Amino acid dipepetide frequency for Senegalimassilia anaerobia

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.871AlaAla: 16.871 ± 0.303
2.385AlaCys: 2.385 ± 0.079
7.401AlaAsp: 7.401 ± 0.124
7.235AlaGlu: 7.235 ± 0.127
4.542AlaPhe: 4.542 ± 0.1
10.256AlaGly: 10.256 ± 0.15
2.203AlaHis: 2.203 ± 0.061
5.501AlaIle: 5.501 ± 0.105
4.966AlaLys: 4.966 ± 0.111
11.204AlaLeu: 11.204 ± 0.174
3.242AlaMet: 3.242 ± 0.071
3.281AlaAsn: 3.281 ± 0.072
4.57AlaPro: 4.57 ± 0.107
4.762AlaGln: 4.762 ± 0.127
6.609AlaArg: 6.609 ± 0.15
6.909AlaSer: 6.909 ± 0.132
5.578AlaThr: 5.578 ± 0.128
9.16AlaVal: 9.16 ± 0.154
1.26AlaTrp: 1.26 ± 0.051
2.923AlaTyr: 2.923 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
2.082CysAla: 2.082 ± 0.071
0.305CysCys: 0.305 ± 0.024
1.101CysAsp: 1.101 ± 0.046
1.068CysGlu: 1.068 ± 0.043
0.557CysPhe: 0.557 ± 0.028
1.852CysGly: 1.852 ± 0.069
0.335CysHis: 0.335 ± 0.03
0.877CysIle: 0.877 ± 0.041
0.592CysLys: 0.592 ± 0.035
1.299CysLeu: 1.299 ± 0.045
0.444CysMet: 0.444 ± 0.026
0.438CysAsn: 0.438 ± 0.028
0.918CysPro: 0.918 ± 0.044
0.4CysGln: 0.4 ± 0.025
0.839CysArg: 0.839 ± 0.042
0.963CysSer: 0.963 ± 0.047
0.877CysThr: 0.877 ± 0.04
1.387CysVal: 1.387 ± 0.055
0.17CysTrp: 0.17 ± 0.017
0.416CysTyr: 0.416 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
8.153AspAla: 8.153 ± 0.141
0.836AspCys: 0.836 ± 0.035
3.836AspAsp: 3.836 ± 0.086
4.816AspGlu: 4.816 ± 0.085
2.429AspPhe: 2.429 ± 0.065
5.77AspGly: 5.77 ± 0.143
0.993AspHis: 0.993 ± 0.048
3.294AspIle: 3.294 ± 0.078
2.249AspLys: 2.249 ± 0.064
5.009AspLeu: 5.009 ± 0.096
1.748AspMet: 1.748 ± 0.049
1.67AspAsn: 1.67 ± 0.058
2.962AspPro: 2.962 ± 0.086
1.691AspGln: 1.691 ± 0.053
3.106AspArg: 3.106 ± 0.079
3.078AspSer: 3.078 ± 0.075
2.611AspThr: 2.611 ± 0.065
5.034AspVal: 5.034 ± 0.103
0.702AspTrp: 0.702 ± 0.037
1.813AspTyr: 1.813 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
7.291GluAla: 7.291 ± 0.14
0.844GluCys: 0.844 ± 0.038
3.495GluAsp: 3.495 ± 0.086
3.882GluGlu: 3.882 ± 0.111
2.017GluPhe: 2.017 ± 0.055
5.306GluGly: 5.306 ± 0.099
1.557GluHis: 1.557 ± 0.052
2.831GluIle: 2.831 ± 0.073
2.716GluLys: 2.716 ± 0.079
5.964GluLeu: 5.964 ± 0.109
1.662GluMet: 1.662 ± 0.062
2.129GluAsn: 2.129 ± 0.059
2.39GluPro: 2.39 ± 0.059
3.194GluGln: 3.194 ± 0.069
4.729GluArg: 4.729 ± 0.12
3.285GluSer: 3.285 ± 0.084
3.151GluThr: 3.151 ± 0.07
4.35GluVal: 4.35 ± 0.095
0.581GluTrp: 0.581 ± 0.035
1.735GluTyr: 1.735 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
4.65PheAla: 4.65 ± 0.106
0.748PheCys: 0.748 ± 0.036
2.8PheAsp: 2.8 ± 0.067
2.48PheGlu: 2.48 ± 0.057
1.351PhePhe: 1.351 ± 0.058
3.563PheGly: 3.563 ± 0.081
0.555PheHis: 0.555 ± 0.032
1.66PheIle: 1.66 ± 0.062
1.365PheLys: 1.365 ± 0.051
2.865PheLeu: 2.865 ± 0.078
0.895PheMet: 0.895 ± 0.037
1.192PheAsn: 1.192 ± 0.049
1.447PhePro: 1.447 ± 0.052
0.892PheGln: 0.892 ± 0.038
1.565PheArg: 1.565 ± 0.048
2.515PheSer: 2.515 ± 0.07
2.229PheThr: 2.229 ± 0.068
2.988PheVal: 2.988 ± 0.083
0.45PheTrp: 0.45 ± 0.03
1.022PheTyr: 1.022 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
9.097GlyAla: 9.097 ± 0.152
1.685GlyCys: 1.685 ± 0.056
4.522GlyAsp: 4.522 ± 0.095
4.887GlyGlu: 4.887 ± 0.093
3.593GlyPhe: 3.593 ± 0.087
6.594GlyGly: 6.594 ± 0.151
1.461GlyHis: 1.461 ± 0.05
4.857GlyIle: 4.857 ± 0.104
4.251GlyLys: 4.251 ± 0.104
6.881GlyLeu: 6.881 ± 0.114
2.602GlyMet: 2.602 ± 0.071
2.761GlyAsn: 2.761 ± 0.082
2.37GlyPro: 2.37 ± 0.078
2.764GlyGln: 2.764 ± 0.066
4.663GlyArg: 4.663 ± 0.101
5.16GlySer: 5.16 ± 0.14
4.673GlyThr: 4.673 ± 0.102
7.0GlyVal: 7.0 ± 0.113
1.085GlyTrp: 1.085 ± 0.057
2.656GlyTyr: 2.656 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
2.086HisAla: 2.086 ± 0.069
0.284HisCys: 0.284 ± 0.022
1.249HisAsp: 1.249 ± 0.042
1.226HisGlu: 1.226 ± 0.044
0.66HisPhe: 0.66 ± 0.03
1.665HisGly: 1.665 ± 0.046
0.393HisHis: 0.393 ± 0.028
0.965HisIle: 0.965 ± 0.034
0.592HisLys: 0.592 ± 0.031
1.543HisLeu: 1.543 ± 0.048
0.499HisMet: 0.499 ± 0.029
0.529HisAsn: 0.529 ± 0.027
1.051HisPro: 1.051 ± 0.043
0.445HisGln: 0.445 ± 0.025
1.036HisArg: 1.036 ± 0.046
1.002HisSer: 1.002 ± 0.037
0.963HisThr: 0.963 ± 0.036
1.646HisVal: 1.646 ± 0.055
0.158HisTrp: 0.158 ± 0.016
0.533HisTyr: 0.533 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.49IleAla: 6.49 ± 0.112
0.937IleCys: 0.937 ± 0.04
3.763IleAsp: 3.763 ± 0.074
3.57IleGlu: 3.57 ± 0.075
1.393IlePhe: 1.393 ± 0.06
4.024IleGly: 4.024 ± 0.111
0.742IleHis: 0.742 ± 0.034
2.322IleIle: 2.322 ± 0.074
1.779IleLys: 1.779 ± 0.062
3.39IleLeu: 3.39 ± 0.096
1.347IleMet: 1.347 ± 0.051
1.444IleAsn: 1.444 ± 0.053
2.389IlePro: 2.389 ± 0.062
1.212IleGln: 1.212 ± 0.046
2.234IleArg: 2.234 ± 0.064
3.044IleSer: 3.044 ± 0.069
2.899IleThr: 2.899 ± 0.074
4.222IleVal: 4.222 ± 0.104
0.447IleTrp: 0.447 ± 0.028
1.068IleTyr: 1.068 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
4.437LysAla: 4.437 ± 0.094
0.521LysCys: 0.521 ± 0.03
2.26LysAsp: 2.26 ± 0.086
2.31LysGlu: 2.31 ± 0.072
1.09LysPhe: 1.09 ± 0.045
2.931LysGly: 2.931 ± 0.084
0.832LysHis: 0.832 ± 0.04
1.654LysIle: 1.654 ± 0.056
2.082LysLys: 2.082 ± 0.07
3.822LysLeu: 3.822 ± 0.083
1.048LysMet: 1.048 ± 0.043
1.374LysAsn: 1.374 ± 0.059
2.186LysPro: 2.186 ± 0.061
1.549LysGln: 1.549 ± 0.052
2.837LysArg: 2.837 ± 0.066
2.191LysSer: 2.191 ± 0.064
2.396LysThr: 2.396 ± 0.065
3.08LysVal: 3.08 ± 0.093
0.407LysTrp: 0.407 ± 0.028
1.037LysTyr: 1.037 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
11.16LeuAla: 11.16 ± 0.182
1.467LeuCys: 1.467 ± 0.054
5.734LeuAsp: 5.734 ± 0.114
5.412LeuGlu: 5.412 ± 0.091
3.392LeuPhe: 3.392 ± 0.08
6.924LeuGly: 6.924 ± 0.116
1.668LeuHis: 1.668 ± 0.052
4.013LeuIle: 4.013 ± 0.105
3.327LeuLys: 3.327 ± 0.072
7.721LeuLeu: 7.721 ± 0.177
2.466LeuMet: 2.466 ± 0.069
2.339LeuAsn: 2.339 ± 0.064
4.179LeuPro: 4.179 ± 0.087
2.447LeuGln: 2.447 ± 0.063
5.167LeuArg: 5.167 ± 0.098
5.872LeuSer: 5.872 ± 0.115
4.677LeuThr: 4.677 ± 0.097
7.064LeuVal: 7.064 ± 0.125
0.788LeuTrp: 0.788 ± 0.037
2.214LeuTyr: 2.214 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
3.131MetAla: 3.131 ± 0.083
0.399MetCys: 0.399 ± 0.027
1.523MetAsp: 1.523 ± 0.057
1.509MetGlu: 1.509 ± 0.056
0.877MetPhe: 0.877 ± 0.04
2.424MetGly: 2.424 ± 0.07
0.516MetHis: 0.516 ± 0.027
1.189MetIle: 1.189 ± 0.05
1.17MetLys: 1.17 ± 0.051
2.607MetLeu: 2.607 ± 0.073
0.77MetMet: 0.77 ± 0.033
0.969MetAsn: 0.969 ± 0.036
1.455MetPro: 1.455 ± 0.048
0.982MetGln: 0.982 ± 0.042
1.776MetArg: 1.776 ± 0.055
1.677MetSer: 1.677 ± 0.047
1.52MetThr: 1.52 ± 0.046
1.889MetVal: 1.889 ± 0.064
0.254MetTrp: 0.254 ± 0.022
0.558MetTyr: 0.558 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.729AsnAla: 3.729 ± 0.088
0.428AsnCys: 0.428 ± 0.028
1.761AsnAsp: 1.761 ± 0.049
1.752AsnGlu: 1.752 ± 0.058
0.863AsnPhe: 0.863 ± 0.037
2.654AsnGly: 2.654 ± 0.074
0.591AsnHis: 0.591 ± 0.032
1.5AsnIle: 1.5 ± 0.053
1.062AsnLys: 1.062 ± 0.048
2.718AsnLeu: 2.718 ± 0.073
0.809AsnMet: 0.809 ± 0.041
0.934AsnAsn: 0.934 ± 0.045
2.038AsnPro: 2.038 ± 0.057
0.894AsnGln: 0.894 ± 0.046
1.626AsnArg: 1.626 ± 0.051
1.515AsnSer: 1.515 ± 0.056
1.575AsnThr: 1.575 ± 0.06
2.565AsnVal: 2.565 ± 0.062
0.331AsnTrp: 0.331 ± 0.021
0.816AsnTyr: 0.816 ± 0.062
0.0AsnXaa: 0.0 ± 0.0
Pro
5.351ProAla: 5.351 ± 0.127
0.654ProCys: 0.654 ± 0.033
3.14ProAsp: 3.14 ± 0.089
3.658ProGlu: 3.658 ± 0.075
1.73ProPhe: 1.73 ± 0.054
3.528ProGly: 3.528 ± 0.091
0.886ProHis: 0.886 ± 0.035
1.92ProIle: 1.92 ± 0.048
1.667ProLys: 1.667 ± 0.05
3.565ProLeu: 3.565 ± 0.075
0.96ProMet: 0.96 ± 0.038
1.221ProAsn: 1.221 ± 0.046
1.096ProPro: 1.096 ± 0.048
1.676ProGln: 1.676 ± 0.067
2.188ProArg: 2.188 ± 0.061
2.44ProSer: 2.44 ± 0.057
2.192ProThr: 2.192 ± 0.062
3.781ProVal: 3.781 ± 0.075
0.459ProTrp: 0.459 ± 0.031
1.387ProTyr: 1.387 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
4.629GlnAla: 4.629 ± 0.13
0.369GlnCys: 0.369 ± 0.024
1.633GlnAsp: 1.633 ± 0.05
1.868GlnGlu: 1.868 ± 0.065
1.011GlnPhe: 1.011 ± 0.041
2.658GlnGly: 2.658 ± 0.061
0.634GlnHis: 0.634 ± 0.031
1.574GlnIle: 1.574 ± 0.055
1.246GlnLys: 1.246 ± 0.043
3.434GlnLeu: 3.434 ± 0.078
0.923GlnMet: 0.923 ± 0.04
0.972GlnAsn: 0.972 ± 0.036
1.625GlnPro: 1.625 ± 0.069
1.577GlnGln: 1.577 ± 0.072
2.263GlnArg: 2.263 ± 0.069
1.557GlnSer: 1.557 ± 0.06
1.817GlnThr: 1.817 ± 0.063
2.804GlnVal: 2.804 ± 0.07
0.382GlnTrp: 0.382 ± 0.026
0.809GlnTyr: 0.809 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
6.445ArgAla: 6.445 ± 0.143
0.972ArgCys: 0.972 ± 0.045
3.41ArgAsp: 3.41 ± 0.076
3.99ArgGlu: 3.99 ± 0.093
2.495ArgPhe: 2.495 ± 0.066
4.058ArgGly: 4.058 ± 0.099
1.071ArgHis: 1.071 ± 0.044
3.191ArgIle: 3.191 ± 0.069
2.619ArgLys: 2.619 ± 0.069
4.658ArgLeu: 4.658 ± 0.11
1.985ArgMet: 1.985 ± 0.065
1.858ArgAsn: 1.858 ± 0.054
2.351ArgPro: 2.351 ± 0.071
2.002ArgGln: 2.002 ± 0.055
3.936ArgArg: 3.936 ± 0.107
3.069ArgSer: 3.069 ± 0.069
2.965ArgThr: 2.965 ± 0.082
4.166ArgVal: 4.166 ± 0.091
0.553ArgTrp: 0.553 ± 0.03
1.806ArgTyr: 1.806 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
6.512SerAla: 6.512 ± 0.132
0.943SerCys: 0.943 ± 0.043
3.465SerAsp: 3.465 ± 0.092
3.277SerGlu: 3.277 ± 0.071
2.503SerPhe: 2.503 ± 0.063
5.545SerGly: 5.545 ± 0.132
1.039SerHis: 1.039 ± 0.044
2.889SerIle: 2.889 ± 0.077
2.263SerLys: 2.263 ± 0.069
5.043SerLeu: 5.043 ± 0.089
1.589SerMet: 1.589 ± 0.054
1.767SerAsn: 1.767 ± 0.063
2.372SerPro: 2.372 ± 0.059
1.999SerGln: 1.999 ± 0.066
3.092SerArg: 3.092 ± 0.082
3.874SerSer: 3.874 ± 0.11
3.055SerThr: 3.055 ± 0.086
4.578SerVal: 4.578 ± 0.092
0.705SerTrp: 0.705 ± 0.038
1.82SerTyr: 1.82 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
5.681ThrAla: 5.681 ± 0.112
0.909ThrCys: 0.909 ± 0.044
3.03ThrAsp: 3.03 ± 0.087
2.716ThrGlu: 2.716 ± 0.068
2.181ThrPhe: 2.181 ± 0.065
4.891ThrGly: 4.891 ± 0.116
0.985ThrHis: 0.985 ± 0.039
2.784ThrIle: 2.784 ± 0.075
1.764ThrLys: 1.764 ± 0.066
4.93ThrLeu: 4.93 ± 0.094
1.232ThrMet: 1.232 ± 0.05
1.526ThrAsn: 1.526 ± 0.061
2.828ThrPro: 2.828 ± 0.079
1.687ThrGln: 1.687 ± 0.054
2.573ThrArg: 2.573 ± 0.063
2.913ThrSer: 2.913 ± 0.083
2.715ThrThr: 2.715 ± 0.074
4.752ThrVal: 4.752 ± 0.14
0.654ThrTrp: 0.654 ± 0.031
1.552ThrTyr: 1.552 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
9.16ValAla: 9.16 ± 0.155
1.557ValCys: 1.557 ± 0.052
5.004ValAsp: 5.004 ± 0.082
5.072ValGlu: 5.072 ± 0.102
3.076ValPhe: 3.076 ± 0.077
5.835ValGly: 5.835 ± 0.111
1.381ValHis: 1.381 ± 0.054
3.964ValIle: 3.964 ± 0.094
3.039ValLys: 3.039 ± 0.074
7.64ValLeu: 7.64 ± 0.131
1.98ValMet: 1.98 ± 0.062
2.484ValAsn: 2.484 ± 0.066
3.761ValPro: 3.761 ± 0.083
2.39ValGln: 2.39 ± 0.063
4.827ValArg: 4.827 ± 0.111
5.116ValSer: 5.116 ± 0.099
4.31ValThr: 4.31 ± 0.167
6.839ValVal: 6.839 ± 0.108
0.737ValTrp: 0.737 ± 0.036
2.052ValTyr: 2.052 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
1.064TrpAla: 1.064 ± 0.05
0.21TrpCys: 0.21 ± 0.021
0.696TrpAsp: 0.696 ± 0.035
0.646TrpGlu: 0.646 ± 0.038
0.444TrpPhe: 0.444 ± 0.029
0.839TrpGly: 0.839 ± 0.042
0.224TrpHis: 0.224 ± 0.017
0.482TrpIle: 0.482 ± 0.032
0.369TrpLys: 0.369 ± 0.021
1.05TrpLeu: 1.05 ± 0.051
0.317TrpMet: 0.317 ± 0.023
0.393TrpAsn: 0.393 ± 0.025
0.373TrpPro: 0.373 ± 0.025
0.365TrpGln: 0.365 ± 0.025
0.751TrpArg: 0.751 ± 0.031
0.549TrpSer: 0.549 ± 0.033
0.504TrpThr: 0.504 ± 0.033
0.795TrpVal: 0.795 ± 0.039
0.155TrpTrp: 0.155 ± 0.018
0.369TrpTyr: 0.369 ± 0.05
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.838TyrAla: 2.838 ± 0.069
0.464TyrCys: 0.464 ± 0.029
1.98TyrAsp: 1.98 ± 0.074
1.736TyrGlu: 1.736 ± 0.053
1.03TyrPhe: 1.03 ± 0.05
2.245TyrGly: 2.245 ± 0.059
0.461TyrHis: 0.461 ± 0.028
1.248TyrIle: 1.248 ± 0.047
0.923TyrLys: 0.923 ± 0.046
2.69TyrLeu: 2.69 ± 0.073
0.674TyrMet: 0.674 ± 0.03
0.878TyrAsn: 0.878 ± 0.043
1.138TyrPro: 1.138 ± 0.046
0.855TyrGln: 0.855 ± 0.035
1.787TyrArg: 1.787 ± 0.062
1.602TyrSer: 1.602 ± 0.062
1.597TyrThr: 1.597 ± 0.07
2.124TyrVal: 2.124 ± 0.062
0.317TyrTrp: 0.317 ± 0.028
0.928TyrTyr: 0.928 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1843 proteins (646842 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski