Amino acid dipepetide frequency for Thalassotalea sp. PP2-459

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.322AlaAla: 6.322 ± 0.086
0.902AlaCys: 0.902 ± 0.03
4.329AlaAsp: 4.329 ± 0.068
5.108AlaGlu: 5.108 ± 0.081
3.619AlaPhe: 3.619 ± 0.062
5.079AlaGly: 5.079 ± 0.072
1.608AlaHis: 1.608 ± 0.04
6.44AlaIle: 6.44 ± 0.081
5.392AlaLys: 5.392 ± 0.079
9.355AlaLeu: 9.355 ± 0.118
2.23AlaMet: 2.23 ± 0.048
4.046AlaAsn: 4.046 ± 0.067
2.47AlaPro: 2.47 ± 0.043
3.693AlaGln: 3.693 ± 0.059
3.008AlaArg: 3.008 ± 0.054
5.346AlaSer: 5.346 ± 0.065
4.435AlaThr: 4.435 ± 0.068
5.167AlaVal: 5.167 ± 0.071
0.8AlaTrp: 0.8 ± 0.021
2.423AlaTyr: 2.423 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.737CysAla: 0.737 ± 0.029
0.151CysCys: 0.151 ± 0.012
0.528CysAsp: 0.528 ± 0.021
0.496CysGlu: 0.496 ± 0.019
0.463CysPhe: 0.463 ± 0.02
0.701CysGly: 0.701 ± 0.028
0.337CysHis: 0.337 ± 0.019
0.641CysIle: 0.641 ± 0.024
0.415CysLys: 0.415 ± 0.018
0.971CysLeu: 0.971 ± 0.029
0.199CysMet: 0.199 ± 0.013
0.378CysAsn: 0.378 ± 0.018
0.395CysPro: 0.395 ± 0.018
0.633CysGln: 0.633 ± 0.027
0.405CysArg: 0.405 ± 0.019
0.671CysSer: 0.671 ± 0.025
0.464CysThr: 0.464 ± 0.019
0.541CysVal: 0.541 ± 0.024
0.126CysTrp: 0.126 ± 0.012
0.347CysTyr: 0.347 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.935AspAla: 3.935 ± 0.065
0.509AspCys: 0.509 ± 0.019
3.289AspAsp: 3.289 ± 0.067
3.795AspGlu: 3.795 ± 0.067
2.551AspPhe: 2.551 ± 0.055
3.416AspGly: 3.416 ± 0.066
1.141AspHis: 1.141 ± 0.038
4.824AspIle: 4.824 ± 0.06
3.571AspLys: 3.571 ± 0.055
4.798AspLeu: 4.798 ± 0.06
1.275AspMet: 1.275 ± 0.035
3.062AspAsn: 3.062 ± 0.053
1.763AspPro: 1.763 ± 0.038
1.985AspGln: 1.985 ± 0.039
1.984AspArg: 1.984 ± 0.045
3.045AspSer: 3.045 ± 0.044
2.759AspThr: 2.759 ± 0.052
3.926AspVal: 3.926 ± 0.06
0.761AspTrp: 0.761 ± 0.027
2.099AspTyr: 2.099 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
4.375GluAla: 4.375 ± 0.073
0.41GluCys: 0.41 ± 0.02
2.829GluAsp: 2.829 ± 0.048
3.452GluGlu: 3.452 ± 0.073
2.367GluPhe: 2.367 ± 0.047
3.122GluGly: 3.122 ± 0.058
1.83GluHis: 1.83 ± 0.041
4.054GluIle: 4.054 ± 0.058
4.57GluLys: 4.57 ± 0.072
6.424GluLeu: 6.424 ± 0.086
1.492GluMet: 1.492 ± 0.04
3.483GluAsn: 3.483 ± 0.066
1.737GluPro: 1.737 ± 0.043
4.761GluGln: 4.761 ± 0.077
2.887GluArg: 2.887 ± 0.055
3.624GluSer: 3.624 ± 0.062
3.088GluThr: 3.088 ± 0.061
3.852GluVal: 3.852 ± 0.056
0.579GluTrp: 0.579 ± 0.024
1.791GluTyr: 1.791 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.476PheAla: 3.476 ± 0.059
0.469PheCys: 0.469 ± 0.02
3.017PheAsp: 3.017 ± 0.057
2.626PheGlu: 2.626 ± 0.046
1.88PhePhe: 1.88 ± 0.048
2.915PheGly: 2.915 ± 0.051
0.851PheHis: 0.851 ± 0.028
3.507PheIle: 3.507 ± 0.057
2.166PheLys: 2.166 ± 0.051
3.582PheLeu: 3.582 ± 0.064
0.943PheMet: 0.943 ± 0.03
2.485PheAsn: 2.485 ± 0.043
1.402PhePro: 1.402 ± 0.03
1.393PheGln: 1.393 ± 0.034
1.403PheArg: 1.403 ± 0.035
3.852PheSer: 3.852 ± 0.062
2.863PheThr: 2.863 ± 0.05
2.808PheVal: 2.808 ± 0.054
0.533PheTrp: 0.533 ± 0.021
1.599PheTyr: 1.599 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
4.616GlyAla: 4.616 ± 0.074
0.718GlyCys: 0.718 ± 0.028
3.544GlyAsp: 3.544 ± 0.066
3.959GlyGlu: 3.959 ± 0.057
3.248GlyPhe: 3.248 ± 0.052
4.182GlyGly: 4.182 ± 0.08
1.444GlyHis: 1.444 ± 0.033
4.647GlyIle: 4.647 ± 0.068
4.1GlyLys: 4.1 ± 0.061
6.138GlyLeu: 6.138 ± 0.081
1.671GlyMet: 1.671 ± 0.039
2.778GlyAsn: 2.778 ± 0.057
1.369GlyPro: 1.369 ± 0.033
2.549GlyGln: 2.549 ± 0.048
2.481GlyArg: 2.481 ± 0.047
3.717GlySer: 3.717 ± 0.065
3.048GlyThr: 3.048 ± 0.058
4.564GlyVal: 4.564 ± 0.074
0.81GlyTrp: 0.81 ± 0.03
2.476GlyTyr: 2.476 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
1.662HisAla: 1.662 ± 0.036
0.312HisCys: 0.312 ± 0.014
1.222HisAsp: 1.222 ± 0.033
1.249HisGlu: 1.249 ± 0.03
1.209HisPhe: 1.209 ± 0.035
1.554HisGly: 1.554 ± 0.037
0.753HisHis: 0.753 ± 0.025
1.598HisIle: 1.598 ± 0.037
1.173HisLys: 1.173 ± 0.033
2.287HisLeu: 2.287 ± 0.048
0.479HisMet: 0.479 ± 0.018
1.036HisAsn: 1.036 ± 0.031
1.033HisPro: 1.033 ± 0.03
1.5HisGln: 1.5 ± 0.037
1.005HisArg: 1.005 ± 0.028
1.388HisSer: 1.388 ± 0.038
1.09HisThr: 1.09 ± 0.032
1.445HisVal: 1.445 ± 0.037
0.368HisTrp: 0.368 ± 0.019
0.963HisTyr: 0.963 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.905IleAla: 6.905 ± 0.087
0.718IleCys: 0.718 ± 0.027
4.811IleAsp: 4.811 ± 0.062
5.286IleGlu: 5.286 ± 0.078
2.622IlePhe: 2.622 ± 0.054
4.615IleGly: 4.615 ± 0.072
1.429IleHis: 1.429 ± 0.043
4.561IleIle: 4.561 ± 0.071
4.388IleLys: 4.388 ± 0.071
5.484IleLeu: 5.484 ± 0.076
1.364IleMet: 1.364 ± 0.035
4.227IleAsn: 4.227 ± 0.076
2.64IlePro: 2.64 ± 0.053
2.312IleGln: 2.312 ± 0.048
2.664IleArg: 2.664 ± 0.054
5.323IleSer: 5.323 ± 0.072
4.567IleThr: 4.567 ± 0.061
4.424IleVal: 4.424 ± 0.067
0.623IleTrp: 0.623 ± 0.023
1.954IleTyr: 1.954 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
5.312LysAla: 5.312 ± 0.082
0.341LysCys: 0.341 ± 0.018
2.851LysAsp: 2.851 ± 0.051
3.549LysGlu: 3.549 ± 0.061
1.915LysPhe: 1.915 ± 0.04
3.311LysGly: 3.311 ± 0.055
1.7LysHis: 1.7 ± 0.036
3.588LysIle: 3.588 ± 0.061
3.756LysLys: 3.756 ± 0.074
5.784LysLeu: 5.784 ± 0.076
1.443LysMet: 1.443 ± 0.04
2.935LysAsn: 2.935 ± 0.053
2.428LysPro: 2.428 ± 0.049
3.665LysGln: 3.665 ± 0.064
2.802LysArg: 2.802 ± 0.046
3.768LysSer: 3.768 ± 0.058
3.422LysThr: 3.422 ± 0.053
4.089LysVal: 4.089 ± 0.059
0.589LysTrp: 0.589 ± 0.02
1.791LysTyr: 1.791 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
9.839LeuAla: 9.839 ± 0.101
0.966LeuCys: 0.966 ± 0.031
5.151LeuAsp: 5.151 ± 0.063
5.236LeuGlu: 5.236 ± 0.065
4.458LeuPhe: 4.458 ± 0.071
6.053LeuGly: 6.053 ± 0.083
1.974LeuHis: 1.974 ± 0.045
6.947LeuIle: 6.947 ± 0.095
5.417LeuLys: 5.417 ± 0.069
10.673LeuLeu: 10.673 ± 0.126
2.494LeuMet: 2.494 ± 0.058
5.027LeuAsn: 5.027 ± 0.071
4.514LeuPro: 4.514 ± 0.069
3.627LeuGln: 3.627 ± 0.055
3.763LeuArg: 3.763 ± 0.067
8.3LeuSer: 8.3 ± 0.095
7.069LeuThr: 7.069 ± 0.071
6.481LeuVal: 6.481 ± 0.09
1.036LeuTrp: 1.036 ± 0.034
2.814LeuTyr: 2.814 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
2.19MetAla: 2.19 ± 0.049
0.198MetCys: 0.198 ± 0.013
1.017MetAsp: 1.017 ± 0.027
1.143MetGlu: 1.143 ± 0.031
0.959MetPhe: 0.959 ± 0.036
1.409MetGly: 1.409 ± 0.036
0.512MetHis: 0.512 ± 0.021
1.503MetIle: 1.503 ± 0.034
1.462MetLys: 1.462 ± 0.033
2.604MetLeu: 2.604 ± 0.057
0.68MetMet: 0.68 ± 0.026
1.106MetAsn: 1.106 ± 0.037
1.143MetPro: 1.143 ± 0.031
1.035MetGln: 1.035 ± 0.024
1.048MetArg: 1.048 ± 0.034
1.781MetSer: 1.781 ± 0.042
1.496MetThr: 1.496 ± 0.037
1.475MetVal: 1.475 ± 0.037
0.215MetTrp: 0.215 ± 0.015
0.56MetTyr: 0.56 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
4.058AsnAla: 4.058 ± 0.061
0.474AsnCys: 0.474 ± 0.022
2.797AsnAsp: 2.797 ± 0.049
3.063AsnGlu: 3.063 ± 0.054
1.975AsnPhe: 1.975 ± 0.043
3.146AsnGly: 3.146 ± 0.06
1.111AsnHis: 1.111 ± 0.03
3.901AsnIle: 3.901 ± 0.057
3.329AsnLys: 3.329 ± 0.062
4.199AsnLeu: 4.199 ± 0.065
1.095AsnMet: 1.095 ± 0.026
3.012AsnAsn: 3.012 ± 0.063
1.863AsnPro: 1.863 ± 0.041
2.396AsnGln: 2.396 ± 0.051
1.979AsnArg: 1.979 ± 0.035
2.992AsnSer: 2.992 ± 0.058
3.082AsnThr: 3.082 ± 0.058
3.279AsnVal: 3.279 ± 0.052
0.623AsnTrp: 0.623 ± 0.023
1.688AsnTyr: 1.688 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
2.596ProAla: 2.596 ± 0.046
0.305ProCys: 0.305 ± 0.017
2.131ProAsp: 2.131 ± 0.048
2.961ProGlu: 2.961 ± 0.051
1.672ProPhe: 1.672 ± 0.041
1.983ProGly: 1.983 ± 0.051
0.798ProHis: 0.798 ± 0.03
2.626ProIle: 2.626 ± 0.054
2.065ProLys: 2.065 ± 0.045
3.792ProLeu: 3.792 ± 0.056
0.849ProMet: 0.849 ± 0.026
1.801ProAsn: 1.801 ± 0.041
0.962ProPro: 0.962 ± 0.028
1.434ProGln: 1.434 ± 0.035
1.161ProArg: 1.161 ± 0.033
2.341ProSer: 2.341 ± 0.047
2.091ProThr: 2.091 ± 0.044
2.606ProVal: 2.606 ± 0.051
0.483ProTrp: 0.483 ± 0.019
1.239ProTyr: 1.239 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
4.302GlnAla: 4.302 ± 0.077
0.428GlnCys: 0.428 ± 0.017
2.056GlnAsp: 2.056 ± 0.042
2.632GlnGlu: 2.632 ± 0.046
1.83GlnPhe: 1.83 ± 0.038
2.894GlnGly: 2.894 ± 0.051
1.548GlnHis: 1.548 ± 0.039
2.64GlnIle: 2.64 ± 0.049
2.443GlnLys: 2.443 ± 0.041
5.758GlnLeu: 5.758 ± 0.081
1.037GlnMet: 1.037 ± 0.029
1.786GlnAsn: 1.786 ± 0.039
1.695GlnPro: 1.695 ± 0.035
4.08GlnGln: 4.08 ± 0.097
2.168GlnArg: 2.168 ± 0.037
2.934GlnSer: 2.934 ± 0.049
2.376GlnThr: 2.376 ± 0.044
3.273GlnVal: 3.273 ± 0.055
0.727GlnTrp: 0.727 ± 0.028
1.723GlnTyr: 1.723 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.923ArgAla: 2.923 ± 0.051
0.363ArgCys: 0.363 ± 0.019
2.073ArgAsp: 2.073 ± 0.044
2.547ArgGlu: 2.547 ± 0.052
2.021ArgPhe: 2.021 ± 0.042
2.272ArgGly: 2.272 ± 0.054
0.919ArgHis: 0.919 ± 0.03
2.928ArgIle: 2.928 ± 0.046
2.467ArgLys: 2.467 ± 0.046
4.207ArgLeu: 4.207 ± 0.066
1.015ArgMet: 1.015 ± 0.034
1.885ArgAsn: 1.885 ± 0.043
1.27ArgPro: 1.27 ± 0.035
1.906ArgGln: 1.906 ± 0.04
1.822ArgArg: 1.822 ± 0.042
2.327ArgSer: 2.327 ± 0.041
1.958ArgThr: 1.958 ± 0.043
2.776ArgVal: 2.776 ± 0.051
0.543ArgTrp: 0.543 ± 0.021
1.661ArgTyr: 1.661 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
5.363SerAla: 5.363 ± 0.065
0.626SerCys: 0.626 ± 0.026
3.525SerAsp: 3.525 ± 0.062
3.888SerGlu: 3.888 ± 0.06
3.195SerPhe: 3.195 ± 0.053
4.682SerGly: 4.682 ± 0.067
1.577SerHis: 1.577 ± 0.036
4.755SerIle: 4.755 ± 0.069
3.598SerLys: 3.598 ± 0.055
7.345SerLeu: 7.345 ± 0.082
1.565SerMet: 1.565 ± 0.036
3.056SerAsn: 3.056 ± 0.057
2.475SerPro: 2.475 ± 0.042
3.017SerGln: 3.017 ± 0.058
2.553SerArg: 2.553 ± 0.046
4.498SerSer: 4.498 ± 0.071
3.764SerThr: 3.764 ± 0.054
4.601SerVal: 4.601 ± 0.06
0.841SerTrp: 0.841 ± 0.029
2.262SerTyr: 2.262 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
4.509ThrAla: 4.509 ± 0.066
0.494ThrCys: 0.494 ± 0.021
3.066ThrAsp: 3.066 ± 0.063
3.38ThrGlu: 3.38 ± 0.054
2.617ThrPhe: 2.617 ± 0.044
3.901ThrGly: 3.901 ± 0.063
1.25ThrHis: 1.25 ± 0.035
4.079ThrIle: 4.079 ± 0.061
2.9ThrLys: 2.9 ± 0.048
6.767ThrLeu: 6.767 ± 0.095
1.167ThrMet: 1.167 ± 0.031
2.594ThrAsn: 2.594 ± 0.051
2.664ThrPro: 2.664 ± 0.052
2.436ThrGln: 2.436 ± 0.051
2.105ThrArg: 2.105 ± 0.042
3.629ThrSer: 3.629 ± 0.06
3.25ThrThr: 3.25 ± 0.057
3.879ThrVal: 3.879 ± 0.065
0.648ThrTrp: 0.648 ± 0.023
1.654ThrTyr: 1.654 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
5.663ValAla: 5.663 ± 0.085
0.681ValCys: 0.681 ± 0.025
4.073ValAsp: 4.073 ± 0.065
4.341ValGlu: 4.341 ± 0.058
2.878ValPhe: 2.878 ± 0.06
4.021ValGly: 4.021 ± 0.062
1.215ValHis: 1.215 ± 0.033
5.128ValIle: 5.128 ± 0.074
3.877ValLys: 3.877 ± 0.068
6.387ValLeu: 6.387 ± 0.086
1.655ValMet: 1.655 ± 0.038
3.632ValAsn: 3.632 ± 0.064
2.306ValPro: 2.306 ± 0.047
2.085ValGln: 2.085 ± 0.043
2.328ValArg: 2.328 ± 0.047
4.853ValSer: 4.853 ± 0.066
4.072ValThr: 4.072 ± 0.06
4.722ValVal: 4.722 ± 0.075
0.625ValTrp: 0.625 ± 0.022
1.891ValTyr: 1.891 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.676TrpAla: 0.676 ± 0.023
0.146TrpCys: 0.146 ± 0.012
0.489TrpAsp: 0.489 ± 0.019
0.404TrpGlu: 0.404 ± 0.02
0.576TrpPhe: 0.576 ± 0.025
0.698TrpGly: 0.698 ± 0.025
0.409TrpHis: 0.409 ± 0.017
0.576TrpIle: 0.576 ± 0.023
0.447TrpLys: 0.447 ± 0.018
1.699TrpLeu: 1.699 ± 0.047
0.261TrpMet: 0.261 ± 0.014
0.418TrpAsn: 0.418 ± 0.022
0.443TrpPro: 0.443 ± 0.019
1.281TrpGln: 1.281 ± 0.034
0.666TrpArg: 0.666 ± 0.021
0.687TrpSer: 0.687 ± 0.026
0.467TrpThr: 0.467 ± 0.021
0.697TrpVal: 0.697 ± 0.028
0.174TrpTrp: 0.174 ± 0.013
0.382TrpTyr: 0.382 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.312TyrAla: 2.312 ± 0.046
0.388TyrCys: 0.388 ± 0.017
1.692TyrAsp: 1.692 ± 0.038
1.612TyrGlu: 1.612 ± 0.043
1.717TyrPhe: 1.717 ± 0.038
2.107TyrGly: 2.107 ± 0.05
0.92TyrHis: 0.92 ± 0.026
1.975TyrIle: 1.975 ± 0.046
1.504TyrLys: 1.504 ± 0.038
3.586TyrLeu: 3.586 ± 0.063
0.624TyrMet: 0.624 ± 0.022
1.314TyrAsn: 1.314 ± 0.035
1.322TyrPro: 1.322 ± 0.038
2.543TyrGln: 2.543 ± 0.048
1.65TyrArg: 1.65 ± 0.038
2.11TyrSer: 2.11 ± 0.046
1.625TyrThr: 1.625 ± 0.042
1.826TyrVal: 1.826 ± 0.041
0.491TyrTrp: 0.491 ± 0.02
1.237TyrTyr: 1.237 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3513 proteins (1188626 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski