Amino acid dipepetide frequency for Malassezia restricta CBS 7877

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.01AlaAla: 10.01 ± 0.101	1.515AlaCys: 1.515 ± 0.034	4.748AlaAsp: 4.748 ± 0.054	5.344AlaGlu: 5.344 ± 0.06	3.274AlaPhe: 3.274 ± 0.045	4.813AlaGly: 4.813 ± 0.051	3.229AlaHis: 3.229 ± 0.05	3.564AlaIle: 3.564 ± 0.045	3.605AlaLys: 3.605 ± 0.053	10.516AlaLeu: 10.516 ± 0.119	2.78AlaMet: 2.78 ± 0.037	2.343AlaAsn: 2.343 ± 0.037	7.063AlaPro: 7.063 ± 0.093	4.81AlaGln: 4.81 ± 0.058	6.742AlaArg: 6.742 ± 0.068	8.826AlaSer: 8.826 ± 0.086	5.183AlaThr: 5.183 ± 0.055	5.602AlaVal: 5.602 ± 0.055	1.804AlaTrp: 1.804 ± 0.042	2.693AlaTyr: 2.693 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.309CysAla: 1.309 ± 0.033	0.176CysCys: 0.176 ± 0.009	0.748CysAsp: 0.748 ± 0.018	0.703CysGlu: 0.703 ± 0.019	0.469CysPhe: 0.469 ± 0.016	0.866CysGly: 0.866 ± 0.023	0.391CysHis: 0.391 ± 0.016	0.731CysIle: 0.731 ± 0.019	0.434CysLys: 0.434 ± 0.017	1.315CysLeu: 1.315 ± 0.027	0.413CysMet: 0.413 ± 0.015	0.297CysAsn: 0.297 ± 0.013	0.584CysPro: 0.584 ± 0.018	0.433CysGln: 0.433 ± 0.016	0.781CysArg: 0.781 ± 0.021	0.753CysSer: 0.753 ± 0.023	0.843CysThr: 0.843 ± 0.019	1.139CysVal: 1.139 ± 0.028	0.168CysTrp: 0.168 ± 0.009	0.31CysTyr: 0.31 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.386AspAla: 7.386 ± 0.078	0.488AspCys: 0.488 ± 0.015	4.862AspAsp: 4.862 ± 0.093	5.025AspGlu: 5.025 ± 0.068	1.688AspPhe: 1.688 ± 0.033	3.398AspGly: 3.398 ± 0.043	1.463AspHis: 1.463 ± 0.024	2.538AspIle: 2.538 ± 0.037	2.081AspLys: 2.081 ± 0.039	4.906AspLeu: 4.906 ± 0.058	2.057AspMet: 2.057 ± 0.036	1.331AspAsn: 1.331 ± 0.029	3.111AspPro: 3.111 ± 0.041	1.847AspGln: 1.847 ± 0.027	2.955AspArg: 2.955 ± 0.038	3.21AspSer: 3.21 ± 0.055	3.724AspThr: 3.724 ± 0.052	4.931AspVal: 4.931 ± 0.053	0.753AspTrp: 0.753 ± 0.02	1.358AspTyr: 1.358 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.621GluAla: 6.621 ± 0.073	0.674GluCys: 0.674 ± 0.021	3.616GluAsp: 3.616 ± 0.059	4.772GluGlu: 4.772 ± 0.089	1.602GluPhe: 1.602 ± 0.029	2.877GluGly: 2.877 ± 0.045	2.197GluHis: 2.197 ± 0.034	2.027GluIle: 2.027 ± 0.04	2.674GluLys: 2.674 ± 0.049	5.713GluLeu: 5.713 ± 0.064	1.441GluMet: 1.441 ± 0.028	1.797GluAsn: 1.797 ± 0.034	3.376GluPro: 3.376 ± 0.054	3.045GluGln: 3.045 ± 0.044	5.081GluArg: 5.081 ± 0.06	4.181GluSer: 4.181 ± 0.049	3.07GluThr: 3.07 ± 0.037	2.997GluVal: 2.997 ± 0.04	0.858GluTrp: 0.858 ± 0.02	1.597GluTyr: 1.597 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	2.844PheAla: 2.844 ± 0.037	0.485PheCys: 0.485 ± 0.017	2.119PheAsp: 2.119 ± 0.037	1.909PheGlu: 1.909 ± 0.03	1.356PhePhe: 1.356 ± 0.028	2.441PheGly: 2.441 ± 0.055	1.05PheHis: 1.05 ± 0.024	1.164PheIle: 1.164 ± 0.027	1.041PheLys: 1.041 ± 0.025	3.254PheLeu: 3.254 ± 0.04	0.794PheMet: 0.794 ± 0.021	0.849PheAsn: 0.849 ± 0.023	1.603PhePro: 1.603 ± 0.031	1.302PheGln: 1.302 ± 0.025	1.981PheArg: 1.981 ± 0.029	2.519PheSer: 2.519 ± 0.043	1.664PheThr: 1.664 ± 0.029	2.661PheVal: 2.661 ± 0.043	0.478PheTrp: 0.478 ± 0.017	0.981PheTyr: 0.981 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	5.354GlyAla: 5.354 ± 0.063	0.715GlyCys: 0.715 ± 0.019	3.043GlyAsp: 3.043 ± 0.045	2.994GlyGlu: 2.994 ± 0.051	2.052GlyPhe: 2.052 ± 0.034	4.01GlyGly: 4.01 ± 0.076	1.8GlyHis: 1.8 ± 0.036	2.69GlyIle: 2.69 ± 0.041	2.43GlyLys: 2.43 ± 0.045	5.23GlyLeu: 5.23 ± 0.062	1.738GlyMet: 1.738 ± 0.031	1.444GlyAsn: 1.444 ± 0.03	2.746GlyPro: 2.746 ± 0.039	2.122GlyGln: 2.122 ± 0.033	3.767GlyArg: 3.767 ± 0.046	4.351GlySer: 4.351 ± 0.054	3.694GlyThr: 3.694 ± 0.042	4.129GlyVal: 4.129 ± 0.047	0.881GlyTrp: 0.881 ± 0.021	1.605GlyTyr: 1.605 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	4.158HisAla: 4.158 ± 0.062	0.349HisCys: 0.349 ± 0.013	2.032HisAsp: 2.032 ± 0.032	1.967HisGlu: 1.967 ± 0.034	1.011HisPhe: 1.011 ± 0.025	2.225HisGly: 2.225 ± 0.04	1.036HisHis: 1.036 ± 0.03	1.56HisIle: 1.56 ± 0.025	0.997HisLys: 0.997 ± 0.025	2.868HisLeu: 2.868 ± 0.042	1.031HisMet: 1.031 ± 0.024	0.716HisAsn: 0.716 ± 0.02	1.833HisPro: 1.833 ± 0.03	1.033HisGln: 1.033 ± 0.018	1.97HisArg: 1.97 ± 0.035	1.889HisSer: 1.889 ± 0.031	2.091HisThr: 2.091 ± 0.036	2.854HisVal: 2.854 ± 0.047	0.416HisTrp: 0.416 ± 0.014	0.715HisTyr: 0.715 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	3.354IleAla: 3.354 ± 0.042	0.527IleCys: 0.527 ± 0.019	2.504IleAsp: 2.504 ± 0.039	2.466IleGlu: 2.466 ± 0.037	1.321IlePhe: 1.321 ± 0.03	2.321IleGly: 2.321 ± 0.041	1.257IleHis: 1.257 ± 0.028	1.53IleIle: 1.53 ± 0.033	1.679IleLys: 1.679 ± 0.038	4.085IleLeu: 4.085 ± 0.05	1.05IleMet: 1.05 ± 0.022	1.14IleAsn: 1.14 ± 0.029	2.503IlePro: 2.503 ± 0.035	1.934IleGln: 1.934 ± 0.032	2.668IleArg: 2.668 ± 0.033	2.797IleSer: 2.797 ± 0.042	2.081IleThr: 2.081 ± 0.04	3.135IleVal: 3.135 ± 0.042	0.533IleTrp: 0.533 ± 0.019	0.941IleTyr: 0.941 ± 0.024	0.0IleXaa: 0.0 ± 0.001
Lys	3.487LysAla: 3.487 ± 0.056	0.397LysCys: 0.397 ± 0.014	2.148LysAsp: 2.148 ± 0.042	2.518LysGlu: 2.518 ± 0.049	1.029LysPhe: 1.029 ± 0.024	1.928LysGly: 1.928 ± 0.038	1.194LysHis: 1.194 ± 0.027	1.53LysIle: 1.53 ± 0.032	2.235LysLys: 2.235 ± 0.055	3.374LysLeu: 3.374 ± 0.047	0.924LysMet: 0.924 ± 0.021	1.345LysAsn: 1.345 ± 0.032	2.221LysPro: 2.221 ± 0.046	1.805LysGln: 1.805 ± 0.032	3.112LysArg: 3.112 ± 0.049	2.691LysSer: 2.691 ± 0.045	2.099LysThr: 2.099 ± 0.037	2.164LysVal: 2.164 ± 0.038	0.428LysTrp: 0.428 ± 0.014	1.108LysTyr: 1.108 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	9.412LeuAla: 9.412 ± 0.095	1.686LeuCys: 1.686 ± 0.034	6.108LeuAsp: 6.108 ± 0.068	5.808LeuGlu: 5.808 ± 0.064	3.403LeuPhe: 3.403 ± 0.052	5.799LeuGly: 5.799 ± 0.057	3.352LeuHis: 3.352 ± 0.045	3.284LeuIle: 3.284 ± 0.045	3.044LeuLys: 3.044 ± 0.047	9.815LeuLeu: 9.815 ± 0.114	2.141LeuMet: 2.141 ± 0.036	2.624LeuAsn: 2.624 ± 0.039	5.801LeuPro: 5.801 ± 0.064	4.428LeuGln: 4.428 ± 0.055	7.299LeuArg: 7.299 ± 0.069	7.867LeuSer: 7.867 ± 0.065	4.738LeuThr: 4.738 ± 0.05	6.739LeuVal: 6.739 ± 0.073	1.335LeuTrp: 1.335 ± 0.03	2.728LeuTyr: 2.728 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.64MetAla: 2.64 ± 0.039	0.329MetCys: 0.329 ± 0.015	1.783MetAsp: 1.783 ± 0.031	1.529MetGlu: 1.529 ± 0.024	0.749MetPhe: 0.749 ± 0.018	1.475MetGly: 1.475 ± 0.028	1.019MetHis: 1.019 ± 0.024	1.005MetIle: 1.005 ± 0.025	0.759MetLys: 0.759 ± 0.019	2.751MetLeu: 2.751 ± 0.04	0.723MetMet: 0.723 ± 0.022	0.861MetAsn: 0.861 ± 0.022	2.044MetPro: 2.044 ± 0.038	1.36MetGln: 1.36 ± 0.027	1.961MetArg: 1.961 ± 0.033	2.509MetSer: 2.509 ± 0.035	1.434MetThr: 1.434 ± 0.027	1.465MetVal: 1.465 ± 0.027	0.319MetTrp: 0.319 ± 0.013	0.858MetTyr: 0.858 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.944AsnAla: 2.944 ± 0.042	0.232AsnCys: 0.232 ± 0.011	1.734AsnAsp: 1.734 ± 0.032	2.02AsnGlu: 2.02 ± 0.033	0.835AsnPhe: 0.835 ± 0.02	1.692AsnGly: 1.692 ± 0.038	0.656AsnHis: 0.656 ± 0.019	1.251AsnIle: 1.251 ± 0.03	1.272AsnLys: 1.272 ± 0.029	2.372AsnLeu: 2.372 ± 0.044	0.867AsnMet: 0.867 ± 0.02	0.84AsnAsn: 0.84 ± 0.024	1.554AsnPro: 1.554 ± 0.033	0.965AsnGln: 0.965 ± 0.025	1.446AsnArg: 1.446 ± 0.027	1.587AsnSer: 1.587 ± 0.036	1.611AsnThr: 1.611 ± 0.033	2.255AsnVal: 2.255 ± 0.038	0.338AsnTrp: 0.338 ± 0.011	0.736AsnTyr: 0.736 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.849ProAla: 5.849 ± 0.081	0.616ProCys: 0.616 ± 0.02	3.356ProAsp: 3.356 ± 0.043	3.603ProGlu: 3.603 ± 0.053	1.927ProPhe: 1.927 ± 0.032	3.224ProGly: 3.224 ± 0.041	1.968ProHis: 1.968 ± 0.034	2.314ProIle: 2.314 ± 0.038	2.343ProLys: 2.343 ± 0.046	5.415ProLeu: 5.415 ± 0.061	1.651ProMet: 1.651 ± 0.029	1.689ProAsn: 1.689 ± 0.03	5.713ProPro: 5.713 ± 0.105	2.238ProGln: 2.238 ± 0.039	3.954ProArg: 3.954 ± 0.054	6.286ProSer: 6.286 ± 0.088	4.063ProThr: 4.063 ± 0.063	3.922ProVal: 3.922 ± 0.047	0.842ProTrp: 0.842 ± 0.024	1.562ProTyr: 1.562 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.505GlnAla: 4.505 ± 0.055	0.566GlnCys: 0.566 ± 0.017	2.425GlnAsp: 2.425 ± 0.037	2.402GlnGlu: 2.402 ± 0.044	1.198GlnPhe: 1.198 ± 0.024	2.388GlnGly: 2.388 ± 0.039	1.55GlnHis: 1.55 ± 0.026	1.538GlnIle: 1.538 ± 0.032	1.556GlnLys: 1.556 ± 0.028	4.228GlnLeu: 4.228 ± 0.054	1.051GlnMet: 1.051 ± 0.024	1.301GlnAsn: 1.301 ± 0.032	2.434GlnPro: 2.434 ± 0.045	2.294GlnGln: 2.294 ± 0.053	3.673GlnArg: 3.673 ± 0.05	2.858GlnSer: 2.858 ± 0.045	2.171GlnThr: 2.171 ± 0.028	2.758GlnVal: 2.758 ± 0.034	0.599GlnTrp: 0.599 ± 0.016	1.1GlnTyr: 1.1 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.195ArgAla: 7.195 ± 0.079	0.824ArgCys: 0.824 ± 0.021	3.828ArgAsp: 3.828 ± 0.046	4.116ArgGlu: 4.116 ± 0.047	2.192ArgPhe: 2.192 ± 0.034	3.714ArgGly: 3.714 ± 0.049	2.356ArgHis: 2.356 ± 0.035	3.261ArgIle: 3.261 ± 0.042	2.749ArgLys: 2.749 ± 0.04	6.684ArgLeu: 6.684 ± 0.063	1.997ArgMet: 1.997 ± 0.032	1.722ArgAsn: 1.722 ± 0.034	3.836ArgPro: 3.836 ± 0.054	2.798ArgGln: 2.798 ± 0.044	5.972ArgArg: 5.972 ± 0.079	4.894ArgSer: 4.894 ± 0.061	4.103ArgThr: 4.103 ± 0.044	4.755ArgVal: 4.755 ± 0.054	0.982ArgTrp: 0.982 ± 0.021	1.694ArgTyr: 1.694 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	7.014SerAla: 7.014 ± 0.064	0.829SerCys: 0.829 ± 0.021	4.511SerAsp: 4.511 ± 0.065	4.182SerGlu: 4.182 ± 0.051	2.702SerPhe: 2.702 ± 0.044	4.309SerGly: 4.309 ± 0.057	2.416SerHis: 2.416 ± 0.041	3.23SerIle: 3.23 ± 0.041	3.071SerLys: 3.071 ± 0.047	7.67SerLeu: 7.67 ± 0.067	2.5SerMet: 2.5 ± 0.036	2.244SerAsn: 2.244 ± 0.04	4.774SerPro: 4.774 ± 0.089	3.07SerGln: 3.07 ± 0.047	4.8SerArg: 4.8 ± 0.052	7.632SerSer: 7.632 ± 0.106	5.078SerThr: 5.078 ± 0.065	4.975SerVal: 4.975 ± 0.054	1.013SerTrp: 1.013 ± 0.024	1.887SerTyr: 1.887 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	4.657ThrAla: 4.657 ± 0.05	0.798ThrCys: 0.798 ± 0.022	2.886ThrAsp: 2.886 ± 0.042	2.989ThrGlu: 2.989 ± 0.041	1.906ThrPhe: 1.906 ± 0.026	3.312ThrGly: 3.312 ± 0.047	1.943ThrHis: 1.943 ± 0.033	2.303ThrIle: 2.303 ± 0.037	2.123ThrLys: 2.123 ± 0.037	5.927ThrLeu: 5.927 ± 0.058	1.606ThrMet: 1.606 ± 0.031	1.635ThrAsn: 1.635 ± 0.029	4.338ThrPro: 4.338 ± 0.065	2.443ThrGln: 2.443 ± 0.039	3.623ThrArg: 3.623 ± 0.045	5.187ThrSer: 5.187 ± 0.067	3.262ThrThr: 3.262 ± 0.052	3.264ThrVal: 3.264 ± 0.04	0.893ThrTrp: 0.893 ± 0.024	1.675ThrTyr: 1.675 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	5.841ValAla: 5.841 ± 0.061	1.079ValCys: 1.079 ± 0.026	3.839ValAsp: 3.839 ± 0.04	3.476ValGlu: 3.476 ± 0.046	2.316ValPhe: 2.316 ± 0.039	3.491ValGly: 3.491 ± 0.049	2.497ValHis: 2.497 ± 0.037	2.473ValIle: 2.473 ± 0.039	2.163ValLys: 2.163 ± 0.041	7.184ValLeu: 7.184 ± 0.082	1.655ValMet: 1.655 ± 0.029	1.719ValAsn: 1.719 ± 0.034	5.055ValPro: 5.055 ± 0.063	3.09ValGln: 3.09 ± 0.042	5.141ValArg: 5.141 ± 0.062	5.244ValSer: 5.244 ± 0.049	3.293ValThr: 3.293 ± 0.046	4.389ValVal: 4.389 ± 0.05	1.069ValTrp: 1.069 ± 0.026	1.995ValTyr: 1.995 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.087TrpAla: 1.087 ± 0.026	0.229TrpCys: 0.229 ± 0.011	1.032TrpAsp: 1.032 ± 0.025	0.707TrpGlu: 0.707 ± 0.02	0.44TrpPhe: 0.44 ± 0.016	0.725TrpGly: 0.725 ± 0.021	0.594TrpHis: 0.594 ± 0.018	0.705TrpIle: 0.705 ± 0.019	0.548TrpLys: 0.548 ± 0.013	1.5TrpLeu: 1.5 ± 0.026	0.381TrpMet: 0.381 ± 0.013	0.552TrpAsn: 0.552 ± 0.019	0.682TrpPro: 0.682 ± 0.02	0.595TrpGln: 0.595 ± 0.017	1.126TrpArg: 1.126 ± 0.024	1.09TrpSer: 1.09 ± 0.025	0.944TrpThr: 0.944 ± 0.026	0.721TrpVal: 0.721 ± 0.019	0.244TrpTrp: 0.244 ± 0.013	0.392TrpTyr: 0.392 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.799TyrAla: 2.799 ± 0.04	0.347TyrCys: 0.347 ± 0.013	1.789TyrAsp: 1.789 ± 0.035	1.689TyrGlu: 1.689 ± 0.03	1.021TyrPhe: 1.021 ± 0.026	1.789TyrGly: 1.789 ± 0.035	0.781TyrHis: 0.781 ± 0.021	1.127TyrIle: 1.127 ± 0.025	0.935TyrLys: 0.935 ± 0.022	2.603TyrLeu: 2.603 ± 0.042	0.775TyrMet: 0.775 ± 0.019	0.756TyrAsn: 0.756 ± 0.019	1.267TyrPro: 1.267 ± 0.026	0.984TyrGln: 0.984 ± 0.029	1.618TyrArg: 1.618 ± 0.03	1.537TyrSer: 1.537 ± 0.034	1.622TyrThr: 1.622 ± 0.029	2.151TyrVal: 2.151 ± 0.035	0.344TyrTrp: 0.344 ± 0.014	0.798TyrTyr: 0.798 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.031XaaXaa: 0.031 ± 0.028

Statistics based on 4096 proteins (2061471 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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