507HisLys: 1.507 ± 0.121
1.601HisLeu: 1.601 ± 0.141
0.283HisMet: 0.283 ± 0.05
0.642HisAsn: 0.642 ± 0.066
0.942HisPro: 0.942 ± 0.083
0.617HisGln: 0.617 ± 0.061
1.01HisArg: 1.01 ± 0.089
1.447HisSer: 1.447 ± 0.102
0.762HisThr: 0.762 ± 0.091
1.062HisVal: 1.062 ± 0.094
0.317HisTrp: 0.317 ± 0.049
0.557HisTyr: 0.557 ± 0.075
0.0HisXaa: 0.0 ± 0.0
Ile
3.048IleAla: 3.048 ± 0.175
1.225IleCys: 1.225 ± 0.105
2.381IleAsp: 2.381 ± 0.139
2.869IleGlu: 2.869 ± 0.148
3.203IlePhe: 3.203 ± 0.164
3.108IleGly: 3.108 ± 0.2
1.07IleHis: 1.07 ± 0.096
2.415IleIle: 2.415 ± 0.142
3.074IleLys: 3.074 ± 0.164
5.386IleLeu: 5.386 ± 0.211
0.839IleMet: 0.839 ± 0.083
1.37IleAsn: 1.37 ± 0.109
2.826IlePro: 2.826 ± 0.163
1.91IleGln: 1.91 ± 0.118
2.826IleArg: 2.826 ± 0.158
4.538IleSer: 4.538 ± 0.197
2.355IleThr: 2.355 ± 0.139
3.519IleVal: 3.519 ± 0.178
0.754IleTrp: 0.754 ± 0.073
1.327IleTyr: 1.327 ± 0.107
0.0IleXaa: 0.0 ± 0.0
Lys
4.059LysAla: 4.059 ± 0.21
1.276LysCys: 1.276 ± 0.101
5.009LysAsp: 5.009 ± 0.23
8.589LysGlu: 8.589 ± 0.344
3.888LysPhe: 3.888 ± 0.189
4.222LysGly: 4.222 ± 0.21
1.892LysHis: 1.892 ± 0.13
3.87LysIle: 3.87 ± 0.177
10.789LysLys: 10.789 ± 0.559
6.311LysLeu: 6.311 ± 0.228
1.918LysMet: 1.918 ± 0.146
4.53LysAsn: 4.53 ± 0.241
2.312LysPro: 2.312 ± 0.158
2.449LysGln: 2.449 ± 0.156
5.189LysArg: 5.189 ± 0.221
4.812LysSer: 4.812 ± 0.246
5.198LysThr: 5.198 ± 0.213
5.232LysVal: 5.232 ± 0.203
0.865LysTrp: 0.865 ± 0.093
2.988LysTyr: 2.988 ± 0.177
0.0LysXaa: 0.0 ± 0.0
Leu
4.744LeuAla: 4.744 ± 0.205
2.689LeuCys: 2.689 ± 0.196
4.144LeuAsp: 4.144 ± 0.208
7.929LeuGlu: 7.929 ± 0.299
5.566LeuPhe: 5.566 ± 0.239
5.215LeuGly: 5.215 ± 0.205
1.618LeuHis: 1.618 ± 0.107
3.074LeuIle: 3.074 ± 0.142
5.797LeuLys: 5.797 ± 0.292
9.137LeuLeu: 9.137 ± 0.374
1.773LeuMet: 1.773 ± 0.131
2.851LeuAsn: 2.851 ± 0.201
4.47LeuPro: 4.47 ± 0.201
3.622LeuGln: 3.622 ± 0.295
4.718LeuArg: 4.718 ± 0.187
8.229LeuSer: 8.229 ± 0.318
3.177LeuThr: 3.177 ± 0.193
6.088LeuVal: 6.088 ± 0.267
1.687LeuTrp: 1.687 ± 0.122
2.526LeuTyr: 2.526 ± 0.125
0.0LeuXaa: 0.0 ± 0.0
Met
1.242MetAla: 1.242 ± 0.092
0.574MetCys: 0.574 ± 0.091
1.156MetAsp: 1.156 ± 0.104
2.072MetGlu: 2.072 ± 0.136
1.147MetPhe: 1.147 ± 0.106
1.293MetGly: 1.293 ± 0.104
0.48MetHis: 0.48 ± 0.057
0.702MetIle: 0.702 ± 0.073
1.507MetLys: 1.507 ± 0.116
1.541MetLeu: 1.541 ± 0.1
0.497MetMet: 0.497 ± 0.07
1.207MetAsn: 1.207 ± 0.099
0.676MetPro: 0.676 ± 0.073
1.036MetGln: 1.036 ± 0.09
1.07MetArg: 1.07 ± 0.089
2.201MetSer: 2.201 ± 0.146
1.319MetThr: 1.319 ± 0.107
1.036MetVal: 1.036 ± 0.096
0.24MetTrp: 0.24 ± 0.048
0.599MetTyr: 0.599 ± 0.076
0.0MetXaa: 0.0 ± 0.0
Asn
2.321AsnAla: 2.321 ± 0.153
0.933AsnCys: 0.933 ± 0.088
1.49AsnAsp: 1.49 ± 0.127
2.372AsnGlu: 2.372 ± 0.147
2.826AsnPhe: 2.826 ± 0.165
3.331AsnGly: 3.331 ± 0.187
0.745AsnHis: 0.745 ± 0.088
3.502AsnIle: 3.502 ± 0.208
3.023AsnLys: 3.023 ± 0.195
3.554AsnLeu: 3.554 ± 0.195
0.95AsnMet: 0.95 ± 0.095
1.79AsnAsn: 1.79 ± 0.131
2.166AsnPro: 2.166 ± 0.154
0.796AsnGln: 0.796 ± 0.08
1.61AsnArg: 1.61 ± 0.125
3.143AsnSer: 3.143 ± 0.151
2.552AsnThr: 2.552 ± 0.258
3.057AsnVal: 3.057 ± 0.196
0.522AsnTrp: 0.522 ± 0.063
1.344AsnTyr: 1.344 ± 0.108
0.0AsnXaa: 0.0 ± 0.0
Pro
1.439ProAla: 1.439 ± 0.129
0.711ProCys: 0.711 ± 0.065
2.149ProAsp: 2.149 ± 0.134
4.102ProGlu: 4.102 ± 0.197
2.243ProPhe: 2.243 ± 0.144
2.132ProGly: 2.132 ± 0.153
0.668ProHis: 0.668 ± 0.073
1.815ProIle: 1.815 ± 0.12
3.511ProLys: 3.511 ± 0.183
3.211ProLeu: 3.211 ± 0.178
0.745ProMet: 0.745 ± 0.073
1.824ProAsn: 1.824 ± 0.118
1.601ProPro: 1.601 ± 0.128
1.456ProGln: 1.456 ± 0.108
1.841ProArg: 1.841 ± 0.137
2.8ProSer: 2.8 ± 0.173
2.218ProThr: 2.218 ± 0.158
2.243ProVal: 2.243 ± 0.136
0.497ProTrp: 0.497 ± 0.069
1.267ProTyr: 1.267 ± 0.119
0.0ProXaa: 0.0 ± 0.0
Gln
1.593GlnAla: 1.593 ± 0.136
0.471GlnCys: 0.471 ± 0.064
1.516GlnAsp: 1.516 ± 0.124
3.04GlnGlu: 3.04 ± 0.187
0.908GlnPhe: 0.908 ± 0.084
2.055GlnGly: 2.055 ± 0.199
0.634GlnHis: 0.634 ± 0.073
1.627GlnIle: 1.627 ± 0.111
4.247GlnLys: 4.247 ± 0.202
2.141GlnLeu: 2.141 ± 0.125
1.122GlnMet: 1.122 ± 0.107
2.029GlnAsn: 2.029 ± 0.14
0.891GlnPro: 0.891 ± 0.106
1.165GlnGln: 1.165 ± 0.117
2.595GlnArg: 2.595 ± 0.168
1.601GlnSer: 1.601 ± 0.111
2.098GlnThr: 2.098 ± 0.183
2.44GlnVal: 2.44 ± 0.18
0.462GlnTrp: 0.462 ± 0.072
1.002GlnTyr: 1.002 ± 0.11
0.0GlnXaa: 0.0 ± 0.0
Arg
2.278ArgAla: 2.278 ± 0.132
1.045ArgCys: 1.045 ± 0.108
3.023ArgAsp: 3.023 ± 0.166
5.266ArgGlu: 5.266 ± 0.213
2.226ArgPhe: 2.226 ± 0.119
2.714ArgGly: 2.714 ± 0.153
1.173ArgHis: 1.173 ± 0.103
3.322ArgIle: 3.322 ± 0.179
5.412ArgLys: 5.412 ± 0.229
4.83ArgLeu: 4.83 ± 0.19
1.336ArgMet: 1.336 ± 0.115
2.911ArgAsn: 2.911 ± 0.158
1.558ArgPro: 1.558 ± 0.133
1.832ArgGln: 1.832 ± 0.142
2.98ArgArg: 2.98 ± 0.182
2.74ArgSer: 2.74 ± 0.151
2.757ArgThr: 2.757 ± 0.153
4.256ArgVal: 4.256 ± 0.191
0.702ArgTrp: 0.702 ± 0.081
1.987ArgTyr: 1.987 ± 0.14
0.0ArgXaa: 0.0 ± 0.0
Ser
3.939SerAla: 3.939 ± 0.177
2.038SerCys: 2.038 ± 0.128
3.528SerAsp: 3.528 ± 0.168
5.437SerGlu: 5.437 ± 0.247
5.497SerPhe: 5.497 ± 0.262
5.36SerGly: 5.36 ± 0.206
1.421SerHis: 1.421 ± 0.133
3.04SerIle: 3.04 ± 0.151
5.643SerLys: 5.643 ± 0.243
7.981SerLeu: 7.981 ± 0.268
1.276SerMet: 1.276 ± 0.094
2.929SerAsn: 2.929 ± 0.177
2.877SerPro: 2.877 ± 0.174
2.86SerGln: 2.86 ± 0.151
3.982SerArg: 3.982 ± 0.212
6.885SerSer: 6.885 ± 0.286
3.605SerThr: 3.605 ± 0.206
4.761SerVal: 4.761 ± 0.194
1.062SerTrp: 1.062 ± 0.088
2.029SerTyr: 2.029 ± 0.144
0.0SerXaa: 0.0 ± 0.0
Thr
2.552ThrAla: 2.552 ± 0.171
1.37ThrCys: 1.37 ± 0.111
2.055ThrAsp: 2.055 ± 0.128
3.408ThrGlu: 3.408 ± 0.17
3.254ThrPhe: 3.254 ± 0.174
3.374ThrGly: 3.374 ± 0.245
0.796ThrHis: 0.796 ± 0.072
2.492ThrIle: 2.492 ± 0.141
4.564ThrLys: 4.564 ± 0.187
5.232ThrLeu: 5.232 ± 0.293
0.976ThrMet: 0.976 ± 0.105
2.612ThrAsn: 2.612 ± 0.266
2.381ThrPro: 2.381 ± 0.15
1.815ThrGln: 1.815 ± 0.145
3.228ThrArg: 3.228 ± 0.172
3.768ThrSer: 3.768 ± 0.228
3.28ThrThr: 3.28 ± 0.225
3.22ThrVal: 3.22 ± 0.171
0.685ThrTrp: 0.685 ± 0.084
1.336ThrTyr: 1.336 ± 0.106
0.0ThrXaa: 0.0 ± 0.0
Val
3.965ValAla: 3.965 ± 0.223
2.012ValCys: 2.012 ± 0.167
2.98ValAsp: 2.98 ± 0.154
4.264ValGlu: 4.264 ± 0.208
4.641ValPhe: 4.641 ± 0.206
3.494ValGly: 3.494 ± 0.247
1.242ValHis: 1.242 ± 0.114
2.946ValIle: 2.946 ± 0.158
4.496ValLys: 4.496 ± 0.188
6.833ValLeu: 6.833 ± 0.268
1.233ValMet: 1.233 ± 0.11
2.038ValAsn: 2.038 ± 0.137
3.066ValPro: 3.066 ± 0.165
2.449ValGln: 2.449 ± 0.159
2.997ValArg: 2.997 ± 0.18
6.602ValSer: 6.602 ± 0.286
3.057ValThr: 3.057 ± 0.155
4.941ValVal: 4.941 ± 0.215
1.199ValTrp: 1.199 ± 0.098
2.278ValTyr: 2.278 ± 0.147
0.0ValXaa: 0.0 ± 0.0
Trp
0.591TrpAla: 0.591 ± 0.058
0.471TrpCys: 0.471 ± 0.068
0.916TrpAsp: 0.916 ± 0.095
1.079TrpGlu: 1.079 ± 0.091
1.028TrpPhe: 1.028 ± 0.094
0.531TrpGly: 0.531 ± 0.081
0.265TrpHis: 0.265 ± 0.044
0.694TrpIle: 0.694 ± 0.068
1.618TrpLys: 1.618 ± 0.124
1.087TrpLeu: 1.087 ± 0.102
0.385TrpMet: 0.385 ± 0.053
0.728TrpAsn: 0.728 ± 0.078
0.248TrpPro: 0.248 ± 0.047
0.428TrpGln: 0.428 ± 0.064
0.891TrpArg: 0.891 ± 0.083
1.31TrpSer: 1.31 ± 0.112
0.702TrpThr: 0.702 ± 0.074
0.796TrpVal: 0.796 ± 0.092
0.223TrpTrp: 0.223 ± 0.045
0.634TrpTyr: 0.634 ± 0.065
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.61TyrAla: 1.61 ± 0.124
0.822TyrCys: 0.822 ± 0.083
2.072TyrAsp: 2.072 ± 0.133
2.406TyrGlu: 2.406 ± 0.143
1.892TyrPhe: 1.892 ± 0.155
2.577TyrGly: 2.577 ± 0.165
0.565TyrHis: 0.565 ± 0.066
1.55TyrIle: 1.55 ± 0.126
2.098TyrLys: 2.098 ± 0.117
2.552TyrLeu: 2.552 ± 0.139
0.625TyrMet: 0.625 ± 0.074
1.259TyrAsn: 1.259 ± 0.122
1.276TyrPro: 1.276 ± 0.108
0.993TyrGln: 0.993 ± 0.089
1.541TyrArg: 1.541 ± 0.125
2.543TyrSer: 2.543 ± 0.146
1.55TyrThr: 1.55 ± 0.124
2.029TyrVal: 2.029 ± 0.13
0.574TyrTrp: 0.574 ± 0.07
0.856TyrTyr: 0.856 ± 0.087
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 491 proteins (116783 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski