Amino acid dipepetide frequency for Wuhan Millipede Virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.578AlaAla: 4.578 ± 1.667
1.579AlaCys: 1.579 ± 0.575
4.104AlaAsp: 4.104 ± 0.898
1.421AlaGlu: 1.421 ± 0.292
1.421AlaPhe: 1.421 ± 0.292
2.368AlaGly: 2.368 ± 0.486
0.789AlaHis: 0.789 ± 0.248
4.262AlaIle: 4.262 ± 0.398
3.157AlaLys: 3.157 ± 0.743
2.841AlaLeu: 2.841 ± 0.72
2.526AlaMet: 2.526 ± 0.541
2.368AlaAsn: 2.368 ± 0.669
1.579AlaPro: 1.579 ± 0.575
1.894AlaGln: 1.894 ± 0.212
1.105AlaArg: 1.105 ± 0.268
3.946AlaSer: 3.946 ± 1.268
3.315AlaThr: 3.315 ± 0.781
3.157AlaVal: 3.157 ± 0.371
0.631AlaTrp: 0.631 ± 0.358
2.526AlaTyr: 2.526 ± 1.432
0.0AlaXaa: 0.0 ± 0.0
Cys
1.579CysAla: 1.579 ± 0.311
0.158CysCys: 0.158 ± 0.087
1.263CysAsp: 1.263 ± 0.488
0.789CysGlu: 0.789 ± 0.248
0.631CysPhe: 0.631 ± 0.341
0.474CysGly: 0.474 ± 0.097
0.158CysHis: 0.158 ± 0.137
1.579CysIle: 1.579 ± 0.186
2.052CysLys: 2.052 ± 0.127
2.841CysLeu: 2.841 ± 0.671
1.105CysMet: 1.105 ± 0.446
1.421CysAsn: 1.421 ± 0.818
1.894CysPro: 1.894 ± 0.875
0.947CysGln: 0.947 ± 0.413
1.579CysArg: 1.579 ± 0.401
1.894CysSer: 1.894 ± 0.425
2.21CysThr: 2.21 ± 0.719
1.105CysVal: 1.105 ± 0.547
0.158CysTrp: 0.158 ± 0.137
0.474CysTyr: 0.474 ± 0.207
0.0CysXaa: 0.0 ± 0.0
Asp
2.684AspAla: 2.684 ± 0.117
1.736AspCys: 1.736 ± 0.298
4.262AspAsp: 4.262 ± 0.484
3.157AspGlu: 3.157 ± 1.167
2.368AspPhe: 2.368 ± 0.379
2.21AspGly: 2.21 ± 1.094
1.105AspHis: 1.105 ± 0.31
6.156AspIle: 6.156 ± 2.342
2.684AspLys: 2.684 ± 0.319
6.314AspLeu: 6.314 ± 0.455
2.841AspMet: 2.841 ± 0.265
2.999AspAsn: 2.999 ± 0.332
2.368AspPro: 2.368 ± 0.846
2.841AspGln: 2.841 ± 2.023
3.315AspArg: 3.315 ± 1.106
5.051AspSer: 5.051 ± 0.602
4.42AspThr: 4.42 ± 0.951
4.262AspVal: 4.262 ± 0.602
0.474AspTrp: 0.474 ± 0.097
2.368AspTyr: 2.368 ± 0.846
0.0AspXaa: 0.0 ± 0.0
Glu
1.736GluAla: 1.736 ± 0.659
0.947GluCys: 0.947 ± 0.533
2.526GluAsp: 2.526 ± 0.769
2.21GluGlu: 2.21 ± 1.031
2.684GluPhe: 2.684 ± 1.094
3.157GluGly: 3.157 ± 1.051
0.947GluHis: 0.947 ± 0.332
4.262GluIle: 4.262 ± 1.335
2.21GluLys: 2.21 ± 0.05
4.893GluLeu: 4.893 ± 1.067
1.421GluMet: 1.421 ± 0.787
1.421GluAsn: 1.421 ± 0.413
1.736GluPro: 1.736 ± 0.51
1.894GluGln: 1.894 ± 0.55
1.263GluArg: 1.263 ± 0.333
5.525GluSer: 5.525 ± 1.056
1.894GluThr: 1.894 ± 0.381
2.999GluVal: 2.999 ± 0.519
0.631GluTrp: 0.631 ± 0.161
1.263GluTyr: 1.263 ± 0.247
0.0GluXaa: 0.0 ± 0.0
Phe
0.947PheAla: 0.947 ± 0.229
0.789PheCys: 0.789 ± 0.248
2.526PheAsp: 2.526 ± 0.642
1.579PheGlu: 1.579 ± 0.291
1.579PhePhe: 1.579 ± 0.993
2.684PheGly: 2.684 ± 0.451
0.316PheHis: 0.316 ± 0.175
3.473PheIle: 3.473 ± 0.726
2.841PheLys: 2.841 ± 0.265
2.526PheLeu: 2.526 ± 0.541
1.105PheMet: 1.105 ± 0.268
3.946PheAsn: 3.946 ± 0.638
1.421PhePro: 1.421 ± 0.438
1.736PheGln: 1.736 ± 0.517
1.894PheArg: 1.894 ± 0.425
3.631PheSer: 3.631 ± 1.073
1.579PheThr: 1.579 ± 0.401
2.052PheVal: 2.052 ± 0.597
0.158PheTrp: 0.158 ± 0.087
1.579PheTyr: 1.579 ± 0.311
0.0PheXaa: 0.0 ± 0.0
Gly
2.841GlyAla: 2.841 ± 2.081
1.736GlyCys: 1.736 ± 0.694
2.999GlyAsp: 2.999 ± 0.405
3.157GlyGlu: 3.157 ± 0.582
2.052GlyPhe: 2.052 ± 0.557
2.999GlyGly: 2.999 ± 0.606
1.421GlyHis: 1.421 ± 0.292
3.788GlyIle: 3.788 ± 0.077
2.999GlyLys: 2.999 ± 0.233
5.367GlyLeu: 5.367 ± 1.346
1.579GlyMet: 1.579 ± 0.186
2.526GlyAsn: 2.526 ± 0.385
1.263GlyPro: 1.263 ± 0.193
2.21GlyGln: 2.21 ± 0.536
1.894GlyArg: 1.894 ± 0.458
5.998GlySer: 5.998 ± 1.163
3.157GlyThr: 3.157 ± 0.979
3.946GlyVal: 3.946 ± 0.362
0.631GlyTrp: 0.631 ± 0.341
1.894GlyTyr: 1.894 ± 0.381
0.0GlyXaa: 0.0 ± 0.0
His
0.947HisAla: 0.947 ± 0.524
0.474HisCys: 0.474 ± 0.41
0.789HisAsp: 0.789 ± 0.282
0.631HisGlu: 0.631 ± 0.167
0.789HisPhe: 0.789 ± 0.282
0.316HisGly: 0.316 ± 0.175
0.158HisHis: 0.158 ± 0.087
1.421HisIle: 1.421 ± 0.413
0.789HisLys: 0.789 ± 0.266
1.736HisLeu: 1.736 ± 0.341
1.579HisMet: 1.579 ± 0.499
1.736HisAsn: 1.736 ± 0.341
0.947HisPro: 0.947 ± 0.524
0.947HisGln: 0.947 ± 0.241
1.579HisArg: 1.579 ± 0.495
1.894HisSer: 1.894 ± 0.664
1.894HisThr: 1.894 ± 0.425
1.105HisVal: 1.105 ± 0.258
0.158HisTrp: 0.158 ± 0.087
0.316HisTyr: 0.316 ± 0.08
0.0HisXaa: 0.0 ± 0.0
Ile
5.209IleAla: 5.209 ± 1.039
2.052IleCys: 2.052 ± 0.46
6.63IleAsp: 6.63 ± 0.521
3.788IleGlu: 3.788 ± 0.477
2.526IlePhe: 2.526 ± 0.385
4.736IleGly: 4.736 ± 0.132
2.526IleHis: 2.526 ± 0.128
5.683IleIle: 5.683 ± 0.589
5.209IleLys: 5.209 ± 2.292
6.788IleLeu: 6.788 ± 0.872
1.263IleMet: 1.263 ± 0.632
4.736IleAsn: 4.736 ± 1.217
2.526IlePro: 2.526 ± 0.738
2.368IleGln: 2.368 ± 0.486
1.894IleArg: 1.894 ± 0.868
7.419IleSer: 7.419 ± 0.909
6.63IleThr: 6.63 ± 0.759
3.631IleVal: 3.631 ± 0.51
0.789IleTrp: 0.789 ± 0.155
3.315IleTyr: 3.315 ± 0.26
0.0IleXaa: 0.0 ± 0.0
Lys
2.21LysAla: 2.21 ± 0.416
1.736LysCys: 1.736 ± 0.424
3.157LysAsp: 3.157 ± 0.311
3.473LysGlu: 3.473 ± 0.514
3.315LysPhe: 3.315 ± 0.394
4.42LysGly: 4.42 ± 0.134
0.947LysHis: 0.947 ± 0.332
3.473LysIle: 3.473 ± 0.478
3.631LysLys: 3.631 ± 0.799
6.788LysLeu: 6.788 ± 1.717
3.788LysMet: 3.788 ± 0.385
2.052LysAsn: 2.052 ± 0.304
2.21LysPro: 2.21 ± 0.172
2.21LysGln: 2.21 ± 1.2
3.473LysArg: 3.473 ± 0.847
4.262LysSer: 4.262 ± 0.833
3.631LysThr: 3.631 ± 0.127
3.315LysVal: 3.315 ± 0.266
0.316LysTrp: 0.316 ± 0.175
2.052LysTyr: 2.052 ± 0.48
0.0LysXaa: 0.0 ± 0.0
Leu
2.999LeuAla: 2.999 ± 0.292
1.263LeuCys: 1.263 ± 0.247
4.42LeuAsp: 4.42 ± 1.392
4.104LeuGlu: 4.104 ± 1.685
2.999LeuPhe: 2.999 ± 0.233
4.736LeuGly: 4.736 ± 0.55
1.894LeuHis: 1.894 ± 0.5
7.419LeuIle: 7.419 ± 1.264
6.946LeuLys: 6.946 ± 1.447
8.366LeuLeu: 8.366 ± 0.53
2.999LeuMet: 2.999 ± 1.134
4.262LeuAsn: 4.262 ± 0.532
2.526LeuPro: 2.526 ± 0.545
2.841LeuGln: 2.841 ± 0.318
3.473LeuArg: 3.473 ± 0.152
12.786LeuSer: 12.786 ± 1.273
5.367LeuThr: 5.367 ± 0.337
4.42LeuVal: 4.42 ± 0.101
0.631LeuTrp: 0.631 ± 0.341
3.631LeuTyr: 3.631 ± 0.304
0.0LeuXaa: 0.0 ± 0.0
Met
1.105MetAla: 1.105 ± 0.418
1.421MetCys: 1.421 ± 0.232
1.736MetAsp: 1.736 ± 0.298
0.789MetGlu: 0.789 ± 0.266
1.421MetPhe: 1.421 ± 0.292
1.421MetGly: 1.421 ± 0.413
1.105MetHis: 1.105 ± 0.258
2.526MetIle: 2.526 ± 0.769
2.368MetLys: 2.368 ± 0.797
2.368MetLeu: 2.368 ± 0.379
1.894MetMet: 1.894 ± 0.225
1.421MetAsn: 1.421 ± 0.643
1.579MetPro: 1.579 ± 0.353
1.579MetGln: 1.579 ± 0.311
1.579MetArg: 1.579 ± 0.532
5.209MetSer: 5.209 ± 0.805
2.526MetThr: 2.526 ± 0.146
2.052MetVal: 2.052 ± 0.089
0.474MetTrp: 0.474 ± 0.097
1.263MetTyr: 1.263 ± 0.247
0.0MetXaa: 0.0 ± 0.0
Asn
1.421AsnAla: 1.421 ± 0.612
1.263AsnCys: 1.263 ± 0.768
3.315AsnAsp: 3.315 ± 0.41
2.684AsnGlu: 2.684 ± 0.459
2.052AsnPhe: 2.052 ± 0.938
1.579AsnGly: 1.579 ± 0.385
1.105AsnHis: 1.105 ± 0.36
6.63AsnIle: 6.63 ± 1.466
4.262AsnLys: 4.262 ± 0.725
4.262AsnLeu: 4.262 ± 0.532
2.052AsnMet: 2.052 ± 0.416
4.104AsnAsn: 4.104 ± 0.959
2.21AsnPro: 2.21 ± 0.386
1.421AsnGln: 1.421 ± 0.232
2.999AsnArg: 2.999 ± 0.908
3.788AsnSer: 3.788 ± 0.423
3.788AsnThr: 3.788 ± 0.423
2.526AsnVal: 2.526 ± 0.666
0.631AsnTrp: 0.631 ± 0.358
2.368AsnTyr: 2.368 ± 0.825
0.0AsnXaa: 0.0 ± 0.0
Pro
1.894ProAla: 1.894 ± 0.878
0.631ProCys: 0.631 ± 0.341
3.315ProAsp: 3.315 ± 0.266
1.894ProGlu: 1.894 ± 0.389
0.947ProPhe: 0.947 ± 0.241
2.21ProGly: 2.21 ± 0.703
0.631ProHis: 0.631 ± 0.161
2.526ProIle: 2.526 ± 0.345
1.894ProLys: 1.894 ± 0.64
3.157ProLeu: 3.157 ± 0.464
0.947ProMet: 0.947 ± 0.241
2.368ProAsn: 2.368 ± 0.258
0.474ProPro: 0.474 ± 0.326
0.474ProGln: 0.474 ± 0.097
1.421ProArg: 1.421 ± 0.133
3.788ProSer: 3.788 ± 0.614
1.894ProThr: 1.894 ± 0.482
2.21ProVal: 2.21 ± 0.05
0.789ProTrp: 0.789 ± 0.433
0.947ProTyr: 0.947 ± 0.332
0.0ProXaa: 0.0 ± 0.0
Gln
2.368GlnAla: 2.368 ± 0.379
1.894GlnCys: 1.894 ± 1.066
3.473GlnAsp: 3.473 ± 1.534
1.263GlnGlu: 1.263 ± 0.564
1.736GlnPhe: 1.736 ± 0.534
2.21GlnGly: 2.21 ± 0.388
0.789GlnHis: 0.789 ± 0.389
2.684GlnIle: 2.684 ± 0.304
1.263GlnLys: 1.263 ± 0.193
2.684GlnLeu: 2.684 ± 1.116
1.421GlnMet: 1.421 ± 0.292
0.789GlnAsn: 0.789 ± 0.248
1.579GlnPro: 1.579 ± 0.311
2.368GlnGln: 2.368 ± 0.761
1.894GlnArg: 1.894 ± 0.875
2.841GlnSer: 2.841 ± 0.826
0.947GlnThr: 0.947 ± 0.194
2.999GlnVal: 2.999 ± 0.457
0.0GlnTrp: 0.0 ± 0.0
2.052GlnTyr: 2.052 ± 0.46
0.0GlnXaa: 0.0 ± 0.0
Arg
2.368ArgAla: 2.368 ± 0.471
1.421ArgCys: 1.421 ± 0.472
2.841ArgAsp: 2.841 ± 1.225
1.736ArgGlu: 1.736 ± 0.156
0.947ArgPhe: 0.947 ± 0.194
2.526ArgGly: 2.526 ± 0.128
0.316ArgHis: 0.316 ± 0.175
3.157ArgIle: 3.157 ± 0.209
1.894ArgLys: 1.894 ± 0.952
5.998ArgLeu: 5.998 ± 1.867
0.631ArgMet: 0.631 ± 0.161
1.894ArgAsn: 1.894 ± 0.882
1.421ArgPro: 1.421 ± 0.413
0.947ArgGln: 0.947 ± 0.275
1.263ArgArg: 1.263 ± 0.195
6.156ArgSer: 6.156 ± 1.57
2.21ArgThr: 2.21 ± 0.261
2.368ArgVal: 2.368 ± 0.459
0.947ArgTrp: 0.947 ± 0.229
0.789ArgTyr: 0.789 ± 0.288
0.0ArgXaa: 0.0 ± 0.0
Ser
5.841SerAla: 5.841 ± 0.14
0.947SerCys: 0.947 ± 0.413
5.998SerAsp: 5.998 ± 1.304
4.893SerGlu: 4.893 ± 1.453
3.946SerPhe: 3.946 ± 0.766
6.156SerGly: 6.156 ± 1.455
2.684SerHis: 2.684 ± 0.745
8.051SerIle: 8.051 ± 0.912
8.208SerLys: 8.208 ± 1.283
8.682SerLeu: 8.682 ± 1.478
3.788SerMet: 3.788 ± 0.778
5.209SerAsn: 5.209 ± 0.378
2.368SerPro: 2.368 ± 0.471
3.315SerGln: 3.315 ± 1.072
4.104SerArg: 4.104 ± 1.214
7.419SerSer: 7.419 ± 0.909
7.419SerThr: 7.419 ± 0.634
5.998SerVal: 5.998 ± 0.624
1.894SerTrp: 1.894 ± 0.641
2.999SerTyr: 2.999 ± 0.457
0.0SerXaa: 0.0 ± 0.0
Thr
2.841ThrAla: 2.841 ± 0.688
1.105ThrCys: 1.105 ± 0.75
4.104ThrAsp: 4.104 ± 0.449
2.999ThrGlu: 2.999 ± 0.189
2.526ThrPhe: 2.526 ± 0.531
4.578ThrGly: 4.578 ± 0.497
1.894ThrHis: 1.894 ± 0.482
5.209ThrIle: 5.209 ± 0.383
2.526ThrLys: 2.526 ± 0.345
4.893ThrLeu: 4.893 ± 1.128
1.736ThrMet: 1.736 ± 0.424
2.841ThrAsn: 2.841 ± 0.893
2.526ThrPro: 2.526 ± 0.746
2.684ThrGln: 2.684 ± 0.63
1.894ThrArg: 1.894 ± 0.425
7.735ThrSer: 7.735 ± 0.7
5.051ThrThr: 5.051 ± 1.432
5.209ThrVal: 5.209 ± 1.415
0.631ThrTrp: 0.631 ± 0.284
1.736ThrTyr: 1.736 ± 0.382
0.0ThrXaa: 0.0 ± 0.0
Val
2.999ValAla: 2.999 ± 0.733
1.421ValCys: 1.421 ± 0.292
3.157ValAsp: 3.157 ± 0.565
2.999ValGlu: 2.999 ± 0.232
2.526ValPhe: 2.526 ± 1.392
2.684ValGly: 2.684 ± 0.593
0.947ValHis: 0.947 ± 0.332
4.578ValIle: 4.578 ± 0.725
3.157ValLys: 3.157 ± 0.663
4.578ValLeu: 4.578 ± 0.497
1.579ValMet: 1.579 ± 0.291
3.946ValAsn: 3.946 ± 0.742
2.21ValPro: 2.21 ± 1.094
2.999ValGln: 2.999 ± 0.652
3.157ValArg: 3.157 ± 0.582
6.63ValSer: 6.63 ± 1.303
3.631ValThr: 3.631 ± 0.488
3.473ValVal: 3.473 ± 0.763
0.631ValTrp: 0.631 ± 0.341
2.684ValTyr: 2.684 ± 0.257
0.0ValXaa: 0.0 ± 0.0
Trp
0.789TrpAla: 0.789 ± 0.282
0.0TrpCys: 0.0 ± 0.0
0.947TrpAsp: 0.947 ± 0.349
0.474TrpGlu: 0.474 ± 0.341
0.474TrpPhe: 0.474 ± 0.41
0.947TrpGly: 0.947 ± 0.349
0.0TrpHis: 0.0 ± 0.0
0.631TrpIle: 0.631 ± 0.284
0.0TrpLys: 0.0 ± 0.0
0.947TrpLeu: 0.947 ± 0.349
0.474TrpMet: 0.474 ± 0.097
0.631TrpAsn: 0.631 ± 0.161
0.631TrpPro: 0.631 ± 0.161
0.316TrpGln: 0.316 ± 0.08
0.474TrpArg: 0.474 ± 0.262
0.947TrpSer: 0.947 ± 0.241
0.947TrpThr: 0.947 ± 0.613
0.789TrpVal: 0.789 ± 0.248
0.0TrpTrp: 0.0 ± 0.0
0.474TrpTyr: 0.474 ± 0.207
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.21TyrAla: 2.21 ± 0.536
1.736TyrCys: 1.736 ± 0.382
2.21TyrAsp: 2.21 ± 0.703
1.579TyrGlu: 1.579 ± 0.353
1.421TyrPhe: 1.421 ± 0.681
2.052TyrGly: 2.052 ± 0.772
0.474TyrHis: 0.474 ± 0.207
2.21TyrIle: 2.21 ± 0.901
2.368TyrLys: 2.368 ± 0.397
2.052TyrLeu: 2.052 ± 0.46
0.947TyrMet: 0.947 ± 0.275
3.788TyrAsn: 3.788 ± 0.763
0.947TyrPro: 0.947 ± 0.349
1.263TyrGln: 1.263 ± 0.606
1.579TyrArg: 1.579 ± 0.532
2.999TyrSer: 2.999 ± 0.756
2.21TyrThr: 2.21 ± 0.69
2.368TyrVal: 2.368 ± 0.486
0.316TyrTrp: 0.316 ± 0.175
1.579TyrTyr: 1.579 ± 0.753
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (6336 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski