Amino acid dipepetide frequency for Leishmania aethiopica RNA virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.735AlaAla: 8.735 ± 1.046
4.576AlaCys: 4.576 ± 0.654
5.408AlaAsp: 5.408 ± 1.201
4.576AlaGlu: 4.576 ± 0.654
0.832AlaPhe: 0.832 ± 0.426
7.903AlaGly: 7.903 ± 2.274
4.16AlaHis: 4.16 ± 1.076
4.16AlaIle: 4.16 ± 1.947
2.912AlaLys: 2.912 ± 0.354
8.319AlaLeu: 8.319 ± 1.225
2.08AlaMet: 2.08 ± 1.513
3.328AlaAsn: 3.328 ± 0.665
2.912AlaPro: 2.912 ± 1.462
1.664AlaGln: 1.664 ± 0.316
3.328AlaArg: 3.328 ± 0.631
5.824AlaSer: 5.824 ± 0.709
3.744AlaThr: 3.744 ± 0.465
3.328AlaVal: 3.328 ± 0.631
0.832AlaTrp: 0.832 ± 0.688
3.328AlaTyr: 3.328 ± 0.631
0.0AlaXaa: 0.0 ± 0.0
Cys
0.416CysAla: 0.416 ± 0.344
0.416CysCys: 0.416 ± 0.344
1.664CysAsp: 1.664 ± 0.316
2.496CysGlu: 2.496 ± 1.279
1.248CysPhe: 1.248 ± 0.149
2.08CysGly: 2.08 ± 0.538
0.416CysHis: 0.416 ± 0.344
0.832CysIle: 0.832 ± 0.426
0.416CysLys: 0.416 ± 0.344
2.496CysLeu: 2.496 ± 0.982
1.248CysMet: 1.248 ± 1.606
0.416CysAsn: 0.416 ± 0.344
0.416CysPro: 0.416 ± 0.344
1.664CysGln: 1.664 ± 0.316
0.832CysArg: 0.832 ± 2.267
1.664CysSer: 1.664 ± 1.52
1.248CysThr: 1.248 ± 0.231
2.08CysVal: 2.08 ± 1.72
0.832CysTrp: 0.832 ± 0.426
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.912AspAla: 2.912 ± 2.062
0.0AspCys: 0.0 ± 0.0
3.328AspAsp: 3.328 ± 0.631
2.08AspGlu: 2.08 ± 0.538
2.496AspPhe: 2.496 ± 0.982
6.24AspGly: 6.24 ± 0.964
1.664AspHis: 1.664 ± 0.316
4.16AspIle: 4.16 ± 1.076
0.832AspLys: 0.832 ± 0.688
3.328AspLeu: 3.328 ± 1.666
0.832AspMet: 0.832 ± 0.688
2.08AspAsn: 2.08 ± 0.538
2.496AspPro: 2.496 ± 0.299
1.664AspGln: 1.664 ± 0.316
2.08AspArg: 2.08 ± 0.538
0.832AspSer: 0.832 ± 0.426
2.496AspThr: 2.496 ± 0.982
4.992AspVal: 4.992 ± 0.598
0.416AspTrp: 0.416 ± 0.344
2.912AspTyr: 2.912 ± 0.959
0.0AspXaa: 0.0 ± 0.0
Glu
6.24GluAla: 6.24 ± 0.747
0.832GluCys: 0.832 ± 0.426
2.496GluAsp: 2.496 ± 0.982
2.496GluGlu: 2.496 ± 0.982
0.832GluPhe: 0.832 ± 0.688
2.912GluGly: 2.912 ± 0.354
0.832GluHis: 0.832 ± 0.688
3.744GluIle: 3.744 ± 0.448
0.832GluLys: 0.832 ± 0.371
8.319GluLeu: 8.319 ± 1.578
1.664GluMet: 1.664 ± 0.316
1.664GluAsn: 1.664 ± 0.852
2.912GluPro: 2.912 ± 0.959
0.832GluGln: 0.832 ± 0.688
2.912GluArg: 2.912 ± 1.323
4.16GluSer: 4.16 ± 0.638
2.496GluThr: 2.496 ± 0.299
1.664GluVal: 1.664 ± 0.316
0.0GluTrp: 0.0 ± 0.0
2.496GluTyr: 2.496 ± 0.299
0.0GluXaa: 0.0 ± 0.0
Phe
1.248PheAla: 1.248 ± 0.149
0.416PheCys: 0.416 ± 0.344
2.496PheAsp: 2.496 ± 0.299
2.08PheGlu: 2.08 ± 1.72
0.416PhePhe: 0.416 ± 0.344
0.416PheGly: 0.416 ± 0.344
0.832PheHis: 0.832 ± 0.426
0.832PheIle: 0.832 ± 0.688
1.664PheLys: 1.664 ± 0.316
2.912PheLeu: 2.912 ± 2.408
1.664PheMet: 1.664 ± 0.852
3.744PheAsn: 3.744 ± 0.448
1.248PhePro: 1.248 ± 0.149
1.248PheGln: 1.248 ± 2.278
2.912PheArg: 2.912 ± 1.462
3.328PheSer: 3.328 ± 1.226
0.832PheThr: 0.832 ± 0.426
1.664PheVal: 1.664 ± 1.376
1.248PheTrp: 1.248 ± 0.149
1.248PheTyr: 1.248 ± 0.149
0.0PheXaa: 0.0 ± 0.0
Gly
5.408GlyAla: 5.408 ± 1.201
1.248GlyCys: 1.248 ± 0.149
5.408GlyAsp: 5.408 ± 1.201
2.496GlyGlu: 2.496 ± 0.299
1.664GlyPhe: 1.664 ± 0.316
6.656GlyGly: 6.656 ± 2.343
2.912GlyHis: 2.912 ± 1.323
2.496GlyIle: 2.496 ± 1.279
2.912GlyLys: 2.912 ± 2.808
7.903GlyLeu: 7.903 ± 1.047
1.664GlyMet: 1.664 ± 0.852
0.832GlyAsn: 0.832 ± 0.688
2.496GlyPro: 2.496 ± 1.279
1.664GlyGln: 1.664 ± 0.852
7.488GlyArg: 7.488 ± 0.896
4.16GlySer: 4.16 ± 1.076
5.408GlyThr: 5.408 ± 2.351
5.408GlyVal: 5.408 ± 1.266
0.832GlyTrp: 0.832 ± 0.426
2.912GlyTyr: 2.912 ± 0.902
0.0GlyXaa: 0.0 ± 0.0
His
3.744HisAla: 3.744 ± 0.448
0.0HisCys: 0.0 ± 0.0
0.832HisAsp: 0.832 ± 0.426
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
1.664HisGly: 1.664 ± 0.316
1.248HisHis: 1.248 ± 0.149
1.248HisIle: 1.248 ± 0.149
3.328HisLys: 3.328 ± 0.631
2.912HisLeu: 2.912 ± 0.959
0.0HisMet: 0.0 ± 0.0
2.08HisAsn: 2.08 ± 0.538
2.08HisPro: 2.08 ± 0.538
0.832HisGln: 0.832 ± 0.371
1.248HisArg: 1.248 ± 0.149
3.328HisSer: 3.328 ± 0.665
0.832HisThr: 0.832 ± 0.688
3.328HisVal: 3.328 ± 0.665
0.832HisTrp: 0.832 ± 0.426
2.08HisTyr: 2.08 ± 0.538
0.0HisXaa: 0.0 ± 0.0
Ile
3.744IleAla: 3.744 ± 0.953
0.832IleCys: 0.832 ± 0.426
1.248IleAsp: 1.248 ± 1.032
1.248IleGlu: 1.248 ± 0.149
3.744IlePhe: 3.744 ± 1.384
2.08IleGly: 2.08 ± 0.385
1.248IleHis: 1.248 ± 0.149
4.16IleIle: 4.16 ± 1.076
2.08IleLys: 2.08 ± 0.643
4.992IleLeu: 4.992 ± 4.349
0.416IleMet: 0.416 ± 0.344
3.744IleAsn: 3.744 ± 0.448
2.496IlePro: 2.496 ± 0.299
0.416IleGln: 0.416 ± 1.638
4.992IleArg: 4.992 ± 1.496
2.08IleSer: 2.08 ± 0.538
2.08IleThr: 2.08 ± 0.538
2.912IleVal: 2.912 ± 0.959
1.248IleTrp: 1.248 ± 0.149
3.744IleTyr: 3.744 ± 1.384
0.0IleXaa: 0.0 ± 0.0
Lys
1.248LysAla: 1.248 ± 0.149
1.248LysCys: 1.248 ± 1.032
2.496LysAsp: 2.496 ± 0.982
2.912LysGlu: 2.912 ± 1.323
1.248LysPhe: 1.248 ± 1.032
2.08LysGly: 2.08 ± 0.538
1.248LysHis: 1.248 ± 0.149
0.416LysIle: 0.416 ± 0.344
2.08LysLys: 2.08 ± 0.643
2.496LysLeu: 2.496 ± 2.064
1.664LysMet: 1.664 ± 0.412
2.08LysAsn: 2.08 ± 2.465
2.08LysPro: 2.08 ± 1.72
2.496LysGln: 2.496 ± 0.299
1.664LysArg: 1.664 ± 0.316
2.08LysSer: 2.08 ± 1.72
2.496LysThr: 2.496 ± 0.982
2.496LysVal: 2.496 ± 2.064
0.0LysTrp: 0.0 ± 0.0
2.912LysTyr: 2.912 ± 0.354
0.0LysXaa: 0.0 ± 0.0
Leu
7.072LeuAla: 7.072 ± 1.197
0.416LeuCys: 0.416 ± 0.344
2.496LeuAsp: 2.496 ± 0.299
6.24LeuGlu: 6.24 ± 0.747
3.328LeuPhe: 3.328 ± 0.631
2.496LeuGly: 2.496 ± 0.982
4.16LeuHis: 4.16 ± 2.131
2.08LeuIle: 2.08 ± 2.334
6.656LeuLys: 6.656 ± 2.266
11.231LeuLeu: 11.231 ± 2.859
2.496LeuMet: 2.496 ± 0.299
3.328LeuAsn: 3.328 ± 0.631
6.656LeuPro: 6.656 ± 1.735
3.328LeuGln: 3.328 ± 0.631
5.408LeuArg: 5.408 ± 2.305
9.983LeuSer: 9.983 ± 1.139
7.903LeuThr: 7.903 ± 1.639
4.576LeuVal: 4.576 ± 1.873
2.08LeuTrp: 2.08 ± 1.271
2.496LeuTyr: 2.496 ± 0.982
0.0LeuXaa: 0.0 ± 0.0
Met
2.912MetAla: 2.912 ± 0.959
0.416MetCys: 0.416 ± 0.344
1.248MetAsp: 1.248 ± 0.149
1.248MetGlu: 1.248 ± 0.149
1.248MetPhe: 1.248 ± 0.149
0.832MetGly: 0.832 ± 0.426
0.0MetHis: 0.0 ± 0.0
1.248MetIle: 1.248 ± 1.734
0.416MetLys: 0.416 ± 0.344
1.248MetLeu: 1.248 ± 1.032
1.248MetMet: 1.248 ± 0.149
1.248MetAsn: 1.248 ± 0.149
0.832MetPro: 0.832 ± 0.371
0.832MetGln: 0.832 ± 0.426
2.496MetArg: 2.496 ± 0.299
1.664MetSer: 1.664 ± 0.316
2.08MetThr: 2.08 ± 0.538
0.416MetVal: 0.416 ± 2.302
0.832MetTrp: 0.832 ± 0.426
0.832MetTyr: 0.832 ± 0.426
0.0MetXaa: 0.0 ± 0.0
Asn
4.16AsnAla: 4.16 ± 1.076
0.832AsnCys: 0.832 ± 0.426
0.0AsnAsp: 0.0 ± 0.0
1.248AsnGlu: 1.248 ± 0.149
0.832AsnPhe: 0.832 ± 0.426
2.08AsnGly: 2.08 ± 0.538
1.664AsnHis: 1.664 ± 0.316
3.744AsnIle: 3.744 ± 0.448
0.832AsnLys: 0.832 ± 0.688
2.08AsnLeu: 2.08 ± 0.538
0.832AsnMet: 0.832 ± 0.688
1.664AsnAsn: 1.664 ± 0.316
2.496AsnPro: 2.496 ± 0.982
0.832AsnGln: 0.832 ± 0.688
4.16AsnArg: 4.16 ± 1.947
3.744AsnSer: 3.744 ± 0.448
2.496AsnThr: 2.496 ± 0.299
6.24AsnVal: 6.24 ± 2.66
0.416AsnTrp: 0.416 ± 0.344
2.08AsnTyr: 2.08 ± 0.538
0.0AsnXaa: 0.0 ± 0.0
Pro
4.992ProAla: 4.992 ± 2.615
1.248ProCys: 1.248 ± 0.149
1.664ProAsp: 1.664 ± 0.852
2.496ProGlu: 2.496 ± 1.606
0.0ProPhe: 0.0 ± 0.0
4.16ProGly: 4.16 ± 1.076
1.664ProHis: 1.664 ± 0.316
2.912ProIle: 2.912 ± 0.959
0.0ProLys: 0.0 ± 0.0
2.912ProLeu: 2.912 ± 2.204
0.416ProMet: 0.416 ± 0.344
0.832ProAsn: 0.832 ± 0.426
2.08ProPro: 2.08 ± 0.538
4.992ProGln: 4.992 ± 2.557
0.416ProArg: 0.416 ± 0.344
1.664ProSer: 1.664 ± 0.316
2.912ProThr: 2.912 ± 0.959
6.656ProVal: 6.656 ± 1.735
1.664ProTrp: 1.664 ± 0.852
2.08ProTyr: 2.08 ± 2.465
0.0ProXaa: 0.0 ± 0.0
Gln
4.16GlnAla: 4.16 ± 2.131
1.664GlnCys: 1.664 ± 1.52
0.416GlnAsp: 0.416 ± 0.344
1.664GlnGlu: 1.664 ± 0.316
0.0GlnPhe: 0.0 ± 0.0
0.416GlnGly: 0.416 ± 0.344
1.248GlnHis: 1.248 ± 0.149
0.0GlnIle: 0.0 ± 0.0
1.664GlnLys: 1.664 ± 0.941
1.248GlnLeu: 1.248 ± 0.149
1.248GlnMet: 1.248 ± 0.149
0.0GlnAsn: 0.0 ± 0.0
4.576GlnPro: 4.576 ± 1.809
0.832GlnGln: 0.832 ± 0.426
3.328GlnArg: 3.328 ± 0.665
2.496GlnSer: 2.496 ± 2.098
0.832GlnThr: 0.832 ± 0.688
1.664GlnVal: 1.664 ± 0.316
1.248GlnTrp: 1.248 ± 0.149
0.832GlnTyr: 0.832 ± 0.688
0.0GlnXaa: 0.0 ± 0.0
Arg
5.408ArgAla: 5.408 ± 1.266
1.664ArgCys: 1.664 ± 0.316
2.912ArgAsp: 2.912 ± 0.959
3.328ArgGlu: 3.328 ± 0.665
4.16ArgPhe: 4.16 ± 0.887
4.992ArgGly: 4.992 ± 0.598
3.328ArgHis: 3.328 ± 0.665
5.824ArgIle: 5.824 ± 0.939
2.08ArgLys: 2.08 ± 0.643
4.576ArgLeu: 4.576 ± 2.696
0.0ArgMet: 0.0 ± 0.0
0.0ArgAsn: 0.0 ± 0.0
1.248ArgPro: 1.248 ± 2.278
1.248ArgGln: 1.248 ± 0.149
3.744ArgArg: 3.744 ± 1.384
7.488ArgSer: 7.488 ± 1.825
6.656ArgThr: 6.656 ± 0.907
7.072ArgVal: 7.072 ± 1.626
0.416ArgTrp: 0.416 ± 0.344
0.416ArgTyr: 0.416 ± 0.344
0.0ArgXaa: 0.0 ± 0.0
Ser
1.664SerAla: 1.664 ± 0.316
3.328SerCys: 3.328 ± 0.451
4.16SerAsp: 4.16 ± 1.286
2.912SerGlu: 2.912 ± 1.323
2.496SerPhe: 2.496 ± 0.299
5.408SerGly: 5.408 ± 1.266
0.832SerHis: 0.832 ± 0.426
2.912SerIle: 2.912 ± 0.959
0.832SerLys: 0.832 ± 0.426
6.656SerLeu: 6.656 ± 1.944
0.832SerMet: 0.832 ± 0.688
4.992SerAsn: 4.992 ± 1.496
0.416SerPro: 0.416 ± 0.344
2.08SerGln: 2.08 ± 1.271
8.735SerArg: 8.735 ± 1.063
4.992SerSer: 4.992 ± 1.522
9.567SerThr: 9.567 ± 2.928
6.656SerVal: 6.656 ± 1.765
0.416SerTrp: 0.416 ± 0.344
3.328SerTyr: 3.328 ± 0.631
0.0SerXaa: 0.0 ± 0.0
Thr
7.488ThrAla: 7.488 ± 1.738
0.416ThrCys: 0.416 ± 0.344
2.496ThrAsp: 2.496 ± 0.299
1.664ThrGlu: 1.664 ± 0.316
2.08ThrPhe: 2.08 ± 0.385
6.656ThrGly: 6.656 ± 2.343
1.248ThrHis: 1.248 ± 0.149
3.744ThrIle: 3.744 ± 0.448
3.744ThrLys: 3.744 ± 2.009
4.992ThrLeu: 4.992 ± 0.598
2.08ThrMet: 2.08 ± 0.69
4.16ThrAsn: 4.16 ± 0.443
2.912ThrPro: 2.912 ± 4.446
0.416ThrGln: 0.416 ± 0.344
2.496ThrArg: 2.496 ± 0.299
5.408ThrSer: 5.408 ± 1.201
3.328ThrThr: 3.328 ± 0.625
6.656ThrVal: 6.656 ± 2.173
1.248ThrTrp: 1.248 ± 0.149
1.248ThrTyr: 1.248 ± 0.149
0.0ThrXaa: 0.0 ± 0.0
Val
7.072ValAla: 7.072 ± 1.546
1.248ValCys: 1.248 ± 2.278
2.496ValAsp: 2.496 ± 2.62
7.488ValGlu: 7.488 ± 1.249
3.328ValPhe: 3.328 ± 2.316
7.072ValGly: 7.072 ± 2.052
1.664ValHis: 1.664 ± 0.852
2.912ValIle: 2.912 ± 1.323
2.08ValLys: 2.08 ± 0.643
9.151ValLeu: 9.151 ± 1.6
2.08ValMet: 2.08 ± 0.358
3.328ValAsn: 3.328 ± 0.665
3.744ValPro: 3.744 ± 1.384
0.832ValGln: 0.832 ± 0.426
5.408ValArg: 5.408 ± 2.519
4.992ValSer: 4.992 ± 0.947
4.16ValThr: 4.16 ± 0.473
5.824ValVal: 5.824 ± 0.939
0.416ValTrp: 0.416 ± 2.302
3.744ValTyr: 3.744 ± 2.0
0.0ValXaa: 0.0 ± 0.0
Trp
1.664TrpAla: 1.664 ± 0.316
0.416TrpCys: 0.416 ± 0.344
2.496TrpAsp: 2.496 ± 0.299
0.0TrpGlu: 0.0 ± 0.0
1.248TrpPhe: 1.248 ± 0.149
1.664TrpGly: 1.664 ± 0.316
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.832TrpLys: 0.832 ± 0.688
1.248TrpLeu: 1.248 ± 0.149
0.416TrpMet: 0.416 ± 0.344
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.832TrpArg: 0.832 ± 0.426
1.664TrpSer: 1.664 ± 0.412
0.832TrpThr: 0.832 ± 0.426
1.664TrpVal: 1.664 ± 2.18
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.08TyrAla: 2.08 ± 0.643
1.664TyrCys: 1.664 ± 2.18
2.08TyrAsp: 2.08 ± 0.643
1.664TyrGlu: 1.664 ± 0.316
1.248TyrPhe: 1.248 ± 1.032
4.16TyrGly: 4.16 ± 0.638
1.248TyrHis: 1.248 ± 0.149
2.08TyrIle: 2.08 ± 0.538
1.248TyrLys: 1.248 ± 1.032
5.408TyrLeu: 5.408 ± 0.558
0.0TyrMet: 0.0 ± 0.0
2.912TyrAsn: 2.912 ± 0.959
1.664TyrPro: 1.664 ± 0.316
1.664TyrGln: 1.664 ± 0.852
2.08TyrArg: 2.08 ± 0.538
1.664TyrSer: 1.664 ± 1.376
2.08TyrThr: 2.08 ± 0.538
3.744TyrVal: 3.744 ± 2.0
0.0TyrTrp: 0.0 ± 0.0
1.664TyrTyr: 1.664 ± 0.852
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (2405 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski