Amino acid dipepetide frequency for Klebsiella phage JD001

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.487AlaAla: 8.487 ± 0.92
1.027AlaCys: 1.027 ± 0.354
5.476AlaAsp: 5.476 ± 0.509
5.202AlaGlu: 5.202 ± 0.628
2.875AlaPhe: 2.875 ± 0.363
6.639AlaGly: 6.639 ± 0.96
1.506AlaHis: 1.506 ± 0.387
4.312AlaIle: 4.312 ± 0.556
3.97AlaLys: 3.97 ± 0.632
6.913AlaLeu: 6.913 ± 0.708
2.464AlaMet: 2.464 ± 0.36
3.285AlaAsn: 3.285 ± 0.484
3.08AlaPro: 3.08 ± 0.458
4.312AlaGln: 4.312 ± 0.532
4.038AlaArg: 4.038 ± 0.64
6.16AlaSer: 6.16 ± 0.854
7.324AlaThr: 7.324 ± 0.893
6.023AlaVal: 6.023 ± 0.796
1.027AlaTrp: 1.027 ± 0.287
2.738AlaTyr: 2.738 ± 0.404
0.0AlaXaa: 0.0 ± 0.0
Cys
1.095CysAla: 1.095 ± 0.242
0.0CysCys: 0.0 ± 0.0
1.095CysAsp: 1.095 ± 0.281
1.027CysGlu: 1.027 ± 0.271
0.068CysPhe: 0.068 ± 0.068
0.89CysGly: 0.89 ± 0.281
0.342CysHis: 0.342 ± 0.155
0.684CysIle: 0.684 ± 0.261
0.821CysLys: 0.821 ± 0.267
1.095CysLeu: 1.095 ± 0.277
0.0CysMet: 0.0 ± 0.0
0.821CysAsn: 0.821 ± 0.231
0.89CysPro: 0.89 ± 0.34
0.342CysGln: 0.342 ± 0.121
0.821CysArg: 0.821 ± 0.242
1.164CysSer: 1.164 ± 0.285
0.753CysThr: 0.753 ± 0.197
1.164CysVal: 1.164 ± 0.313
0.137CysTrp: 0.137 ± 0.095
0.616CysTyr: 0.616 ± 0.162
0.0CysXaa: 0.0 ± 0.0
Asp
6.023AspAla: 6.023 ± 0.612
0.753AspCys: 0.753 ± 0.203
3.491AspAsp: 3.491 ± 0.455
4.312AspGlu: 4.312 ± 0.592
3.08AspPhe: 3.08 ± 0.446
7.324AspGly: 7.324 ± 0.755
0.684AspHis: 0.684 ± 0.171
4.381AspIle: 4.381 ± 0.557
3.08AspLys: 3.08 ± 0.469
3.833AspLeu: 3.833 ± 0.495
1.506AspMet: 1.506 ± 0.389
3.08AspAsn: 3.08 ± 0.509
2.053AspPro: 2.053 ± 0.355
1.3AspGln: 1.3 ± 0.259
3.012AspArg: 3.012 ± 0.569
3.833AspSer: 3.833 ± 0.373
4.038AspThr: 4.038 ± 0.549
4.791AspVal: 4.791 ± 0.673
1.506AspTrp: 1.506 ± 0.272
1.711AspTyr: 1.711 ± 0.348
0.0AspXaa: 0.0 ± 0.0
Glu
4.86GluAla: 4.86 ± 0.66
0.821GluCys: 0.821 ± 0.282
2.396GluAsp: 2.396 ± 0.498
3.217GluGlu: 3.217 ± 0.562
1.916GluPhe: 1.916 ± 0.402
2.601GluGly: 2.601 ± 0.335
0.89GluHis: 0.89 ± 0.259
3.696GluIle: 3.696 ± 0.556
3.012GluLys: 3.012 ± 0.472
5.955GluLeu: 5.955 ± 0.697
1.506GluMet: 1.506 ± 0.415
2.122GluAsn: 2.122 ± 0.356
1.643GluPro: 1.643 ± 0.337
3.765GluGln: 3.765 ± 0.562
3.285GluArg: 3.285 ± 0.426
2.875GluSer: 2.875 ± 0.459
2.806GluThr: 2.806 ± 0.454
3.491GluVal: 3.491 ± 0.485
1.369GluTrp: 1.369 ± 0.27
2.738GluTyr: 2.738 ± 0.435
0.0GluXaa: 0.0 ± 0.0
Phe
2.669PheAla: 2.669 ± 0.432
0.821PheCys: 0.821 ± 0.213
2.806PheAsp: 2.806 ± 0.355
1.848PheGlu: 1.848 ± 0.364
1.437PhePhe: 1.437 ± 0.292
2.738PheGly: 2.738 ± 0.383
0.342PheHis: 0.342 ± 0.155
1.985PheIle: 1.985 ± 0.394
2.396PheLys: 2.396 ± 0.376
1.985PheLeu: 1.985 ± 0.389
0.616PheMet: 0.616 ± 0.177
2.053PheAsn: 2.053 ± 0.452
1.164PhePro: 1.164 ± 0.32
1.095PheGln: 1.095 ± 0.256
1.916PheArg: 1.916 ± 0.321
2.396PheSer: 2.396 ± 0.444
2.533PheThr: 2.533 ± 0.35
2.806PheVal: 2.806 ± 0.437
0.479PheTrp: 0.479 ± 0.166
1.232PheTyr: 1.232 ± 0.275
0.0PheXaa: 0.0 ± 0.0
Gly
5.749GlyAla: 5.749 ± 0.997
1.095GlyCys: 1.095 ± 0.365
5.339GlyAsp: 5.339 ± 0.649
4.038GlyGlu: 4.038 ± 0.604
2.327GlyPhe: 2.327 ± 0.393
7.324GlyGly: 7.324 ± 1.812
1.437GlyHis: 1.437 ± 0.448
4.654GlyIle: 4.654 ± 0.64
4.723GlyLys: 4.723 ± 0.542
5.202GlyLeu: 5.202 ± 0.623
2.327GlyMet: 2.327 ± 0.384
3.149GlyAsn: 3.149 ± 0.432
1.643GlyPro: 1.643 ± 0.365
2.943GlyGln: 2.943 ± 0.404
3.491GlyArg: 3.491 ± 0.483
4.791GlySer: 4.791 ± 0.599
5.749GlyThr: 5.749 ± 0.856
5.955GlyVal: 5.955 ± 0.504
1.232GlyTrp: 1.232 ± 0.263
3.491GlyTyr: 3.491 ± 0.347
0.0GlyXaa: 0.0 ± 0.0
His
1.506HisAla: 1.506 ± 0.319
0.548HisCys: 0.548 ± 0.207
1.369HisAsp: 1.369 ± 0.29
0.684HisGlu: 0.684 ± 0.25
0.548HisPhe: 0.548 ± 0.189
1.574HisGly: 1.574 ± 0.383
0.821HisHis: 0.821 ± 0.279
1.506HisIle: 1.506 ± 0.373
0.753HisLys: 0.753 ± 0.222
1.506HisLeu: 1.506 ± 0.27
0.411HisMet: 0.411 ± 0.162
1.027HisAsn: 1.027 ± 0.246
0.479HisPro: 0.479 ± 0.139
0.274HisGln: 0.274 ± 0.132
1.095HisArg: 1.095 ± 0.316
1.027HisSer: 1.027 ± 0.219
0.684HisThr: 0.684 ± 0.214
1.437HisVal: 1.437 ± 0.266
0.479HisTrp: 0.479 ± 0.17
0.753HisTyr: 0.753 ± 0.265
0.0HisXaa: 0.0 ± 0.0
Ile
4.928IleAla: 4.928 ± 0.582
1.095IleCys: 1.095 ± 0.302
4.244IleAsp: 4.244 ± 0.473
3.422IleGlu: 3.422 ± 0.577
2.053IlePhe: 2.053 ± 0.439
3.354IleGly: 3.354 ± 0.428
1.369IleHis: 1.369 ± 0.297
3.628IleIle: 3.628 ± 0.574
3.696IleLys: 3.696 ± 0.534
3.696IleLeu: 3.696 ± 0.502
1.369IleMet: 1.369 ± 0.295
2.738IleAsn: 2.738 ± 0.573
3.149IlePro: 3.149 ± 0.515
1.78IleGln: 1.78 ± 0.368
3.628IleArg: 3.628 ± 0.421
3.491IleSer: 3.491 ± 0.589
4.586IleThr: 4.586 ± 0.441
4.449IleVal: 4.449 ± 0.483
0.684IleTrp: 0.684 ± 0.202
1.574IleTyr: 1.574 ± 0.287
0.0IleXaa: 0.0 ± 0.0
Lys
5.407LysAla: 5.407 ± 0.612
1.232LysCys: 1.232 ± 0.356
3.901LysAsp: 3.901 ± 0.558
2.396LysGlu: 2.396 ± 0.464
2.601LysPhe: 2.601 ± 0.449
3.012LysGly: 3.012 ± 0.387
1.437LysHis: 1.437 ± 0.391
2.738LysIle: 2.738 ± 0.435
2.533LysLys: 2.533 ± 0.465
4.449LysLeu: 4.449 ± 0.495
1.985LysMet: 1.985 ± 0.326
2.533LysAsn: 2.533 ± 0.419
2.533LysPro: 2.533 ± 0.335
2.738LysGln: 2.738 ± 0.56
3.559LysArg: 3.559 ± 0.439
3.354LysSer: 3.354 ± 0.474
2.738LysThr: 2.738 ± 0.438
3.217LysVal: 3.217 ± 0.512
1.095LysTrp: 1.095 ± 0.239
1.437LysTyr: 1.437 ± 0.33
0.0LysXaa: 0.0 ± 0.0
Leu
6.16LeuAla: 6.16 ± 0.771
1.027LeuCys: 1.027 ± 0.262
6.229LeuAsp: 6.229 ± 0.718
4.038LeuGlu: 4.038 ± 0.584
2.533LeuPhe: 2.533 ± 0.385
5.407LeuGly: 5.407 ± 0.535
1.506LeuHis: 1.506 ± 0.409
4.449LeuIle: 4.449 ± 0.603
4.107LeuLys: 4.107 ± 0.691
6.023LeuLeu: 6.023 ± 0.776
2.396LeuMet: 2.396 ± 0.452
4.654LeuAsn: 4.654 ± 0.678
2.327LeuPro: 2.327 ± 0.414
2.396LeuGln: 2.396 ± 0.376
4.038LeuArg: 4.038 ± 0.545
4.928LeuSer: 4.928 ± 0.541
5.133LeuThr: 5.133 ± 0.532
4.244LeuVal: 4.244 ± 0.515
1.232LeuTrp: 1.232 ± 0.282
2.533LeuTyr: 2.533 ± 0.36
0.0LeuXaa: 0.0 ± 0.0
Met
2.464MetAla: 2.464 ± 0.362
0.548MetCys: 0.548 ± 0.234
1.3MetAsp: 1.3 ± 0.349
0.89MetGlu: 0.89 ± 0.228
1.164MetPhe: 1.164 ± 0.347
1.711MetGly: 1.711 ± 0.255
0.205MetHis: 0.205 ± 0.113
1.095MetIle: 1.095 ± 0.299
0.89MetLys: 0.89 ± 0.22
2.053MetLeu: 2.053 ± 0.433
0.89MetMet: 0.89 ± 0.233
1.574MetAsn: 1.574 ± 0.355
0.548MetPro: 0.548 ± 0.217
1.164MetGln: 1.164 ± 0.288
2.327MetArg: 2.327 ± 0.459
2.122MetSer: 2.122 ± 0.35
2.464MetThr: 2.464 ± 0.422
1.232MetVal: 1.232 ± 0.278
0.205MetTrp: 0.205 ± 0.121
1.3MetTyr: 1.3 ± 0.291
0.0MetXaa: 0.0 ± 0.0
Asn
4.244AsnAla: 4.244 ± 0.598
1.027AsnCys: 1.027 ± 0.343
2.669AsnAsp: 2.669 ± 0.393
2.464AsnGlu: 2.464 ± 0.417
1.506AsnPhe: 1.506 ± 0.342
4.517AsnGly: 4.517 ± 0.625
1.095AsnHis: 1.095 ± 0.304
3.08AsnIle: 3.08 ± 0.563
2.943AsnLys: 2.943 ± 0.521
3.217AsnLeu: 3.217 ± 0.424
1.369AsnMet: 1.369 ± 0.347
2.806AsnAsn: 2.806 ± 0.549
2.053AsnPro: 2.053 ± 0.418
1.506AsnGln: 1.506 ± 0.302
1.711AsnArg: 1.711 ± 0.27
3.08AsnSer: 3.08 ± 0.529
3.285AsnThr: 3.285 ± 0.446
3.97AsnVal: 3.97 ± 0.567
0.684AsnTrp: 0.684 ± 0.192
1.574AsnTyr: 1.574 ± 0.329
0.0AsnXaa: 0.0 ± 0.0
Pro
3.765ProAla: 3.765 ± 0.499
0.411ProCys: 0.411 ± 0.158
2.601ProAsp: 2.601 ± 0.425
2.122ProGlu: 2.122 ± 0.412
0.89ProPhe: 0.89 ± 0.24
3.491ProGly: 3.491 ± 0.618
0.479ProHis: 0.479 ± 0.184
1.985ProIle: 1.985 ± 0.387
1.643ProLys: 1.643 ± 0.402
3.149ProLeu: 3.149 ± 0.507
0.479ProMet: 0.479 ± 0.147
2.259ProAsn: 2.259 ± 0.346
2.806ProPro: 2.806 ± 0.6
1.369ProGln: 1.369 ± 0.266
2.053ProArg: 2.053 ± 0.328
1.985ProSer: 1.985 ± 0.297
2.122ProThr: 2.122 ± 0.465
4.312ProVal: 4.312 ± 0.54
0.548ProTrp: 0.548 ± 0.156
1.506ProTyr: 1.506 ± 0.271
0.0ProXaa: 0.0 ± 0.0
Gln
2.464GlnAla: 2.464 ± 0.42
0.342GlnCys: 0.342 ± 0.14
1.506GlnAsp: 1.506 ± 0.285
2.327GlnGlu: 2.327 ± 0.391
1.643GlnPhe: 1.643 ± 0.359
2.122GlnGly: 2.122 ± 0.462
0.684GlnHis: 0.684 ± 0.18
2.19GlnIle: 2.19 ± 0.415
1.916GlnLys: 1.916 ± 0.477
3.97GlnLeu: 3.97 ± 0.512
1.643GlnMet: 1.643 ± 0.441
1.711GlnAsn: 1.711 ± 0.333
0.958GlnPro: 0.958 ± 0.249
2.669GlnGln: 2.669 ± 0.424
2.327GlnArg: 2.327 ± 0.537
2.464GlnSer: 2.464 ± 0.436
2.875GlnThr: 2.875 ± 0.452
2.669GlnVal: 2.669 ± 0.407
0.411GlnTrp: 0.411 ± 0.16
1.985GlnTyr: 1.985 ± 0.299
0.0GlnXaa: 0.0 ± 0.0
Arg
3.97ArgAla: 3.97 ± 0.525
0.548ArgCys: 0.548 ± 0.197
3.012ArgAsp: 3.012 ± 0.443
3.422ArgGlu: 3.422 ± 0.567
1.574ArgPhe: 1.574 ± 0.315
3.217ArgGly: 3.217 ± 0.414
1.232ArgHis: 1.232 ± 0.276
3.901ArgIle: 3.901 ± 0.477
3.217ArgLys: 3.217 ± 0.499
4.038ArgLeu: 4.038 ± 0.57
0.821ArgMet: 0.821 ± 0.259
2.396ArgAsn: 2.396 ± 0.364
2.327ArgPro: 2.327 ± 0.371
2.533ArgGln: 2.533 ± 0.427
2.259ArgArg: 2.259 ± 0.386
2.669ArgSer: 2.669 ± 0.354
2.327ArgThr: 2.327 ± 0.339
3.765ArgVal: 3.765 ± 0.504
1.232ArgTrp: 1.232 ± 0.261
2.19ArgTyr: 2.19 ± 0.446
0.0ArgXaa: 0.0 ± 0.0
Ser
5.818SerAla: 5.818 ± 0.654
0.616SerCys: 0.616 ± 0.184
4.107SerAsp: 4.107 ± 0.543
2.738SerGlu: 2.738 ± 0.475
1.916SerPhe: 1.916 ± 0.509
5.133SerGly: 5.133 ± 0.475
1.164SerHis: 1.164 ± 0.374
3.901SerIle: 3.901 ± 0.482
4.517SerLys: 4.517 ± 0.519
4.107SerLeu: 4.107 ± 0.438
1.78SerMet: 1.78 ± 0.36
3.354SerAsn: 3.354 ± 0.558
2.327SerPro: 2.327 ± 0.372
2.669SerGln: 2.669 ± 0.425
2.669SerArg: 2.669 ± 0.415
3.354SerSer: 3.354 ± 0.468
3.901SerThr: 3.901 ± 0.74
3.901SerVal: 3.901 ± 0.489
0.684SerTrp: 0.684 ± 0.203
2.806SerTyr: 2.806 ± 0.437
0.0SerXaa: 0.0 ± 0.0
Thr
6.297ThrAla: 6.297 ± 0.848
0.821ThrCys: 0.821 ± 0.208
3.765ThrAsp: 3.765 ± 0.548
3.491ThrGlu: 3.491 ± 0.527
2.396ThrPhe: 2.396 ± 0.375
6.845ThrGly: 6.845 ± 0.847
1.574ThrHis: 1.574 ± 0.427
4.654ThrIle: 4.654 ± 0.547
2.943ThrLys: 2.943 ± 0.516
5.407ThrLeu: 5.407 ± 0.646
1.164ThrMet: 1.164 ± 0.256
2.806ThrAsn: 2.806 ± 0.579
4.723ThrPro: 4.723 ± 0.672
1.643ThrGln: 1.643 ± 0.45
2.053ThrArg: 2.053 ± 0.338
4.586ThrSer: 4.586 ± 0.613
5.065ThrThr: 5.065 ± 0.842
6.502ThrVal: 6.502 ± 0.905
1.027ThrTrp: 1.027 ± 0.294
2.259ThrTyr: 2.259 ± 0.39
0.0ThrXaa: 0.0 ± 0.0
Val
7.529ValAla: 7.529 ± 0.854
0.411ValCys: 0.411 ± 0.139
4.586ValAsp: 4.586 ± 0.667
4.723ValGlu: 4.723 ± 0.539
2.669ValPhe: 2.669 ± 0.417
4.791ValGly: 4.791 ± 0.584
0.958ValHis: 0.958 ± 0.263
3.833ValIle: 3.833 ± 0.536
4.244ValLys: 4.244 ± 0.485
4.723ValLeu: 4.723 ± 0.538
2.053ValMet: 2.053 ± 0.29
3.696ValAsn: 3.696 ± 0.444
3.149ValPro: 3.149 ± 0.448
2.259ValGln: 2.259 ± 0.344
3.354ValArg: 3.354 ± 0.529
3.696ValSer: 3.696 ± 0.549
7.803ValThr: 7.803 ± 0.74
4.928ValVal: 4.928 ± 0.616
0.616ValTrp: 0.616 ± 0.212
2.601ValTyr: 2.601 ± 0.373
0.0ValXaa: 0.0 ± 0.0
Trp
0.89TrpAla: 0.89 ± 0.198
0.342TrpCys: 0.342 ± 0.166
1.164TrpAsp: 1.164 ± 0.246
0.548TrpGlu: 0.548 ± 0.198
0.821TrpPhe: 0.821 ± 0.315
1.095TrpGly: 1.095 ± 0.303
0.137TrpHis: 0.137 ± 0.087
0.616TrpIle: 0.616 ± 0.212
1.574TrpLys: 1.574 ± 0.378
1.164TrpLeu: 1.164 ± 0.288
0.205TrpMet: 0.205 ± 0.114
0.548TrpAsn: 0.548 ± 0.168
0.616TrpPro: 0.616 ± 0.209
0.753TrpGln: 0.753 ± 0.219
0.958TrpArg: 0.958 ± 0.292
0.753TrpSer: 0.753 ± 0.209
1.095TrpThr: 1.095 ± 0.254
1.232TrpVal: 1.232 ± 0.304
0.342TrpTrp: 0.342 ± 0.16
0.684TrpTyr: 0.684 ± 0.173
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.533TyrAla: 2.533 ± 0.482
0.342TyrCys: 0.342 ± 0.147
2.738TyrAsp: 2.738 ± 0.491
2.053TyrGlu: 2.053 ± 0.366
1.3TyrPhe: 1.3 ± 0.292
2.943TyrGly: 2.943 ± 0.521
0.616TyrHis: 0.616 ± 0.225
1.643TyrIle: 1.643 ± 0.285
1.916TyrLys: 1.916 ± 0.365
2.875TyrLeu: 2.875 ± 0.571
1.095TyrMet: 1.095 ± 0.238
2.19TyrAsn: 2.19 ± 0.337
1.506TyrPro: 1.506 ± 0.469
1.369TyrGln: 1.369 ± 0.259
2.053TyrArg: 2.053 ± 0.409
2.738TyrSer: 2.738 ± 0.364
2.738TyrThr: 2.738 ± 0.43
2.533TyrVal: 2.533 ± 0.468
0.548TyrTrp: 0.548 ± 0.21
1.095TyrTyr: 1.095 ± 0.251
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 68 proteins (14611 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski