Amino acid dipepetide frequency for Hoeflea olei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.16AlaAla: 18.16 ± 0.191	1.091AlaCys: 1.091 ± 0.033	7.389AlaAsp: 7.389 ± 0.08	8.168AlaGlu: 8.168 ± 0.092	4.722AlaPhe: 4.722 ± 0.067	11.813AlaGly: 11.813 ± 0.135	2.399AlaHis: 2.399 ± 0.041	6.729AlaIle: 6.729 ± 0.078	3.689AlaLys: 3.689 ± 0.067	13.43AlaLeu: 13.43 ± 0.111	3.779AlaMet: 3.779 ± 0.06	2.998AlaAsn: 2.998 ± 0.056	5.829AlaPro: 5.829 ± 0.07	3.656AlaGln: 3.656 ± 0.058	9.464AlaArg: 9.464 ± 0.094	6.729AlaSer: 6.729 ± 0.071	6.005AlaThr: 6.005 ± 0.09	8.875AlaVal: 8.875 ± 0.092	1.54AlaTrp: 1.54 ± 0.035	2.572AlaTyr: 2.572 ± 0.045	0.001AlaXaa: 0.001 ± 0.001
Cys	1.028CysAla: 1.028 ± 0.029	0.094CysCys: 0.094 ± 0.009	0.546CysAsp: 0.546 ± 0.024	0.438CysGlu: 0.438 ± 0.02	0.344CysPhe: 0.344 ± 0.018	0.925CysGly: 0.925 ± 0.029	0.247CysHis: 0.247 ± 0.019	0.346CysIle: 0.346 ± 0.015	0.17CysLys: 0.17 ± 0.011	0.84CysLeu: 0.84 ± 0.025	0.17CysMet: 0.17 ± 0.013	0.203CysAsn: 0.203 ± 0.013	0.435CysPro: 0.435 ± 0.019	0.203CysGln: 0.203 ± 0.013	0.619CysArg: 0.619 ± 0.022	0.413CysSer: 0.413 ± 0.018	0.368CysThr: 0.368 ± 0.017	0.57CysVal: 0.57 ± 0.022	0.093CysTrp: 0.093 ± 0.009	0.205CysTyr: 0.205 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.027AspAla: 7.027 ± 0.072	0.518AspCys: 0.518 ± 0.02	3.041AspAsp: 3.041 ± 0.061	3.458AspGlu: 3.458 ± 0.06	2.299AspPhe: 2.299 ± 0.039	5.377AspGly: 5.377 ± 0.071	1.383AspHis: 1.383 ± 0.031	3.366AspIle: 3.366 ± 0.053	1.77AspLys: 1.77 ± 0.04	5.939AspLeu: 5.939 ± 0.074	1.562AspMet: 1.562 ± 0.036	1.371AspAsn: 1.371 ± 0.035	3.642AspPro: 3.642 ± 0.057	1.634AspGln: 1.634 ± 0.033	4.595AspArg: 4.595 ± 0.069	2.253AspSer: 2.253 ± 0.043	2.868AspThr: 2.868 ± 0.052	3.863AspVal: 3.863 ± 0.062	0.999AspTrp: 0.999 ± 0.03	1.575AspTyr: 1.575 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.316GluAla: 8.316 ± 0.101	0.355GluCys: 0.355 ± 0.016	2.99GluAsp: 2.99 ± 0.052	3.147GluGlu: 3.147 ± 0.062	1.829GluPhe: 1.829 ± 0.04	4.472GluGly: 4.472 ± 0.066	1.122GluHis: 1.122 ± 0.028	3.885GluIle: 3.885 ± 0.06	2.181GluLys: 2.181 ± 0.052	5.346GluLeu: 5.346 ± 0.074	1.602GluMet: 1.602 ± 0.035	1.561GluAsn: 1.561 ± 0.036	2.766GluPro: 2.766 ± 0.049	1.96GluGln: 1.96 ± 0.044	4.702GluArg: 4.702 ± 0.067	2.425GluSer: 2.425 ± 0.042	3.822GluThr: 3.822 ± 0.059	3.755GluVal: 3.755 ± 0.056	0.652GluTrp: 0.652 ± 0.021	0.91GluTyr: 0.91 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.822PheAla: 4.822 ± 0.061	0.411PheCys: 0.411 ± 0.018	2.699PheAsp: 2.699 ± 0.045	2.269PheGlu: 2.269 ± 0.041	1.469PhePhe: 1.469 ± 0.036	3.789PheGly: 3.789 ± 0.061	0.766PheHis: 0.766 ± 0.023	1.778PheIle: 1.778 ± 0.041	0.984PheLys: 0.984 ± 0.032	3.445PheLeu: 3.445 ± 0.062	0.887PheMet: 0.887 ± 0.026	1.074PheAsn: 1.074 ± 0.027	1.578PhePro: 1.578 ± 0.037	0.943PheGln: 0.943 ± 0.028	2.312PheArg: 2.312 ± 0.043	2.422PheSer: 2.422 ± 0.045	2.006PheThr: 2.006 ± 0.044	2.933PheVal: 2.933 ± 0.051	0.543PheTrp: 0.543 ± 0.022	0.881PheTyr: 0.881 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	9.911GlyAla: 9.911 ± 0.115	0.851GlyCys: 0.851 ± 0.025	4.655GlyAsp: 4.655 ± 0.075	5.113GlyGlu: 5.113 ± 0.072	3.983GlyPhe: 3.983 ± 0.055	7.741GlyGly: 7.741 ± 0.143	1.965GlyHis: 1.965 ± 0.045	4.725GlyIle: 4.725 ± 0.066	3.225GlyLys: 3.225 ± 0.055	9.346GlyLeu: 9.346 ± 0.097	2.505GlyMet: 2.505 ± 0.041	2.144GlyAsn: 2.144 ± 0.057	3.495GlyPro: 3.495 ± 0.058	2.717GlyGln: 2.717 ± 0.05	6.151GlyArg: 6.151 ± 0.075	4.876GlySer: 4.876 ± 0.087	4.648GlyThr: 4.648 ± 0.113	6.439GlyVal: 6.439 ± 0.071	1.321GlyTrp: 1.321 ± 0.034	2.378GlyTyr: 2.378 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.461HisAla: 2.461 ± 0.038	0.216HisCys: 0.216 ± 0.013	1.268HisAsp: 1.268 ± 0.034	1.048HisGlu: 1.048 ± 0.032	0.868HisPhe: 0.868 ± 0.027	2.023HisGly: 2.023 ± 0.043	0.552HisHis: 0.552 ± 0.03	0.873HisIle: 0.873 ± 0.025	0.457HisLys: 0.457 ± 0.019	2.005HisLeu: 2.005 ± 0.04	0.501HisMet: 0.501 ± 0.018	0.424HisAsn: 0.424 ± 0.018	1.33HisPro: 1.33 ± 0.035	0.567HisGln: 0.567 ± 0.019	1.359HisArg: 1.359 ± 0.034	0.973HisSer: 0.973 ± 0.028	0.834HisThr: 0.834 ± 0.026	1.645HisVal: 1.645 ± 0.031	0.298HisTrp: 0.298 ± 0.015	0.536HisTyr: 0.536 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.805IleAla: 7.805 ± 0.084	0.509IleCys: 0.509 ± 0.022	3.835IleAsp: 3.835 ± 0.06	3.65IleGlu: 3.65 ± 0.056	1.665IlePhe: 1.665 ± 0.042	5.271IleGly: 5.271 ± 0.062	0.931IleHis: 0.931 ± 0.025	2.374IleIle: 2.374 ± 0.046	1.418IleLys: 1.418 ± 0.037	4.583IleLeu: 4.583 ± 0.062	1.009IleMet: 1.009 ± 0.029	1.501IleAsn: 1.501 ± 0.036	2.192IlePro: 2.192 ± 0.041	1.138IleGln: 1.138 ± 0.03	3.571IleArg: 3.571 ± 0.059	3.083IleSer: 3.083 ± 0.056	2.716IleThr: 2.716 ± 0.057	4.13IleVal: 4.13 ± 0.058	0.575IleTrp: 0.575 ± 0.021	1.153IleTyr: 1.153 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.263LysAla: 4.263 ± 0.073	0.146LysCys: 0.146 ± 0.01	1.614LysAsp: 1.614 ± 0.044	1.365LysGlu: 1.365 ± 0.039	0.828LysPhe: 0.828 ± 0.026	2.585LysGly: 2.585 ± 0.051	0.584LysHis: 0.584 ± 0.02	1.72LysIle: 1.72 ± 0.041	1.155LysLys: 1.155 ± 0.038	3.101LysLeu: 3.101 ± 0.053	0.763LysMet: 0.763 ± 0.026	0.759LysAsn: 0.759 ± 0.023	2.1LysPro: 2.1 ± 0.043	0.964LysGln: 0.964 ± 0.03	2.197LysArg: 2.197 ± 0.044	1.87LysSer: 1.87 ± 0.038	2.015LysThr: 2.015 ± 0.039	2.239LysVal: 2.239 ± 0.047	0.338LysTrp: 0.338 ± 0.015	0.59LysTyr: 0.59 ± 0.023	0.001LysXaa: 0.001 ± 0.001
Leu	13.888LeuAla: 13.888 ± 0.136	0.907LeuCys: 0.907 ± 0.025	6.219LeuAsp: 6.219 ± 0.075	5.494LeuGlu: 5.494 ± 0.072	3.659LeuPhe: 3.659 ± 0.061	8.381LeuGly: 8.381 ± 0.086	1.653LeuHis: 1.653 ± 0.037	5.178LeuIle: 5.178 ± 0.078	3.623LeuLys: 3.623 ± 0.058	8.743LeuLeu: 8.743 ± 0.111	2.542LeuMet: 2.542 ± 0.048	2.435LeuAsn: 2.435 ± 0.048	5.214LeuPro: 5.214 ± 0.069	2.311LeuGln: 2.311 ± 0.045	6.09LeuArg: 6.09 ± 0.072	6.78LeuSer: 6.78 ± 0.081	5.519LeuThr: 5.519 ± 0.068	7.721LeuVal: 7.721 ± 0.085	1.096LeuTrp: 1.096 ± 0.034	1.978LeuTyr: 1.978 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	3.437MetAla: 3.437 ± 0.051	0.162MetCys: 0.162 ± 0.011	1.255MetAsp: 1.255 ± 0.034	1.196MetGlu: 1.196 ± 0.03	0.754MetPhe: 0.754 ± 0.024	1.947MetGly: 1.947 ± 0.037	0.457MetHis: 0.457 ± 0.019	1.537MetIle: 1.537 ± 0.033	1.002MetLys: 1.002 ± 0.028	2.64MetLeu: 2.64 ± 0.052	0.737MetMet: 0.737 ± 0.024	0.79MetAsn: 0.79 ± 0.022	1.531MetPro: 1.531 ± 0.04	0.878MetGln: 0.878 ± 0.028	1.882MetArg: 1.882 ± 0.034	1.74MetSer: 1.74 ± 0.039	1.991MetThr: 1.991 ± 0.039	1.855MetVal: 1.855 ± 0.04	0.223MetTrp: 0.223 ± 0.011	0.295MetTyr: 0.295 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.167AsnAla: 3.167 ± 0.056	0.232AsnCys: 0.232 ± 0.014	1.354AsnAsp: 1.354 ± 0.034	1.221AsnGlu: 1.221 ± 0.036	0.916AsnPhe: 0.916 ± 0.025	2.356AsnGly: 2.356 ± 0.061	0.516AsnHis: 0.516 ± 0.02	1.283AsnIle: 1.283 ± 0.035	0.61AsnLys: 0.61 ± 0.025	2.546AsnLeu: 2.546 ± 0.043	0.63AsnMet: 0.63 ± 0.02	0.642AsnAsn: 0.642 ± 0.023	1.82AsnPro: 1.82 ± 0.039	0.759AsnGln: 0.759 ± 0.024	1.896AsnArg: 1.896 ± 0.044	1.232AsnSer: 1.232 ± 0.034	1.232AsnThr: 1.232 ± 0.035	1.8AsnVal: 1.8 ± 0.042	0.425AsnTrp: 0.425 ± 0.017	0.676AsnTyr: 0.676 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	6.581ProAla: 6.581 ± 0.102	0.308ProCys: 0.308 ± 0.015	3.907ProAsp: 3.907 ± 0.062	3.878ProGlu: 3.878 ± 0.074	2.012ProPhe: 2.012 ± 0.045	4.802ProGly: 4.802 ± 0.07	1.076ProHis: 1.076 ± 0.033	1.981ProIle: 1.981 ± 0.045	1.516ProLys: 1.516 ± 0.033	4.622ProLeu: 4.622 ± 0.068	1.143ProMet: 1.143 ± 0.028	1.15ProAsn: 1.15 ± 0.03	2.203ProPro: 2.203 ± 0.048	1.462ProGln: 1.462 ± 0.037	2.812ProArg: 2.812 ± 0.049	2.614ProSer: 2.614 ± 0.047	2.085ProThr: 2.085 ± 0.043	4.463ProVal: 4.463 ± 0.068	0.645ProTrp: 0.645 ± 0.024	1.129ProTyr: 1.129 ± 0.031	0.001ProXaa: 0.001 ± 0.001
Gln	4.071GlnAla: 4.071 ± 0.061	0.185GlnCys: 0.185 ± 0.012	1.391GlnAsp: 1.391 ± 0.037	1.345GlnGlu: 1.345 ± 0.034	0.967GlnPhe: 0.967 ± 0.032	2.173GlnGly: 2.173 ± 0.041	0.503GlnHis: 0.503 ± 0.018	1.741GlnIle: 1.741 ± 0.038	0.976GlnLys: 0.976 ± 0.028	2.53GlnLeu: 2.53 ± 0.047	0.892GlnMet: 0.892 ± 0.026	0.734GlnAsn: 0.734 ± 0.025	1.533GlnPro: 1.533 ± 0.039	0.965GlnGln: 0.965 ± 0.032	2.018GlnArg: 2.018 ± 0.047	1.746GlnSer: 1.746 ± 0.036	1.697GlnThr: 1.697 ± 0.035	2.113GlnVal: 2.113 ± 0.041	0.361GlnTrp: 0.361 ± 0.016	0.474GlnTyr: 0.474 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.229ArgAla: 8.229 ± 0.097	0.447ArgCys: 0.447 ± 0.022	4.153ArgAsp: 4.153 ± 0.058	4.031ArgGlu: 4.031 ± 0.057	2.969ArgPhe: 2.969 ± 0.052	4.703ArgGly: 4.703 ± 0.067	1.778ArgHis: 1.778 ± 0.04	4.279ArgIle: 4.279 ± 0.062	2.401ArgLys: 2.401 ± 0.05	7.804ArgLeu: 7.804 ± 0.096	1.994ArgMet: 1.994 ± 0.035	1.819ArgAsn: 1.819 ± 0.034	3.447ArgPro: 3.447 ± 0.061	2.447ArgGln: 2.447 ± 0.045	5.168ArgArg: 5.168 ± 0.076	3.532ArgSer: 3.532 ± 0.054	3.429ArgThr: 3.429 ± 0.054	4.385ArgVal: 4.385 ± 0.063	0.824ArgTrp: 0.824 ± 0.027	1.652ArgTyr: 1.652 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.484SerAla: 6.484 ± 0.081	0.423SerCys: 0.423 ± 0.019	3.112SerAsp: 3.112 ± 0.049	2.934SerGlu: 2.934 ± 0.046	2.422SerPhe: 2.422 ± 0.049	6.072SerGly: 6.072 ± 0.097	1.182SerHis: 1.182 ± 0.035	2.781SerIle: 2.781 ± 0.052	1.527SerLys: 1.527 ± 0.04	5.466SerLeu: 5.466 ± 0.067	1.416SerMet: 1.416 ± 0.03	1.38SerAsn: 1.38 ± 0.034	2.661SerPro: 2.661 ± 0.053	1.562SerGln: 1.562 ± 0.042	3.646SerArg: 3.646 ± 0.053	3.033SerSer: 3.033 ± 0.06	2.771SerThr: 2.771 ± 0.055	4.145SerVal: 4.145 ± 0.058	0.761SerTrp: 0.761 ± 0.022	1.373SerTyr: 1.373 ± 0.034	0.001SerXaa: 0.001 ± 0.001
Thr	6.549ThrAla: 6.549 ± 0.087	0.416ThrCys: 0.416 ± 0.019	2.916ThrAsp: 2.916 ± 0.047	2.808ThrGlu: 2.808 ± 0.05	1.864ThrPhe: 1.864 ± 0.05	5.584ThrGly: 5.584 ± 0.104	1.029ThrHis: 1.029 ± 0.027	2.822ThrIle: 2.822 ± 0.058	1.262ThrLys: 1.262 ± 0.034	5.873ThrLeu: 5.873 ± 0.088	1.271ThrMet: 1.271 ± 0.029	1.235ThrAsn: 1.235 ± 0.037	3.24ThrPro: 3.24 ± 0.049	1.283ThrGln: 1.283 ± 0.029	3.387ThrArg: 3.387 ± 0.051	2.708ThrSer: 2.708 ± 0.046	2.723ThrThr: 2.723 ± 0.065	4.425ThrVal: 4.425 ± 0.076	0.654ThrTrp: 0.654 ± 0.022	1.192ThrTyr: 1.192 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.197ValAla: 9.197 ± 0.086	0.623ValCys: 0.623 ± 0.022	4.064ValAsp: 4.064 ± 0.058	4.484ValGlu: 4.484 ± 0.063	2.967ValPhe: 2.967 ± 0.049	5.243ValGly: 5.243 ± 0.057	1.318ValHis: 1.318 ± 0.031	4.205ValIle: 4.205 ± 0.067	2.154ValLys: 2.154 ± 0.043	7.392ValLeu: 7.392 ± 0.092	2.027ValMet: 2.027 ± 0.042	2.083ValAsn: 2.083 ± 0.047	3.625ValPro: 3.625 ± 0.063	1.737ValGln: 1.737 ± 0.037	4.83ValArg: 4.83 ± 0.066	4.76ValSer: 4.76 ± 0.061	4.661ValThr: 4.661 ± 0.078	5.504ValVal: 5.504 ± 0.075	0.881ValTrp: 0.881 ± 0.026	1.475ValTyr: 1.475 ± 0.031	0.001ValXaa: 0.001 ± 0.001
Trp	1.175TrpAla: 1.175 ± 0.033	0.117TrpCys: 0.117 ± 0.011	0.673TrpAsp: 0.673 ± 0.025	0.551TrpGlu: 0.551 ± 0.02	0.549TrpPhe: 0.549 ± 0.021	0.848TrpGly: 0.848 ± 0.025	0.289TrpHis: 0.289 ± 0.018	0.672TrpIle: 0.672 ± 0.022	0.458TrpLys: 0.458 ± 0.017	1.564TrpLeu: 1.564 ± 0.039	0.397TrpMet: 0.397 ± 0.019	0.431TrpAsn: 0.431 ± 0.018	0.666TrpPro: 0.666 ± 0.026	0.522TrpGln: 0.522 ± 0.019	1.044TrpArg: 1.044 ± 0.029	0.808TrpSer: 0.808 ± 0.026	0.717TrpThr: 0.717 ± 0.023	0.799TrpVal: 0.799 ± 0.026	0.205TrpTrp: 0.205 ± 0.014	0.27TrpTyr: 0.27 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.466TyrAla: 2.466 ± 0.05	0.25TyrCys: 0.25 ± 0.016	1.46TyrAsp: 1.46 ± 0.039	1.199TyrGlu: 1.199 ± 0.033	0.924TyrPhe: 0.924 ± 0.028	2.083TyrGly: 2.083 ± 0.041	0.49TyrHis: 0.49 ± 0.018	0.832TyrIle: 0.832 ± 0.025	0.621TyrLys: 0.621 ± 0.021	2.216TyrLeu: 2.216 ± 0.049	0.482TyrMet: 0.482 ± 0.018	0.579TyrAsn: 0.579 ± 0.021	1.082TyrPro: 1.082 ± 0.032	0.704TyrGln: 0.704 ± 0.025	1.75TyrArg: 1.75 ± 0.037	1.152TyrSer: 1.152 ± 0.033	1.135TyrThr: 1.135 ± 0.03	1.571TyrVal: 1.571 ± 0.032	0.318TyrTrp: 0.318 ± 0.016	0.574TyrTyr: 0.574 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.002

Statistics based on 4182 proteins (1338745 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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