Amino acid dipepetide frequency for Lactococcus virus ASCC532

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.531AlaAla: 0.531 ± 0.32
0.212AlaCys: 0.212 ± 0.143
3.29AlaAsp: 3.29 ± 0.578
4.776AlaGlu: 4.776 ± 0.872
3.608AlaPhe: 3.608 ± 0.801
4.245AlaGly: 4.245 ± 0.881
0.743AlaHis: 0.743 ± 0.332
5.094AlaIle: 5.094 ± 0.863
5.2AlaLys: 5.2 ± 0.711
5.731AlaLeu: 5.731 ± 0.812
1.91AlaMet: 1.91 ± 0.633
4.139AlaAsn: 4.139 ± 0.805
1.061AlaPro: 1.061 ± 0.306
2.122AlaGln: 2.122 ± 0.43
2.229AlaArg: 2.229 ± 0.426
2.759AlaSer: 2.759 ± 0.597
3.714AlaThr: 3.714 ± 0.833
4.245AlaVal: 4.245 ± 1.343
1.592AlaTrp: 1.592 ± 0.698
1.486AlaTyr: 1.486 ± 0.399
0.0AlaXaa: 0.0 ± 0.0
Cys
0.318CysAla: 0.318 ± 0.184
0.424CysCys: 0.424 ± 0.252
0.531CysAsp: 0.531 ± 0.292
0.424CysGlu: 0.424 ± 0.199
0.212CysPhe: 0.212 ± 0.153
0.849CysGly: 0.849 ± 0.344
0.212CysHis: 0.212 ± 0.162
0.743CysIle: 0.743 ± 0.271
0.637CysLys: 0.637 ± 0.288
0.424CysLeu: 0.424 ± 0.165
0.0CysMet: 0.0 ± 0.0
0.637CysAsn: 0.637 ± 0.286
0.212CysPro: 0.212 ± 0.148
0.212CysGln: 0.212 ± 0.144
0.637CysArg: 0.637 ± 0.267
0.212CysSer: 0.212 ± 0.152
0.212CysThr: 0.212 ± 0.146
0.531CysVal: 0.531 ± 0.306
0.106CysTrp: 0.106 ± 0.104
0.637CysTyr: 0.637 ± 0.31
0.0CysXaa: 0.0 ± 0.0
Asp
1.592AspAla: 1.592 ± 0.453
0.424AspCys: 0.424 ± 0.21
3.502AspAsp: 3.502 ± 0.84
4.776AspGlu: 4.776 ± 0.996
3.82AspPhe: 3.82 ± 0.547
3.396AspGly: 3.396 ± 0.559
0.531AspHis: 0.531 ± 0.311
3.396AspIle: 3.396 ± 0.658
5.625AspLys: 5.625 ± 0.686
5.731AspLeu: 5.731 ± 0.889
0.849AspMet: 0.849 ± 0.276
4.139AspAsn: 4.139 ± 0.69
1.38AspPro: 1.38 ± 0.393
0.849AspGln: 0.849 ± 0.33
1.804AspArg: 1.804 ± 0.56
2.759AspSer: 2.759 ± 0.547
4.776AspThr: 4.776 ± 0.769
3.396AspVal: 3.396 ± 0.845
0.955AspTrp: 0.955 ± 0.329
3.078AspTyr: 3.078 ± 0.576
0.0AspXaa: 0.0 ± 0.0
Glu
3.396GluAla: 3.396 ± 0.56
0.637GluCys: 0.637 ± 0.26
3.396GluAsp: 3.396 ± 0.638
5.625GluGlu: 5.625 ± 1.071
3.82GluPhe: 3.82 ± 0.555
2.759GluGly: 2.759 ± 0.437
0.955GluHis: 0.955 ± 0.351
5.731GluIle: 5.731 ± 0.705
7.535GluLys: 7.535 ± 1.295
10.506GluLeu: 10.506 ± 1.777
2.441GluMet: 2.441 ± 0.551
5.2GluAsn: 5.2 ± 0.662
1.38GluPro: 1.38 ± 0.392
3.29GluGln: 3.29 ± 0.714
2.759GluArg: 2.759 ± 0.577
4.033GluSer: 4.033 ± 0.509
4.139GluThr: 4.139 ± 0.616
4.669GluVal: 4.669 ± 0.624
1.273GluTrp: 1.273 ± 0.431
3.29GluTyr: 3.29 ± 0.721
0.0GluXaa: 0.0 ± 0.0
Phe
3.608PheAla: 3.608 ± 0.597
0.212PheCys: 0.212 ± 0.163
3.184PheAsp: 3.184 ± 0.497
2.865PheGlu: 2.865 ± 0.605
2.122PhePhe: 2.122 ± 0.856
2.441PheGly: 2.441 ± 0.513
0.531PheHis: 0.531 ± 0.271
3.184PheIle: 3.184 ± 0.554
4.245PheLys: 4.245 ± 0.818
2.759PheLeu: 2.759 ± 0.532
0.637PheMet: 0.637 ± 0.299
3.396PheAsn: 3.396 ± 0.738
1.061PhePro: 1.061 ± 0.329
1.592PheGln: 1.592 ± 0.524
1.167PheArg: 1.167 ± 0.277
4.245PheSer: 4.245 ± 1.005
2.865PheThr: 2.865 ± 0.437
2.547PheVal: 2.547 ± 0.46
0.318PheTrp: 0.318 ± 0.174
2.122PheTyr: 2.122 ± 0.357
0.0PheXaa: 0.0 ± 0.0
Gly
3.396GlyAla: 3.396 ± 0.951
0.531GlyCys: 0.531 ± 0.264
3.502GlyAsp: 3.502 ± 0.756
3.927GlyGlu: 3.927 ± 0.496
2.441GlyPhe: 2.441 ± 0.574
4.882GlyGly: 4.882 ± 1.056
0.637GlyHis: 0.637 ± 0.255
4.882GlyIle: 4.882 ± 1.923
5.731GlyLys: 5.731 ± 0.737
6.155GlyLeu: 6.155 ± 0.893
1.167GlyMet: 1.167 ± 0.374
4.033GlyAsn: 4.033 ± 0.687
0.212GlyPro: 0.212 ± 0.139
2.653GlyGln: 2.653 ± 0.548
1.698GlyArg: 1.698 ± 0.316
5.094GlySer: 5.094 ± 1.115
3.396GlyThr: 3.396 ± 0.992
5.518GlyVal: 5.518 ± 1.459
1.38GlyTrp: 1.38 ± 0.329
3.82GlyTyr: 3.82 ± 0.743
0.0GlyXaa: 0.0 ± 0.0
His
0.531HisAla: 0.531 ± 0.198
0.637HisCys: 0.637 ± 0.297
0.743HisAsp: 0.743 ± 0.271
0.955HisGlu: 0.955 ± 0.359
0.531HisPhe: 0.531 ± 0.243
1.061HisGly: 1.061 ± 0.352
0.106HisHis: 0.106 ± 0.107
0.955HisIle: 0.955 ± 0.344
0.637HisLys: 0.637 ± 0.269
1.273HisLeu: 1.273 ± 0.431
0.0HisMet: 0.0 ± 0.0
1.592HisAsn: 1.592 ± 0.482
0.106HisPro: 0.106 ± 0.115
0.424HisGln: 0.424 ± 0.222
0.318HisArg: 0.318 ± 0.184
0.531HisSer: 0.531 ± 0.219
0.743HisThr: 0.743 ± 0.313
0.849HisVal: 0.849 ± 0.318
0.106HisTrp: 0.106 ± 0.118
0.424HisTyr: 0.424 ± 0.217
0.0HisXaa: 0.0 ± 0.0
Ile
4.033IleAla: 4.033 ± 0.757
0.318IleCys: 0.318 ± 0.173
4.139IleAsp: 4.139 ± 0.574
6.049IleGlu: 6.049 ± 0.937
3.078IlePhe: 3.078 ± 0.659
4.033IleGly: 4.033 ± 0.908
1.061IleHis: 1.061 ± 0.3
4.882IleIle: 4.882 ± 0.595
6.049IleLys: 6.049 ± 0.76
4.033IleLeu: 4.033 ± 0.874
1.486IleMet: 1.486 ± 0.329
5.518IleAsn: 5.518 ± 0.615
1.804IlePro: 1.804 ± 0.476
2.335IleGln: 2.335 ± 0.468
2.016IleArg: 2.016 ± 0.443
3.82IleSer: 3.82 ± 0.816
5.094IleThr: 5.094 ± 0.734
4.882IleVal: 4.882 ± 0.773
1.061IleTrp: 1.061 ± 0.387
2.653IleTyr: 2.653 ± 0.514
0.0IleXaa: 0.0 ± 0.0
Lys
6.58LysAla: 6.58 ± 1.086
0.424LysCys: 0.424 ± 0.257
3.927LysAsp: 3.927 ± 0.65
8.596LysGlu: 8.596 ± 1.401
2.229LysPhe: 2.229 ± 0.49
5.731LysGly: 5.731 ± 0.935
1.698LysHis: 1.698 ± 0.521
5.306LysIle: 5.306 ± 0.743
8.702LysLys: 8.702 ± 1.141
7.004LysLeu: 7.004 ± 0.766
3.396LysMet: 3.396 ± 0.568
4.669LysAsn: 4.669 ± 0.724
1.486LysPro: 1.486 ± 0.395
3.078LysGln: 3.078 ± 0.633
3.078LysArg: 3.078 ± 0.679
5.094LysSer: 5.094 ± 0.764
5.094LysThr: 5.094 ± 0.782
7.11LysVal: 7.11 ± 1.004
1.061LysTrp: 1.061 ± 0.289
3.608LysTyr: 3.608 ± 0.688
0.0LysXaa: 0.0 ± 0.0
Leu
5.2LeuAla: 5.2 ± 0.639
0.106LeuCys: 0.106 ± 0.124
5.2LeuAsp: 5.2 ± 0.819
5.731LeuGlu: 5.731 ± 0.966
4.139LeuPhe: 4.139 ± 0.805
4.351LeuGly: 4.351 ± 0.907
1.061LeuHis: 1.061 ± 0.355
6.261LeuIle: 6.261 ± 0.801
7.747LeuLys: 7.747 ± 1.177
5.625LeuLeu: 5.625 ± 1.12
1.592LeuMet: 1.592 ± 0.448
5.518LeuAsn: 5.518 ± 0.822
3.184LeuPro: 3.184 ± 0.581
3.078LeuGln: 3.078 ± 0.564
2.547LeuArg: 2.547 ± 0.626
5.094LeuSer: 5.094 ± 0.785
5.625LeuThr: 5.625 ± 0.77
5.412LeuVal: 5.412 ± 0.788
1.38LeuTrp: 1.38 ± 0.372
4.669LeuTyr: 4.669 ± 0.855
0.0LeuXaa: 0.0 ± 0.0
Met
2.547MetAla: 2.547 ± 0.593
0.212MetCys: 0.212 ± 0.139
1.486MetAsp: 1.486 ± 0.466
1.91MetGlu: 1.91 ± 0.61
0.212MetPhe: 0.212 ± 0.136
0.955MetGly: 0.955 ± 0.354
0.212MetHis: 0.212 ± 0.165
2.229MetIle: 2.229 ± 0.499
2.971MetLys: 2.971 ± 0.637
1.061MetLeu: 1.061 ± 0.335
0.531MetMet: 0.531 ± 0.278
1.804MetAsn: 1.804 ± 0.42
0.637MetPro: 0.637 ± 0.24
1.486MetGln: 1.486 ± 0.366
0.424MetArg: 0.424 ± 0.268
1.592MetSer: 1.592 ± 0.397
1.592MetThr: 1.592 ± 0.468
0.955MetVal: 0.955 ± 0.194
0.0MetTrp: 0.0 ± 0.0
1.273MetTyr: 1.273 ± 0.355
0.0MetXaa: 0.0 ± 0.0
Asn
5.412AsnAla: 5.412 ± 1.406
0.212AsnCys: 0.212 ± 0.178
3.927AsnAsp: 3.927 ± 0.608
4.988AsnGlu: 4.988 ± 1.014
2.335AsnPhe: 2.335 ± 0.696
6.792AsnGly: 6.792 ± 0.758
0.743AsnHis: 0.743 ± 0.241
4.139AsnIle: 4.139 ± 0.676
6.049AsnLys: 6.049 ± 1.042
5.518AsnLeu: 5.518 ± 0.775
1.698AsnMet: 1.698 ± 0.333
3.502AsnAsn: 3.502 ± 0.786
2.229AsnPro: 2.229 ± 0.509
2.122AsnGln: 2.122 ± 0.46
1.592AsnArg: 1.592 ± 0.361
5.306AsnSer: 5.306 ± 1.063
4.139AsnThr: 4.139 ± 0.693
3.502AsnVal: 3.502 ± 0.569
1.273AsnTrp: 1.273 ± 0.293
2.759AsnTyr: 2.759 ± 0.624
0.0AsnXaa: 0.0 ± 0.0
Pro
1.486ProAla: 1.486 ± 0.368
0.212ProCys: 0.212 ± 0.151
1.273ProAsp: 1.273 ± 0.417
2.653ProGlu: 2.653 ± 0.576
1.061ProPhe: 1.061 ± 0.257
0.743ProGly: 0.743 ± 0.573
0.106ProHis: 0.106 ± 0.107
1.592ProIle: 1.592 ± 0.392
1.38ProLys: 1.38 ± 0.402
1.698ProLeu: 1.698 ± 0.364
0.743ProMet: 0.743 ± 0.238
2.229ProAsn: 2.229 ± 0.652
0.743ProPro: 0.743 ± 0.293
0.637ProGln: 0.637 ± 0.298
0.318ProArg: 0.318 ± 0.174
1.38ProSer: 1.38 ± 0.416
1.804ProThr: 1.804 ± 0.45
2.016ProVal: 2.016 ± 0.518
0.106ProTrp: 0.106 ± 0.115
0.531ProTyr: 0.531 ± 0.22
0.0ProXaa: 0.0 ± 0.0
Gln
3.078GlnAla: 3.078 ± 0.63
0.106GlnCys: 0.106 ± 0.11
1.804GlnAsp: 1.804 ± 0.51
2.653GlnGlu: 2.653 ± 0.535
0.955GlnPhe: 0.955 ± 0.334
2.971GlnGly: 2.971 ± 0.499
0.424GlnHis: 0.424 ± 0.195
1.167GlnIle: 1.167 ± 0.265
2.547GlnLys: 2.547 ± 0.543
3.184GlnLeu: 3.184 ± 0.605
0.849GlnMet: 0.849 ± 0.261
2.229GlnAsn: 2.229 ± 0.411
1.167GlnPro: 1.167 ± 0.374
1.38GlnGln: 1.38 ± 0.413
1.804GlnArg: 1.804 ± 0.504
2.653GlnSer: 2.653 ± 0.401
2.016GlnThr: 2.016 ± 0.325
2.229GlnVal: 2.229 ± 0.506
0.637GlnTrp: 0.637 ± 0.222
1.592GlnTyr: 1.592 ± 0.407
0.0GlnXaa: 0.0 ± 0.0
Arg
2.335ArgAla: 2.335 ± 0.584
0.318ArgCys: 0.318 ± 0.203
1.486ArgAsp: 1.486 ± 0.423
2.016ArgGlu: 2.016 ± 0.459
0.955ArgPhe: 0.955 ± 0.283
1.804ArgGly: 1.804 ± 0.428
0.424ArgHis: 0.424 ± 0.204
2.122ArgIle: 2.122 ± 0.476
3.29ArgLys: 3.29 ± 0.725
3.29ArgLeu: 3.29 ± 0.666
0.531ArgMet: 0.531 ± 0.242
2.335ArgAsn: 2.335 ± 0.462
0.212ArgPro: 0.212 ± 0.151
1.38ArgGln: 1.38 ± 0.362
1.38ArgArg: 1.38 ± 0.412
1.804ArgSer: 1.804 ± 0.452
2.016ArgThr: 2.016 ± 0.387
1.804ArgVal: 1.804 ± 0.486
0.531ArgTrp: 0.531 ± 0.21
1.592ArgTyr: 1.592 ± 0.452
0.0ArgXaa: 0.0 ± 0.0
Ser
4.457SerAla: 4.457 ± 1.095
0.743SerCys: 0.743 ± 0.31
4.563SerAsp: 4.563 ± 0.713
4.139SerGlu: 4.139 ± 0.676
3.396SerPhe: 3.396 ± 0.848
5.943SerGly: 5.943 ± 1.369
0.637SerHis: 0.637 ± 0.252
4.139SerIle: 4.139 ± 0.754
4.669SerLys: 4.669 ± 0.659
5.625SerLeu: 5.625 ± 0.692
2.229SerMet: 2.229 ± 0.361
4.033SerAsn: 4.033 ± 0.791
1.167SerPro: 1.167 ± 0.388
2.229SerGln: 2.229 ± 0.507
2.441SerArg: 2.441 ± 0.379
5.943SerSer: 5.943 ± 1.194
2.759SerThr: 2.759 ± 0.631
4.139SerVal: 4.139 ± 0.561
0.743SerTrp: 0.743 ± 0.344
2.122SerTyr: 2.122 ± 0.427
0.0SerXaa: 0.0 ± 0.0
Thr
4.245ThrAla: 4.245 ± 0.636
0.531ThrCys: 0.531 ± 0.273
3.927ThrAsp: 3.927 ± 0.83
5.412ThrGlu: 5.412 ± 0.651
3.396ThrPhe: 3.396 ± 0.701
4.882ThrGly: 4.882 ± 0.855
0.424ThrHis: 0.424 ± 0.186
4.563ThrIle: 4.563 ± 0.81
5.094ThrLys: 5.094 ± 0.544
4.988ThrLeu: 4.988 ± 0.568
0.955ThrMet: 0.955 ± 0.332
4.457ThrAsn: 4.457 ± 0.702
2.122ThrPro: 2.122 ± 0.446
1.91ThrGln: 1.91 ± 0.487
1.167ThrArg: 1.167 ± 0.428
4.139ThrSer: 4.139 ± 0.716
4.563ThrThr: 4.563 ± 0.791
4.882ThrVal: 4.882 ± 0.824
0.743ThrTrp: 0.743 ± 0.323
1.804ThrTyr: 1.804 ± 0.442
0.0ThrXaa: 0.0 ± 0.0
Val
3.714ValAla: 3.714 ± 0.618
0.531ValCys: 0.531 ± 0.206
3.927ValAsp: 3.927 ± 0.663
4.669ValGlu: 4.669 ± 0.742
3.29ValPhe: 3.29 ± 0.886
3.714ValGly: 3.714 ± 0.594
0.531ValHis: 0.531 ± 0.242
4.351ValIle: 4.351 ± 0.664
6.367ValLys: 6.367 ± 0.698
3.714ValLeu: 3.714 ± 0.668
2.016ValMet: 2.016 ± 0.435
3.502ValAsn: 3.502 ± 0.773
1.38ValPro: 1.38 ± 0.397
1.804ValGln: 1.804 ± 0.45
2.759ValArg: 2.759 ± 0.648
6.049ValSer: 6.049 ± 1.315
5.837ValThr: 5.837 ± 0.915
3.82ValVal: 3.82 ± 0.851
0.743ValTrp: 0.743 ± 0.224
3.396ValTyr: 3.396 ± 0.55
0.0ValXaa: 0.0 ± 0.0
Trp
0.531TrpAla: 0.531 ± 0.164
0.531TrpCys: 0.531 ± 0.242
0.849TrpAsp: 0.849 ± 0.374
1.061TrpGlu: 1.061 ± 0.358
0.743TrpPhe: 0.743 ± 0.349
0.531TrpGly: 0.531 ± 0.219
0.212TrpHis: 0.212 ± 0.143
0.849TrpIle: 0.849 ± 0.26
0.955TrpLys: 0.955 ± 0.274
1.273TrpLeu: 1.273 ± 0.457
0.318TrpMet: 0.318 ± 0.21
1.592TrpAsn: 1.592 ± 0.595
0.0TrpPro: 0.0 ± 0.0
0.955TrpGln: 0.955 ± 0.29
0.424TrpArg: 0.424 ± 0.241
1.273TrpSer: 1.273 ± 0.351
0.531TrpThr: 0.531 ± 0.24
0.849TrpVal: 0.849 ± 0.289
0.212TrpTrp: 0.212 ± 0.155
0.955TrpTyr: 0.955 ± 0.284
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.698TyrAla: 1.698 ± 0.494
0.849TyrCys: 0.849 ± 0.361
2.122TyrAsp: 2.122 ± 0.706
3.608TyrGlu: 3.608 ± 0.817
2.759TyrPhe: 2.759 ± 0.432
2.971TyrGly: 2.971 ± 0.531
1.273TyrHis: 1.273 ± 0.422
2.759TyrIle: 2.759 ± 0.664
2.547TyrLys: 2.547 ± 0.554
3.927TyrLeu: 3.927 ± 0.754
0.637TyrMet: 0.637 ± 0.293
3.714TyrAsn: 3.714 ± 0.486
1.167TyrPro: 1.167 ± 0.384
1.91TyrGln: 1.91 ± 0.615
1.061TyrArg: 1.061 ± 0.394
2.335TyrSer: 2.335 ± 0.607
3.29TyrThr: 3.29 ± 0.786
2.759TyrVal: 2.759 ± 0.615
0.424TyrTrp: 0.424 ± 0.183
2.122TyrTyr: 2.122 ± 0.566
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (9424 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski