Amino acid dipepetide frequency for Thermocrinis minervae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.631AlaAla: 2.631 ± 0.12
0.815AlaCys: 0.815 ± 0.051
2.56AlaAsp: 2.56 ± 0.073
3.622AlaGlu: 3.622 ± 0.082
3.361AlaPhe: 3.361 ± 0.079
4.249AlaGly: 4.249 ± 0.113
1.098AlaHis: 1.098 ± 0.047
5.029AlaIle: 5.029 ± 0.126
4.894AlaLys: 4.894 ± 0.111
7.773AlaLeu: 7.773 ± 0.151
1.54AlaMet: 1.54 ± 0.066
1.773AlaAsn: 1.773 ± 0.065
1.801AlaPro: 1.801 ± 0.069
2.309AlaGln: 2.309 ± 0.095
3.174AlaArg: 3.174 ± 0.085
3.398AlaSer: 3.398 ± 0.082
2.398AlaThr: 2.398 ± 0.075
4.844AlaVal: 4.844 ± 0.128
0.49AlaTrp: 0.49 ± 0.037
3.082AlaTyr: 3.082 ± 0.091
0.0AlaXaa: 0.0 ± 0.0
Cys
0.709CysAla: 0.709 ± 0.041
0.117CysCys: 0.117 ± 0.019
0.426CysAsp: 0.426 ± 0.034
0.535CysGlu: 0.535 ± 0.035
0.316CysPhe: 0.316 ± 0.027
0.892CysGly: 0.892 ± 0.052
0.236CysHis: 0.236 ± 0.022
0.609CysIle: 0.609 ± 0.037
0.625CysLys: 0.625 ± 0.042
0.771CysLeu: 0.771 ± 0.048
0.231CysMet: 0.231 ± 0.021
0.265CysAsn: 0.265 ± 0.03
0.597CysPro: 0.597 ± 0.042
0.316CysGln: 0.316 ± 0.027
0.444CysArg: 0.444 ± 0.033
0.549CysSer: 0.549 ± 0.041
0.378CysThr: 0.378 ± 0.032
0.7CysVal: 0.7 ± 0.051
0.073CysTrp: 0.073 ± 0.014
0.371CysTyr: 0.371 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
2.75AspAla: 2.75 ± 0.076
0.426AspCys: 0.426 ± 0.029
1.583AspAsp: 1.583 ± 0.07
3.414AspGlu: 3.414 ± 0.093
2.716AspPhe: 2.716 ± 0.079
3.016AspGly: 3.016 ± 0.087
0.691AspHis: 0.691 ± 0.04
3.86AspIle: 3.86 ± 0.088
3.252AspLys: 3.252 ± 0.097
6.32AspLeu: 6.32 ± 0.106
1.13AspMet: 1.13 ± 0.047
1.263AspAsn: 1.263 ± 0.059
2.714AspPro: 2.714 ± 0.074
1.101AspGln: 1.101 ± 0.053
2.741AspArg: 2.741 ± 0.086
2.057AspSer: 2.057 ± 0.063
2.046AspThr: 2.046 ± 0.073
4.638AspVal: 4.638 ± 0.108
0.579AspTrp: 0.579 ± 0.038
2.579AspTyr: 2.579 ± 0.076
0.0AspXaa: 0.0 ± 0.0
Glu
4.643GluAla: 4.643 ± 0.126
0.62GluCys: 0.62 ± 0.04
5.167GluAsp: 5.167 ± 0.107
9.732GluGlu: 9.732 ± 0.212
3.332GluPhe: 3.332 ± 0.098
6.595GluGly: 6.595 ± 0.138
1.311GluHis: 1.311 ± 0.054
5.034GluIle: 5.034 ± 0.128
7.07GluLys: 7.07 ± 0.163
8.727GluLeu: 8.727 ± 0.176
1.284GluMet: 1.284 ± 0.059
2.849GluAsn: 2.849 ± 0.085
2.247GluPro: 2.247 ± 0.065
1.581GluGln: 1.581 ± 0.074
5.174GluArg: 5.174 ± 0.117
3.416GluSer: 3.416 ± 0.084
2.334GluThr: 2.334 ± 0.075
6.787GluVal: 6.787 ± 0.126
0.698GluTrp: 0.698 ± 0.037
2.933GluTyr: 2.933 ± 0.082
0.0GluXaa: 0.0 ± 0.0
Phe
2.554PheAla: 2.554 ± 0.083
0.503PheCys: 0.503 ± 0.035
2.178PheAsp: 2.178 ± 0.079
3.254PheGlu: 3.254 ± 0.088
2.572PhePhe: 2.572 ± 0.1
3.384PheGly: 3.384 ± 0.091
0.771PheHis: 0.771 ± 0.039
2.965PheIle: 2.965 ± 0.074
2.744PheLys: 2.744 ± 0.086
6.146PheLeu: 6.146 ± 0.167
1.256PheMet: 1.256 ± 0.052
1.437PheAsn: 1.437 ± 0.061
1.831PhePro: 1.831 ± 0.066
1.176PheGln: 1.176 ± 0.057
1.885PheArg: 1.885 ± 0.062
3.29PheSer: 3.29 ± 0.101
2.155PheThr: 2.155 ± 0.065
3.865PheVal: 3.865 ± 0.093
0.519PheTrp: 0.519 ± 0.036
2.249PheTyr: 2.249 ± 0.075
0.0PheXaa: 0.0 ± 0.0
Gly
3.988GlyAla: 3.988 ± 0.129
0.732GlyCys: 0.732 ± 0.05
2.995GlyAsp: 2.995 ± 0.084
4.164GlyGlu: 4.164 ± 0.103
3.84GlyPhe: 3.84 ± 0.099
4.595GlyGly: 4.595 ± 0.111
1.24GlyHis: 1.24 ± 0.058
5.446GlyIle: 5.446 ± 0.127
5.913GlyLys: 5.913 ± 0.14
6.853GlyLeu: 6.853 ± 0.137
1.75GlyMet: 1.75 ± 0.069
2.192GlyAsn: 2.192 ± 0.068
1.81GlyPro: 1.81 ± 0.065
1.945GlyGln: 1.945 ± 0.068
3.705GlyArg: 3.705 ± 0.092
3.796GlySer: 3.796 ± 0.102
3.199GlyThr: 3.199 ± 0.095
5.853GlyVal: 5.853 ± 0.135
0.764GlyTrp: 0.764 ± 0.04
3.29GlyTyr: 3.29 ± 0.095
0.0GlyXaa: 0.0 ± 0.0
His
1.137HisAla: 1.137 ± 0.049
0.176HisCys: 0.176 ± 0.02
0.551HisAsp: 0.551 ± 0.034
0.979HisGlu: 0.979 ± 0.047
0.769HisPhe: 0.769 ± 0.043
1.082HisGly: 1.082 ± 0.054
0.435HisHis: 0.435 ± 0.033
1.444HisIle: 1.444 ± 0.061
1.021HisLys: 1.021 ± 0.048
1.94HisLeu: 1.94 ± 0.066
0.508HisMet: 0.508 ± 0.035
0.481HisAsn: 0.481 ± 0.03
1.105HisPro: 1.105 ± 0.045
0.458HisGln: 0.458 ± 0.034
0.924HisArg: 0.924 ± 0.049
0.865HisSer: 0.865 ± 0.044
0.961HisThr: 0.961 ± 0.045
1.439HisVal: 1.439 ± 0.059
0.146HisTrp: 0.146 ± 0.019
0.783HisTyr: 0.783 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
4.73IleAla: 4.73 ± 0.115
0.49IleCys: 0.49 ± 0.033
3.517IleAsp: 3.517 ± 0.11
5.256IleGlu: 5.256 ± 0.132
2.837IlePhe: 2.837 ± 0.096
4.316IleGly: 4.316 ± 0.116
1.169IleHis: 1.169 ± 0.057
3.682IleIle: 3.682 ± 0.095
6.039IleLys: 6.039 ± 0.123
7.535IleLeu: 7.535 ± 0.146
1.181IleMet: 1.181 ± 0.051
2.501IleAsn: 2.501 ± 0.081
3.361IlePro: 3.361 ± 0.088
1.837IleGln: 1.837 ± 0.065
4.183IleArg: 4.183 ± 0.105
4.283IleSer: 4.283 ± 0.109
3.247IleThr: 3.247 ± 0.085
5.32IleVal: 5.32 ± 0.128
0.43IleTrp: 0.43 ± 0.028
2.336IleTyr: 2.336 ± 0.079
0.0IleXaa: 0.0 ± 0.0
Lys
5.716LysAla: 5.716 ± 0.128
0.318LysCys: 0.318 ± 0.028
5.464LysAsp: 5.464 ± 0.136
8.988LysGlu: 8.988 ± 0.175
2.03LysPhe: 2.03 ± 0.076
5.773LysGly: 5.773 ± 0.111
1.359LysHis: 1.359 ± 0.063
4.21LysIle: 4.21 ± 0.106
6.107LysLys: 6.107 ± 0.141
8.128LysLeu: 8.128 ± 0.143
1.252LysMet: 1.252 ± 0.051
2.588LysAsn: 2.588 ± 0.09
2.949LysPro: 2.949 ± 0.089
1.684LysGln: 1.684 ± 0.063
4.265LysArg: 4.265 ± 0.094
3.489LysSer: 3.489 ± 0.083
3.062LysThr: 3.062 ± 0.081
7.288LysVal: 7.288 ± 0.139
0.474LysTrp: 0.474 ± 0.037
2.458LysTyr: 2.458 ± 0.094
0.0LysXaa: 0.0 ± 0.0
Leu
6.965LeuAla: 6.965 ± 0.142
0.924LeuCys: 0.924 ± 0.042
4.929LeuAsp: 4.929 ± 0.117
9.649LeuGlu: 9.649 ± 0.174
5.007LeuPhe: 5.007 ± 0.141
7.626LeuGly: 7.626 ± 0.152
1.714LeuHis: 1.714 ± 0.059
7.183LeuIle: 7.183 ± 0.149
9.899LeuLys: 9.899 ± 0.169
12.958LeuLeu: 12.958 ± 0.271
2.78LeuMet: 2.78 ± 0.083
3.377LeuAsn: 3.377 ± 0.094
4.707LeuPro: 4.707 ± 0.112
3.133LeuGln: 3.133 ± 0.086
6.073LeuArg: 6.073 ± 0.112
8.386LeuSer: 8.386 ± 0.193
4.753LeuThr: 4.753 ± 0.102
8.077LeuVal: 8.077 ± 0.138
1.204LeuTrp: 1.204 ± 0.051
4.691LeuTyr: 4.691 ± 0.119
0.0LeuXaa: 0.0 ± 0.0
Met
1.728MetAla: 1.728 ± 0.064
0.192MetCys: 0.192 ± 0.023
1.27MetAsp: 1.27 ± 0.047
1.979MetGlu: 1.979 ± 0.071
0.977MetPhe: 0.977 ± 0.05
1.826MetGly: 1.826 ± 0.066
0.439MetHis: 0.439 ± 0.031
1.123MetIle: 1.123 ± 0.057
1.771MetLys: 1.771 ± 0.065
2.547MetLeu: 2.547 ± 0.089
0.43MetMet: 0.43 ± 0.03
0.718MetAsn: 0.718 ± 0.041
0.954MetPro: 0.954 ± 0.046
0.583MetGln: 0.583 ± 0.038
1.094MetArg: 1.094 ± 0.052
1.215MetSer: 1.215 ± 0.059
0.773MetThr: 0.773 ± 0.043
1.755MetVal: 1.755 ± 0.054
0.245MetTrp: 0.245 ± 0.022
0.721MetTyr: 0.721 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
1.801AsnAla: 1.801 ± 0.067
0.348AsnCys: 0.348 ± 0.031
0.876AsnAsp: 0.876 ± 0.05
1.352AsnGlu: 1.352 ± 0.066
1.677AsnPhe: 1.677 ± 0.061
1.476AsnGly: 1.476 ± 0.056
0.529AsnHis: 0.529 ± 0.032
2.512AsnIle: 2.512 ± 0.081
1.943AsnLys: 1.943 ± 0.082
4.73AsnLeu: 4.73 ± 0.128
0.755AsnMet: 0.755 ± 0.037
0.959AsnAsn: 0.959 ± 0.063
2.444AsnPro: 2.444 ± 0.076
0.819AsnGln: 0.819 ± 0.04
1.744AsnArg: 1.744 ± 0.056
1.698AsnSer: 1.698 ± 0.068
1.723AsnThr: 1.723 ± 0.073
2.483AsnVal: 2.483 ± 0.075
0.355AsnTrp: 0.355 ± 0.034
1.519AsnTyr: 1.519 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
2.135ProAla: 2.135 ± 0.071
0.35ProCys: 0.35 ± 0.031
2.071ProAsp: 2.071 ± 0.068
3.803ProGlu: 3.803 ± 0.103
2.133ProPhe: 2.133 ± 0.078
2.229ProGly: 2.229 ± 0.082
0.853ProHis: 0.853 ± 0.05
2.947ProIle: 2.947 ± 0.088
2.977ProLys: 2.977 ± 0.091
3.78ProLeu: 3.78 ± 0.1
1.034ProMet: 1.034 ± 0.05
1.51ProAsn: 1.51 ± 0.065
1.776ProPro: 1.776 ± 0.074
1.348ProGln: 1.348 ± 0.049
1.577ProArg: 1.577 ± 0.069
2.446ProSer: 2.446 ± 0.073
2.027ProThr: 2.027 ± 0.07
3.32ProVal: 3.32 ± 0.078
0.366ProTrp: 0.366 ± 0.028
2.169ProTyr: 2.169 ± 0.068
0.0ProXaa: 0.0 ± 0.0
Gln
2.059GlnAla: 2.059 ± 0.072
0.178GlnCys: 0.178 ± 0.027
1.435GlnAsp: 1.435 ± 0.065
3.121GlnGlu: 3.121 ± 0.095
0.67GlnPhe: 0.67 ± 0.039
1.581GlnGly: 1.581 ± 0.063
0.38GlnHis: 0.38 ± 0.029
2.048GlnIle: 2.048 ± 0.067
2.86GlnLys: 2.86 ± 0.101
2.16GlnLeu: 2.16 ± 0.08
0.739GlnMet: 0.739 ± 0.041
1.03GlnAsn: 1.03 ± 0.05
0.796GlnPro: 0.796 ± 0.041
0.849GlnGln: 0.849 ± 0.088
1.879GlnArg: 1.879 ± 0.066
1.229GlnSer: 1.229 ± 0.055
1.332GlnThr: 1.332 ± 0.067
2.226GlnVal: 2.226 ± 0.075
0.245GlnTrp: 0.245 ± 0.024
0.702GlnTyr: 0.702 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
3.167ArgAla: 3.167 ± 0.086
0.444ArgCys: 0.444 ± 0.031
2.721ArgAsp: 2.721 ± 0.083
4.872ArgGlu: 4.872 ± 0.116
2.487ArgPhe: 2.487 ± 0.081
2.977ArgGly: 2.977 ± 0.091
0.833ArgHis: 0.833 ± 0.041
4.521ArgIle: 4.521 ± 0.114
3.851ArgLys: 3.851 ± 0.078
6.029ArgLeu: 6.029 ± 0.124
1.275ArgMet: 1.275 ± 0.05
1.638ArgAsn: 1.638 ± 0.066
1.897ArgPro: 1.897 ± 0.071
1.529ArgGln: 1.529 ± 0.058
3.206ArgArg: 3.206 ± 0.091
2.59ArgSer: 2.59 ± 0.067
2.018ArgThr: 2.018 ± 0.065
4.487ArgVal: 4.487 ± 0.105
0.622ArgTrp: 0.622 ± 0.038
2.201ArgTyr: 2.201 ± 0.072
0.0ArgXaa: 0.0 ± 0.0
Ser
3.174SerAla: 3.174 ± 0.099
0.618SerCys: 0.618 ± 0.041
2.098SerAsp: 2.098 ± 0.072
3.48SerGlu: 3.48 ± 0.101
3.389SerPhe: 3.389 ± 0.109
3.657SerGly: 3.657 ± 0.096
0.977SerHis: 0.977 ± 0.043
4.096SerIle: 4.096 ± 0.095
3.899SerLys: 3.899 ± 0.091
7.771SerLeu: 7.771 ± 0.161
1.551SerMet: 1.551 ± 0.064
1.554SerAsn: 1.554 ± 0.062
2.302SerPro: 2.302 ± 0.076
1.851SerGln: 1.851 ± 0.06
2.496SerArg: 2.496 ± 0.074
3.446SerSer: 3.446 ± 0.103
2.565SerThr: 2.565 ± 0.08
4.123SerVal: 4.123 ± 0.11
0.483SerTrp: 0.483 ± 0.038
2.75SerTyr: 2.75 ± 0.091
0.0SerXaa: 0.0 ± 0.0
Thr
2.785ThrAla: 2.785 ± 0.076
0.366ThrCys: 0.366 ± 0.028
2.091ThrAsp: 2.091 ± 0.067
2.368ThrGlu: 2.368 ± 0.079
2.297ThrPhe: 2.297 ± 0.073
3.311ThrGly: 3.311 ± 0.099
0.817ThrHis: 0.817 ± 0.047
2.654ThrIle: 2.654 ± 0.097
2.634ThrLys: 2.634 ± 0.067
5.235ThrLeu: 5.235 ± 0.136
0.783ThrMet: 0.783 ± 0.039
1.268ThrAsn: 1.268 ± 0.064
2.245ThrPro: 2.245 ± 0.068
1.297ThrGln: 1.297 ± 0.058
1.705ThrArg: 1.705 ± 0.068
2.405ThrSer: 2.405 ± 0.082
1.872ThrThr: 1.872 ± 0.075
3.384ThrVal: 3.384 ± 0.089
0.327ThrTrp: 0.327 ± 0.026
1.842ThrTyr: 1.842 ± 0.069
0.0ThrXaa: 0.0 ± 0.0
Val
4.94ValAla: 4.94 ± 0.126
1.069ValCys: 1.069 ± 0.058
4.668ValAsp: 4.668 ± 0.102
6.901ValGlu: 6.901 ± 0.133
4.059ValPhe: 4.059 ± 0.11
6.029ValGly: 6.029 ± 0.138
1.329ValHis: 1.329 ± 0.06
5.208ValIle: 5.208 ± 0.121
6.402ValLys: 6.402 ± 0.114
8.725ValLeu: 8.725 ± 0.153
1.57ValMet: 1.57 ± 0.053
2.581ValAsn: 2.581 ± 0.074
3.261ValPro: 3.261 ± 0.096
2.121ValGln: 2.121 ± 0.078
4.007ValArg: 4.007 ± 0.108
4.753ValSer: 4.753 ± 0.113
2.167ValThr: 2.167 ± 0.076
7.308ValVal: 7.308 ± 0.128
0.76ValTrp: 0.76 ± 0.045
3.947ValTyr: 3.947 ± 0.094
0.0ValXaa: 0.0 ± 0.0
Trp
0.57TrpAla: 0.57 ± 0.043
0.085TrpCys: 0.085 ± 0.014
0.492TrpAsp: 0.492 ± 0.034
0.94TrpGlu: 0.94 ± 0.049
0.421TrpPhe: 0.421 ± 0.038
0.586TrpGly: 0.586 ± 0.039
0.199TrpHis: 0.199 ± 0.023
0.709TrpIle: 0.709 ± 0.042
0.76TrpLys: 0.76 ± 0.04
0.888TrpLeu: 0.888 ± 0.049
0.265TrpMet: 0.265 ± 0.021
0.348TrpAsn: 0.348 ± 0.027
0.185TrpPro: 0.185 ± 0.019
0.362TrpGln: 0.362 ± 0.027
0.462TrpArg: 0.462 ± 0.033
0.426TrpSer: 0.426 ± 0.026
0.412TrpThr: 0.412 ± 0.031
0.744TrpVal: 0.744 ± 0.045
0.096TrpTrp: 0.096 ± 0.017
0.318TrpTyr: 0.318 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.661TyrAla: 2.661 ± 0.079
0.389TyrCys: 0.389 ± 0.03
1.782TyrAsp: 1.782 ± 0.059
3.121TyrGlu: 3.121 ± 0.079
1.847TyrPhe: 1.847 ± 0.069
2.872TyrGly: 2.872 ± 0.096
0.824TyrHis: 0.824 ± 0.039
2.968TyrIle: 2.968 ± 0.079
2.945TyrLys: 2.945 ± 0.083
5.018TyrLeu: 5.018 ± 0.125
1.025TyrMet: 1.025 ± 0.054
1.41TyrAsn: 1.41 ± 0.059
1.869TyrPro: 1.869 ± 0.075
1.222TyrGln: 1.222 ± 0.057
2.629TyrArg: 2.629 ± 0.069
2.542TyrSer: 2.542 ± 0.094
2.265TyrThr: 2.265 ± 0.066
3.162TyrVal: 3.162 ± 0.084
0.391TyrTrp: 0.391 ± 0.026
1.895TyrTyr: 1.895 ± 0.087
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1463 proteins (437030 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski