Amino acid dipepetide frequency for Poseidonocella pacifica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.318AlaAla: 15.318 ± 0.155	1.056AlaCys: 1.056 ± 0.036	6.549AlaAsp: 6.549 ± 0.111	8.557AlaGlu: 8.557 ± 0.111	4.259AlaPhe: 4.259 ± 0.064	10.45AlaGly: 10.45 ± 0.158	2.33AlaHis: 2.33 ± 0.06	5.925AlaIle: 5.925 ± 0.08	3.575AlaLys: 3.575 ± 0.069	13.557AlaLeu: 13.557 ± 0.14	3.545AlaMet: 3.545 ± 0.065	2.708AlaAsn: 2.708 ± 0.058	5.832AlaPro: 5.832 ± 0.101	4.227AlaGln: 4.227 ± 0.068	8.841AlaArg: 8.841 ± 0.121	5.9AlaSer: 5.9 ± 0.118	5.911AlaThr: 5.911 ± 0.109	7.939AlaVal: 7.939 ± 0.099	1.357AlaTrp: 1.357 ± 0.038	2.439AlaTyr: 2.439 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.059CysAla: 1.059 ± 0.034	0.092CysCys: 0.092 ± 0.009	0.577CysAsp: 0.577 ± 0.026	0.465CysGlu: 0.465 ± 0.021	0.351CysPhe: 0.351 ± 0.022	0.961CysGly: 0.961 ± 0.038	0.266CysHis: 0.266 ± 0.018	0.417CysIle: 0.417 ± 0.022	0.185CysLys: 0.185 ± 0.013	0.877CysLeu: 0.877 ± 0.032	0.186CysMet: 0.186 ± 0.013	0.21CysAsn: 0.21 ± 0.014	0.483CysPro: 0.483 ± 0.026	0.22CysGln: 0.22 ± 0.013	0.566CysArg: 0.566 ± 0.029	0.476CysSer: 0.476 ± 0.025	0.413CysThr: 0.413 ± 0.021	0.617CysVal: 0.617 ± 0.024	0.13CysTrp: 0.13 ± 0.012	0.196CysTyr: 0.196 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.399AspAla: 7.399 ± 0.102	0.491AspCys: 0.491 ± 0.02	3.419AspAsp: 3.419 ± 0.084	3.832AspGlu: 3.832 ± 0.064	2.347AspPhe: 2.347 ± 0.051	5.665AspGly: 5.665 ± 0.134	1.347AspHis: 1.347 ± 0.038	3.27AspIle: 3.27 ± 0.081	1.545AspLys: 1.545 ± 0.044	6.641AspLeu: 6.641 ± 0.103	1.589AspMet: 1.589 ± 0.039	1.228AspAsn: 1.228 ± 0.039	3.654AspPro: 3.654 ± 0.076	1.742AspGln: 1.742 ± 0.04	4.356AspArg: 4.356 ± 0.074	2.109AspSer: 2.109 ± 0.046	2.981AspThr: 2.981 ± 0.063	4.352AspVal: 4.352 ± 0.094	1.119AspTrp: 1.119 ± 0.04	1.486AspTyr: 1.486 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.556GluAla: 8.556 ± 0.103	0.378GluCys: 0.378 ± 0.022	3.662GluAsp: 3.662 ± 0.064	4.188GluGlu: 4.188 ± 0.085	1.903GluPhe: 1.903 ± 0.043	5.286GluGly: 5.286 ± 0.081	1.21GluHis: 1.21 ± 0.034	4.109GluIle: 4.109 ± 0.069	2.16GluLys: 2.16 ± 0.05	5.466GluLeu: 5.466 ± 0.075	1.867GluMet: 1.867 ± 0.041	1.772GluAsn: 1.772 ± 0.042	2.644GluPro: 2.644 ± 0.063	2.031GluGln: 2.031 ± 0.045	4.672GluArg: 4.672 ± 0.092	2.538GluSer: 2.538 ± 0.044	4.208GluThr: 4.208 ± 0.063	4.548GluVal: 4.548 ± 0.068	0.771GluTrp: 0.771 ± 0.025	1.106GluTyr: 1.106 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.519PheAla: 4.519 ± 0.068	0.411PheCys: 0.411 ± 0.021	2.953PheAsp: 2.953 ± 0.052	2.307PheGlu: 2.307 ± 0.048	1.467PhePhe: 1.467 ± 0.042	3.891PheGly: 3.891 ± 0.066	0.741PheHis: 0.741 ± 0.028	1.665PheIle: 1.665 ± 0.048	0.873PheLys: 0.873 ± 0.033	3.514PheLeu: 3.514 ± 0.076	0.846PheMet: 0.846 ± 0.033	0.993PheAsn: 0.993 ± 0.031	1.631PhePro: 1.631 ± 0.047	0.982PheGln: 0.982 ± 0.025	2.255PheArg: 2.255 ± 0.054	2.244PheSer: 2.244 ± 0.047	2.049PheThr: 2.049 ± 0.051	2.758PheVal: 2.758 ± 0.056	0.551PheTrp: 0.551 ± 0.023	0.918PheTyr: 0.918 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.123GlyAla: 10.123 ± 0.195	0.843GlyCys: 0.843 ± 0.035	4.807GlyAsp: 4.807 ± 0.14	5.107GlyGlu: 5.107 ± 0.083	3.613GlyPhe: 3.613 ± 0.062	7.669GlyGly: 7.669 ± 0.168	1.905GlyHis: 1.905 ± 0.054	4.902GlyIle: 4.902 ± 0.068	2.938GlyLys: 2.938 ± 0.067	9.296GlyLeu: 9.296 ± 0.12	2.529GlyMet: 2.529 ± 0.054	2.134GlyAsn: 2.134 ± 0.073	3.779GlyPro: 3.779 ± 0.069	2.964GlyGln: 2.964 ± 0.056	6.031GlyArg: 6.031 ± 0.09	4.367GlySer: 4.367 ± 0.147	4.915GlyThr: 4.915 ± 0.177	6.415GlyVal: 6.415 ± 0.091	1.377GlyTrp: 1.377 ± 0.037	2.3GlyTyr: 2.3 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.322HisAla: 2.322 ± 0.054	0.245HisCys: 0.245 ± 0.015	1.345HisAsp: 1.345 ± 0.043	1.168HisGlu: 1.168 ± 0.041	0.862HisPhe: 0.862 ± 0.031	1.863HisGly: 1.863 ± 0.051	0.562HisHis: 0.562 ± 0.027	0.971HisIle: 0.971 ± 0.035	0.48HisLys: 0.48 ± 0.023	2.084HisLeu: 2.084 ± 0.051	0.551HisMet: 0.551 ± 0.024	0.432HisAsn: 0.432 ± 0.021	1.359HisPro: 1.359 ± 0.046	0.56HisGln: 0.56 ± 0.026	1.356HisArg: 1.356 ± 0.039	0.984HisSer: 0.984 ± 0.037	0.851HisThr: 0.851 ± 0.026	1.559HisVal: 1.559 ± 0.045	0.353HisTrp: 0.353 ± 0.017	0.53HisTyr: 0.53 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.136IleAla: 7.136 ± 0.079	0.61IleCys: 0.61 ± 0.026	3.694IleAsp: 3.694 ± 0.063	3.641IleGlu: 3.641 ± 0.065	1.902IlePhe: 1.902 ± 0.052	4.871IleGly: 4.871 ± 0.081	0.897IleHis: 0.897 ± 0.03	2.276IleIle: 2.276 ± 0.046	1.316IleLys: 1.316 ± 0.035	4.959IleLeu: 4.959 ± 0.079	1.084IleMet: 1.084 ± 0.04	1.401IleAsn: 1.401 ± 0.041	2.434IlePro: 2.434 ± 0.045	1.15IleGln: 1.15 ± 0.032	3.335IleArg: 3.335 ± 0.061	3.309IleSer: 3.309 ± 0.077	2.956IleThr: 2.956 ± 0.087	3.986IleVal: 3.986 ± 0.067	0.715IleTrp: 0.715 ± 0.027	1.115IleTyr: 1.115 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.565LysAla: 3.565 ± 0.074	0.178LysCys: 0.178 ± 0.012	1.59LysAsp: 1.59 ± 0.049	1.567LysGlu: 1.567 ± 0.049	0.898LysPhe: 0.898 ± 0.031	2.47LysGly: 2.47 ± 0.061	0.584LysHis: 0.584 ± 0.028	1.603LysIle: 1.603 ± 0.041	1.027LysLys: 1.027 ± 0.04	2.803LysLeu: 2.803 ± 0.059	0.813LysMet: 0.813 ± 0.031	0.729LysAsn: 0.729 ± 0.024	1.647LysPro: 1.647 ± 0.046	0.839LysGln: 0.839 ± 0.03	2.146LysArg: 2.146 ± 0.06	1.76LysSer: 1.76 ± 0.042	1.871LysThr: 1.871 ± 0.047	2.283LysVal: 2.283 ± 0.06	0.384LysTrp: 0.384 ± 0.018	0.583LysTyr: 0.583 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	12.303LeuAla: 12.303 ± 0.141	1.015LeuCys: 1.015 ± 0.037	6.26LeuAsp: 6.26 ± 0.092	5.66LeuGlu: 5.66 ± 0.075	3.578LeuPhe: 3.578 ± 0.079	8.79LeuGly: 8.79 ± 0.111	1.983LeuHis: 1.983 ± 0.044	5.065LeuIle: 5.065 ± 0.079	2.928LeuLys: 2.928 ± 0.062	9.604LeuLeu: 9.604 ± 0.137	2.539LeuMet: 2.539 ± 0.06	2.633LeuAsn: 2.633 ± 0.05	5.561LeuPro: 5.561 ± 0.091	2.686LeuGln: 2.686 ± 0.058	7.7LeuArg: 7.7 ± 0.105	7.002LeuSer: 7.002 ± 0.118	5.914LeuThr: 5.914 ± 0.132	6.713LeuVal: 6.713 ± 0.096	1.249LeuTrp: 1.249 ± 0.037	2.007LeuTyr: 2.007 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.205MetAla: 3.205 ± 0.062	0.184MetCys: 0.184 ± 0.014	1.353MetAsp: 1.353 ± 0.037	1.409MetGlu: 1.409 ± 0.041	0.757MetPhe: 0.757 ± 0.027	2.18MetGly: 2.18 ± 0.055	0.458MetHis: 0.458 ± 0.019	1.544MetIle: 1.544 ± 0.039	1.006MetLys: 1.006 ± 0.036	2.466MetLeu: 2.466 ± 0.062	0.676MetMet: 0.676 ± 0.031	0.809MetAsn: 0.809 ± 0.027	1.471MetPro: 1.471 ± 0.038	0.917MetGln: 0.917 ± 0.033	1.889MetArg: 1.889 ± 0.042	1.83MetSer: 1.83 ± 0.045	2.024MetThr: 2.024 ± 0.043	1.719MetVal: 1.719 ± 0.041	0.216MetTrp: 0.216 ± 0.015	0.297MetTyr: 0.297 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.013AsnAla: 3.013 ± 0.051	0.252AsnCys: 0.252 ± 0.016	1.43AsnAsp: 1.43 ± 0.04	1.277AsnGlu: 1.277 ± 0.036	0.978AsnPhe: 0.978 ± 0.031	2.276AsnGly: 2.276 ± 0.06	0.489AsnHis: 0.489 ± 0.02	1.326AsnIle: 1.326 ± 0.035	0.595AsnLys: 0.595 ± 0.028	2.561AsnLeu: 2.561 ± 0.054	0.633AsnMet: 0.633 ± 0.021	0.592AsnAsn: 0.592 ± 0.023	1.788AsnPro: 1.788 ± 0.044	0.65AsnGln: 0.65 ± 0.025	1.709AsnArg: 1.709 ± 0.042	1.217AsnSer: 1.217 ± 0.039	1.31AsnThr: 1.31 ± 0.039	1.852AsnVal: 1.852 ± 0.058	0.441AsnTrp: 0.441 ± 0.021	0.639AsnTyr: 0.639 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.684ProAla: 5.684 ± 0.099	0.367ProCys: 0.367 ± 0.018	3.756ProAsp: 3.756 ± 0.064	4.375ProGlu: 4.375 ± 0.078	1.997ProPhe: 1.997 ± 0.045	4.462ProGly: 4.462 ± 0.08	1.077ProHis: 1.077 ± 0.034	2.356ProIle: 2.356 ± 0.049	1.585ProLys: 1.585 ± 0.043	4.63ProLeu: 4.63 ± 0.086	1.246ProMet: 1.246 ± 0.038	1.25ProAsn: 1.25 ± 0.036	2.306ProPro: 2.306 ± 0.062	1.563ProGln: 1.563 ± 0.041	2.985ProArg: 2.985 ± 0.081	2.691ProSer: 2.691 ± 0.058	2.434ProThr: 2.434 ± 0.045	4.081ProVal: 4.081 ± 0.075	0.63ProTrp: 0.63 ± 0.024	1.126ProTyr: 1.126 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.534GlnAla: 3.534 ± 0.06	0.187GlnCys: 0.187 ± 0.013	1.671GlnAsp: 1.671 ± 0.041	1.668GlnGlu: 1.668 ± 0.044	1.13GlnPhe: 1.13 ± 0.035	2.501GlnGly: 2.501 ± 0.049	0.573GlnHis: 0.573 ± 0.026	2.049GlnIle: 2.049 ± 0.043	0.977GlnLys: 0.977 ± 0.033	2.722GlnLeu: 2.722 ± 0.06	0.959GlnMet: 0.959 ± 0.03	0.834GlnAsn: 0.834 ± 0.029	1.452GlnPro: 1.452 ± 0.045	1.036GlnGln: 1.036 ± 0.035	2.178GlnArg: 2.178 ± 0.052	1.861GlnSer: 1.861 ± 0.041	1.794GlnThr: 1.794 ± 0.046	2.195GlnVal: 2.195 ± 0.042	0.355GlnTrp: 0.355 ± 0.018	0.567GlnTyr: 0.567 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.09ArgAla: 8.09 ± 0.125	0.495ArgCys: 0.495 ± 0.024	4.426ArgAsp: 4.426 ± 0.066	4.294ArgGlu: 4.294 ± 0.071	2.851ArgPhe: 2.851 ± 0.046	4.929ArgGly: 4.929 ± 0.086	1.58ArgHis: 1.58 ± 0.048	4.131ArgIle: 4.131 ± 0.064	2.323ArgLys: 2.323 ± 0.064	7.428ArgLeu: 7.428 ± 0.101	1.952ArgMet: 1.952 ± 0.045	1.803ArgAsn: 1.803 ± 0.045	3.408ArgPro: 3.408 ± 0.069	2.266ArgGln: 2.266 ± 0.049	5.445ArgArg: 5.445 ± 0.104	3.56ArgSer: 3.56 ± 0.062	3.366ArgThr: 3.366 ± 0.05	4.743ArgVal: 4.743 ± 0.063	0.925ArgTrp: 0.925 ± 0.033	1.58ArgTyr: 1.58 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.232SerAla: 6.232 ± 0.127	0.457SerCys: 0.457 ± 0.025	3.441SerAsp: 3.441 ± 0.073	3.318SerGlu: 3.318 ± 0.051	2.306SerPhe: 2.306 ± 0.051	5.751SerGly: 5.751 ± 0.188	1.103SerHis: 1.103 ± 0.038	2.614SerIle: 2.614 ± 0.063	1.429SerLys: 1.429 ± 0.04	5.336SerLeu: 5.336 ± 0.107	1.361SerMet: 1.361 ± 0.035	1.341SerAsn: 1.341 ± 0.039	2.731SerPro: 2.731 ± 0.056	1.631SerGln: 1.631 ± 0.038	3.479SerArg: 3.479 ± 0.056	2.916SerSer: 2.916 ± 0.063	2.661SerThr: 2.661 ± 0.073	4.013SerVal: 4.013 ± 0.099	0.709SerTrp: 0.709 ± 0.027	1.322SerTyr: 1.322 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.114ThrAla: 6.114 ± 0.14	0.481ThrCys: 0.481 ± 0.024	3.149ThrAsp: 3.149 ± 0.068	3.311ThrGlu: 3.311 ± 0.056	2.017ThrPhe: 2.017 ± 0.044	5.416ThrGly: 5.416 ± 0.138	1.116ThrHis: 1.116 ± 0.034	2.795ThrIle: 2.795 ± 0.067	1.413ThrLys: 1.413 ± 0.04	6.196ThrLeu: 6.196 ± 0.13	1.268ThrMet: 1.268 ± 0.03	1.319ThrAsn: 1.319 ± 0.038	3.223ThrPro: 3.223 ± 0.059	1.522ThrGln: 1.522 ± 0.039	3.579ThrArg: 3.579 ± 0.054	2.912ThrSer: 2.912 ± 0.092	2.889ThrThr: 2.889 ± 0.103	4.324ThrVal: 4.324 ± 0.111	0.635ThrTrp: 0.635 ± 0.024	1.229ThrTyr: 1.229 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.446ValAla: 8.446 ± 0.11	0.638ValCys: 0.638 ± 0.026	4.183ValAsp: 4.183 ± 0.083	4.847ValGlu: 4.847 ± 0.076	2.878ValPhe: 2.878 ± 0.055	5.527ValGly: 5.527 ± 0.087	1.369ValHis: 1.369 ± 0.041	4.117ValIle: 4.117 ± 0.071	1.984ValLys: 1.984 ± 0.046	7.186ValLeu: 7.186 ± 0.087	1.961ValMet: 1.961 ± 0.047	1.877ValAsn: 1.877 ± 0.041	3.512ValPro: 3.512 ± 0.064	2.065ValGln: 2.065 ± 0.042	4.482ValArg: 4.482 ± 0.069	4.437ValSer: 4.437 ± 0.099	4.538ValThr: 4.538 ± 0.118	5.588ValVal: 5.588 ± 0.073	0.855ValTrp: 0.855 ± 0.028	1.504ValTyr: 1.504 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.283TrpAla: 1.283 ± 0.037	0.13TrpCys: 0.13 ± 0.011	0.717TrpAsp: 0.717 ± 0.027	0.694TrpGlu: 0.694 ± 0.028	0.56TrpPhe: 0.56 ± 0.025	0.989TrpGly: 0.989 ± 0.03	0.322TrpHis: 0.322 ± 0.018	0.771TrpIle: 0.771 ± 0.029	0.452TrpLys: 0.452 ± 0.023	1.588TrpLeu: 1.588 ± 0.039	0.377TrpMet: 0.377 ± 0.018	0.407TrpAsn: 0.407 ± 0.02	0.649TrpPro: 0.649 ± 0.026	0.508TrpGln: 0.508 ± 0.024	1.028TrpArg: 1.028 ± 0.037	0.839TrpSer: 0.839 ± 0.037	0.747TrpThr: 0.747 ± 0.028	0.794TrpVal: 0.794 ± 0.029	0.211TrpTrp: 0.211 ± 0.016	0.262TrpTyr: 0.262 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.371TyrAla: 2.371 ± 0.046	0.236TyrCys: 0.236 ± 0.015	1.589TyrAsp: 1.589 ± 0.047	1.391TyrGlu: 1.391 ± 0.041	0.916TyrPhe: 0.916 ± 0.029	2.065TyrGly: 2.065 ± 0.051	0.526TyrHis: 0.526 ± 0.026	0.881TyrIle: 0.881 ± 0.033	0.549TyrLys: 0.549 ± 0.023	2.276TyrLeu: 2.276 ± 0.052	0.427TyrMet: 0.427 ± 0.018	0.562TyrAsn: 0.562 ± 0.022	1.04TyrPro: 1.04 ± 0.03	0.684TyrGln: 0.684 ± 0.029	1.564TyrArg: 1.564 ± 0.041	1.195TyrSer: 1.195 ± 0.033	1.075TyrThr: 1.075 ± 0.033	1.514TyrVal: 1.514 ± 0.031	0.345TyrTrp: 0.345 ± 0.019	0.536TyrTyr: 0.536 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3383 proteins (1091612 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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