Amino acid dipepetide frequency for Tessaracoccus sp. OH4464_COT-324

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.5AlaAla: 16.5 ± 0.203	1.014AlaCys: 1.014 ± 0.041	7.067AlaAsp: 7.067 ± 0.101	8.884AlaGlu: 8.884 ± 0.125	3.438AlaPhe: 3.438 ± 0.075	10.562AlaGly: 10.562 ± 0.14	2.393AlaHis: 2.393 ± 0.058	4.913AlaIle: 4.913 ± 0.073	3.758AlaLys: 3.758 ± 0.088	12.602AlaLeu: 12.602 ± 0.184	2.489AlaMet: 2.489 ± 0.057	2.655AlaAsn: 2.655 ± 0.063	5.404AlaPro: 5.404 ± 0.106	4.388AlaGln: 4.388 ± 0.073	9.004AlaArg: 9.004 ± 0.141	6.348AlaSer: 6.348 ± 0.089	6.493AlaThr: 6.493 ± 0.087	9.695AlaVal: 9.695 ± 0.143	1.678AlaTrp: 1.678 ± 0.049	2.136AlaTyr: 2.136 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.982CysAla: 0.982 ± 0.032	0.094CysCys: 0.094 ± 0.011	0.451CysAsp: 0.451 ± 0.025	0.417CysGlu: 0.417 ± 0.023	0.257CysPhe: 0.257 ± 0.016	0.91CysGly: 0.91 ± 0.033	0.196CysHis: 0.196 ± 0.018	0.298CysIle: 0.298 ± 0.019	0.13CysLys: 0.13 ± 0.013	0.763CysLeu: 0.763 ± 0.033	0.144CysMet: 0.144 ± 0.015	0.151CysAsn: 0.151 ± 0.012	0.505CysPro: 0.505 ± 0.026	0.223CysGln: 0.223 ± 0.016	0.535CysArg: 0.535 ± 0.024	0.56CysSer: 0.56 ± 0.027	0.438CysThr: 0.438 ± 0.022	0.647CysVal: 0.647 ± 0.03	0.123CysTrp: 0.123 ± 0.013	0.202CysTyr: 0.202 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.262AspAla: 6.262 ± 0.1	0.442AspCys: 0.442 ± 0.021	3.671AspAsp: 3.671 ± 0.089	4.465AspGlu: 4.465 ± 0.079	1.934AspPhe: 1.934 ± 0.05	5.422AspGly: 5.422 ± 0.093	1.107AspHis: 1.107 ± 0.039	2.219AspIle: 2.219 ± 0.055	1.422AspLys: 1.422 ± 0.056	5.603AspLeu: 5.603 ± 0.09	0.908AspMet: 0.908 ± 0.033	1.072AspAsn: 1.072 ± 0.039	3.748AspPro: 3.748 ± 0.079	1.747AspGln: 1.747 ± 0.051	3.621AspArg: 3.621 ± 0.08	2.822AspSer: 2.822 ± 0.066	2.37AspThr: 2.37 ± 0.059	5.064AspVal: 5.064 ± 0.086	1.016AspTrp: 1.016 ± 0.033	1.374AspTyr: 1.374 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.451GluAla: 7.451 ± 0.129	0.469GluCys: 0.469 ± 0.025	2.71GluAsp: 2.71 ± 0.057	4.01GluGlu: 4.01 ± 0.092	2.019GluPhe: 2.019 ± 0.05	4.417GluGly: 4.417 ± 0.08	1.53GluHis: 1.53 ± 0.041	2.883GluIle: 2.883 ± 0.067	1.658GluLys: 1.658 ± 0.057	7.995GluLeu: 7.995 ± 0.117	1.241GluMet: 1.241 ± 0.037	1.363GluAsn: 1.363 ± 0.046	3.305GluPro: 3.305 ± 0.08	2.739GluGln: 2.739 ± 0.064	5.433GluArg: 5.433 ± 0.102	2.904GluSer: 2.904 ± 0.058	2.888GluThr: 2.888 ± 0.06	5.453GluVal: 5.453 ± 0.087	0.821GluTrp: 0.821 ± 0.032	1.279GluTyr: 1.279 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.954PheAla: 3.954 ± 0.077	0.289PheCys: 0.289 ± 0.017	2.4PheAsp: 2.4 ± 0.062	1.865PheGlu: 1.865 ± 0.052	1.078PhePhe: 1.078 ± 0.044	3.267PheGly: 3.267 ± 0.084	0.599PheHis: 0.599 ± 0.027	1.187PheIle: 1.187 ± 0.045	0.743PheLys: 0.743 ± 0.041	3.071PheLeu: 3.071 ± 0.071	0.521PheMet: 0.521 ± 0.028	0.878PheAsn: 0.878 ± 0.033	1.467PhePro: 1.467 ± 0.048	0.884PheGln: 0.884 ± 0.034	1.94PheArg: 1.94 ± 0.055	2.02PheSer: 2.02 ± 0.05	1.981PheThr: 1.981 ± 0.052	2.809PheVal: 2.809 ± 0.063	0.508PheTrp: 0.508 ± 0.029	0.66PheTyr: 0.66 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.238GlyAla: 9.238 ± 0.128	0.847GlyCys: 0.847 ± 0.031	4.558GlyAsp: 4.558 ± 0.089	5.505GlyGlu: 5.505 ± 0.089	3.256GlyPhe: 3.256 ± 0.075	7.15GlyGly: 7.15 ± 0.12	1.915GlyHis: 1.915 ± 0.049	4.04GlyIle: 4.04 ± 0.07	3.085GlyLys: 3.085 ± 0.074	9.127GlyLeu: 9.127 ± 0.131	2.036GlyMet: 2.036 ± 0.064	1.897GlyAsn: 1.897 ± 0.053	3.683GlyPro: 3.683 ± 0.07	3.159GlyGln: 3.159 ± 0.066	6.443GlyArg: 6.443 ± 0.09	5.128GlySer: 5.128 ± 0.082	4.632GlyThr: 4.632 ± 0.08	7.278GlyVal: 7.278 ± 0.105	1.87GlyTrp: 1.87 ± 0.056	2.288GlyTyr: 2.288 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.081HisAla: 2.081 ± 0.057	0.191HisCys: 0.191 ± 0.015	1.274HisAsp: 1.274 ± 0.041	1.238HisGlu: 1.238 ± 0.036	0.646HisPhe: 0.646 ± 0.028	1.802HisGly: 1.802 ± 0.046	0.511HisHis: 0.511 ± 0.027	0.8HisIle: 0.8 ± 0.034	0.438HisLys: 0.438 ± 0.026	2.117HisLeu: 2.117 ± 0.048	0.38HisMet: 0.38 ± 0.022	0.484HisAsn: 0.484 ± 0.025	1.435HisPro: 1.435 ± 0.045	0.666HisGln: 0.666 ± 0.031	1.594HisArg: 1.594 ± 0.047	1.161HisSer: 1.161 ± 0.035	1.023HisThr: 1.023 ± 0.038	1.723HisVal: 1.723 ± 0.043	0.324HisTrp: 0.324 ± 0.022	0.518HisTyr: 0.518 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.193IleAla: 5.193 ± 0.085	0.391IleCys: 0.391 ± 0.026	2.938IleAsp: 2.938 ± 0.066	2.722IleGlu: 2.722 ± 0.062	1.151IlePhe: 1.151 ± 0.037	3.856IleGly: 3.856 ± 0.074	0.74IleHis: 0.74 ± 0.029	1.829IleIle: 1.829 ± 0.056	1.13IleLys: 1.13 ± 0.04	3.423IleLeu: 3.423 ± 0.068	0.721IleMet: 0.721 ± 0.031	1.13IleAsn: 1.13 ± 0.038	2.166IlePro: 2.166 ± 0.053	1.136IleGln: 1.136 ± 0.036	2.719IleArg: 2.719 ± 0.059	2.53IleSer: 2.53 ± 0.06	2.601IleThr: 2.601 ± 0.057	4.176IleVal: 4.176 ± 0.083	0.558IleTrp: 0.558 ± 0.026	0.865IleTyr: 0.865 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.088LysAla: 3.088 ± 0.074	0.143LysCys: 0.143 ± 0.016	1.343LysAsp: 1.343 ± 0.051	1.739LysGlu: 1.739 ± 0.05	0.768LysPhe: 0.768 ± 0.038	2.017LysGly: 2.017 ± 0.056	0.614LysHis: 0.614 ± 0.028	1.112LysIle: 1.112 ± 0.042	1.142LysLys: 1.142 ± 0.048	3.059LysLeu: 3.059 ± 0.067	0.592LysMet: 0.592 ± 0.032	0.707LysAsn: 0.707 ± 0.035	1.904LysPro: 1.904 ± 0.083	1.078LysGln: 1.078 ± 0.038	2.102LysArg: 2.102 ± 0.054	1.596LysSer: 1.596 ± 0.05	1.513LysThr: 1.513 ± 0.052	2.442LysVal: 2.442 ± 0.066	0.369LysTrp: 0.369 ± 0.022	0.655LysTyr: 0.655 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	14.914LeuAla: 14.914 ± 0.195	0.74LeuCys: 0.74 ± 0.032	6.395LeuAsp: 6.395 ± 0.103	5.213LeuGlu: 5.213 ± 0.098	3.039LeuPhe: 3.039 ± 0.059	9.743LeuGly: 9.743 ± 0.141	1.929LeuHis: 1.929 ± 0.051	4.263LeuIle: 4.263 ± 0.085	2.629LeuLys: 2.629 ± 0.069	11.107LeuLeu: 11.107 ± 0.196	1.875LeuMet: 1.875 ± 0.056	2.344LeuAsn: 2.344 ± 0.051	6.109LeuPro: 6.109 ± 0.09	2.562LeuGln: 2.562 ± 0.061	7.763LeuArg: 7.763 ± 0.116	6.529LeuSer: 6.529 ± 0.104	6.291LeuThr: 6.291 ± 0.092	8.837LeuVal: 8.837 ± 0.146	1.348LeuTrp: 1.348 ± 0.044	1.642LeuTyr: 1.642 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.374MetAla: 2.374 ± 0.062	0.128MetCys: 0.128 ± 0.012	0.817MetAsp: 0.817 ± 0.035	0.953MetGlu: 0.953 ± 0.038	0.588MetPhe: 0.588 ± 0.03	1.478MetGly: 1.478 ± 0.053	0.395MetHis: 0.395 ± 0.023	0.95MetIle: 0.95 ± 0.038	0.649MetLys: 0.649 ± 0.029	2.117MetLeu: 2.117 ± 0.051	0.474MetMet: 0.474 ± 0.027	0.581MetAsn: 0.581 ± 0.027	1.044MetPro: 1.044 ± 0.048	0.593MetGln: 0.593 ± 0.025	1.545MetArg: 1.545 ± 0.047	1.561MetSer: 1.561 ± 0.043	1.334MetThr: 1.334 ± 0.039	1.564MetVal: 1.564 ± 0.044	0.268MetTrp: 0.268 ± 0.018	0.303MetTyr: 0.303 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.447AsnAla: 2.447 ± 0.059	0.209AsnCys: 0.209 ± 0.015	1.203AsnAsp: 1.203 ± 0.041	1.347AsnGlu: 1.347 ± 0.043	0.731AsnPhe: 0.731 ± 0.035	1.92AsnGly: 1.92 ± 0.061	0.517AsnHis: 0.517 ± 0.028	0.974AsnIle: 0.974 ± 0.036	0.654AsnLys: 0.654 ± 0.027	2.339AsnLeu: 2.339 ± 0.052	0.454AsnMet: 0.454 ± 0.02	0.597AsnAsn: 0.597 ± 0.037	1.739AsnPro: 1.739 ± 0.052	0.814AsnGln: 0.814 ± 0.033	1.557AsnArg: 1.557 ± 0.05	1.231AsnSer: 1.231 ± 0.049	1.224AsnThr: 1.224 ± 0.041	1.782AsnVal: 1.782 ± 0.051	0.43AsnTrp: 0.43 ± 0.024	0.683AsnTyr: 0.683 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.259ProAla: 6.259 ± 0.104	0.335ProCys: 0.335 ± 0.019	3.582ProAsp: 3.582 ± 0.078	4.462ProGlu: 4.462 ± 0.083	1.507ProPhe: 1.507 ± 0.041	5.582ProGly: 5.582 ± 0.11	1.08ProHis: 1.08 ± 0.042	1.994ProIle: 1.994 ± 0.049	1.795ProLys: 1.795 ± 0.064	4.553ProLeu: 4.553 ± 0.076	1.002ProMet: 1.002 ± 0.038	1.302ProAsn: 1.302 ± 0.043	2.622ProPro: 2.622 ± 0.083	1.87ProGln: 1.87 ± 0.05	3.214ProArg: 3.214 ± 0.068	3.311ProSer: 3.311 ± 0.093	3.57ProThr: 3.57 ± 0.079	4.481ProVal: 4.481 ± 0.082	0.816ProTrp: 0.816 ± 0.036	1.055ProTyr: 1.055 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.929GlnAla: 3.929 ± 0.076	0.21GlnCys: 0.21 ± 0.016	1.228GlnAsp: 1.228 ± 0.042	1.795GlnGlu: 1.795 ± 0.053	1.067GlnPhe: 1.067 ± 0.032	2.387GlnGly: 2.387 ± 0.064	0.785GlnHis: 0.785 ± 0.033	1.467GlnIle: 1.467 ± 0.043	0.729GlnLys: 0.729 ± 0.028	4.625GlnLeu: 4.625 ± 0.08	0.663GlnMet: 0.663 ± 0.031	0.654GlnAsn: 0.654 ± 0.029	2.234GlnPro: 2.234 ± 0.063	1.58GlnGln: 1.58 ± 0.059	2.73GlnArg: 2.73 ± 0.06	1.571GlnSer: 1.571 ± 0.043	1.443GlnThr: 1.443 ± 0.046	2.905GlnVal: 2.905 ± 0.06	0.535GlnTrp: 0.535 ± 0.027	0.593GlnTyr: 0.593 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.311ArgAla: 8.311 ± 0.126	0.524ArgCys: 0.524 ± 0.028	3.827ArgAsp: 3.827 ± 0.079	4.46ArgGlu: 4.46 ± 0.082	2.576ArgPhe: 2.576 ± 0.061	5.197ArgGly: 5.197 ± 0.087	1.505ArgHis: 1.505 ± 0.045	3.614ArgIle: 3.614 ± 0.065	2.021ArgLys: 2.021 ± 0.06	8.056ArgLeu: 8.056 ± 0.13	1.823ArgMet: 1.823 ± 0.045	1.665ArgAsn: 1.665 ± 0.051	3.836ArgPro: 3.836 ± 0.072	2.473ArgGln: 2.473 ± 0.064	6.595ArgArg: 6.595 ± 0.13	4.109ArgSer: 4.109 ± 0.076	3.503ArgThr: 3.503 ± 0.067	6.114ArgVal: 6.114 ± 0.097	1.301ArgTrp: 1.301 ± 0.04	1.688ArgTyr: 1.688 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.93SerAla: 6.93 ± 0.094	0.494SerCys: 0.494 ± 0.025	3.019SerAsp: 3.019 ± 0.069	2.981SerGlu: 2.981 ± 0.066	2.085SerPhe: 2.085 ± 0.056	5.908SerGly: 5.908 ± 0.096	1.125SerHis: 1.125 ± 0.041	2.372SerIle: 2.372 ± 0.059	1.462SerLys: 1.462 ± 0.044	5.614SerLeu: 5.614 ± 0.068	1.289SerMet: 1.289 ± 0.045	1.283SerAsn: 1.283 ± 0.046	3.433SerPro: 3.433 ± 0.082	1.712SerGln: 1.712 ± 0.043	3.967SerArg: 3.967 ± 0.078	3.49SerSer: 3.49 ± 0.07	2.99SerThr: 2.99 ± 0.057	4.627SerVal: 4.627 ± 0.085	1.089SerTrp: 1.089 ± 0.037	1.338SerTyr: 1.338 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	5.924ThrAla: 5.924 ± 0.098	0.452ThrCys: 0.452 ± 0.03	2.918ThrAsp: 2.918 ± 0.071	2.804ThrGlu: 2.804 ± 0.066	1.795ThrPhe: 1.795 ± 0.052	4.94ThrGly: 4.94 ± 0.089	1.103ThrHis: 1.103 ± 0.036	2.485ThrIle: 2.485 ± 0.059	1.67ThrLys: 1.67 ± 0.054	5.533ThrLeu: 5.533 ± 0.079	1.132ThrMet: 1.132 ± 0.037	1.26ThrAsn: 1.26 ± 0.042	3.451ThrPro: 3.451 ± 0.079	1.717ThrGln: 1.717 ± 0.047	3.533ThrArg: 3.533 ± 0.063	3.029ThrSer: 3.029 ± 0.062	3.146ThrThr: 3.146 ± 0.073	5.023ThrVal: 5.023 ± 0.097	0.838ThrTrp: 0.838 ± 0.035	1.129ThrTyr: 1.129 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	11.5ValAla: 11.5 ± 0.14	0.665ValCys: 0.665 ± 0.03	4.85ValAsp: 4.85 ± 0.094	5.667ValGlu: 5.667 ± 0.092	2.774ValPhe: 2.774 ± 0.06	7.686ValGly: 7.686 ± 0.115	1.603ValHis: 1.603 ± 0.041	3.396ValIle: 3.396 ± 0.073	2.074ValLys: 2.074 ± 0.063	9.042ValLeu: 9.042 ± 0.125	1.456ValMet: 1.456 ± 0.053	1.982ValAsn: 1.982 ± 0.06	4.277ValPro: 4.277 ± 0.075	2.312ValGln: 2.312 ± 0.05	5.843ValArg: 5.843 ± 0.086	5.132ValSer: 5.132 ± 0.084	4.685ValThr: 4.685 ± 0.095	8.384ValVal: 8.384 ± 0.106	1.182ValTrp: 1.182 ± 0.038	1.45ValTyr: 1.45 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.824TrpAla: 1.824 ± 0.058	0.193TrpCys: 0.193 ± 0.016	0.756TrpAsp: 0.756 ± 0.034	0.773TrpGlu: 0.773 ± 0.033	0.618TrpPhe: 0.618 ± 0.028	1.113TrpGly: 1.113 ± 0.045	0.35TrpHis: 0.35 ± 0.02	0.517TrpIle: 0.517 ± 0.029	0.348TrpLys: 0.348 ± 0.022	2.211TrpLeu: 2.211 ± 0.058	0.257TrpMet: 0.257 ± 0.017	0.366TrpAsn: 0.366 ± 0.022	0.831TrpPro: 0.831 ± 0.033	0.735TrpGln: 0.735 ± 0.029	1.382TrpArg: 1.382 ± 0.049	0.921TrpSer: 0.921 ± 0.031	0.682TrpThr: 0.682 ± 0.029	1.242TrpVal: 1.242 ± 0.044	0.398TrpTrp: 0.398 ± 0.026	0.298TrpTyr: 0.298 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.256TyrAla: 2.256 ± 0.057	0.197TyrCys: 0.197 ± 0.015	1.28TyrAsp: 1.28 ± 0.038	1.268TyrGlu: 1.268 ± 0.041	0.793TyrPhe: 0.793 ± 0.034	1.776TyrGly: 1.776 ± 0.04	0.411TyrHis: 0.411 ± 0.021	0.665TyrIle: 0.665 ± 0.031	0.447TyrLys: 0.447 ± 0.024	2.312TyrLeu: 2.312 ± 0.064	0.26TyrMet: 0.26 ± 0.017	0.481TyrAsn: 0.481 ± 0.025	1.196TyrPro: 1.196 ± 0.039	0.745TyrGln: 0.745 ± 0.033	1.678TyrArg: 1.678 ± 0.046	1.258TyrSer: 1.258 ± 0.036	1.08TyrThr: 1.08 ± 0.04	1.711TyrVal: 1.711 ± 0.045	0.342TyrTrp: 0.342 ± 0.023	0.497TyrTyr: 0.497 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2457 proteins (812406 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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