Amino acid dipepetide frequency for Goutanap virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.831AlaAla: 3.831 ± 1.348
1.393AlaCys: 1.393 ± 0.718
2.786AlaAsp: 2.786 ± 1.437
1.045AlaGlu: 1.045 ± 0.51
2.786AlaPhe: 2.786 ± 0.998
1.045AlaGly: 1.045 ± 1.35
1.393AlaHis: 1.393 ± 0.718
3.483AlaIle: 3.483 ± 1.126
2.09AlaLys: 2.09 ± 1.078
4.876AlaLeu: 4.876 ± 2.431
0.348AlaMet: 0.348 ± 0.18
3.831AlaAsn: 3.831 ± 2.127
4.18AlaPro: 4.18 ± 2.518
1.742AlaGln: 1.742 ± 0.898
1.393AlaArg: 1.393 ± 0.879
4.18AlaSer: 4.18 ± 0.614
1.742AlaThr: 1.742 ± 0.885
5.225AlaVal: 5.225 ± 2.303
0.348AlaTrp: 0.348 ± 0.744
3.135AlaTyr: 3.135 ± 0.916
0.0AlaXaa: 0.0 ± 0.0
Cys
1.393CysAla: 1.393 ± 0.459
0.697CysCys: 0.697 ± 0.612
0.697CysAsp: 0.697 ± 0.359
1.045CysGlu: 1.045 ± 0.539
2.438CysPhe: 2.438 ± 1.844
0.348CysGly: 0.348 ± 0.744
0.697CysHis: 0.697 ± 0.359
1.393CysIle: 1.393 ± 0.459
1.045CysLys: 1.045 ± 0.937
2.09CysLeu: 2.09 ± 1.02
0.697CysMet: 0.697 ± 0.359
1.742CysAsn: 1.742 ± 0.475
0.348CysPro: 0.348 ± 1.132
0.697CysGln: 0.697 ± 0.359
0.697CysArg: 0.697 ± 0.359
2.09CysSer: 2.09 ± 1.078
1.393CysThr: 1.393 ± 0.879
2.786CysVal: 2.786 ± 1.02
0.0CysTrp: 0.0 ± 0.0
0.697CysTyr: 0.697 ± 0.359
0.0CysXaa: 0.0 ± 0.0
Asp
2.786AspAla: 2.786 ± 1.437
1.393AspCys: 1.393 ± 0.459
3.483AspAsp: 3.483 ± 1.126
2.09AspGlu: 2.09 ± 1.078
2.786AspPhe: 2.786 ± 1.858
1.742AspGly: 1.742 ± 0.898
1.045AspHis: 1.045 ± 0.539
6.966AspIle: 6.966 ± 3.592
2.438AspLys: 2.438 ± 1.257
6.966AspLeu: 6.966 ± 1.945
1.045AspMet: 1.045 ± 0.539
2.786AspAsn: 2.786 ± 1.437
2.786AspPro: 2.786 ± 0.811
1.393AspGln: 1.393 ± 0.718
2.09AspArg: 2.09 ± 0.729
4.528AspSer: 4.528 ± 1.652
4.18AspThr: 4.18 ± 2.155
6.27AspVal: 6.27 ± 0.514
0.0AspTrp: 0.0 ± 0.0
2.786AspTyr: 2.786 ± 1.858
0.0AspXaa: 0.0 ± 0.0
Glu
1.393GluAla: 1.393 ± 0.718
1.045GluCys: 1.045 ± 0.539
4.18GluAsp: 4.18 ± 2.155
2.438GluGlu: 2.438 ± 1.257
3.483GluPhe: 3.483 ± 1.71
0.697GluGly: 0.697 ± 0.359
0.697GluHis: 0.697 ± 0.359
3.831GluIle: 3.831 ± 1.014
4.18GluLys: 4.18 ± 1.461
5.225GluLeu: 5.225 ± 1.424
1.393GluMet: 1.393 ± 0.851
1.742GluAsn: 1.742 ± 0.475
1.393GluPro: 1.393 ± 1.224
0.0GluGln: 0.0 ± 0.0
2.09GluArg: 2.09 ± 1.379
3.483GluSer: 3.483 ± 0.95
1.742GluThr: 1.742 ± 0.898
1.045GluVal: 1.045 ± 0.539
0.0GluTrp: 0.0 ± 0.0
2.786GluTyr: 2.786 ± 0.998
0.0GluXaa: 0.0 ± 0.0
Phe
3.483PheAla: 3.483 ± 1.516
1.742PheCys: 1.742 ± 0.898
4.528PheAsp: 4.528 ± 1.312
5.225PheGlu: 5.225 ± 1.489
3.135PhePhe: 3.135 ± 3.65
1.045PheGly: 1.045 ± 0.539
2.786PheHis: 2.786 ± 1.02
4.876PheIle: 4.876 ± 2.636
6.27PheLys: 6.27 ± 1.929
5.921PheLeu: 5.921 ± 5.946
2.09PheMet: 2.09 ± 0.869
1.393PheAsn: 1.393 ± 0.718
2.786PhePro: 2.786 ± 1.858
0.348PheGln: 0.348 ± 0.18
0.697PheArg: 0.697 ± 0.359
8.708PheSer: 8.708 ± 0.486
3.831PheThr: 3.831 ± 1.348
5.225PheVal: 5.225 ± 3.446
0.348PheTrp: 0.348 ± 0.18
1.045PheTyr: 1.045 ± 0.539
0.0PheXaa: 0.0 ± 0.0
Gly
2.09GlyAla: 2.09 ± 1.873
1.045GlyCys: 1.045 ± 0.539
2.438GlyAsp: 2.438 ± 1.257
1.045GlyGlu: 1.045 ± 0.51
1.742GlyPhe: 1.742 ± 0.898
0.348GlyGly: 0.348 ± 0.18
1.742GlyHis: 1.742 ± 0.475
1.393GlyIle: 1.393 ± 0.879
3.135GlyLys: 3.135 ± 0.916
2.09GlyLeu: 2.09 ± 1.379
1.045GlyMet: 1.045 ± 0.51
2.09GlyAsn: 2.09 ± 0.552
0.0GlyPro: 0.0 ± 0.0
0.0GlyGln: 0.0 ± 0.0
1.045GlyArg: 1.045 ± 0.51
3.135GlySer: 3.135 ± 1.616
1.393GlyThr: 1.393 ± 1.049
1.742GlyVal: 1.742 ± 0.475
0.0GlyTrp: 0.0 ± 0.0
1.393GlyTyr: 1.393 ± 0.879
0.0GlyXaa: 0.0 ± 0.0
His
1.045HisAla: 1.045 ± 0.51
1.393HisCys: 1.393 ± 0.718
1.045HisAsp: 1.045 ± 0.539
1.393HisGlu: 1.393 ± 0.718
1.393HisPhe: 1.393 ± 0.459
1.742HisGly: 1.742 ± 0.855
0.697HisHis: 0.697 ± 0.612
2.09HisIle: 2.09 ± 1.836
0.348HisLys: 0.348 ± 0.18
3.135HisLeu: 3.135 ± 0.916
0.348HisMet: 0.348 ± 0.744
2.438HisAsn: 2.438 ± 0.67
1.393HisPro: 1.393 ± 0.718
0.348HisGln: 0.348 ± 0.18
0.0HisArg: 0.0 ± 0.0
2.786HisSer: 2.786 ± 0.811
1.742HisThr: 1.742 ± 0.898
1.393HisVal: 1.393 ± 0.459
0.0HisTrp: 0.0 ± 0.0
2.09HisTyr: 2.09 ± 1.078
0.0HisXaa: 0.0 ± 0.0
Ile
5.921IleAla: 5.921 ± 1.422
0.348IleCys: 0.348 ± 0.18
3.831IleAsp: 3.831 ± 1.407
2.786IleGlu: 2.786 ± 1.437
3.483IlePhe: 3.483 ± 2.398
2.09IleGly: 2.09 ± 0.552
1.742IleHis: 1.742 ± 0.475
3.831IleIle: 3.831 ± 1.292
5.573IleLys: 5.573 ± 1.484
6.966IleLeu: 6.966 ± 1.897
1.045IleMet: 1.045 ± 0.539
2.438IleAsn: 2.438 ± 1.257
8.708IlePro: 8.708 ± 2.036
2.09IleGln: 2.09 ± 1.078
5.921IleArg: 5.921 ± 2.331
8.011IleSer: 8.011 ± 0.341
2.786IleThr: 2.786 ± 0.998
4.18IleVal: 4.18 ± 0.614
0.348IleTrp: 0.348 ± 0.18
4.876IleTyr: 4.876 ± 2.657
0.0IleXaa: 0.0 ± 0.0
Lys
1.742LysAla: 1.742 ± 0.898
1.742LysCys: 1.742 ± 0.855
2.438LysAsp: 2.438 ± 0.67
4.18LysGlu: 4.18 ± 1.461
6.966LysPhe: 6.966 ± 3.911
1.742LysGly: 1.742 ± 0.475
0.697LysHis: 0.697 ± 0.359
6.618LysIle: 6.618 ± 0.959
2.786LysLys: 2.786 ± 0.918
9.056LysLeu: 9.056 ± 3.844
1.393LysMet: 1.393 ± 0.45
4.528LysAsn: 4.528 ± 1.283
1.045LysPro: 1.045 ± 0.937
0.348LysGln: 0.348 ± 1.132
2.09LysArg: 2.09 ± 1.078
5.921LysSer: 5.921 ± 1.562
3.483LysThr: 3.483 ± 2.372
2.09LysVal: 2.09 ± 0.869
0.348LysTrp: 0.348 ± 0.18
5.921LysTyr: 5.921 ± 1.773
0.0LysXaa: 0.0 ± 0.0
Leu
3.135LeuAla: 3.135 ± 0.405
1.742LeuCys: 1.742 ± 2.122
5.225LeuAsp: 5.225 ± 1.424
3.483LeuGlu: 3.483 ± 1.126
5.921LeuPhe: 5.921 ± 1.348
4.18LeuGly: 4.18 ± 0.614
2.786LeuHis: 2.786 ± 0.811
8.708LeuIle: 8.708 ± 1.369
7.315LeuLys: 7.315 ± 2.417
11.843LeuLeu: 11.843 ± 3.721
1.045LeuMet: 1.045 ± 0.539
5.921LeuAsn: 5.921 ± 1.348
4.528LeuPro: 4.528 ± 5.875
3.135LeuGln: 3.135 ± 0.964
4.528LeuArg: 4.528 ± 1.214
10.101LeuSer: 10.101 ± 1.998
5.225LeuThr: 5.225 ± 3.336
5.573LeuVal: 5.573 ± 3.728
0.0LeuTrp: 0.0 ± 0.0
4.528LeuTyr: 4.528 ± 0.759
0.0LeuXaa: 0.0 ± 0.0
Met
2.09MetAla: 2.09 ± 0.869
0.348MetCys: 0.348 ± 0.18
1.393MetAsp: 1.393 ± 0.718
0.697MetGlu: 0.697 ± 0.359
2.438MetPhe: 2.438 ± 0.918
0.348MetGly: 0.348 ± 0.18
0.0MetHis: 0.0 ± 0.0
0.697MetIle: 0.697 ± 0.359
1.045MetLys: 1.045 ± 0.539
1.393MetLeu: 1.393 ± 0.459
0.697MetMet: 0.697 ± 0.359
1.045MetAsn: 1.045 ± 1.35
0.348MetPro: 0.348 ± 0.18
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
1.742MetSer: 1.742 ± 0.855
0.697MetThr: 0.697 ± 0.612
0.697MetVal: 0.697 ± 0.359
0.0MetTrp: 0.0 ± 0.0
1.742MetTyr: 1.742 ± 1.96
0.0MetXaa: 0.0 ± 0.0
Asn
3.135AsnAla: 3.135 ± 0.964
0.697AsnCys: 0.697 ± 0.359
3.831AsnAsp: 3.831 ± 1.292
1.742AsnGlu: 1.742 ± 0.898
4.528AsnPhe: 4.528 ± 1.918
2.786AsnGly: 2.786 ± 0.471
0.697AsnHis: 0.697 ± 0.612
3.831AsnIle: 3.831 ± 1.407
3.831AsnLys: 3.831 ± 0.483
6.618AsnLeu: 6.618 ± 2.685
0.0AsnMet: 0.0 ± 0.0
2.438AsnAsn: 2.438 ± 0.67
2.438AsnPro: 2.438 ± 0.67
1.045AsnGln: 1.045 ± 0.539
1.742AsnArg: 1.742 ± 0.885
3.831AsnSer: 3.831 ± 1.405
4.18AsnThr: 4.18 ± 1.461
4.528AsnVal: 4.528 ± 1.967
0.348AsnTrp: 0.348 ± 0.18
2.438AsnTyr: 2.438 ± 1.721
0.0AsnXaa: 0.0 ± 0.0
Pro
1.742ProAla: 1.742 ± 1.954
0.348ProCys: 0.348 ± 0.744
2.438ProAsp: 2.438 ± 1.257
1.393ProGlu: 1.393 ± 0.879
3.831ProPhe: 3.831 ± 2.235
0.697ProGly: 0.697 ± 1.023
0.697ProHis: 0.697 ± 0.359
6.618ProIle: 6.618 ± 1.959
2.438ProLys: 2.438 ± 2.264
3.831ProLeu: 3.831 ± 2.62
1.393ProMet: 1.393 ± 2.092
3.483ProAsn: 3.483 ± 1.126
3.831ProPro: 3.831 ± 5.112
1.742ProGln: 1.742 ± 0.855
2.438ProArg: 2.438 ± 3.101
3.483ProSer: 3.483 ± 0.413
4.528ProThr: 4.528 ± 1.283
2.09ProVal: 2.09 ± 0.729
0.0ProTrp: 0.0 ± 0.0
3.135ProTyr: 3.135 ± 0.964
0.0ProXaa: 0.0 ± 0.0
Gln
0.348GlnAla: 0.348 ± 0.18
1.045GlnCys: 1.045 ± 0.539
1.742GlnAsp: 1.742 ± 0.475
0.0GlnGlu: 0.0 ± 0.0
1.742GlnPhe: 1.742 ± 0.855
1.045GlnGly: 1.045 ± 0.539
0.348GlnHis: 0.348 ± 0.18
1.742GlnIle: 1.742 ± 0.475
1.393GlnLys: 1.393 ± 0.718
2.09GlnLeu: 2.09 ± 1.078
0.697GlnMet: 0.697 ± 0.359
2.438GlnAsn: 2.438 ± 0.918
0.697GlnPro: 0.697 ± 1.023
0.697GlnGln: 0.697 ± 0.359
1.393GlnArg: 1.393 ± 0.718
2.09GlnSer: 2.09 ± 1.078
0.697GlnThr: 0.697 ± 0.359
0.348GlnVal: 0.348 ± 0.18
0.348GlnTrp: 0.348 ± 0.18
2.438GlnTyr: 2.438 ± 0.918
0.0GlnXaa: 0.0 ± 0.0
Arg
2.09ArgAla: 2.09 ± 1.873
1.393ArgCys: 1.393 ± 0.879
1.045ArgAsp: 1.045 ± 0.539
2.09ArgGlu: 2.09 ± 0.552
2.438ArgPhe: 2.438 ± 1.257
0.697ArgGly: 0.697 ± 0.359
1.393ArgHis: 1.393 ± 0.459
2.786ArgIle: 2.786 ± 1.437
2.438ArgLys: 2.438 ± 1.807
2.786ArgLeu: 2.786 ± 0.811
0.0ArgMet: 0.0 ± 0.0
3.135ArgAsn: 3.135 ± 0.964
1.742ArgPro: 1.742 ± 0.885
1.045ArgGln: 1.045 ± 0.539
1.045ArgArg: 1.045 ± 0.937
2.786ArgSer: 2.786 ± 0.918
4.876ArgThr: 4.876 ± 1.257
3.135ArgVal: 3.135 ± 0.916
0.0ArgTrp: 0.0 ± 0.0
2.09ArgTyr: 2.09 ± 1.02
0.0ArgXaa: 0.0 ± 0.0
Ser
3.831SerAla: 3.831 ± 1.014
2.09SerCys: 2.09 ± 1.02
5.573SerAsp: 5.573 ± 1.996
4.876SerGlu: 4.876 ± 1.34
3.831SerPhe: 3.831 ± 0.491
2.786SerGly: 2.786 ± 0.471
2.438SerHis: 2.438 ± 1.257
6.618SerIle: 6.618 ± 2.645
6.618SerLys: 6.618 ± 0.959
7.315SerLeu: 7.315 ± 0.89
1.393SerMet: 1.393 ± 0.879
4.528SerAsn: 4.528 ± 1.633
3.483SerPro: 3.483 ± 1.223
2.786SerGln: 2.786 ± 1.437
2.786SerArg: 2.786 ± 0.811
6.966SerSer: 6.966 ± 4.409
5.921SerThr: 5.921 ± 4.029
7.315SerVal: 7.315 ± 1.318
0.697SerTrp: 0.697 ± 0.359
2.786SerTyr: 2.786 ± 0.918
0.0SerXaa: 0.0 ± 0.0
Thr
4.528ThrAla: 4.528 ± 1.967
1.045ThrCys: 1.045 ± 0.539
3.483ThrAsp: 3.483 ± 0.662
3.831ThrGlu: 3.831 ± 1.976
4.876ThrPhe: 4.876 ± 1.765
2.438ThrGly: 2.438 ± 1.199
3.483ThrHis: 3.483 ± 1.459
3.135ThrIle: 3.135 ± 0.916
4.528ThrLys: 4.528 ± 0.133
6.618ThrLeu: 6.618 ± 1.502
1.045ThrMet: 1.045 ± 0.539
2.786ThrAsn: 2.786 ± 1.717
4.528ThrPro: 4.528 ± 1.025
1.393ThrGln: 1.393 ± 0.879
2.09ThrArg: 2.09 ± 1.078
3.483ThrSer: 3.483 ± 1.71
5.225ThrThr: 5.225 ± 1.618
4.528ThrVal: 4.528 ± 1.312
0.348ThrTrp: 0.348 ± 0.744
3.135ThrTyr: 3.135 ± 0.405
0.0ThrXaa: 0.0 ± 0.0
Val
4.18ValAla: 4.18 ± 1.333
1.742ValCys: 1.742 ± 0.885
4.528ValAsp: 4.528 ± 1.652
2.786ValGlu: 2.786 ± 0.471
4.18ValPhe: 4.18 ± 0.305
1.742ValGly: 1.742 ± 0.475
1.742ValHis: 1.742 ± 0.898
4.876ValIle: 4.876 ± 1.257
3.483ValLys: 3.483 ± 0.413
4.876ValLeu: 4.876 ± 1.765
1.045ValMet: 1.045 ± 0.986
2.786ValAsn: 2.786 ± 0.918
4.18ValPro: 4.18 ± 2.706
2.438ValGln: 2.438 ± 0.918
3.135ValArg: 3.135 ± 0.405
4.876ValSer: 4.876 ± 2.431
6.27ValThr: 6.27 ± 3.061
6.618ValVal: 6.618 ± 2.04
0.0ValTrp: 0.0 ± 0.0
3.135ValTyr: 3.135 ± 0.916
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.348TrpPhe: 0.348 ± 0.18
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.348TrpIle: 0.348 ± 0.18
0.348TrpLys: 0.348 ± 0.18
1.045TrpLeu: 1.045 ± 0.539
0.0TrpMet: 0.0 ± 0.0
0.348TrpAsn: 0.348 ± 0.744
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
0.697TrpThr: 0.697 ± 0.359
0.348TrpVal: 0.348 ± 0.744
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.09TyrAla: 2.09 ± 2.205
1.742TyrCys: 1.742 ± 2.38
4.876TyrAsp: 4.876 ± 2.514
1.045TyrGlu: 1.045 ± 1.35
3.135TyrPhe: 3.135 ± 1.102
1.393TyrGly: 1.393 ± 0.718
1.742TyrHis: 1.742 ± 0.475
3.135TyrIle: 3.135 ± 1.102
3.831TyrLys: 3.831 ± 3.313
4.18TyrLeu: 4.18 ± 1.104
0.348TyrMet: 0.348 ± 0.18
2.786TyrAsn: 2.786 ± 1.619
1.742TyrPro: 1.742 ± 1.112
2.09TyrGln: 2.09 ± 0.552
3.831TyrArg: 3.831 ± 1.292
2.438TyrSer: 2.438 ± 0.67
5.921TyrThr: 5.921 ± 1.562
3.483TyrVal: 3.483 ± 0.95
0.348TyrTrp: 0.348 ± 0.18
3.483TyrTyr: 3.483 ± 0.413
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (2872 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski