Amino acid dipepetide frequency for Halopiger xanaduensis (strain DSM 18323 / JCM 14033 / SH-6)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.445AlaAla: 13.445 ± 0.174	0.699AlaCys: 0.699 ± 0.024	10.828AlaAsp: 10.828 ± 0.131	8.934AlaGlu: 8.934 ± 0.113	3.794AlaPhe: 3.794 ± 0.059	9.108AlaGly: 9.108 ± 0.11	1.633AlaHis: 1.633 ± 0.036	5.352AlaIle: 5.352 ± 0.068	1.763AlaLys: 1.763 ± 0.04	9.975AlaLeu: 9.975 ± 0.126	2.068AlaMet: 2.068 ± 0.039	2.456AlaAsn: 2.456 ± 0.045	3.69AlaPro: 3.69 ± 0.061	2.257AlaGln: 2.257 ± 0.046	5.864AlaArg: 5.864 ± 0.079	5.271AlaSer: 5.271 ± 0.067	6.986AlaThr: 6.986 ± 0.09	9.855AlaVal: 9.855 ± 0.103	1.022AlaTrp: 1.022 ± 0.031	2.632AlaTyr: 2.632 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.63CysAla: 0.63 ± 0.027	0.1CysCys: 0.1 ± 0.009	0.614CysAsp: 0.614 ± 0.023	0.64CysGlu: 0.64 ± 0.026	0.192CysPhe: 0.192 ± 0.012	0.831CysGly: 0.831 ± 0.029	0.192CysHis: 0.192 ± 0.013	0.262CysIle: 0.262 ± 0.014	0.124CysLys: 0.124 ± 0.009	0.557CysLeu: 0.557 ± 0.023	0.114CysMet: 0.114 ± 0.009	0.18CysAsn: 0.18 ± 0.013	0.54CysPro: 0.54 ± 0.022	0.174CysGln: 0.174 ± 0.014	0.514CysArg: 0.514 ± 0.022	0.441CysSer: 0.441 ± 0.021	0.395CysThr: 0.395 ± 0.016	0.447CysVal: 0.447 ± 0.025	0.107CysTrp: 0.107 ± 0.01	0.259CysTyr: 0.259 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	10.482AspAla: 10.482 ± 0.12	0.663AspCys: 0.663 ± 0.024	8.701AspAsp: 8.701 ± 0.133	9.386AspGlu: 9.386 ± 0.105	1.932AspPhe: 1.932 ± 0.045	8.688AspGly: 8.688 ± 0.115	1.819AspHis: 1.819 ± 0.042	3.001AspIle: 3.001 ± 0.059	0.927AspLys: 0.927 ± 0.031	7.444AspLeu: 7.444 ± 0.094	1.205AspMet: 1.205 ± 0.031	1.379AspAsn: 1.379 ± 0.043	4.734AspPro: 4.734 ± 0.068	1.704AspGln: 1.704 ± 0.045	7.107AspArg: 7.107 ± 0.093	4.062AspSer: 4.062 ± 0.066	3.786AspThr: 3.786 ± 0.057	7.85AspVal: 7.85 ± 0.088	1.093AspTrp: 1.093 ± 0.032	2.059AspTyr: 2.059 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	9.18GluAla: 9.18 ± 0.11	0.573GluCys: 0.573 ± 0.024	6.859GluAsp: 6.859 ± 0.092	7.82GluGlu: 7.82 ± 0.121	3.245GluPhe: 3.245 ± 0.051	5.904GluGly: 5.904 ± 0.08	2.126GluHis: 2.126 ± 0.048	4.548GluIle: 4.548 ± 0.063	1.883GluLys: 1.883 ± 0.045	7.844GluLeu: 7.844 ± 0.094	1.909GluMet: 1.909 ± 0.043	2.702GluAsn: 2.702 ± 0.05	5.008GluPro: 5.008 ± 0.077	3.023GluGln: 3.023 ± 0.069	8.392GluArg: 8.392 ± 0.127	5.982GluSer: 5.982 ± 0.083	7.387GluThr: 7.387 ± 0.087	5.621GluVal: 5.621 ± 0.075	1.242GluTrp: 1.242 ± 0.037	3.122GluTyr: 3.122 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.588PheAla: 3.588 ± 0.061	0.278PheCys: 0.278 ± 0.016	3.402PheAsp: 3.402 ± 0.053	3.12PheGlu: 3.12 ± 0.051	1.009PhePhe: 1.009 ± 0.031	3.056PheGly: 3.056 ± 0.06	0.616PheHis: 0.616 ± 0.02	1.102PheIle: 1.102 ± 0.033	0.449PheLys: 0.449 ± 0.02	2.707PheLeu: 2.707 ± 0.058	0.506PheMet: 0.506 ± 0.022	0.696PheAsn: 0.696 ± 0.024	1.256PhePro: 1.256 ± 0.035	0.798PheGln: 0.798 ± 0.029	1.746PheArg: 1.746 ± 0.039	1.579PheSer: 1.579 ± 0.041	1.767PheThr: 1.767 ± 0.035	3.208PheVal: 3.208 ± 0.064	0.394PheTrp: 0.394 ± 0.019	0.895PheTyr: 0.895 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	8.01GlyAla: 8.01 ± 0.105	0.756GlyCys: 0.756 ± 0.027	7.114GlyAsp: 7.114 ± 0.091	7.074GlyGlu: 7.074 ± 0.079	2.95GlyPhe: 2.95 ± 0.053	6.935GlyGly: 6.935 ± 0.114	1.513GlyHis: 1.513 ± 0.041	4.183GlyIle: 4.183 ± 0.065	1.747GlyLys: 1.747 ± 0.042	7.222GlyLeu: 7.222 ± 0.095	1.58GlyMet: 1.58 ± 0.04	2.141GlyAsn: 2.141 ± 0.056	3.349GlyPro: 3.349 ± 0.056	1.978GlyGln: 1.978 ± 0.052	4.754GlyArg: 4.754 ± 0.08	5.164GlySer: 5.164 ± 0.071	5.908GlyThr: 5.908 ± 0.082	6.803GlyVal: 6.803 ± 0.082	1.135GlyTrp: 1.135 ± 0.03	2.672GlyTyr: 2.672 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.891HisAla: 1.891 ± 0.043	0.226HisCys: 0.226 ± 0.014	1.763HisAsp: 1.763 ± 0.039	1.788HisGlu: 1.788 ± 0.045	0.533HisPhe: 0.533 ± 0.021	1.82HisGly: 1.82 ± 0.044	0.526HisHis: 0.526 ± 0.022	0.643HisIle: 0.643 ± 0.021	0.259HisLys: 0.259 ± 0.014	1.718HisLeu: 1.718 ± 0.041	0.291HisMet: 0.291 ± 0.015	0.448HisAsn: 0.448 ± 0.019	1.216HisPro: 1.216 ± 0.034	0.466HisGln: 0.466 ± 0.021	1.288HisArg: 1.288 ± 0.032	0.864HisSer: 0.864 ± 0.026	0.929HisThr: 0.929 ± 0.03	1.741HisVal: 1.741 ± 0.039	0.252HisTrp: 0.252 ± 0.013	0.577HisTyr: 0.577 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.212IleAla: 5.212 ± 0.067	0.286IleCys: 0.286 ± 0.015	4.579IleAsp: 4.579 ± 0.067	4.48IleGlu: 4.48 ± 0.071	1.044IlePhe: 1.044 ± 0.032	4.13IleGly: 4.13 ± 0.073	0.781IleHis: 0.781 ± 0.024	1.333IleIle: 1.333 ± 0.039	0.646IleLys: 0.646 ± 0.025	3.032IleLeu: 3.032 ± 0.061	0.522IleMet: 0.522 ± 0.022	1.009IleAsn: 1.009 ± 0.032	2.049IlePro: 2.049 ± 0.043	1.029IleGln: 1.029 ± 0.03	2.563IleArg: 2.563 ± 0.049	2.12IleSer: 2.12 ± 0.047	2.481IleThr: 2.481 ± 0.05	4.125IleVal: 4.125 ± 0.063	0.363IleTrp: 0.363 ± 0.02	1.031IleTyr: 1.031 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	1.628LysAla: 1.628 ± 0.041	0.107LysCys: 0.107 ± 0.01	1.064LysAsp: 1.064 ± 0.033	1.306LysGlu: 1.306 ± 0.039	0.485LysPhe: 0.485 ± 0.019	1.235LysGly: 1.235 ± 0.034	0.455LysHis: 0.455 ± 0.022	0.756LysIle: 0.756 ± 0.026	0.49LysLys: 0.49 ± 0.022	1.57LysLeu: 1.57 ± 0.039	0.366LysMet: 0.366 ± 0.019	0.523LysAsn: 0.523 ± 0.021	0.889LysPro: 0.889 ± 0.029	0.66LysGln: 0.66 ± 0.026	1.539LysArg: 1.539 ± 0.04	1.064LysSer: 1.064 ± 0.035	1.17LysThr: 1.17 ± 0.036	1.092LysVal: 1.092 ± 0.03	0.228LysTrp: 0.228 ± 0.015	0.543LysTyr: 0.543 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	10.4LeuAla: 10.4 ± 0.131	0.666LeuCys: 0.666 ± 0.025	5.608LeuAsp: 5.608 ± 0.082	12.17LeuGlu: 12.17 ± 0.113	3.016LeuPhe: 3.016 ± 0.063	7.001LeuGly: 7.001 ± 0.1	1.463LeuHis: 1.463 ± 0.034	3.087LeuIle: 3.087 ± 0.062	1.365LeuLys: 1.365 ± 0.034	8.417LeuLeu: 8.417 ± 0.126	1.208LeuMet: 1.208 ± 0.028	1.715LeuAsn: 1.715 ± 0.037	4.056LeuPro: 4.056 ± 0.067	2.097LeuGln: 2.097 ± 0.046	5.098LeuArg: 5.098 ± 0.067	5.109LeuSer: 5.109 ± 0.074	4.746LeuThr: 4.746 ± 0.061	7.796LeuVal: 7.796 ± 0.103	0.851LeuTrp: 0.851 ± 0.03	2.226LeuTyr: 2.226 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	1.774MetAla: 1.774 ± 0.039	0.097MetCys: 0.097 ± 0.008	1.213MetAsp: 1.213 ± 0.036	1.091MetGlu: 1.091 ± 0.03	0.471MetPhe: 0.471 ± 0.021	1.405MetGly: 1.405 ± 0.034	0.338MetHis: 0.338 ± 0.017	0.71MetIle: 0.71 ± 0.024	0.388MetLys: 0.388 ± 0.017	1.489MetLeu: 1.489 ± 0.033	0.312MetMet: 0.312 ± 0.018	0.608MetAsn: 0.608 ± 0.022	0.807MetPro: 0.807 ± 0.025	0.488MetGln: 0.488 ± 0.019	1.046MetArg: 1.046 ± 0.027	1.479MetSer: 1.479 ± 0.034	1.52MetThr: 1.52 ± 0.035	1.252MetVal: 1.252 ± 0.038	0.17MetTrp: 0.17 ± 0.013	0.399MetTyr: 0.399 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.645AsnAla: 2.645 ± 0.052	0.226AsnCys: 0.226 ± 0.014	1.824AsnAsp: 1.824 ± 0.04	2.187AsnGlu: 2.187 ± 0.055	0.67AsnPhe: 0.67 ± 0.025	2.266AsnGly: 2.266 ± 0.044	0.51AsnHis: 0.51 ± 0.02	0.863AsnIle: 0.863 ± 0.026	0.411AsnLys: 0.411 ± 0.02	1.905AsnLeu: 1.905 ± 0.043	0.416AsnMet: 0.416 ± 0.019	0.538AsnAsn: 0.538 ± 0.023	1.513AsnPro: 1.513 ± 0.04	0.669AsnGln: 0.669 ± 0.027	1.641AsnArg: 1.641 ± 0.036	1.009AsnSer: 1.009 ± 0.03	1.198AsnThr: 1.198 ± 0.029	2.292AsnVal: 2.292 ± 0.043	0.36AsnTrp: 0.36 ± 0.017	0.693AsnTyr: 0.693 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.543ProAla: 4.543 ± 0.065	0.231ProCys: 0.231 ± 0.014	5.292ProAsp: 5.292 ± 0.073	4.806ProGlu: 4.806 ± 0.08	1.604ProPhe: 1.604 ± 0.04	3.53ProGly: 3.53 ± 0.062	0.863ProHis: 0.863 ± 0.025	2.199ProIle: 2.199 ± 0.044	0.829ProLys: 0.829 ± 0.028	3.816ProLeu: 3.816 ± 0.068	0.789ProMet: 0.789 ± 0.025	1.229ProAsn: 1.229 ± 0.033	2.162ProPro: 2.162 ± 0.045	1.015ProGln: 1.015 ± 0.03	2.286ProArg: 2.286 ± 0.042	2.71ProSer: 2.71 ± 0.053	3.171ProThr: 3.171 ± 0.059	3.848ProVal: 3.848 ± 0.059	0.529ProTrp: 0.529 ± 0.019	1.191ProTyr: 1.191 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.364GlnAla: 2.364 ± 0.044	0.17GlnCys: 0.17 ± 0.012	1.446GlnAsp: 1.446 ± 0.036	1.892GlnGlu: 1.892 ± 0.05	1.019GlnPhe: 1.019 ± 0.031	1.626GlnGly: 1.626 ± 0.04	0.558GlnHis: 0.558 ± 0.026	1.133GlnIle: 1.133 ± 0.032	0.533GlnLys: 0.533 ± 0.021	2.567GlnLeu: 2.567 ± 0.051	0.516GlnMet: 0.516 ± 0.023	0.715GlnAsn: 0.715 ± 0.028	1.237GlnPro: 1.237 ± 0.04	1.125GlnGln: 1.125 ± 0.042	2.088GlnArg: 2.088 ± 0.049	1.625GlnSer: 1.625 ± 0.043	1.529GlnThr: 1.529 ± 0.03	1.683GlnVal: 1.683 ± 0.039	0.351GlnTrp: 0.351 ± 0.02	0.883GlnTyr: 0.883 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	6.187ArgAla: 6.187 ± 0.08	0.473ArgCys: 0.473 ± 0.022	5.238ArgAsp: 5.238 ± 0.086	6.884ArgGlu: 6.884 ± 0.092	2.253ArgPhe: 2.253 ± 0.048	4.365ArgGly: 4.365 ± 0.057	1.198ArgHis: 1.198 ± 0.032	3.205ArgIle: 3.205 ± 0.053	1.345ArgLys: 1.345 ± 0.039	6.17ArgLeu: 6.17 ± 0.081	1.274ArgMet: 1.274 ± 0.038	1.659ArgAsn: 1.659 ± 0.035	2.565ArgPro: 2.565 ± 0.042	1.798ArgGln: 1.798 ± 0.041	5.04ArgArg: 5.04 ± 0.069	3.851ArgSer: 3.851 ± 0.065	4.213ArgThr: 4.213 ± 0.055	4.939ArgVal: 4.939 ± 0.063	0.804ArgTrp: 0.804 ± 0.028	1.991ArgTyr: 1.991 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.292SerAla: 5.292 ± 0.076	0.316SerCys: 0.316 ± 0.016	5.027SerAsp: 5.027 ± 0.073	4.685SerGlu: 4.685 ± 0.074	1.86SerPhe: 1.86 ± 0.037	5.128SerGly: 5.128 ± 0.076	0.971SerHis: 0.971 ± 0.028	2.666SerIle: 2.666 ± 0.046	1.119SerLys: 1.119 ± 0.035	4.754SerLeu: 4.754 ± 0.068	1.113SerMet: 1.113 ± 0.031	1.496SerAsn: 1.496 ± 0.035	2.542SerPro: 2.542 ± 0.049	1.448SerGln: 1.448 ± 0.042	3.195SerArg: 3.195 ± 0.061	3.553SerSer: 3.553 ± 0.076	3.469SerThr: 3.469 ± 0.048	4.638SerVal: 4.638 ± 0.074	0.573SerTrp: 0.573 ± 0.023	1.392SerTyr: 1.392 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.993ThrAla: 6.993 ± 0.08	0.424ThrCys: 0.424 ± 0.018	5.997ThrAsp: 5.997 ± 0.086	4.883ThrGlu: 4.883 ± 0.073	1.985ThrPhe: 1.985 ± 0.048	5.598ThrGly: 5.598 ± 0.078	1.148ThrHis: 1.148 ± 0.029	3.23ThrIle: 3.23 ± 0.054	0.985ThrLys: 0.985 ± 0.029	5.44ThrLeu: 5.44 ± 0.075	1.028ThrMet: 1.028 ± 0.031	1.523ThrAsn: 1.523 ± 0.034	3.037ThrPro: 3.037 ± 0.055	1.324ThrGln: 1.324 ± 0.031	3.146ThrArg: 3.146 ± 0.054	2.796ThrSer: 2.796 ± 0.053	3.961ThrThr: 3.961 ± 0.07	6.682ThrVal: 6.682 ± 0.076	0.651ThrTrp: 0.651 ± 0.023	1.724ThrTyr: 1.724 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	9.538ValAla: 9.538 ± 0.104	0.652ValCys: 0.652 ± 0.023	7.839ValAsp: 7.839 ± 0.085	7.483ValGlu: 7.483 ± 0.101	2.797ValPhe: 2.797 ± 0.053	7.107ValGly: 7.107 ± 0.092	1.629ValHis: 1.629 ± 0.042	3.226ValIle: 3.226 ± 0.058	1.241ValLys: 1.241 ± 0.035	7.738ValLeu: 7.738 ± 0.098	1.236ValMet: 1.236 ± 0.032	1.784ValAsn: 1.784 ± 0.039	4.21ValPro: 4.21 ± 0.06	1.905ValGln: 1.905 ± 0.035	5.262ValArg: 5.262 ± 0.068	4.789ValSer: 4.789 ± 0.067	5.673ValThr: 5.673 ± 0.069	8.167ValVal: 8.167 ± 0.102	0.816ValTrp: 0.816 ± 0.028	2.082ValTyr: 2.082 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.938TrpAla: 0.938 ± 0.029	0.089TrpCys: 0.089 ± 0.008	0.819TrpAsp: 0.819 ± 0.03	0.907TrpGlu: 0.907 ± 0.03	0.44TrpPhe: 0.44 ± 0.02	0.831TrpGly: 0.831 ± 0.023	0.277TrpHis: 0.277 ± 0.014	0.54TrpIle: 0.54 ± 0.024	0.273TrpLys: 0.273 ± 0.017	1.268TrpLeu: 1.268 ± 0.042	0.221TrpMet: 0.221 ± 0.012	0.42TrpAsn: 0.42 ± 0.018	0.465TrpPro: 0.465 ± 0.02	0.385TrpGln: 0.385 ± 0.019	0.859TrpArg: 0.859 ± 0.03	0.57TrpSer: 0.57 ± 0.025	0.837TrpThr: 0.837 ± 0.028	0.798TrpVal: 0.798 ± 0.026	0.212TrpTrp: 0.212 ± 0.013	0.381TrpTyr: 0.381 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.891TyrAla: 2.891 ± 0.057	0.282TyrCys: 0.282 ± 0.016	2.795TyrAsp: 2.795 ± 0.049	2.836TyrGlu: 2.836 ± 0.051	0.875TyrPhe: 0.875 ± 0.027	2.428TyrGly: 2.428 ± 0.041	0.621TyrHis: 0.621 ± 0.022	0.777TyrIle: 0.777 ± 0.027	0.394TyrLys: 0.394 ± 0.02	2.464TyrLeu: 2.464 ± 0.043	0.381TyrMet: 0.381 ± 0.015	0.615TyrAsn: 0.615 ± 0.027	1.32TyrPro: 1.32 ± 0.034	0.717TyrGln: 0.717 ± 0.023	2.022TyrArg: 2.022 ± 0.039	1.194TyrSer: 1.194 ± 0.034	1.428TyrThr: 1.428 ± 0.029	2.335TyrVal: 2.335 ± 0.043	0.376TyrTrp: 0.376 ± 0.019	0.896TyrTyr: 0.896 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4221 proteins (1232325 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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