Amino acid dipepetide frequency for Limnohabitans sp. T6-5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.047AlaAla: 15.047 ± 0.848
1.253AlaCys: 1.253 ± 0.042
6.228AlaAsp: 6.228 ± 0.128
5.679AlaGlu: 5.679 ± 0.116
3.64AlaPhe: 3.64 ± 0.082
9.875AlaGly: 9.875 ± 0.266
2.52AlaHis: 2.52 ± 0.075
4.958AlaIle: 4.958 ± 0.074
4.471AlaLys: 4.471 ± 0.105
13.486AlaLeu: 13.486 ± 0.185
3.419AlaMet: 3.419 ± 0.078
3.572AlaAsn: 3.572 ± 0.149
5.339AlaPro: 5.339 ± 0.147
6.692AlaGln: 6.692 ± 0.132
6.222AlaArg: 6.222 ± 0.159
7.234AlaSer: 7.234 ± 0.233
6.719AlaThr: 6.719 ± 0.43
8.263AlaVal: 8.263 ± 0.108
1.877AlaTrp: 1.877 ± 0.055
2.38AlaTyr: 2.38 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
1.041CysAla: 1.041 ± 0.04
0.115CysCys: 0.115 ± 0.01
0.573CysAsp: 0.573 ± 0.049
0.48CysGlu: 0.48 ± 0.021
0.3CysPhe: 0.3 ± 0.016
0.881CysGly: 0.881 ± 0.036
0.268CysHis: 0.268 ± 0.016
0.42CysIle: 0.42 ± 0.02
0.287CysLys: 0.287 ± 0.017
0.847CysLeu: 0.847 ± 0.033
0.234CysMet: 0.234 ± 0.017
0.266CysAsn: 0.266 ± 0.014
0.499CysPro: 0.499 ± 0.025
0.339CysGln: 0.339 ± 0.02
0.477CysArg: 0.477 ± 0.025
0.514CysSer: 0.514 ± 0.027
0.533CysThr: 0.533 ± 0.026
0.682CysVal: 0.682 ± 0.035
0.132CysTrp: 0.132 ± 0.011
0.177CysTyr: 0.177 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.757AspAla: 6.757 ± 0.15
0.412AspCys: 0.412 ± 0.023
2.49AspAsp: 2.49 ± 0.059
2.794AspGlu: 2.794 ± 0.08
2.078AspPhe: 2.078 ± 0.047
4.463AspGly: 4.463 ± 0.134
1.105AspHis: 1.105 ± 0.056
2.666AspIle: 2.666 ± 0.058
2.335AspLys: 2.335 ± 0.068
5.43AspLeu: 5.43 ± 0.085
1.438AspMet: 1.438 ± 0.036
1.548AspAsn: 1.548 ± 0.06
2.572AspPro: 2.572 ± 0.083
1.884AspGln: 1.884 ± 0.051
2.591AspArg: 2.591 ± 0.067
2.772AspSer: 2.772 ± 0.144
3.225AspThr: 3.225 ± 0.218
4.272AspVal: 4.272 ± 0.07
0.963AspTrp: 0.963 ± 0.034
1.351AspTyr: 1.351 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
5.754GluAla: 5.754 ± 0.092
0.374GluCys: 0.374 ± 0.021
2.087GluAsp: 2.087 ± 0.055
2.105GluGlu: 2.105 ± 0.068
1.658GluPhe: 1.658 ± 0.054
3.566GluGly: 3.566 ± 0.069
1.248GluHis: 1.248 ± 0.044
2.43GluIle: 2.43 ± 0.075
2.232GluLys: 2.232 ± 0.06
5.128GluLeu: 5.128 ± 0.127
1.243GluMet: 1.243 ± 0.045
1.404GluAsn: 1.404 ± 0.053
2.08GluPro: 2.08 ± 0.061
2.476GluGln: 2.476 ± 0.072
3.688GluArg: 3.688 ± 0.092
2.533GluSer: 2.533 ± 0.057
2.506GluThr: 2.506 ± 0.055
3.83GluVal: 3.83 ± 0.079
0.689GluTrp: 0.689 ± 0.031
0.952GluTyr: 0.952 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.816PheAla: 3.816 ± 0.058
0.392PheCys: 0.392 ± 0.021
2.346PheAsp: 2.346 ± 0.05
2.03PheGlu: 2.03 ± 0.058
1.299PhePhe: 1.299 ± 0.045
3.095PheGly: 3.095 ± 0.078
0.708PheHis: 0.708 ± 0.033
1.532PheIle: 1.532 ± 0.044
1.523PheLys: 1.523 ± 0.05
2.725PheLeu: 2.725 ± 0.079
0.924PheMet: 0.924 ± 0.038
1.344PheAsn: 1.344 ± 0.04
1.333PhePro: 1.333 ± 0.043
1.113PheGln: 1.113 ± 0.036
1.537PheArg: 1.537 ± 0.047
2.349PheSer: 2.349 ± 0.071
2.287PheThr: 2.287 ± 0.143
2.691PheVal: 2.691 ± 0.069
0.51PheTrp: 0.51 ± 0.026
0.822PheTyr: 0.822 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
8.622GlyAla: 8.622 ± 0.179
0.801GlyCys: 0.801 ± 0.032
4.213GlyAsp: 4.213 ± 0.146
3.727GlyGlu: 3.727 ± 0.067
3.183GlyPhe: 3.183 ± 0.065
6.778GlyGly: 6.778 ± 0.17
1.915GlyHis: 1.915 ± 0.046
3.721GlyIle: 3.721 ± 0.082
3.523GlyLys: 3.523 ± 0.08
8.741GlyLeu: 8.741 ± 0.117
2.336GlyMet: 2.336 ± 0.064
3.094GlyAsn: 3.094 ± 0.238
2.746GlyPro: 2.746 ± 0.059
4.322GlyGln: 4.322 ± 0.066
4.289GlyArg: 4.289 ± 0.091
5.021GlySer: 5.021 ± 0.161
5.691GlyThr: 5.691 ± 0.404
6.431GlyVal: 6.431 ± 0.098
1.338GlyTrp: 1.338 ± 0.044
2.173GlyTyr: 2.173 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.702HisAla: 2.702 ± 0.082
0.277HisCys: 0.277 ± 0.018
1.129HisAsp: 1.129 ± 0.044
1.123HisGlu: 1.123 ± 0.044
0.825HisPhe: 0.825 ± 0.034
1.885HisGly: 1.885 ± 0.061
0.648HisHis: 0.648 ± 0.032
1.11HisIle: 1.11 ± 0.046
0.686HisLys: 0.686 ± 0.027
2.245HisLeu: 2.245 ± 0.071
0.578HisMet: 0.578 ± 0.028
0.603HisAsn: 0.603 ± 0.025
1.369HisPro: 1.369 ± 0.049
0.898HisGln: 0.898 ± 0.034
1.296HisArg: 1.296 ± 0.047
1.151HisSer: 1.151 ± 0.038
1.221HisThr: 1.221 ± 0.039
1.473HisVal: 1.473 ± 0.048
0.458HisTrp: 0.458 ± 0.021
0.62HisTyr: 0.62 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.302IleAla: 5.302 ± 0.083
0.442IleCys: 0.442 ± 0.022
3.047IleAsp: 3.047 ± 0.072
3.057IleGlu: 3.057 ± 0.062
1.409IlePhe: 1.409 ± 0.043
3.782IleGly: 3.782 ± 0.067
0.948IleHis: 0.948 ± 0.033
1.645IleIle: 1.645 ± 0.044
1.939IleLys: 1.939 ± 0.053
3.357IleLeu: 3.357 ± 0.085
0.859IleMet: 0.859 ± 0.034
1.813IleAsn: 1.813 ± 0.063
1.872IlePro: 1.872 ± 0.06
1.756IleGln: 1.756 ± 0.051
2.367IleArg: 2.367 ± 0.065
2.954IleSer: 2.954 ± 0.084
3.332IleThr: 3.332 ± 0.152
3.183IleVal: 3.183 ± 0.071
0.563IleTrp: 0.563 ± 0.023
1.068IleTyr: 1.068 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
4.912LysAla: 4.912 ± 0.097
0.205LysCys: 0.205 ± 0.014
2.182LysAsp: 2.182 ± 0.061
1.655LysGlu: 1.655 ± 0.055
1.197LysPhe: 1.197 ± 0.036
2.769LysGly: 2.769 ± 0.071
0.801LysHis: 0.801 ± 0.034
1.838LysIle: 1.838 ± 0.05
1.769LysLys: 1.769 ± 0.067
3.917LysLeu: 3.917 ± 0.083
0.97LysMet: 0.97 ± 0.036
1.346LysAsn: 1.346 ± 0.046
2.221LysPro: 2.221 ± 0.069
1.502LysGln: 1.502 ± 0.048
2.153LysArg: 2.153 ± 0.077
2.265LysSer: 2.265 ± 0.059
2.633LysThr: 2.633 ± 0.067
3.102LysVal: 3.102 ± 0.06
0.413LysTrp: 0.413 ± 0.02
0.758LysTyr: 0.758 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
12.741LeuAla: 12.741 ± 0.195
1.005LeuCys: 1.005 ± 0.039
5.608LeuAsp: 5.608 ± 0.098
4.451LeuGlu: 4.451 ± 0.099
3.13LeuPhe: 3.13 ± 0.09
8.132LeuGly: 8.132 ± 0.124
2.291LeuHis: 2.291 ± 0.073
4.48LeuIle: 4.48 ± 0.08
4.27LeuLys: 4.27 ± 0.099
9.967LeuLeu: 9.967 ± 0.235
2.715LeuMet: 2.715 ± 0.076
3.726LeuAsn: 3.726 ± 0.073
5.695LeuPro: 5.695 ± 0.116
5.048LeuGln: 5.048 ± 0.103
5.947LeuArg: 5.947 ± 0.148
7.693LeuSer: 7.693 ± 0.166
6.093LeuThr: 6.093 ± 0.115
7.22LeuVal: 7.22 ± 0.093
1.367LeuTrp: 1.367 ± 0.047
1.868LeuTyr: 1.868 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
3.208MetAla: 3.208 ± 0.078
0.201MetCys: 0.201 ± 0.016
1.331MetAsp: 1.331 ± 0.042
1.028MetGlu: 1.028 ± 0.04
0.715MetPhe: 0.715 ± 0.03
2.309MetGly: 2.309 ± 0.06
0.602MetHis: 0.602 ± 0.023
0.983MetIle: 0.983 ± 0.035
1.092MetLys: 1.092 ± 0.039
2.604MetLeu: 2.604 ± 0.076
0.606MetMet: 0.606 ± 0.026
1.041MetAsn: 1.041 ± 0.031
1.505MetPro: 1.505 ± 0.044
1.262MetGln: 1.262 ± 0.043
1.54MetArg: 1.54 ± 0.054
1.746MetSer: 1.746 ± 0.046
1.755MetThr: 1.755 ± 0.045
1.851MetVal: 1.851 ± 0.058
0.224MetTrp: 0.224 ± 0.014
0.381MetTyr: 0.381 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
4.087AsnAla: 4.087 ± 0.134
0.263AsnCys: 0.263 ± 0.015
1.723AsnAsp: 1.723 ± 0.084
1.411AsnGlu: 1.411 ± 0.041
1.239AsnPhe: 1.239 ± 0.058
3.045AsnGly: 3.045 ± 0.166
0.568AsnHis: 0.568 ± 0.024
1.552AsnIle: 1.552 ± 0.046
1.204AsnLys: 1.204 ± 0.042
3.268AsnLeu: 3.268 ± 0.07
0.772AsnMet: 0.772 ± 0.03
1.341AsnAsn: 1.341 ± 0.105
1.997AsnPro: 1.997 ± 0.053
1.173AsnGln: 1.173 ± 0.032
1.587AsnArg: 1.587 ± 0.046
1.726AsnSer: 1.726 ± 0.069
2.31AsnThr: 2.31 ± 0.156
2.465AsnVal: 2.465 ± 0.12
0.492AsnTrp: 0.492 ± 0.02
0.898AsnTyr: 0.898 ± 0.065
0.0AsnXaa: 0.0 ± 0.0
Pro
5.917ProAla: 5.917 ± 0.147
0.357ProCys: 0.357 ± 0.019
2.757ProAsp: 2.757 ± 0.061
3.161ProGlu: 3.161 ± 0.083
1.611ProPhe: 1.611 ± 0.048
4.124ProGly: 4.124 ± 0.069
1.096ProHis: 1.096 ± 0.045
1.834ProIle: 1.834 ± 0.051
1.685ProLys: 1.685 ± 0.047
4.724ProLeu: 4.724 ± 0.11
1.341ProMet: 1.341 ± 0.044
1.392ProAsn: 1.392 ± 0.045
2.059ProPro: 2.059 ± 0.062
2.248ProGln: 2.248 ± 0.05
2.161ProArg: 2.161 ± 0.071
2.789ProSer: 2.789 ± 0.056
3.216ProThr: 3.216 ± 0.201
4.032ProVal: 4.032 ± 0.068
0.746ProTrp: 0.746 ± 0.035
1.086ProTyr: 1.086 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
6.81GlnAla: 6.81 ± 0.129
0.329GlnCys: 0.329 ± 0.018
2.074GlnAsp: 2.074 ± 0.045
1.827GlnGlu: 1.827 ± 0.053
1.37GlnPhe: 1.37 ± 0.038
3.953GlnGly: 3.953 ± 0.064
1.1GlnHis: 1.1 ± 0.043
2.066GlnIle: 2.066 ± 0.051
1.63GlnLys: 1.63 ± 0.052
4.731GlnLeu: 4.731 ± 0.102
1.127GlnMet: 1.127 ± 0.039
1.264GlnAsn: 1.264 ± 0.038
2.127GlnPro: 2.127 ± 0.047
2.215GlnGln: 2.215 ± 0.066
3.087GlnArg: 3.087 ± 0.095
2.721GlnSer: 2.721 ± 0.055
2.72GlnThr: 2.72 ± 0.055
3.673GlnVal: 3.673 ± 0.065
0.817GlnTrp: 0.817 ± 0.033
0.91GlnTyr: 0.91 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
5.362ArgAla: 5.362 ± 0.12
0.517ArgCys: 0.517 ± 0.024
2.835ArgAsp: 2.835 ± 0.072
3.157ArgGlu: 3.157 ± 0.099
2.15ArgPhe: 2.15 ± 0.06
3.39ArgGly: 3.39 ± 0.08
1.447ArgHis: 1.447 ± 0.056
2.96ArgIle: 2.96 ± 0.073
1.983ArgLys: 1.983 ± 0.062
6.315ArgLeu: 6.315 ± 0.155
1.784ArgMet: 1.784 ± 0.06
1.656ArgAsn: 1.656 ± 0.052
2.375ArgPro: 2.375 ± 0.067
3.026ArgGln: 3.026 ± 0.092
3.159ArgArg: 3.159 ± 0.11
2.992ArgSer: 2.992 ± 0.077
2.684ArgThr: 2.684 ± 0.061
4.245ArgVal: 4.245 ± 0.092
1.052ArgTrp: 1.052 ± 0.038
1.534ArgTyr: 1.534 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
7.208SerAla: 7.208 ± 0.228
0.475SerCys: 0.475 ± 0.022
3.27SerAsp: 3.27 ± 0.132
2.756SerGlu: 2.756 ± 0.061
2.243SerPhe: 2.243 ± 0.073
6.232SerGly: 6.232 ± 0.224
1.314SerHis: 1.314 ± 0.041
2.676SerIle: 2.676 ± 0.065
2.095SerLys: 2.095 ± 0.066
6.222SerLeu: 6.222 ± 0.093
1.458SerMet: 1.458 ± 0.042
2.135SerAsn: 2.135 ± 0.128
2.871SerPro: 2.871 ± 0.053
2.573SerGln: 2.573 ± 0.057
3.018SerArg: 3.018 ± 0.081
3.802SerSer: 3.802 ± 0.141
3.942SerThr: 3.942 ± 0.221
4.661SerVal: 4.661 ± 0.115
0.894SerTrp: 0.894 ± 0.035
1.39SerTyr: 1.39 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
7.294ThrAla: 7.294 ± 0.468
0.45ThrCys: 0.45 ± 0.021
3.363ThrAsp: 3.363 ± 0.204
2.549ThrGlu: 2.549 ± 0.05
2.147ThrPhe: 2.147 ± 0.102
5.883ThrGly: 5.883 ± 0.279
1.316ThrHis: 1.316 ± 0.041
2.641ThrIle: 2.641 ± 0.171
1.502ThrLys: 1.502 ± 0.038
7.377ThrLeu: 7.377 ± 0.265
1.054ThrMet: 1.054 ± 0.03
1.773ThrAsn: 1.773 ± 0.127
4.205ThrPro: 4.205 ± 0.225
2.57ThrGln: 2.57 ± 0.058
2.865ThrArg: 2.865 ± 0.069
3.671ThrSer: 3.671 ± 0.174
3.927ThrThr: 3.927 ± 0.258
4.963ThrVal: 4.963 ± 0.227
0.944ThrTrp: 0.944 ± 0.056
1.331ThrTyr: 1.331 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
8.367ValAla: 8.367 ± 0.126
0.775ValCys: 0.775 ± 0.036
4.044ValAsp: 4.044 ± 0.084
3.43ValGlu: 3.43 ± 0.07
2.752ValPhe: 2.752 ± 0.051
5.46ValGly: 5.46 ± 0.082
1.611ValHis: 1.611 ± 0.051
3.707ValIle: 3.707 ± 0.086
3.004ValLys: 3.004 ± 0.063
8.108ValLeu: 8.108 ± 0.105
2.173ValMet: 2.173 ± 0.048
2.635ValAsn: 2.635 ± 0.085
3.647ValPro: 3.647 ± 0.077
3.639ValGln: 3.639 ± 0.077
4.162ValArg: 4.162 ± 0.087
4.837ValSer: 4.837 ± 0.117
4.75ValThr: 4.75 ± 0.205
6.245ValVal: 6.245 ± 0.102
1.008ValTrp: 1.008 ± 0.036
1.616ValTyr: 1.616 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.547TrpAla: 1.547 ± 0.052
0.196TrpCys: 0.196 ± 0.015
0.626TrpAsp: 0.626 ± 0.026
0.422TrpGlu: 0.422 ± 0.02
0.524TrpPhe: 0.524 ± 0.021
1.154TrpGly: 1.154 ± 0.035
0.386TrpHis: 0.386 ± 0.022
0.62TrpIle: 0.62 ± 0.027
0.466TrpLys: 0.466 ± 0.021
2.068TrpLeu: 2.068 ± 0.07
0.477TrpMet: 0.477 ± 0.021
0.422TrpAsn: 0.422 ± 0.022
0.805TrpPro: 0.805 ± 0.036
0.912TrpGln: 0.912 ± 0.033
1.08TrpArg: 1.08 ± 0.043
0.94TrpSer: 0.94 ± 0.037
0.817TrpThr: 0.817 ± 0.04
1.127TrpVal: 1.127 ± 0.035
0.28TrpTrp: 0.28 ± 0.02
0.261TrpTyr: 0.261 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.383TyrAla: 2.383 ± 0.053
0.227TyrCys: 0.227 ± 0.015
1.223TyrAsp: 1.223 ± 0.042
1.138TyrGlu: 1.138 ± 0.047
0.908TyrPhe: 0.908 ± 0.033
1.887TyrGly: 1.887 ± 0.045
0.403TyrHis: 0.403 ± 0.019
0.853TyrIle: 0.853 ± 0.025
0.912TyrLys: 0.912 ± 0.034
2.188TyrLeu: 2.188 ± 0.057
0.474TyrMet: 0.474 ± 0.022
0.746TyrAsn: 0.746 ± 0.032
1.022TyrPro: 1.022 ± 0.034
0.906TyrGln: 0.906 ± 0.031
1.393TyrArg: 1.393 ± 0.05
1.525TyrSer: 1.525 ± 0.093
1.464TyrThr: 1.464 ± 0.059
1.563TyrVal: 1.563 ± 0.039
0.361TyrTrp: 0.361 ± 0.019
0.5TyrTyr: 0.5 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3511 proteins (1236762 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski