Amino acid dipepetide frequency for Apis mellifera associated microvirus 47

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.593AlaAla: 12.593 ± 3.549
0.741AlaCys: 0.741 ± 0.678
4.444AlaAsp: 4.444 ± 1.194
5.926AlaGlu: 5.926 ± 3.323
2.222AlaPhe: 2.222 ± 0.864
8.889AlaGly: 8.889 ± 1.551
2.222AlaHis: 2.222 ± 1.519
4.444AlaIle: 4.444 ± 1.301
4.444AlaLys: 4.444 ± 1.273
9.63AlaLeu: 9.63 ± 3.338
2.963AlaMet: 2.963 ± 1.478
2.963AlaAsn: 2.963 ± 1.577
5.185AlaPro: 5.185 ± 1.94
1.481AlaGln: 1.481 ± 0.739
17.037AlaArg: 17.037 ± 3.324
11.111AlaSer: 11.111 ± 5.07
5.185AlaThr: 5.185 ± 1.574
2.963AlaVal: 2.963 ± 1.285
1.481AlaTrp: 1.481 ± 0.642
2.963AlaTyr: 2.963 ± 1.076
0.0AlaXaa: 0.0 ± 0.0
Cys
2.222CysAla: 2.222 ± 1.519
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
1.481CysHis: 1.481 ± 1.355
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.741CysLeu: 0.741 ± 0.678
0.741CysMet: 0.741 ± 0.546
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
2.963CysArg: 2.963 ± 2.114
0.741CysSer: 0.741 ± 0.678
0.0CysThr: 0.0 ± 0.0
0.741CysVal: 0.741 ± 0.678
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
6.667AspAla: 6.667 ± 2.784
0.0AspCys: 0.0 ± 0.0
2.963AspAsp: 2.963 ± 2.768
1.481AspGlu: 1.481 ± 0.739
2.963AspPhe: 2.963 ± 0.777
1.481AspGly: 1.481 ± 0.895
0.741AspHis: 0.741 ± 0.678
0.0AspIle: 0.0 ± 0.0
0.741AspLys: 0.741 ± 0.741
4.444AspLeu: 4.444 ± 1.637
0.741AspMet: 0.741 ± 0.932
0.741AspAsn: 0.741 ± 0.546
1.481AspPro: 1.481 ± 0.739
3.704AspGln: 3.704 ± 1.603
5.926AspArg: 5.926 ± 0.761
0.741AspSer: 0.741 ± 0.678
5.185AspThr: 5.185 ± 1.714
2.222AspVal: 2.222 ± 0.845
1.481AspTrp: 1.481 ± 1.062
2.222AspTyr: 2.222 ± 1.067
0.0AspXaa: 0.0 ± 0.0
Glu
6.667GluAla: 6.667 ± 1.961
0.0GluCys: 0.0 ± 0.0
3.704GluAsp: 3.704 ± 1.801
1.481GluGlu: 1.481 ± 0.895
2.963GluPhe: 2.963 ± 1.096
4.444GluGly: 4.444 ± 1.707
2.963GluHis: 2.963 ± 0.711
2.222GluIle: 2.222 ± 1.046
0.741GluLys: 0.741 ± 0.546
2.963GluLeu: 2.963 ± 1.838
0.741GluMet: 0.741 ± 0.741
0.0GluAsn: 0.0 ± 0.0
3.704GluPro: 3.704 ± 1.585
1.481GluGln: 1.481 ± 1.092
4.444GluArg: 4.444 ± 2.066
5.926GluSer: 5.926 ± 1.351
0.741GluThr: 0.741 ± 0.932
4.444GluVal: 4.444 ± 1.423
0.741GluTrp: 0.741 ± 0.546
3.704GluTyr: 3.704 ± 1.296
0.0GluXaa: 0.0 ± 0.0
Phe
4.444PheAla: 4.444 ± 1.146
0.741PheCys: 0.741 ± 0.678
1.481PheAsp: 1.481 ± 1.863
2.963PheGlu: 2.963 ± 1.15
2.963PhePhe: 2.963 ± 1.843
5.185PheGly: 5.185 ± 1.278
0.0PheHis: 0.0 ± 0.0
1.481PheIle: 1.481 ± 1.092
0.0PheLys: 0.0 ± 0.0
0.0PheLeu: 0.0 ± 0.0
0.741PheMet: 0.741 ± 0.629
1.481PheAsn: 1.481 ± 0.642
2.963PhePro: 2.963 ± 1.047
0.0PheGln: 0.0 ± 0.0
2.222PheArg: 2.222 ± 1.638
5.926PheSer: 5.926 ± 1.657
1.481PheThr: 1.481 ± 1.092
2.963PheVal: 2.963 ± 0.711
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
8.148GlyAla: 8.148 ± 1.281
0.0GlyCys: 0.0 ± 0.0
3.704GlyAsp: 3.704 ± 0.89
2.963GlyGlu: 2.963 ± 1.843
1.481GlyPhe: 1.481 ± 0.779
11.111GlyGly: 11.111 ± 2.989
1.481GlyHis: 1.481 ± 1.092
4.444GlyIle: 4.444 ± 1.137
4.444GlyLys: 4.444 ± 1.919
6.667GlyLeu: 6.667 ± 2.021
2.222GlyMet: 2.222 ± 0.845
1.481GlyAsn: 1.481 ± 1.21
1.481GlyPro: 1.481 ± 1.062
5.185GlyGln: 5.185 ± 0.925
4.444GlyArg: 4.444 ± 2.441
7.407GlySer: 7.407 ± 2.425
5.926GlyThr: 5.926 ± 2.806
5.926GlyVal: 5.926 ± 1.506
0.741GlyTrp: 0.741 ± 0.858
2.222GlyTyr: 2.222 ± 0.508
0.0GlyXaa: 0.0 ± 0.0
His
1.481HisAla: 1.481 ± 1.031
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
2.222HisGlu: 2.222 ± 0.845
1.481HisPhe: 1.481 ± 0.642
2.963HisGly: 2.963 ± 0.711
1.481HisHis: 1.481 ± 0.642
0.741HisIle: 0.741 ± 0.546
0.741HisLys: 0.741 ± 0.678
1.481HisLeu: 1.481 ± 1.355
0.741HisMet: 0.741 ± 0.546
0.0HisAsn: 0.0 ± 0.0
2.963HisPro: 2.963 ± 1.096
1.481HisGln: 1.481 ± 0.779
2.963HisArg: 2.963 ± 1.283
1.481HisSer: 1.481 ± 0.642
0.0HisThr: 0.0 ± 0.0
0.741HisVal: 0.741 ± 0.546
0.741HisTrp: 0.741 ± 0.546
2.222HisTyr: 2.222 ± 0.864
0.0HisXaa: 0.0 ± 0.0
Ile
1.481IleAla: 1.481 ± 0.642
0.0IleCys: 0.0 ± 0.0
1.481IleAsp: 1.481 ± 0.739
2.963IleGlu: 2.963 ± 1.864
2.222IlePhe: 2.222 ± 0.981
3.704IleGly: 3.704 ± 1.162
1.481IleHis: 1.481 ± 0.642
0.741IleIle: 0.741 ± 0.741
0.0IleLys: 0.0 ± 0.0
0.741IleLeu: 0.741 ± 0.741
0.741IleMet: 0.741 ± 0.546
0.741IleAsn: 0.741 ± 0.678
2.222IlePro: 2.222 ± 1.046
2.222IleGln: 2.222 ± 1.638
2.963IleArg: 2.963 ± 2.619
1.481IleSer: 1.481 ± 1.061
1.481IleThr: 1.481 ± 1.092
2.963IleVal: 2.963 ± 1.15
1.481IleTrp: 1.481 ± 0.642
0.741IleTyr: 0.741 ± 0.546
0.0IleXaa: 0.0 ± 0.0
Lys
5.185LysAla: 5.185 ± 2.232
0.0LysCys: 0.0 ± 0.0
1.481LysAsp: 1.481 ± 0.895
2.963LysGlu: 2.963 ± 0.711
0.741LysPhe: 0.741 ± 0.546
1.481LysGly: 1.481 ± 0.739
0.0LysHis: 0.0 ± 0.0
0.741LysIle: 0.741 ± 0.546
1.481LysLys: 1.481 ± 1.031
2.963LysLeu: 2.963 ± 1.462
0.741LysMet: 0.741 ± 0.648
0.0LysAsn: 0.0 ± 0.0
2.963LysPro: 2.963 ± 1.616
1.481LysGln: 1.481 ± 0.642
3.704LysArg: 3.704 ± 1.104
1.481LysSer: 1.481 ± 0.642
0.741LysThr: 0.741 ± 0.546
0.0LysVal: 0.0 ± 0.0
0.741LysTrp: 0.741 ± 0.741
1.481LysTyr: 1.481 ± 0.739
0.0LysXaa: 0.0 ± 0.0
Leu
8.148LeuAla: 8.148 ± 2.624
0.0LeuCys: 0.0 ± 0.0
2.963LeuAsp: 2.963 ± 1.15
3.704LeuGlu: 3.704 ± 1.262
2.222LeuPhe: 2.222 ± 1.772
6.667LeuGly: 6.667 ± 2.574
0.741LeuHis: 0.741 ± 0.741
0.741LeuIle: 0.741 ± 0.678
2.222LeuLys: 2.222 ± 1.376
2.222LeuLeu: 2.222 ± 0.864
1.481LeuMet: 1.481 ± 0.996
2.222LeuAsn: 2.222 ± 0.981
5.185LeuPro: 5.185 ± 1.699
5.926LeuGln: 5.926 ± 2.94
6.667LeuArg: 6.667 ± 1.446
8.148LeuSer: 8.148 ± 2.175
5.185LeuThr: 5.185 ± 3.107
6.667LeuVal: 6.667 ± 1.744
1.481LeuTrp: 1.481 ± 0.739
0.741LeuTyr: 0.741 ± 0.546
0.0LeuXaa: 0.0 ± 0.0
Met
2.222MetAla: 2.222 ± 0.981
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.741MetGlu: 0.741 ± 0.932
0.741MetPhe: 0.741 ± 0.932
0.741MetGly: 0.741 ± 0.546
2.222MetHis: 2.222 ± 1.067
0.0MetIle: 0.0 ± 0.0
0.741MetLys: 0.741 ± 0.546
4.444MetLeu: 4.444 ± 1.088
0.741MetMet: 0.741 ± 0.546
0.741MetAsn: 0.741 ± 0.741
0.741MetPro: 0.741 ± 0.741
2.222MetGln: 2.222 ± 0.845
1.481MetArg: 1.481 ± 1.092
3.704MetSer: 3.704 ± 0.641
1.481MetThr: 1.481 ± 1.092
0.741MetVal: 0.741 ± 0.546
0.0MetTrp: 0.0 ± 0.0
0.741MetTyr: 0.741 ± 0.546
0.0MetXaa: 0.0 ± 0.0
Asn
2.963AsnAla: 2.963 ± 1.557
0.0AsnCys: 0.0 ± 0.0
1.481AsnAsp: 1.481 ± 0.895
2.222AsnGlu: 2.222 ± 0.845
0.741AsnPhe: 0.741 ± 0.741
0.741AsnGly: 0.741 ± 0.546
0.0AsnHis: 0.0 ± 0.0
0.741AsnIle: 0.741 ± 0.741
0.741AsnLys: 0.741 ± 0.546
2.222AsnLeu: 2.222 ± 0.508
0.0AsnMet: 0.0 ± 0.0
0.0AsnAsn: 0.0 ± 0.0
2.222AsnPro: 2.222 ± 1.154
0.741AsnGln: 0.741 ± 0.546
2.222AsnArg: 2.222 ± 1.179
1.481AsnSer: 1.481 ± 0.739
1.481AsnThr: 1.481 ± 0.642
0.0AsnVal: 0.0 ± 0.0
0.0AsnTrp: 0.0 ± 0.0
1.481AsnTyr: 1.481 ± 0.739
0.0AsnXaa: 0.0 ± 0.0
Pro
5.185ProAla: 5.185 ± 1.345
1.481ProCys: 1.481 ± 1.355
4.444ProAsp: 4.444 ± 2.368
2.222ProGlu: 2.222 ± 0.845
0.741ProPhe: 0.741 ± 0.546
8.148ProGly: 8.148 ± 3.1
2.222ProHis: 2.222 ± 1.517
3.704ProIle: 3.704 ± 1.213
0.0ProLys: 0.0 ± 0.0
2.963ProLeu: 2.963 ± 0.711
0.0ProMet: 0.0 ± 0.0
0.741ProAsn: 0.741 ± 0.741
5.185ProPro: 5.185 ± 2.579
0.741ProGln: 0.741 ± 0.546
4.444ProArg: 4.444 ± 2.012
6.667ProSer: 6.667 ± 3.426
4.444ProThr: 4.444 ± 2.134
5.926ProVal: 5.926 ± 1.497
1.481ProTrp: 1.481 ± 0.739
2.963ProTyr: 2.963 ± 1.616
0.0ProXaa: 0.0 ± 0.0
Gln
7.407GlnAla: 7.407 ± 1.912
1.481GlnCys: 1.481 ± 1.355
1.481GlnAsp: 1.481 ± 1.092
3.704GlnGlu: 3.704 ± 1.753
2.222GlnPhe: 2.222 ± 1.046
2.963GlnGly: 2.963 ± 1.577
0.741GlnHis: 0.741 ± 0.546
1.481GlnIle: 1.481 ± 1.092
2.222GlnLys: 2.222 ± 1.179
1.481GlnLeu: 1.481 ± 0.642
2.222GlnMet: 2.222 ± 1.576
0.0GlnAsn: 0.0 ± 0.0
2.963GlnPro: 2.963 ± 1.076
0.741GlnGln: 0.741 ± 0.546
5.926GlnArg: 5.926 ± 1.704
0.741GlnSer: 0.741 ± 0.678
2.963GlnThr: 2.963 ± 1.616
3.704GlnVal: 3.704 ± 0.698
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
8.889ArgAla: 8.889 ± 1.816
2.222ArgCys: 2.222 ± 2.033
5.185ArgAsp: 5.185 ± 1.278
6.667ArgGlu: 6.667 ± 3.119
3.704ArgPhe: 3.704 ± 1.566
2.963ArgGly: 2.963 ± 0.777
2.222ArgHis: 2.222 ± 0.864
3.704ArgIle: 3.704 ± 1.861
3.704ArgLys: 3.704 ± 1.974
6.667ArgLeu: 6.667 ± 1.75
2.222ArgMet: 2.222 ± 0.945
2.222ArgAsn: 2.222 ± 0.845
4.444ArgPro: 4.444 ± 1.87
4.444ArgGln: 4.444 ± 1.755
8.889ArgArg: 8.889 ± 3.423
8.889ArgSer: 8.889 ± 5.454
3.704ArgThr: 3.704 ± 1.805
5.185ArgVal: 5.185 ± 0.673
0.0ArgTrp: 0.0 ± 0.0
4.444ArgTyr: 4.444 ± 2.134
0.0ArgXaa: 0.0 ± 0.0
Ser
6.667SerAla: 6.667 ± 1.75
1.481SerCys: 1.481 ± 1.031
5.926SerAsp: 5.926 ± 1.664
5.185SerGlu: 5.185 ± 1.444
3.704SerPhe: 3.704 ± 0.641
5.185SerGly: 5.185 ± 1.733
2.222SerHis: 2.222 ± 0.864
1.481SerIle: 1.481 ± 0.895
2.963SerLys: 2.963 ± 1.368
9.63SerLeu: 9.63 ± 1.984
1.481SerMet: 1.481 ± 1.031
1.481SerAsn: 1.481 ± 0.875
8.148SerPro: 8.148 ± 2.391
5.185SerGln: 5.185 ± 1.91
4.444SerArg: 4.444 ± 1.649
5.926SerSer: 5.926 ± 1.896
9.63SerThr: 9.63 ± 3.532
7.407SerVal: 7.407 ± 2.915
1.481SerTrp: 1.481 ± 1.092
0.741SerTyr: 0.741 ± 0.678
0.0SerXaa: 0.0 ± 0.0
Thr
5.185ThrAla: 5.185 ± 1.109
0.0ThrCys: 0.0 ± 0.0
2.222ThrAsp: 2.222 ± 0.508
2.222ThrGlu: 2.222 ± 1.174
1.481ThrPhe: 1.481 ± 0.895
8.889ThrGly: 8.889 ± 2.5
0.741ThrHis: 0.741 ± 0.741
2.963ThrIle: 2.963 ± 1.285
2.222ThrLys: 2.222 ± 0.508
8.148ThrLeu: 8.148 ± 1.579
0.741ThrMet: 0.741 ± 0.546
3.704ThrAsn: 3.704 ± 1.162
2.963ThrPro: 2.963 ± 0.777
0.741ThrGln: 0.741 ± 0.741
2.222ThrArg: 2.222 ± 1.645
7.407ThrSer: 7.407 ± 2.359
4.444ThrThr: 4.444 ± 3.277
1.481ThrVal: 1.481 ± 1.031
0.741ThrTrp: 0.741 ± 0.741
2.222ThrTyr: 2.222 ± 0.508
0.0ThrXaa: 0.0 ± 0.0
Val
9.63ValAla: 9.63 ± 2.114
0.741ValCys: 0.741 ± 0.858
2.222ValAsp: 2.222 ± 0.508
1.481ValGlu: 1.481 ± 1.21
2.222ValPhe: 2.222 ± 1.202
3.704ValGly: 3.704 ± 0.89
1.481ValHis: 1.481 ± 0.642
1.481ValIle: 1.481 ± 1.061
2.222ValLys: 2.222 ± 1.638
2.963ValLeu: 2.963 ± 1.085
2.222ValMet: 2.222 ± 0.981
0.741ValAsn: 0.741 ± 0.546
4.444ValPro: 4.444 ± 1.962
2.222ValGln: 2.222 ± 1.154
5.185ValArg: 5.185 ± 1.642
6.667ValSer: 6.667 ± 1.52
4.444ValThr: 4.444 ± 1.7
1.481ValVal: 1.481 ± 1.355
0.0ValTrp: 0.0 ± 0.0
2.963ValTyr: 2.963 ± 1.085
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
2.222TrpGlu: 2.222 ± 1.638
1.481TrpPhe: 1.481 ± 1.092
0.741TrpGly: 0.741 ± 0.741
0.741TrpHis: 0.741 ± 0.546
0.0TrpIle: 0.0 ± 0.0
0.741TrpLys: 0.741 ± 0.741
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
1.481TrpPro: 1.481 ± 1.062
1.481TrpGln: 1.481 ± 0.739
0.0TrpArg: 0.0 ± 0.0
2.222TrpSer: 2.222 ± 1.025
0.741TrpThr: 0.741 ± 0.546
1.481TrpVal: 1.481 ± 0.642
0.0TrpTrp: 0.0 ± 0.0
0.741TrpTyr: 0.741 ± 0.546
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.704TyrAla: 3.704 ± 1.072
0.741TyrCys: 0.741 ± 0.546
0.741TyrAsp: 0.741 ± 0.546
0.741TyrGlu: 0.741 ± 0.678
0.741TyrPhe: 0.741 ± 0.546
1.481TyrGly: 1.481 ± 0.779
0.741TyrHis: 0.741 ± 0.678
0.741TyrIle: 0.741 ± 0.932
0.0TyrLys: 0.0 ± 0.0
3.704TyrLeu: 3.704 ± 1.162
2.222TyrMet: 2.222 ± 1.638
2.222TyrAsn: 2.222 ± 1.067
2.963TyrPro: 2.963 ± 1.429
2.963TyrGln: 2.963 ± 1.085
2.222TyrArg: 2.222 ± 1.638
2.222TyrSer: 2.222 ± 2.009
1.481TyrThr: 1.481 ± 1.092
1.481TyrVal: 1.481 ± 0.642
1.481TyrTrp: 1.481 ± 1.092
0.741TyrTyr: 0.741 ± 0.741
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1351 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski