Amino acid dipepetide frequency for Mycobacterium leprae (strain TN)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.136AlaAla: 16.136 ± 0.256	1.084AlaCys: 1.084 ± 0.049	6.973AlaAsp: 6.973 ± 0.114	6.756AlaGlu: 6.756 ± 0.122	3.152AlaPhe: 3.152 ± 0.081	10.271AlaGly: 10.271 ± 0.145	2.193AlaHis: 2.193 ± 0.064	5.689AlaIle: 5.689 ± 0.106	3.557AlaLys: 3.557 ± 0.101	11.81AlaLeu: 11.81 ± 0.165	2.772AlaMet: 2.772 ± 0.075	2.92AlaAsn: 2.92 ± 0.076	4.926AlaPro: 4.926 ± 0.114	3.917AlaGln: 3.917 ± 0.087	7.46AlaArg: 7.46 ± 0.136	6.166AlaSer: 6.166 ± 0.108	6.888AlaThr: 6.888 ± 0.128	10.842AlaVal: 10.842 ± 0.152	1.433AlaTrp: 1.433 ± 0.055	2.332AlaTyr: 2.332 ± 0.071	0.0AlaXaa: 0.0 ± 0.0
Cys	1.129CysAla: 1.129 ± 0.05	0.141CysCys: 0.141 ± 0.017	0.587CysAsp: 0.587 ± 0.032	0.455CysGlu: 0.455 ± 0.028	0.252CysPhe: 0.252 ± 0.021	1.066CysGly: 1.066 ± 0.039	0.21CysHis: 0.21 ± 0.018	0.369CysIle: 0.369 ± 0.027	0.197CysLys: 0.197 ± 0.019	0.724CysLeu: 0.724 ± 0.037	0.165CysMet: 0.165 ± 0.016	0.267CysAsn: 0.267 ± 0.022	0.49CysPro: 0.49 ± 0.031	0.319CysGln: 0.319 ± 0.025	0.743CysArg: 0.743 ± 0.033	0.654CysSer: 0.654 ± 0.032	0.579CysThr: 0.579 ± 0.031	0.741CysVal: 0.741 ± 0.036	0.202CysTrp: 0.202 ± 0.017	0.236CysTyr: 0.236 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	6.548AspAla: 6.548 ± 0.127	0.518AspCys: 0.518 ± 0.032	3.641AspAsp: 3.641 ± 0.091	3.663AspGlu: 3.663 ± 0.088	1.671AspPhe: 1.671 ± 0.059	5.08AspGly: 5.08 ± 0.102	1.327AspHis: 1.327 ± 0.049	3.06AspIle: 3.06 ± 0.075	1.539AspLys: 1.539 ± 0.054	5.846AspLeu: 5.846 ± 0.115	1.047AspMet: 1.047 ± 0.042	1.474AspAsn: 1.474 ± 0.054	3.784AspPro: 3.784 ± 0.088	1.806AspGln: 1.806 ± 0.064	3.964AspArg: 3.964 ± 0.079	3.101AspSer: 3.101 ± 0.069	3.258AspThr: 3.258 ± 0.079	5.373AspVal: 5.373 ± 0.105	0.813AspTrp: 0.813 ± 0.041	1.444AspTyr: 1.444 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	5.553GluAla: 5.553 ± 0.13	0.451GluCys: 0.451 ± 0.028	2.224GluAsp: 2.224 ± 0.069	2.428GluGlu: 2.428 ± 0.081	1.855GluPhe: 1.855 ± 0.056	3.191GluGly: 3.191 ± 0.078	1.48GluHis: 1.48 ± 0.05	2.809GluIle: 2.809 ± 0.087	1.459GluLys: 1.459 ± 0.063	6.591GluLeu: 6.591 ± 0.134	0.991GluMet: 0.991 ± 0.043	1.183GluAsn: 1.183 ± 0.043	2.635GluPro: 2.635 ± 0.074	2.282GluGln: 2.282 ± 0.071	3.741GluArg: 3.741 ± 0.09	2.842GluSer: 2.842 ± 0.069	2.59GluThr: 2.59 ± 0.057	4.801GluVal: 4.801 ± 0.101	0.585GluTrp: 0.585 ± 0.034	1.142GluTyr: 1.142 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.57PheAla: 3.57 ± 0.086	0.36PheCys: 0.36 ± 0.025	2.334PheAsp: 2.334 ± 0.068	1.532PheGlu: 1.532 ± 0.045	1.004PhePhe: 1.004 ± 0.046	3.266PheGly: 3.266 ± 0.086	0.587PheHis: 0.587 ± 0.031	1.294PheIle: 1.294 ± 0.054	0.652PheLys: 0.652 ± 0.033	2.412PheLeu: 2.412 ± 0.072	0.49PheMet: 0.49 ± 0.034	0.826PheAsn: 0.826 ± 0.041	1.426PhePro: 1.426 ± 0.052	0.7PheGln: 0.7 ± 0.039	1.53PheArg: 1.53 ± 0.047	1.959PheSer: 1.959 ± 0.056	2.074PheThr: 2.074 ± 0.063	2.649PheVal: 2.649 ± 0.073	0.399PheTrp: 0.399 ± 0.027	0.72PheTyr: 0.72 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	8.577GlyAla: 8.577 ± 0.132	0.917GlyCys: 0.917 ± 0.043	4.541GlyAsp: 4.541 ± 0.088	4.094GlyGlu: 4.094 ± 0.09	2.753GlyPhe: 2.753 ± 0.065	6.816GlyGly: 6.816 ± 0.144	2.033GlyHis: 2.033 ± 0.06	4.409GlyIle: 4.409 ± 0.087	2.848GlyLys: 2.848 ± 0.074	8.305GlyLeu: 8.305 ± 0.139	2.156GlyMet: 2.156 ± 0.065	2.23GlyAsn: 2.23 ± 0.062	4.083GlyPro: 4.083 ± 0.084	2.935GlyGln: 2.935 ± 0.073	5.817GlyArg: 5.817 ± 0.12	5.349GlySer: 5.349 ± 0.102	4.927GlyThr: 4.927 ± 0.099	7.803GlyVal: 7.803 ± 0.131	1.35GlyTrp: 1.35 ± 0.052	2.356GlyTyr: 2.356 ± 0.073	0.0GlyXaa: 0.0 ± 0.0
His	2.3HisAla: 2.3 ± 0.077	0.24HisCys: 0.24 ± 0.02	1.359HisAsp: 1.359 ± 0.052	1.062HisGlu: 1.062 ± 0.051	0.626HisPhe: 0.626 ± 0.04	2.003HisGly: 2.003 ± 0.067	0.624HisHis: 0.624 ± 0.041	0.951HisIle: 0.951 ± 0.042	0.514HisLys: 0.514 ± 0.033	1.981HisLeu: 1.981 ± 0.059	0.399HisMet: 0.399 ± 0.024	0.709HisAsn: 0.709 ± 0.034	1.612HisPro: 1.612 ± 0.048	0.796HisGln: 0.796 ± 0.04	1.773HisArg: 1.773 ± 0.061	1.283HisSer: 1.283 ± 0.049	1.381HisThr: 1.381 ± 0.051	1.717HisVal: 1.717 ± 0.061	0.355HisTrp: 0.355 ± 0.022	0.589HisTyr: 0.589 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	6.437IleAla: 6.437 ± 0.122	0.518IleCys: 0.518 ± 0.032	3.849IleAsp: 3.849 ± 0.079	2.893IleGlu: 2.893 ± 0.083	1.21IlePhe: 1.21 ± 0.053	4.764IleGly: 4.764 ± 0.099	0.86IleHis: 0.86 ± 0.043	1.961IleIle: 1.961 ± 0.067	1.326IleLys: 1.326 ± 0.052	3.529IleLeu: 3.529 ± 0.081	0.817IleMet: 0.817 ± 0.043	1.53IleAsn: 1.53 ± 0.048	2.57IlePro: 2.57 ± 0.073	1.168IleGln: 1.168 ± 0.044	2.982IleArg: 2.982 ± 0.08	2.854IleSer: 2.854 ± 0.074	3.368IleThr: 3.368 ± 0.084	4.287IleVal: 4.287 ± 0.111	0.498IleTrp: 0.498 ± 0.034	0.984IleTyr: 0.984 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	2.989LysAla: 2.989 ± 0.098	0.182LysCys: 0.182 ± 0.021	1.337LysAsp: 1.337 ± 0.05	1.229LysGlu: 1.229 ± 0.052	0.75LysPhe: 0.75 ± 0.038	1.79LysGly: 1.79 ± 0.069	0.594LysHis: 0.594 ± 0.034	1.478LysIle: 1.478 ± 0.056	0.925LysLys: 0.925 ± 0.06	2.77LysLeu: 2.77 ± 0.072	0.613LysMet: 0.613 ± 0.035	0.769LysAsn: 0.769 ± 0.039	1.593LysPro: 1.593 ± 0.056	1.04LysGln: 1.04 ± 0.048	1.912LysArg: 1.912 ± 0.06	1.673LysSer: 1.673 ± 0.056	1.745LysThr: 1.745 ± 0.061	2.434LysVal: 2.434 ± 0.069	0.356LysTrp: 0.356 ± 0.026	0.59LysTyr: 0.59 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	13.343LeuAla: 13.343 ± 0.185	0.958LeuCys: 0.958 ± 0.046	6.155LeuAsp: 6.155 ± 0.108	4.484LeuGlu: 4.484 ± 0.128	2.746LeuPhe: 2.746 ± 0.09	8.364LeuGly: 8.364 ± 0.137	2.172LeuHis: 2.172 ± 0.067	4.617LeuIle: 4.617 ± 0.098	2.172LeuLys: 2.172 ± 0.068	10.115LeuLeu: 10.115 ± 0.161	1.985LeuMet: 1.985 ± 0.072	2.395LeuAsn: 2.395 ± 0.063	5.633LeuPro: 5.633 ± 0.121	3.019LeuGln: 3.019 ± 0.085	7.452LeuArg: 7.452 ± 0.127	6.013LeuSer: 6.013 ± 0.101	6.518LeuThr: 6.518 ± 0.097	9.198LeuVal: 9.198 ± 0.145	1.177LeuTrp: 1.177 ± 0.06	1.758LeuTyr: 1.758 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.642MetAla: 2.642 ± 0.06	0.169MetCys: 0.169 ± 0.019	0.902MetAsp: 0.902 ± 0.041	0.763MetGlu: 0.763 ± 0.042	0.667MetPhe: 0.667 ± 0.035	1.526MetGly: 1.526 ± 0.058	0.425MetHis: 0.425 ± 0.025	0.969MetIle: 0.969 ± 0.046	0.49MetLys: 0.49 ± 0.03	2.397MetLeu: 2.397 ± 0.074	0.464MetMet: 0.464 ± 0.029	0.538MetAsn: 0.538 ± 0.033	1.255MetPro: 1.255 ± 0.053	0.587MetGln: 0.587 ± 0.03	1.591MetArg: 1.591 ± 0.048	1.634MetSer: 1.634 ± 0.056	1.641MetThr: 1.641 ± 0.057	1.81MetVal: 1.81 ± 0.063	0.262MetTrp: 0.262 ± 0.027	0.336MetTyr: 0.336 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.898AsnAla: 2.898 ± 0.076	0.24AsnCys: 0.24 ± 0.021	1.448AsnAsp: 1.448 ± 0.054	1.205AsnGlu: 1.205 ± 0.054	0.835AsnPhe: 0.835 ± 0.04	2.295AsnGly: 2.295 ± 0.071	0.566AsnHis: 0.566 ± 0.033	1.313AsnIle: 1.313 ± 0.05	0.744AsnLys: 0.744 ± 0.037	2.555AsnLeu: 2.555 ± 0.073	0.483AsnMet: 0.483 ± 0.032	0.867AsnAsn: 0.867 ± 0.047	1.847AsnPro: 1.847 ± 0.058	0.891AsnGln: 0.891 ± 0.043	1.894AsnArg: 1.894 ± 0.061	1.619AsnSer: 1.619 ± 0.052	1.578AsnThr: 1.578 ± 0.056	2.12AsnVal: 2.12 ± 0.069	0.468AsnTrp: 0.468 ± 0.03	0.681AsnTyr: 0.681 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	5.835ProAla: 5.835 ± 0.119	0.423ProCys: 0.423 ± 0.028	3.802ProAsp: 3.802 ± 0.084	3.125ProGlu: 3.125 ± 0.094	1.456ProPhe: 1.456 ± 0.053	5.083ProGly: 5.083 ± 0.125	1.238ProHis: 1.238 ± 0.05	2.323ProIle: 2.323 ± 0.06	1.435ProLys: 1.435 ± 0.058	4.597ProLeu: 4.597 ± 0.091	1.101ProMet: 1.101 ± 0.048	1.513ProAsn: 1.513 ± 0.059	3.069ProPro: 3.069 ± 0.103	1.814ProGln: 1.814 ± 0.06	3.151ProArg: 3.151 ± 0.081	3.292ProSer: 3.292 ± 0.08	3.44ProThr: 3.44 ± 0.088	5.013ProVal: 5.013 ± 0.112	0.808ProTrp: 0.808 ± 0.041	1.242ProTyr: 1.242 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	3.717GlnAla: 3.717 ± 0.093	0.271GlnCys: 0.271 ± 0.022	1.277GlnAsp: 1.277 ± 0.047	1.159GlnGlu: 1.159 ± 0.047	1.077GlnPhe: 1.077 ± 0.047	2.078GlnGly: 2.078 ± 0.074	0.882GlnHis: 0.882 ± 0.038	1.816GlnIle: 1.816 ± 0.055	0.772GlnLys: 0.772 ± 0.04	4.138GlnLeu: 4.138 ± 0.095	0.724GlnMet: 0.724 ± 0.039	0.728GlnAsn: 0.728 ± 0.034	1.957GlnPro: 1.957 ± 0.065	1.563GlnGln: 1.563 ± 0.059	2.839GlnArg: 2.839 ± 0.087	1.767GlnSer: 1.767 ± 0.059	1.723GlnThr: 1.723 ± 0.061	3.06GlnVal: 3.06 ± 0.073	0.52GlnTrp: 0.52 ± 0.035	0.694GlnTyr: 0.694 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	6.968ArgAla: 6.968 ± 0.117	0.722ArgCys: 0.722 ± 0.039	3.771ArgAsp: 3.771 ± 0.095	3.32ArgGlu: 3.32 ± 0.079	2.43ArgPhe: 2.43 ± 0.068	4.97ArgGly: 4.97 ± 0.099	1.728ArgHis: 1.728 ± 0.05	3.654ArgIle: 3.654 ± 0.089	1.957ArgLys: 1.957 ± 0.07	7.486ArgLeu: 7.486 ± 0.144	1.732ArgMet: 1.732 ± 0.061	1.914ArgAsn: 1.914 ± 0.06	3.516ArgPro: 3.516 ± 0.087	2.391ArgGln: 2.391 ± 0.073	6.088ArgArg: 6.088 ± 0.14	4.369ArgSer: 4.369 ± 0.095	3.865ArgThr: 3.865 ± 0.089	5.52ArgVal: 5.52 ± 0.111	1.216ArgTrp: 1.216 ± 0.051	1.944ArgTyr: 1.944 ± 0.064	0.0ArgXaa: 0.0 ± 0.0
Ser	6.78SerAla: 6.78 ± 0.116	0.566SerCys: 0.566 ± 0.029	3.308SerAsp: 3.308 ± 0.091	2.945SerGlu: 2.945 ± 0.076	1.71SerPhe: 1.71 ± 0.067	5.932SerGly: 5.932 ± 0.105	1.249SerHis: 1.249 ± 0.047	2.727SerIle: 2.727 ± 0.079	1.639SerLys: 1.639 ± 0.054	5.451SerLeu: 5.451 ± 0.104	1.482SerMet: 1.482 ± 0.058	1.532SerAsn: 1.532 ± 0.056	3.139SerPro: 3.139 ± 0.083	1.797SerGln: 1.797 ± 0.056	4.125SerArg: 4.125 ± 0.087	3.849SerSer: 3.849 ± 0.091	3.839SerThr: 3.839 ± 0.091	5.18SerVal: 5.18 ± 0.108	0.936SerTrp: 0.936 ± 0.042	1.478SerTyr: 1.478 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	7.2ThrAla: 7.2 ± 0.114	0.477ThrCys: 0.477 ± 0.024	3.546ThrAsp: 3.546 ± 0.073	3.245ThrGlu: 3.245 ± 0.08	1.758ThrPhe: 1.758 ± 0.06	5.702ThrGly: 5.702 ± 0.102	1.309ThrHis: 1.309 ± 0.05	2.839ThrIle: 2.839 ± 0.082	1.625ThrLys: 1.625 ± 0.05	5.804ThrLeu: 5.804 ± 0.102	1.307ThrMet: 1.307 ± 0.046	1.701ThrAsn: 1.701 ± 0.07	3.596ThrPro: 3.596 ± 0.092	1.825ThrGln: 1.825 ± 0.062	3.6ThrArg: 3.6 ± 0.09	3.529ThrSer: 3.529 ± 0.089	3.849ThrThr: 3.849 ± 0.092	6.006ThrVal: 6.006 ± 0.108	0.743ThrTrp: 0.743 ± 0.035	1.363ThrTyr: 1.363 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	11.019ValAla: 11.019 ± 0.144	0.867ValCys: 0.867 ± 0.038	5.878ValAsp: 5.878 ± 0.101	4.768ValGlu: 4.768 ± 0.115	2.627ValPhe: 2.627 ± 0.065	7.105ValGly: 7.105 ± 0.122	1.977ValHis: 1.977 ± 0.058	4.619ValIle: 4.619 ± 0.099	2.172ValLys: 2.172 ± 0.072	9.493ValLeu: 9.493 ± 0.156	1.714ValMet: 1.714 ± 0.059	2.475ValAsn: 2.475 ± 0.073	4.641ValPro: 4.641 ± 0.091	2.402ValGln: 2.402 ± 0.067	6.0ValArg: 6.0 ± 0.095	5.434ValSer: 5.434 ± 0.1	5.612ValThr: 5.612 ± 0.104	9.478ValVal: 9.478 ± 0.168	1.008ValTrp: 1.008 ± 0.042	1.695ValTyr: 1.695 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	1.301TrpAla: 1.301 ± 0.055	0.156TrpCys: 0.156 ± 0.016	0.683TrpAsp: 0.683 ± 0.038	0.603TrpGlu: 0.603 ± 0.037	0.427TrpPhe: 0.427 ± 0.032	0.882TrpGly: 0.882 ± 0.046	0.347TrpHis: 0.347 ± 0.025	0.696TrpIle: 0.696 ± 0.032	0.278TrpLys: 0.278 ± 0.023	1.723TrpLeu: 1.723 ± 0.055	0.329TrpMet: 0.329 ± 0.027	0.362TrpAsn: 0.362 ± 0.03	0.724TrpPro: 0.724 ± 0.037	0.605TrpGln: 0.605 ± 0.031	1.123TrpArg: 1.123 ± 0.046	0.943TrpSer: 0.943 ± 0.043	0.8TrpThr: 0.8 ± 0.039	1.153TrpVal: 1.153 ± 0.045	0.355TrpTrp: 0.355 ± 0.029	0.334TrpTyr: 0.334 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.334TyrAla: 2.334 ± 0.071	0.265TyrCys: 0.265 ± 0.025	1.342TyrAsp: 1.342 ± 0.052	1.107TyrGlu: 1.107 ± 0.047	0.776TyrPhe: 0.776 ± 0.037	2.117TyrGly: 2.117 ± 0.066	0.472TyrHis: 0.472 ± 0.025	0.809TyrIle: 0.809 ± 0.043	0.466TyrLys: 0.466 ± 0.029	2.549TyrLeu: 2.549 ± 0.074	0.297TyrMet: 0.297 ± 0.022	0.615TyrAsn: 0.615 ± 0.033	1.264TyrPro: 1.264 ± 0.044	0.904TyrGln: 0.904 ± 0.046	1.777TyrArg: 1.777 ± 0.053	1.337TyrSer: 1.337 ± 0.055	1.344TyrThr: 1.344 ± 0.054	1.801TyrVal: 1.801 ± 0.059	0.343TyrTrp: 0.343 ± 0.022	0.49TyrTyr: 0.49 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1603 proteins (538623 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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