Amino acid dipepetide frequency for Feline coronavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.633AlaAla: 4.633 ± 0.684
2.5AlaCys: 2.5 ± 0.509
2.5AlaAsp: 2.5 ± 0.428
2.721AlaGlu: 2.721 ± 0.302
3.898AlaPhe: 3.898 ± 0.504
3.603AlaGly: 3.603 ± 0.418
1.03AlaHis: 1.03 ± 0.15
5.221AlaIle: 5.221 ± 0.719
4.486AlaLys: 4.486 ± 0.8
5.148AlaLeu: 5.148 ± 0.72
1.691AlaMet: 1.691 ± 0.351
3.383AlaAsn: 3.383 ± 0.426
1.691AlaPro: 1.691 ± 0.151
1.03AlaGln: 1.03 ± 0.354
2.574AlaArg: 2.574 ± 0.48
4.265AlaSer: 4.265 ± 0.339
3.309AlaThr: 3.309 ± 0.285
5.221AlaVal: 5.221 ± 1.068
0.662AlaTrp: 0.662 ± 0.111
4.045AlaTyr: 4.045 ± 0.587
0.0AlaXaa: 0.0 ± 0.0
Cys
1.618CysAla: 1.618 ± 0.206
0.956CysCys: 0.956 ± 0.249
2.206CysAsp: 2.206 ± 0.502
0.735CysGlu: 0.735 ± 0.258
1.471CysPhe: 1.471 ± 0.304
2.647CysGly: 2.647 ± 0.418
0.588CysHis: 0.588 ± 0.322
1.691CysIle: 1.691 ± 0.295
1.544CysLys: 1.544 ± 0.376
2.059CysLeu: 2.059 ± 0.25
0.662CysMet: 0.662 ± 0.199
1.765CysAsn: 1.765 ± 0.33
1.25CysPro: 1.25 ± 0.139
0.662CysGln: 0.662 ± 0.182
0.588CysArg: 0.588 ± 0.191
1.691CysSer: 1.691 ± 0.275
2.28CysThr: 2.28 ± 0.577
3.089CysVal: 3.089 ± 0.161
0.515CysTrp: 0.515 ± 0.164
2.28CysTyr: 2.28 ± 0.602
0.0CysXaa: 0.0 ± 0.0
Asp
4.192AspAla: 4.192 ± 0.677
1.691AspCys: 1.691 ± 0.387
3.456AspAsp: 3.456 ± 0.3
2.206AspGlu: 2.206 ± 0.38
3.383AspPhe: 3.383 ± 0.494
4.486AspGly: 4.486 ± 0.483
1.324AspHis: 1.324 ± 0.286
2.353AspIle: 2.353 ± 0.501
2.795AspLys: 2.795 ± 0.594
5.516AspLeu: 5.516 ± 0.691
1.471AspMet: 1.471 ± 0.26
2.942AspAsn: 2.942 ± 0.356
1.544AspPro: 1.544 ± 0.378
1.103AspGln: 1.103 ± 0.254
1.839AspArg: 1.839 ± 0.187
3.824AspSer: 3.824 ± 0.529
2.795AspThr: 2.795 ± 0.526
5.442AspVal: 5.442 ± 0.507
0.956AspTrp: 0.956 ± 0.216
3.53AspTyr: 3.53 ± 0.535
0.0AspXaa: 0.0 ± 0.0
Glu
2.5GluAla: 2.5 ± 0.243
1.618GluCys: 1.618 ± 0.319
3.089GluAsp: 3.089 ± 0.65
2.647GluGlu: 2.647 ± 0.51
2.942GluPhe: 2.942 ± 0.517
3.015GluGly: 3.015 ± 0.747
1.397GluHis: 1.397 ± 0.196
2.206GluIle: 2.206 ± 0.698
2.942GluLys: 2.942 ± 0.293
3.751GluLeu: 3.751 ± 0.356
0.515GluMet: 0.515 ± 0.176
2.647GluAsn: 2.647 ± 0.442
1.839GluPro: 1.839 ± 0.334
2.206GluGln: 2.206 ± 0.278
1.839GluArg: 1.839 ± 0.356
2.721GluSer: 2.721 ± 0.435
1.691GluThr: 1.691 ± 0.157
3.824GluVal: 3.824 ± 0.767
0.368GluTrp: 0.368 ± 0.172
1.544GluTyr: 1.544 ± 0.246
0.0GluXaa: 0.0 ± 0.0
Phe
2.647PheAla: 2.647 ± 0.552
1.765PheCys: 1.765 ± 0.32
3.677PheAsp: 3.677 ± 0.476
3.236PheGlu: 3.236 ± 0.237
2.647PhePhe: 2.647 ± 0.545
3.309PheGly: 3.309 ± 0.188
0.294PheHis: 0.294 ± 0.354
3.309PheIle: 3.309 ± 0.804
4.559PheLys: 4.559 ± 0.942
3.898PheLeu: 3.898 ± 0.466
1.397PheMet: 1.397 ± 0.363
3.898PheAsn: 3.898 ± 0.679
0.294PhePro: 0.294 ± 0.165
0.882PheGln: 0.882 ± 0.75
0.809PheArg: 0.809 ± 0.225
4.192PheSer: 4.192 ± 1.267
3.309PheThr: 3.309 ± 0.506
7.133PheVal: 7.133 ± 0.96
1.03PheTrp: 1.03 ± 0.353
3.309PheTyr: 3.309 ± 0.381
0.0PheXaa: 0.0 ± 0.0
Gly
4.045GlyAla: 4.045 ± 0.579
1.691GlyCys: 1.691 ± 0.312
5.074GlyAsp: 5.074 ± 0.839
3.603GlyGlu: 3.603 ± 0.523
4.854GlyPhe: 4.854 ± 0.342
3.603GlyGly: 3.603 ± 0.394
0.588GlyHis: 0.588 ± 0.176
2.868GlyIle: 2.868 ± 0.611
4.339GlyLys: 4.339 ± 0.54
4.559GlyLeu: 4.559 ± 0.443
1.471GlyMet: 1.471 ± 0.25
3.236GlyAsn: 3.236 ± 0.351
1.397GlyPro: 1.397 ± 0.382
0.735GlyGln: 0.735 ± 0.259
1.544GlyArg: 1.544 ± 0.649
5.001GlySer: 5.001 ± 0.612
4.265GlyThr: 4.265 ± 0.391
6.251GlyVal: 6.251 ± 0.759
0.294GlyTrp: 0.294 ± 0.175
2.795GlyTyr: 2.795 ± 0.196
0.0GlyXaa: 0.0 ± 0.0
His
1.177HisAla: 1.177 ± 0.26
0.441HisCys: 0.441 ± 0.12
1.25HisAsp: 1.25 ± 0.383
0.735HisGlu: 0.735 ± 0.257
1.471HisPhe: 1.471 ± 0.463
0.809HisGly: 0.809 ± 0.528
0.294HisHis: 0.294 ± 0.195
1.103HisIle: 1.103 ± 0.17
1.691HisLys: 1.691 ± 0.442
1.912HisLeu: 1.912 ± 0.266
0.294HisMet: 0.294 ± 0.168
1.397HisAsn: 1.397 ± 0.274
0.882HisPro: 0.882 ± 0.305
0.221HisGln: 0.221 ± 0.188
0.294HisArg: 0.294 ± 0.142
0.662HisSer: 0.662 ± 0.361
1.177HisThr: 1.177 ± 0.384
2.059HisVal: 2.059 ± 0.48
0.221HisTrp: 0.221 ± 0.21
0.956HisTyr: 0.956 ± 0.283
0.0HisXaa: 0.0 ± 0.0
Ile
4.265IleAla: 4.265 ± 0.85
1.103IleCys: 1.103 ± 0.177
2.721IleAsp: 2.721 ± 0.435
2.059IleGlu: 2.059 ± 0.233
2.28IlePhe: 2.28 ± 0.2
3.751IleGly: 3.751 ± 0.311
0.588IleHis: 0.588 ± 0.311
2.574IleIle: 2.574 ± 1.124
4.118IleLys: 4.118 ± 0.565
5.663IleLeu: 5.663 ± 0.684
1.03IleMet: 1.03 ± 0.237
3.383IleAsn: 3.383 ± 0.474
2.427IlePro: 2.427 ± 0.39
1.544IleGln: 1.544 ± 0.331
1.397IleArg: 1.397 ± 0.369
2.942IleSer: 2.942 ± 0.446
4.118IleThr: 4.118 ± 0.984
6.472IleVal: 6.472 ± 0.844
0.441IleTrp: 0.441 ± 0.114
2.427IleTyr: 2.427 ± 0.381
0.0IleXaa: 0.0 ± 0.0
Lys
4.265LysAla: 4.265 ± 0.575
2.721LysCys: 2.721 ± 0.602
3.53LysAsp: 3.53 ± 0.613
2.059LysGlu: 2.059 ± 0.498
2.5LysPhe: 2.5 ± 0.606
2.721LysGly: 2.721 ± 0.755
1.912LysHis: 1.912 ± 0.482
4.633LysIle: 4.633 ± 0.489
2.28LysLys: 2.28 ± 0.372
5.81LysLeu: 5.81 ± 0.921
2.059LysMet: 2.059 ± 0.341
2.942LysAsn: 2.942 ± 0.302
3.383LysPro: 3.383 ± 0.327
2.574LysGln: 2.574 ± 0.619
1.691LysArg: 1.691 ± 0.369
4.559LysSer: 4.559 ± 0.476
4.707LysThr: 4.707 ± 0.568
4.707LysVal: 4.707 ± 0.463
0.662LysTrp: 0.662 ± 0.361
3.53LysTyr: 3.53 ± 0.328
0.0LysXaa: 0.0 ± 0.0
Leu
5.295LeuAla: 5.295 ± 0.69
3.089LeuCys: 3.089 ± 0.425
3.751LeuAsp: 3.751 ± 0.594
5.589LeuGlu: 5.589 ± 0.514
4.559LeuPhe: 4.559 ± 0.602
5.663LeuGly: 5.663 ± 0.565
1.618LeuHis: 1.618 ± 0.46
3.824LeuIle: 3.824 ± 1.03
5.589LeuLys: 5.589 ± 0.892
8.237LeuLeu: 8.237 ± 1.882
1.765LeuMet: 1.765 ± 0.376
5.295LeuAsn: 5.295 ± 0.987
3.603LeuPro: 3.603 ± 0.769
4.045LeuGln: 4.045 ± 0.694
2.5LeuArg: 2.5 ± 0.508
5.883LeuSer: 5.883 ± 0.397
5.074LeuThr: 5.074 ± 0.445
6.251LeuVal: 6.251 ± 0.907
1.471LeuTrp: 1.471 ± 0.342
3.383LeuTyr: 3.383 ± 0.628
0.0LeuXaa: 0.0 ± 0.0
Met
2.427MetAla: 2.427 ± 0.413
0.956MetCys: 0.956 ± 0.339
0.809MetAsp: 0.809 ± 0.22
0.147MetGlu: 0.147 ± 0.1
0.735MetPhe: 0.735 ± 0.946
1.544MetGly: 1.544 ± 0.399
1.25MetHis: 1.25 ± 0.181
1.839MetIle: 1.839 ± 0.22
0.588MetLys: 0.588 ± 0.138
3.089MetLeu: 3.089 ± 0.36
0.662MetMet: 0.662 ± 0.241
0.441MetAsn: 0.441 ± 0.179
1.324MetPro: 1.324 ± 0.195
0.735MetGln: 0.735 ± 0.129
1.03MetArg: 1.03 ± 0.336
1.544MetSer: 1.544 ± 0.275
1.471MetThr: 1.471 ± 0.411
1.618MetVal: 1.618 ± 0.467
0.074MetTrp: 0.074 ± 0.134
1.177MetTyr: 1.177 ± 0.182
0.0MetXaa: 0.0 ± 0.0
Asn
3.971AsnAla: 3.971 ± 0.386
1.765AsnCys: 1.765 ± 0.22
2.647AsnAsp: 2.647 ± 0.466
2.427AsnGlu: 2.427 ± 0.431
3.236AsnPhe: 3.236 ± 0.901
5.663AsnGly: 5.663 ± 0.698
0.956AsnHis: 0.956 ± 0.15
2.5AsnIle: 2.5 ± 0.226
2.647AsnLys: 2.647 ± 0.589
4.486AsnLeu: 4.486 ± 0.39
1.544AsnMet: 1.544 ± 0.272
4.412AsnAsn: 4.412 ± 0.398
1.471AsnPro: 1.471 ± 0.192
1.618AsnGln: 1.618 ± 0.954
1.618AsnArg: 1.618 ± 0.631
4.265AsnSer: 4.265 ± 0.408
3.677AsnThr: 3.677 ± 0.924
7.207AsnVal: 7.207 ± 0.979
0.515AsnTrp: 0.515 ± 0.445
1.986AsnTyr: 1.986 ± 0.617
0.0AsnXaa: 0.0 ± 0.0
Pro
2.28ProAla: 2.28 ± 0.372
0.588ProCys: 0.588 ± 0.089
2.059ProAsp: 2.059 ± 0.273
1.618ProGlu: 1.618 ± 0.269
1.986ProPhe: 1.986 ± 0.462
2.427ProGly: 2.427 ± 0.435
0.809ProHis: 0.809 ± 0.334
1.691ProIle: 1.691 ± 0.172
2.133ProLys: 2.133 ± 0.447
2.5ProLeu: 2.5 ± 0.598
0.368ProMet: 0.368 ± 0.415
1.177ProAsn: 1.177 ± 0.45
1.324ProPro: 1.324 ± 0.28
1.544ProGln: 1.544 ± 0.479
0.882ProArg: 0.882 ± 0.235
2.647ProSer: 2.647 ± 0.709
2.059ProThr: 2.059 ± 0.231
3.309ProVal: 3.309 ± 0.456
0.735ProTrp: 0.735 ± 0.13
0.809ProTyr: 0.809 ± 0.262
0.0ProXaa: 0.0 ± 0.0
Gln
1.986GlnAla: 1.986 ± 0.178
0.441GlnCys: 0.441 ± 0.164
1.397GlnAsp: 1.397 ± 0.264
1.691GlnGlu: 1.691 ± 0.305
1.544GlnPhe: 1.544 ± 1.057
1.986GlnGly: 1.986 ± 0.212
0.588GlnHis: 0.588 ± 0.8
1.618GlnIle: 1.618 ± 0.479
1.691GlnLys: 1.691 ± 0.247
4.118GlnLeu: 4.118 ± 0.776
0.515GlnMet: 0.515 ± 0.163
1.103GlnAsn: 1.103 ± 0.144
1.25GlnPro: 1.25 ± 0.182
1.03GlnGln: 1.03 ± 0.364
1.397GlnArg: 1.397 ± 0.457
1.912GlnSer: 1.912 ± 0.374
1.691GlnThr: 1.691 ± 0.562
2.206GlnVal: 2.206 ± 0.267
0.294GlnTrp: 0.294 ± 0.158
1.618GlnTyr: 1.618 ± 0.351
0.0GlnXaa: 0.0 ± 0.0
Arg
1.765ArgAla: 1.765 ± 0.679
0.956ArgCys: 0.956 ± 0.466
1.765ArgAsp: 1.765 ± 0.37
0.735ArgGlu: 0.735 ± 0.119
2.353ArgPhe: 2.353 ± 0.39
1.839ArgGly: 1.839 ± 0.601
0.588ArgHis: 0.588 ± 0.235
1.471ArgIle: 1.471 ± 0.286
2.427ArgLys: 2.427 ± 0.502
2.868ArgLeu: 2.868 ± 0.899
0.441ArgMet: 0.441 ± 0.209
2.206ArgAsn: 2.206 ± 0.453
0.662ArgPro: 0.662 ± 0.296
1.397ArgGln: 1.397 ± 0.377
1.544ArgArg: 1.544 ± 0.761
2.5ArgSer: 2.5 ± 1.387
2.059ArgThr: 2.059 ± 0.305
2.353ArgVal: 2.353 ± 0.532
0.368ArgTrp: 0.368 ± 0.134
0.662ArgTyr: 0.662 ± 0.288
0.0ArgXaa: 0.0 ± 0.0
Ser
4.339SerAla: 4.339 ± 0.596
0.809SerCys: 0.809 ± 0.353
4.559SerAsp: 4.559 ± 0.655
2.353SerGlu: 2.353 ± 0.328
3.089SerPhe: 3.089 ± 0.524
3.971SerGly: 3.971 ± 0.515
1.03SerHis: 1.03 ± 0.231
3.751SerIle: 3.751 ± 1.03
3.751SerLys: 3.751 ± 0.887
5.736SerLeu: 5.736 ± 0.801
1.618SerMet: 1.618 ± 0.459
3.53SerAsn: 3.53 ± 0.435
1.471SerPro: 1.471 ± 0.257
2.647SerGln: 2.647 ± 0.648
2.721SerArg: 2.721 ± 1.621
4.045SerSer: 4.045 ± 0.492
3.456SerThr: 3.456 ± 0.48
8.898SerVal: 8.898 ± 1.165
1.03SerTrp: 1.03 ± 0.415
3.824SerTyr: 3.824 ± 0.411
0.0SerXaa: 0.0 ± 0.0
Thr
4.486ThrAla: 4.486 ± 0.539
2.059ThrCys: 2.059 ± 0.563
2.647ThrAsp: 2.647 ± 0.759
2.427ThrGlu: 2.427 ± 0.204
2.868ThrPhe: 2.868 ± 0.344
3.456ThrGly: 3.456 ± 0.479
0.809ThrHis: 0.809 ± 0.422
4.265ThrIle: 4.265 ± 0.633
2.721ThrLys: 2.721 ± 0.455
5.81ThrLeu: 5.81 ± 0.918
1.912ThrMet: 1.912 ± 0.418
4.118ThrAsn: 4.118 ± 0.568
2.942ThrPro: 2.942 ± 0.361
2.353ThrGln: 2.353 ± 0.252
1.618ThrArg: 1.618 ± 0.284
4.045ThrSer: 4.045 ± 0.905
5.442ThrThr: 5.442 ± 0.877
5.81ThrVal: 5.81 ± 0.38
1.03ThrTrp: 1.03 ± 0.297
2.5ThrTyr: 2.5 ± 0.633
0.0ThrXaa: 0.0 ± 0.0
Val
4.118ValAla: 4.118 ± 0.648
3.162ValCys: 3.162 ± 0.37
5.001ValAsp: 5.001 ± 0.52
5.883ValGlu: 5.883 ± 0.677
5.295ValPhe: 5.295 ± 0.381
3.677ValGly: 3.677 ± 0.572
2.059ValHis: 2.059 ± 0.207
5.442ValIle: 5.442 ± 0.657
8.751ValLys: 8.751 ± 1.366
8.163ValLeu: 8.163 ± 1.271
2.206ValMet: 2.206 ± 0.412
7.133ValAsn: 7.133 ± 0.556
2.5ValPro: 2.5 ± 0.243
2.574ValGln: 2.574 ± 0.36
3.236ValArg: 3.236 ± 0.518
6.619ValSer: 6.619 ± 0.671
6.692ValThr: 6.692 ± 0.387
9.781ValVal: 9.781 ± 0.99
0.882ValTrp: 0.882 ± 0.199
3.603ValTyr: 3.603 ± 0.779
0.0ValXaa: 0.0 ± 0.0
Trp
0.515TrpAla: 0.515 ± 0.115
0.294TrpCys: 0.294 ± 0.117
1.03TrpAsp: 1.03 ± 0.17
0.515TrpGlu: 0.515 ± 0.137
1.471TrpPhe: 1.471 ± 0.316
0.147TrpGly: 0.147 ± 0.122
0.147TrpHis: 0.147 ± 0.125
0.662TrpIle: 0.662 ± 0.215
0.588TrpLys: 0.588 ± 0.152
1.25TrpLeu: 1.25 ± 0.341
0.221TrpMet: 0.221 ± 0.183
1.324TrpAsn: 1.324 ± 0.306
0.515TrpPro: 0.515 ± 0.203
0.074TrpGln: 0.074 ± 0.049
0.441TrpArg: 0.441 ± 0.12
0.809TrpSer: 0.809 ± 0.333
0.588TrpThr: 0.588 ± 0.134
0.588TrpVal: 0.588 ± 0.12
0.074TrpTrp: 0.074 ± 0.134
0.662TrpTyr: 0.662 ± 0.414
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.089TyrAla: 3.089 ± 0.527
1.691TyrCys: 1.691 ± 0.258
3.677TyrAsp: 3.677 ± 0.757
1.912TyrGlu: 1.912 ± 0.512
3.015TyrPhe: 3.015 ± 0.205
3.898TyrGly: 3.898 ± 0.291
1.177TyrHis: 1.177 ± 0.145
2.28TyrIle: 2.28 ± 0.622
3.603TyrLys: 3.603 ± 0.303
1.986TyrLeu: 1.986 ± 0.193
1.544TyrMet: 1.544 ± 0.315
2.28TyrAsn: 2.28 ± 0.797
1.177TyrPro: 1.177 ± 0.445
1.103TyrGln: 1.103 ± 0.283
1.397TyrArg: 1.397 ± 0.355
2.5TyrSer: 2.5 ± 0.503
3.456TyrThr: 3.456 ± 0.872
4.559TyrVal: 4.559 ± 0.586
0.294TyrTrp: 0.294 ± 0.124
2.721TyrTyr: 2.721 ± 0.336
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (13599 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski