Amino acid dipepetide frequency for Acidihalobacter ferrooxydans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.107AlaAla: 16.107 ± 0.197	1.231AlaCys: 1.231 ± 0.036	6.26AlaAsp: 6.26 ± 0.091	6.61AlaGlu: 6.61 ± 0.11	3.855AlaPhe: 3.855 ± 0.056	9.843AlaGly: 9.843 ± 0.103	3.173AlaHis: 3.173 ± 0.056	5.27AlaIle: 5.27 ± 0.072	2.895AlaLys: 2.895 ± 0.074	15.262AlaLeu: 15.262 ± 0.161	2.932AlaMet: 2.932 ± 0.055	2.698AlaAsn: 2.698 ± 0.052	5.446AlaPro: 5.446 ± 0.091	5.341AlaGln: 5.341 ± 0.082	9.324AlaArg: 9.324 ± 0.114	5.534AlaSer: 5.534 ± 0.079	5.557AlaThr: 5.557 ± 0.078	8.857AlaVal: 8.857 ± 0.126	1.893AlaTrp: 1.893 ± 0.055	2.94AlaTyr: 2.94 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	1.191CysAla: 1.191 ± 0.041	0.124CysCys: 0.124 ± 0.012	0.501CysAsp: 0.501 ± 0.025	0.506CysGlu: 0.506 ± 0.025	0.271CysPhe: 0.271 ± 0.016	0.958CysGly: 0.958 ± 0.038	0.264CysHis: 0.264 ± 0.015	0.396CysIle: 0.396 ± 0.018	0.181CysLys: 0.181 ± 0.015	0.873CysLeu: 0.873 ± 0.03	0.178CysMet: 0.178 ± 0.013	0.23CysAsn: 0.23 ± 0.017	0.511CysPro: 0.511 ± 0.027	0.272CysGln: 0.272 ± 0.018	0.666CysArg: 0.666 ± 0.028	0.444CysSer: 0.444 ± 0.021	0.463CysThr: 0.463 ± 0.022	0.717CysVal: 0.717 ± 0.028	0.116CysTrp: 0.116 ± 0.011	0.228CysTyr: 0.228 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	7.252AspAla: 7.252 ± 0.1	0.501AspCys: 0.501 ± 0.023	2.838AspAsp: 2.838 ± 0.067	3.375AspGlu: 3.375 ± 0.067	1.949AspPhe: 1.949 ± 0.048	4.175AspGly: 4.175 ± 0.067	1.178AspHis: 1.178 ± 0.035	2.747AspIle: 2.747 ± 0.052	1.48AspLys: 1.48 ± 0.047	5.455AspLeu: 5.455 ± 0.079	1.249AspMet: 1.249 ± 0.036	1.245AspAsn: 1.245 ± 0.037	3.011AspPro: 3.011 ± 0.059	1.567AspGln: 1.567 ± 0.044	3.683AspArg: 3.683 ± 0.068	2.244AspSer: 2.244 ± 0.045	3.011AspThr: 3.011 ± 0.054	3.794AspVal: 3.794 ± 0.063	0.987AspTrp: 0.987 ± 0.032	1.733AspTyr: 1.733 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	6.83GluAla: 6.83 ± 0.108	0.406GluCys: 0.406 ± 0.022	2.455GluAsp: 2.455 ± 0.062	2.64GluGlu: 2.64 ± 0.068	1.779GluPhe: 1.779 ± 0.042	3.397GluGly: 3.397 ± 0.067	1.802GluHis: 1.802 ± 0.046	2.819GluIle: 2.819 ± 0.062	1.653GluLys: 1.653 ± 0.052	6.183GluLeu: 6.183 ± 0.094	1.262GluMet: 1.262 ± 0.041	1.487GluAsn: 1.487 ± 0.038	2.561GluPro: 2.561 ± 0.057	2.659GluGln: 2.659 ± 0.069	5.322GluArg: 5.322 ± 0.095	2.498GluSer: 2.498 ± 0.06	3.053GluThr: 3.053 ± 0.059	3.774GluVal: 3.774 ± 0.071	0.69GluTrp: 0.69 ± 0.026	1.195GluTyr: 1.195 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.149PheAla: 4.149 ± 0.073	0.358PheCys: 0.358 ± 0.021	2.359PheAsp: 2.359 ± 0.053	1.933PheGlu: 1.933 ± 0.048	1.418PhePhe: 1.418 ± 0.048	3.319PheGly: 3.319 ± 0.071	0.806PheHis: 0.806 ± 0.027	1.743PheIle: 1.743 ± 0.039	1.002PheLys: 1.002 ± 0.038	3.136PheLeu: 3.136 ± 0.065	0.831PheMet: 0.831 ± 0.032	1.119PheAsn: 1.119 ± 0.037	1.454PhePro: 1.454 ± 0.039	0.96PheGln: 0.96 ± 0.029	1.869PheArg: 1.869 ± 0.046	2.04PheSer: 2.04 ± 0.049	1.931PheThr: 1.931 ± 0.049	2.672PheVal: 2.672 ± 0.061	0.547PheTrp: 0.547 ± 0.023	1.008PheTyr: 1.008 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	8.432GlyAla: 8.432 ± 0.108	0.874GlyCys: 0.874 ± 0.034	3.911GlyAsp: 3.911 ± 0.079	4.488GlyGlu: 4.488 ± 0.069	3.239GlyPhe: 3.239 ± 0.067	6.471GlyGly: 6.471 ± 0.1	2.21GlyHis: 2.21 ± 0.049	4.285GlyIle: 4.285 ± 0.071	2.991GlyLys: 2.991 ± 0.067	9.42GlyLeu: 9.42 ± 0.13	2.435GlyMet: 2.435 ± 0.049	2.071GlyAsn: 2.071 ± 0.051	2.931GlyPro: 2.931 ± 0.058	3.098GlyGln: 3.098 ± 0.059	5.643GlyArg: 5.643 ± 0.076	4.08GlySer: 4.08 ± 0.072	4.153GlyThr: 4.153 ± 0.082	6.486GlyVal: 6.486 ± 0.09	1.431GlyTrp: 1.431 ± 0.044	2.479GlyTyr: 2.479 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	3.2HisAla: 3.2 ± 0.06	0.31HisCys: 0.31 ± 0.019	1.42HisAsp: 1.42 ± 0.042	1.378HisGlu: 1.378 ± 0.041	1.0HisPhe: 1.0 ± 0.031	2.398HisGly: 2.398 ± 0.052	0.752HisHis: 0.752 ± 0.028	1.218HisIle: 1.218 ± 0.033	0.623HisLys: 0.623 ± 0.027	2.788HisLeu: 2.788 ± 0.055	0.602HisMet: 0.602 ± 0.025	0.64HisAsn: 0.64 ± 0.027	1.749HisPro: 1.749 ± 0.043	0.829HisGln: 0.829 ± 0.027	1.796HisArg: 1.796 ± 0.048	1.182HisSer: 1.182 ± 0.039	1.388HisThr: 1.388 ± 0.042	1.677HisVal: 1.677 ± 0.043	0.539HisTrp: 0.539 ± 0.025	0.859HisTyr: 0.859 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	6.296IleAla: 6.296 ± 0.089	0.416IleCys: 0.416 ± 0.023	3.483IleAsp: 3.483 ± 0.068	3.451IleGlu: 3.451 ± 0.072	1.41IlePhe: 1.41 ± 0.045	4.65IleGly: 4.65 ± 0.075	1.117IleHis: 1.117 ± 0.034	2.121IleIle: 2.121 ± 0.055	1.617IleLys: 1.617 ± 0.05	4.122IleLeu: 4.122 ± 0.073	0.93IleMet: 0.93 ± 0.035	1.488IleAsn: 1.488 ± 0.041	2.416IlePro: 2.416 ± 0.048	1.349IleGln: 1.349 ± 0.039	3.07IleArg: 3.07 ± 0.059	2.385IleSer: 2.385 ± 0.056	2.447IleThr: 2.447 ± 0.05	3.727IleVal: 3.727 ± 0.068	0.559IleTrp: 0.559 ± 0.024	1.165IleTyr: 1.165 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.308LysAla: 3.308 ± 0.073	0.142LysCys: 0.142 ± 0.012	1.409LysAsp: 1.409 ± 0.045	1.201LysGlu: 1.201 ± 0.038	0.69LysPhe: 0.69 ± 0.03	2.043LysGly: 2.043 ± 0.055	0.747LysHis: 0.747 ± 0.029	1.384LysIle: 1.384 ± 0.041	1.129LysLys: 1.129 ± 0.048	3.025LysLeu: 3.025 ± 0.058	0.637LysMet: 0.637 ± 0.027	0.928LysAsn: 0.928 ± 0.032	1.847LysPro: 1.847 ± 0.049	1.191LysGln: 1.191 ± 0.039	2.358LysArg: 2.358 ± 0.069	1.603LysSer: 1.603 ± 0.042	1.861LysThr: 1.861 ± 0.05	1.963LysVal: 1.963 ± 0.056	0.297LysTrp: 0.297 ± 0.016	0.71LysTyr: 0.71 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	14.259LeuAla: 14.259 ± 0.159	1.027LeuCys: 1.027 ± 0.036	6.818LeuAsp: 6.818 ± 0.099	5.981LeuGlu: 5.981 ± 0.091	3.966LeuPhe: 3.966 ± 0.091	9.223LeuGly: 9.223 ± 0.122	2.944LeuHis: 2.944 ± 0.057	5.47LeuIle: 5.47 ± 0.083	3.311LeuLys: 3.311 ± 0.064	12.582LeuLeu: 12.582 ± 0.207	2.398LeuMet: 2.398 ± 0.053	3.119LeuAsn: 3.119 ± 0.052	6.145LeuPro: 6.145 ± 0.083	3.607LeuGln: 3.607 ± 0.062	9.199LeuArg: 9.199 ± 0.125	6.413LeuSer: 6.413 ± 0.09	5.705LeuThr: 5.705 ± 0.079	7.031LeuVal: 7.031 ± 0.095	1.442LeuTrp: 1.442 ± 0.048	2.694LeuTyr: 2.694 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.606MetAla: 2.606 ± 0.055	0.134MetCys: 0.134 ± 0.011	1.129MetAsp: 1.129 ± 0.035	1.011MetGlu: 1.011 ± 0.034	0.603MetPhe: 0.603 ± 0.031	1.666MetGly: 1.666 ± 0.048	0.63MetHis: 0.63 ± 0.029	1.099MetIle: 1.099 ± 0.037	0.84MetLys: 0.84 ± 0.033	2.712MetLeu: 2.712 ± 0.054	0.526MetMet: 0.526 ± 0.027	0.863MetAsn: 0.863 ± 0.031	1.447MetPro: 1.447 ± 0.04	1.067MetGln: 1.067 ± 0.032	1.887MetArg: 1.887 ± 0.044	1.67MetSer: 1.67 ± 0.043	1.429MetThr: 1.429 ± 0.038	1.488MetVal: 1.488 ± 0.047	0.185MetTrp: 0.185 ± 0.016	0.399MetTyr: 0.399 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.247AsnAla: 3.247 ± 0.071	0.223AsnCys: 0.223 ± 0.017	1.242AsnAsp: 1.242 ± 0.039	1.21AsnGlu: 1.21 ± 0.033	0.906AsnPhe: 0.906 ± 0.034	2.282AsnGly: 2.282 ± 0.062	0.625AsnHis: 0.625 ± 0.025	1.335AsnIle: 1.335 ± 0.036	0.772AsnLys: 0.772 ± 0.032	2.765AsnLeu: 2.765 ± 0.048	0.61AsnMet: 0.61 ± 0.026	0.793AsnAsn: 0.793 ± 0.033	1.966AsnPro: 1.966 ± 0.051	0.925AsnGln: 0.925 ± 0.034	1.907AsnArg: 1.907 ± 0.048	1.244AsnSer: 1.244 ± 0.041	1.517AsnThr: 1.517 ± 0.047	1.885AsnVal: 1.885 ± 0.05	0.416AsnTrp: 0.416 ± 0.024	0.79AsnTyr: 0.79 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	6.141ProAla: 6.141 ± 0.085	0.332ProCys: 0.332 ± 0.024	3.242ProAsp: 3.242 ± 0.062	3.47ProGlu: 3.47 ± 0.069	1.722ProPhe: 1.722 ± 0.045	4.477ProGly: 4.477 ± 0.07	1.299ProHis: 1.299 ± 0.041	2.045ProIle: 2.045 ± 0.044	1.406ProLys: 1.406 ± 0.045	5.52ProLeu: 5.52 ± 0.086	1.126ProMet: 1.126 ± 0.033	1.349ProAsn: 1.349 ± 0.036	2.78ProPro: 2.78 ± 0.066	2.101ProGln: 2.101 ± 0.058	3.199ProArg: 3.199 ± 0.062	2.477ProSer: 2.477 ± 0.052	2.621ProThr: 2.621 ± 0.046	4.031ProVal: 4.031 ± 0.072	0.85ProTrp: 0.85 ± 0.031	1.389ProTyr: 1.389 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	5.272GlnAla: 5.272 ± 0.095	0.282GlnCys: 0.282 ± 0.018	1.487GlnAsp: 1.487 ± 0.042	1.567GlnGlu: 1.567 ± 0.045	1.105GlnPhe: 1.105 ± 0.034	2.832GlnGly: 2.832 ± 0.063	1.072GlnHis: 1.072 ± 0.037	1.929GlnIle: 1.929 ± 0.044	0.948GlnLys: 0.948 ± 0.038	3.805GlnLeu: 3.805 ± 0.068	0.823GlnMet: 0.823 ± 0.028	0.922GlnAsn: 0.922 ± 0.034	2.072GlnPro: 2.072 ± 0.049	1.772GlnGln: 1.772 ± 0.053	3.395GlnArg: 3.395 ± 0.068	1.943GlnSer: 1.943 ± 0.043	2.112GlnThr: 2.112 ± 0.054	2.611GlnVal: 2.611 ± 0.057	0.593GlnTrp: 0.593 ± 0.026	0.864GlnTyr: 0.864 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.044ArgAla: 8.044 ± 0.11	0.705ArgCys: 0.705 ± 0.033	3.78ArgAsp: 3.78 ± 0.081	4.907ArgGlu: 4.907 ± 0.091	2.877ArgPhe: 2.877 ± 0.059	4.916ArgGly: 4.916 ± 0.075	2.261ArgHis: 2.261 ± 0.047	4.146ArgIle: 4.146 ± 0.069	2.299ArgLys: 2.299 ± 0.066	9.382ArgLeu: 9.382 ± 0.119	1.978ArgMet: 1.978 ± 0.043	1.896ArgAsn: 1.896 ± 0.047	3.429ArgPro: 3.429 ± 0.071	2.99ArgGln: 2.99 ± 0.064	6.425ArgArg: 6.425 ± 0.108	3.32ArgSer: 3.32 ± 0.061	3.26ArgThr: 3.26 ± 0.067	5.42ArgVal: 5.42 ± 0.077	1.21ArgTrp: 1.21 ± 0.037	2.318ArgTyr: 2.318 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	5.91SerAla: 5.91 ± 0.094	0.402SerCys: 0.402 ± 0.022	2.516SerAsp: 2.516 ± 0.055	2.504SerGlu: 2.504 ± 0.053	1.737SerPhe: 1.737 ± 0.045	5.177SerGly: 5.177 ± 0.081	1.175SerHis: 1.175 ± 0.039	2.427SerIle: 2.427 ± 0.051	1.356SerLys: 1.356 ± 0.038	5.639SerLeu: 5.639 ± 0.093	1.317SerMet: 1.317 ± 0.038	1.425SerAsn: 1.425 ± 0.044	2.536SerPro: 2.536 ± 0.057	1.697SerGln: 1.697 ± 0.04	3.435SerArg: 3.435 ± 0.058	2.597SerSer: 2.597 ± 0.058	2.761SerThr: 2.761 ± 0.061	3.639SerVal: 3.639 ± 0.06	0.667SerTrp: 0.667 ± 0.029	1.221SerTyr: 1.221 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.022ThrAla: 6.022 ± 0.084	0.41ThrCys: 0.41 ± 0.025	2.666ThrAsp: 2.666 ± 0.059	2.232ThrGlu: 2.232 ± 0.051	1.655ThrPhe: 1.655 ± 0.039	4.65ThrGly: 4.65 ± 0.074	1.481ThrHis: 1.481 ± 0.039	2.115ThrIle: 2.115 ± 0.052	1.008ThrLys: 1.008 ± 0.039	7.092ThrLeu: 7.092 ± 0.082	0.889ThrMet: 0.889 ± 0.03	1.15ThrAsn: 1.15 ± 0.039	3.496ThrPro: 3.496 ± 0.074	2.055ThrGln: 2.055 ± 0.052	3.75ThrArg: 3.75 ± 0.072	2.37ThrSer: 2.37 ± 0.06	2.645ThrThr: 2.645 ± 0.057	4.052ThrVal: 4.052 ± 0.069	0.64ThrTrp: 0.64 ± 0.026	1.23ThrTyr: 1.23 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	8.237ValAla: 8.237 ± 0.103	0.778ValCys: 0.778 ± 0.029	4.031ValAsp: 4.031 ± 0.071	4.22ValGlu: 4.22 ± 0.07	2.828ValPhe: 2.828 ± 0.054	5.387ValGly: 5.387 ± 0.092	1.693ValHis: 1.693 ± 0.041	3.895ValIle: 3.895 ± 0.076	1.995ValLys: 1.995 ± 0.058	8.252ValLeu: 8.252 ± 0.114	1.755ValMet: 1.755 ± 0.048	2.074ValAsn: 2.074 ± 0.054	3.576ValPro: 3.576 ± 0.06	2.287ValGln: 2.287 ± 0.057	5.059ValArg: 5.059 ± 0.072	4.057ValSer: 4.057 ± 0.071	3.692ValThr: 3.692 ± 0.066	5.685ValVal: 5.685 ± 0.089	0.977ValTrp: 0.977 ± 0.031	1.899ValTyr: 1.899 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.249TrpAla: 1.249 ± 0.038	0.169TrpCys: 0.169 ± 0.013	0.579TrpAsp: 0.579 ± 0.026	0.554TrpGlu: 0.554 ± 0.023	0.613TrpPhe: 0.613 ± 0.027	0.923TrpGly: 0.923 ± 0.032	0.422TrpHis: 0.422 ± 0.021	0.72TrpIle: 0.72 ± 0.024	0.38TrpLys: 0.38 ± 0.021	2.28TrpLeu: 2.28 ± 0.059	0.407TrpMet: 0.407 ± 0.02	0.449TrpAsn: 0.449 ± 0.023	0.805TrpPro: 0.805 ± 0.033	0.685TrpGln: 0.685 ± 0.033	1.338TrpArg: 1.338 ± 0.04	0.78TrpSer: 0.78 ± 0.03	0.673TrpThr: 0.673 ± 0.026	1.036TrpVal: 1.036 ± 0.034	0.284TrpTrp: 0.284 ± 0.016	0.406TrpTyr: 0.406 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.276TyrAla: 3.276 ± 0.061	0.266TyrCys: 0.266 ± 0.018	1.348TyrAsp: 1.348 ± 0.041	1.228TyrGlu: 1.228 ± 0.041	1.029TyrPhe: 1.029 ± 0.034	2.341TyrGly: 2.341 ± 0.059	0.696TyrHis: 0.696 ± 0.022	1.058TyrIle: 1.058 ± 0.035	0.588TyrLys: 0.588 ± 0.024	3.04TyrLeu: 3.04 ± 0.061	0.503TyrMet: 0.503 ± 0.026	0.71TyrAsn: 0.71 ± 0.031	1.401TyrPro: 1.401 ± 0.041	0.954TyrGln: 0.954 ± 0.035	2.238TyrArg: 2.238 ± 0.045	1.259TyrSer: 1.259 ± 0.039	1.329TyrThr: 1.329 ± 0.036	1.834TyrVal: 1.834 ± 0.039	0.427TyrTrp: 0.427 ± 0.02	0.785TyrTyr: 0.785 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3065 proteins (965551 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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