Amino acid dipepetide frequency for Streptomyces sp. Ag109_O5-10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.537AlaAla: 21.537 ± 0.147	1.054AlaCys: 1.054 ± 0.022	8.453AlaAsp: 8.453 ± 0.063	8.687AlaGlu: 8.687 ± 0.088	3.513AlaPhe: 3.513 ± 0.04	13.256AlaGly: 13.256 ± 0.074	2.931AlaHis: 2.931 ± 0.037	3.282AlaIle: 3.282 ± 0.041	2.878AlaLys: 2.878 ± 0.035	14.309AlaLeu: 14.309 ± 0.111	2.389AlaMet: 2.389 ± 0.032	2.003AlaAsn: 2.003 ± 0.031	7.075AlaPro: 7.075 ± 0.064	3.832AlaGln: 3.832 ± 0.041	10.327AlaArg: 10.327 ± 0.072	5.874AlaSer: 5.874 ± 0.052	7.21AlaThr: 7.21 ± 0.07	12.663AlaVal: 12.663 ± 0.079	1.902AlaTrp: 1.902 ± 0.028	2.801AlaTyr: 2.801 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.066CysAla: 1.066 ± 0.021	0.092CysCys: 0.092 ± 0.006	0.433CysAsp: 0.433 ± 0.012	0.382CysGlu: 0.382 ± 0.012	0.216CysPhe: 0.216 ± 0.01	0.934CysGly: 0.934 ± 0.021	0.193CysHis: 0.193 ± 0.009	0.158CysIle: 0.158 ± 0.007	0.11CysLys: 0.11 ± 0.007	0.754CysLeu: 0.754 ± 0.018	0.126CysMet: 0.126 ± 0.007	0.147CysAsn: 0.147 ± 0.007	0.486CysPro: 0.486 ± 0.015	0.172CysGln: 0.172 ± 0.008	0.62CysArg: 0.62 ± 0.016	0.435CysSer: 0.435 ± 0.012	0.564CysThr: 0.564 ± 0.016	0.667CysVal: 0.667 ± 0.016	0.124CysTrp: 0.124 ± 0.006	0.157CysTyr: 0.157 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.467AspAla: 7.467 ± 0.062	0.43AspCys: 0.43 ± 0.013	3.528AspAsp: 3.528 ± 0.042	3.662AspGlu: 3.662 ± 0.045	1.667AspPhe: 1.667 ± 0.028	6.439AspGly: 6.439 ± 0.056	1.428AspHis: 1.428 ± 0.022	1.867AspIle: 1.867 ± 0.034	1.185AspLys: 1.185 ± 0.025	6.246AspLeu: 6.246 ± 0.059	0.811AspMet: 0.811 ± 0.017	1.019AspAsn: 1.019 ± 0.02	4.447AspPro: 4.447 ± 0.047	1.587AspGln: 1.587 ± 0.027	4.866AspArg: 4.866 ± 0.052	2.586AspSer: 2.586 ± 0.033	3.295AspThr: 3.295 ± 0.042	4.768AspVal: 4.768 ± 0.043	1.063AspTrp: 1.063 ± 0.021	1.174AspTyr: 1.174 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	7.095GluAla: 7.095 ± 0.066	0.355GluCys: 0.355 ± 0.012	2.681GluAsp: 2.681 ± 0.034	3.395GluGlu: 3.395 ± 0.046	1.456GluPhe: 1.456 ± 0.023	4.077GluGly: 4.077 ± 0.048	1.485GluHis: 1.485 ± 0.027	2.139GluIle: 2.139 ± 0.034	1.336GluLys: 1.336 ± 0.026	6.569GluLeu: 6.569 ± 0.059	0.831GluMet: 0.831 ± 0.017	1.024GluAsn: 1.024 ± 0.022	3.249GluPro: 3.249 ± 0.045	2.165GluGln: 2.165 ± 0.029	5.226GluArg: 5.226 ± 0.055	2.463GluSer: 2.463 ± 0.032	2.928GluThr: 2.928 ± 0.036	4.312GluVal: 4.312 ± 0.051	0.751GluTrp: 0.751 ± 0.018	1.097GluTyr: 1.097 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.707PheAla: 3.707 ± 0.037	0.265PheCys: 0.265 ± 0.011	1.893PheAsp: 1.893 ± 0.028	1.379PheGlu: 1.379 ± 0.024	0.877PhePhe: 0.877 ± 0.021	3.076PheGly: 3.076 ± 0.039	0.636PheHis: 0.636 ± 0.017	0.671PheIle: 0.671 ± 0.018	0.521PheLys: 0.521 ± 0.014	2.585PheLeu: 2.585 ± 0.034	0.396PheMet: 0.396 ± 0.013	0.57PheAsn: 0.57 ± 0.013	1.432PhePro: 1.432 ± 0.024	0.696PheGln: 0.696 ± 0.018	1.907PheArg: 1.907 ± 0.028	1.443PheSer: 1.443 ± 0.024	2.027PheThr: 2.027 ± 0.03	2.306PheVal: 2.306 ± 0.029	0.439PheTrp: 0.439 ± 0.013	0.604PheTyr: 0.604 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	11.11GlyAla: 11.11 ± 0.084	0.816GlyCys: 0.816 ± 0.02	5.149GlyAsp: 5.149 ± 0.051	4.815GlyGlu: 4.815 ± 0.054	2.93GlyPhe: 2.93 ± 0.04	8.874GlyGly: 8.874 ± 0.092	2.433GlyHis: 2.433 ± 0.037	3.447GlyIle: 3.447 ± 0.039	2.364GlyLys: 2.364 ± 0.031	9.413GlyLeu: 9.413 ± 0.068	1.939GlyMet: 1.939 ± 0.026	1.85GlyAsn: 1.85 ± 0.031	5.179GlyPro: 5.179 ± 0.048	2.682GlyGln: 2.682 ± 0.037	7.844GlyArg: 7.844 ± 0.06	5.553GlySer: 5.553 ± 0.055	6.867GlyThr: 6.867 ± 0.063	7.574GlyVal: 7.574 ± 0.057	1.779GlyTrp: 1.779 ± 0.031	2.369GlyTyr: 2.369 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.734HisAla: 2.734 ± 0.037	0.205HisCys: 0.205 ± 0.009	1.378HisAsp: 1.378 ± 0.025	1.174HisGlu: 1.174 ± 0.02	0.679HisPhe: 0.679 ± 0.016	2.555HisGly: 2.555 ± 0.028	0.72HisHis: 0.72 ± 0.017	0.674HisIle: 0.674 ± 0.016	0.361HisLys: 0.361 ± 0.012	2.438HisLeu: 2.438 ± 0.032	0.327HisMet: 0.327 ± 0.012	0.401HisAsn: 0.401 ± 0.014	1.866HisPro: 1.866 ± 0.032	0.604HisGln: 0.604 ± 0.017	2.174HisArg: 2.174 ± 0.027	1.046HisSer: 1.046 ± 0.023	1.43HisThr: 1.43 ± 0.024	1.76HisVal: 1.76 ± 0.024	0.403HisTrp: 0.403 ± 0.013	0.516HisTyr: 0.516 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.541IleAla: 4.541 ± 0.045	0.271IleCys: 0.271 ± 0.01	2.148IleAsp: 2.148 ± 0.028	1.827IleGlu: 1.827 ± 0.031	0.683IlePhe: 0.683 ± 0.017	3.41IleGly: 3.41 ± 0.04	0.602IleHis: 0.602 ± 0.015	0.84IleIle: 0.84 ± 0.022	0.696IleLys: 0.696 ± 0.017	2.391IleLeu: 2.391 ± 0.034	0.434IleMet: 0.434 ± 0.013	0.684IleAsn: 0.684 ± 0.016	1.757IlePro: 1.757 ± 0.025	0.754IleGln: 0.754 ± 0.018	2.21IleArg: 2.21 ± 0.032	1.647IleSer: 1.647 ± 0.026	2.193IleThr: 2.193 ± 0.033	2.653IleVal: 2.653 ± 0.037	0.371IleTrp: 0.371 ± 0.012	0.512IleTyr: 0.512 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.966LysAla: 2.966 ± 0.042	0.117LysCys: 0.117 ± 0.007	1.346LysAsp: 1.346 ± 0.024	1.1LysGlu: 1.1 ± 0.024	0.452LysPhe: 0.452 ± 0.014	1.824LysGly: 1.824 ± 0.03	0.423LysHis: 0.423 ± 0.012	0.853LysIle: 0.853 ± 0.02	0.821LysLys: 0.821 ± 0.023	1.986LysLeu: 1.986 ± 0.03	0.372LysMet: 0.372 ± 0.011	0.541LysAsn: 0.541 ± 0.017	1.299LysPro: 1.299 ± 0.023	0.714LysGln: 0.714 ± 0.017	1.387LysArg: 1.387 ± 0.024	1.178LysSer: 1.178 ± 0.024	1.312LysThr: 1.312 ± 0.028	1.941LysVal: 1.941 ± 0.033	0.266LysTrp: 0.266 ± 0.01	0.483LysTyr: 0.483 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.032LeuAla: 15.032 ± 0.101	0.825LeuCys: 0.825 ± 0.019	6.645LeuAsp: 6.645 ± 0.061	4.485LeuGlu: 4.485 ± 0.056	2.586LeuPhe: 2.586 ± 0.038	9.231LeuGly: 9.231 ± 0.073	2.34LeuHis: 2.34 ± 0.031	3.079LeuIle: 3.079 ± 0.037	2.018LeuLys: 2.018 ± 0.029	11.259LeuLeu: 11.259 ± 0.104	1.559LeuMet: 1.559 ± 0.027	1.684LeuAsn: 1.684 ± 0.024	6.511LeuPro: 6.511 ± 0.055	2.225LeuGln: 2.225 ± 0.028	8.633LeuArg: 8.633 ± 0.071	5.257LeuSer: 5.257 ± 0.051	6.943LeuThr: 6.943 ± 0.062	8.896LeuVal: 8.896 ± 0.069	1.317LeuTrp: 1.317 ± 0.026	1.93LeuTyr: 1.93 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.156MetAla: 2.156 ± 0.03	0.138MetCys: 0.138 ± 0.007	0.853MetAsp: 0.853 ± 0.018	0.7MetGlu: 0.7 ± 0.019	0.457MetPhe: 0.457 ± 0.014	1.256MetGly: 1.256 ± 0.022	0.358MetHis: 0.358 ± 0.011	0.636MetIle: 0.636 ± 0.017	0.404MetLys: 0.404 ± 0.012	1.546MetLeu: 1.546 ± 0.025	0.285MetMet: 0.285 ± 0.011	0.431MetAsn: 0.431 ± 0.012	1.083MetPro: 1.083 ± 0.022	0.447MetGln: 0.447 ± 0.013	1.38MetArg: 1.38 ± 0.024	1.33MetSer: 1.33 ± 0.022	1.585MetThr: 1.585 ± 0.024	1.213MetVal: 1.213 ± 0.023	0.219MetTrp: 0.219 ± 0.009	0.335MetTyr: 0.335 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.263AsnAla: 2.263 ± 0.032	0.17AsnCys: 0.17 ± 0.008	0.965AsnAsp: 0.965 ± 0.022	0.785AsnGlu: 0.785 ± 0.017	0.496AsnPhe: 0.496 ± 0.014	2.032AsnGly: 2.032 ± 0.037	0.404AsnHis: 0.404 ± 0.011	0.659AsnIle: 0.659 ± 0.014	0.41AsnLys: 0.41 ± 0.012	1.704AsnLeu: 1.704 ± 0.027	0.308AsnMet: 0.308 ± 0.011	0.474AsnAsn: 0.474 ± 0.017	1.4AsnPro: 1.4 ± 0.026	0.548AsnGln: 0.548 ± 0.015	1.273AsnArg: 1.273 ± 0.022	1.044AsnSer: 1.044 ± 0.025	1.164AsnThr: 1.164 ± 0.027	1.389AsnVal: 1.389 ± 0.021	0.315AsnTrp: 0.315 ± 0.011	0.436AsnTyr: 0.436 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.893ProAla: 8.893 ± 0.072	0.351ProCys: 0.351 ± 0.012	4.38ProAsp: 4.38 ± 0.044	4.193ProGlu: 4.193 ± 0.045	1.53ProPhe: 1.53 ± 0.026	6.64ProGly: 6.64 ± 0.061	1.478ProHis: 1.478 ± 0.026	1.203ProIle: 1.203 ± 0.022	1.183ProLys: 1.183 ± 0.025	5.303ProLeu: 5.303 ± 0.048	0.977ProMet: 0.977 ± 0.021	0.926ProAsn: 0.926 ± 0.019	3.547ProPro: 3.547 ± 0.054	1.773ProGln: 1.773 ± 0.032	3.981ProArg: 3.981 ± 0.043	3.147ProSer: 3.147 ± 0.043	3.198ProThr: 3.198 ± 0.04	5.636ProVal: 5.636 ± 0.051	0.903ProTrp: 0.903 ± 0.021	1.444ProTyr: 1.444 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.732GlnAla: 3.732 ± 0.04	0.165GlnCys: 0.165 ± 0.008	1.441GlnAsp: 1.441 ± 0.023	1.466GlnGlu: 1.466 ± 0.023	0.716GlnPhe: 0.716 ± 0.018	2.379GlnGly: 2.379 ± 0.046	0.702GlnHis: 0.702 ± 0.017	1.101GlnIle: 1.101 ± 0.021	0.635GlnLys: 0.635 ± 0.015	3.044GlnLeu: 3.044 ± 0.034	0.489GlnMet: 0.489 ± 0.015	0.527GlnAsn: 0.527 ± 0.016	1.684GlnPro: 1.684 ± 0.03	1.268GlnGln: 1.268 ± 0.03	2.316GlnArg: 2.316 ± 0.032	1.34GlnSer: 1.34 ± 0.027	1.465GlnThr: 1.465 ± 0.026	2.426GlnVal: 2.426 ± 0.029	0.481GlnTrp: 0.481 ± 0.014	0.663GlnTyr: 0.663 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	9.939ArgAla: 9.939 ± 0.076	0.598ArgCys: 0.598 ± 0.016	4.178ArgAsp: 4.178 ± 0.043	4.57ArgGlu: 4.57 ± 0.054	2.274ArgPhe: 2.274 ± 0.028	5.73ArgGly: 5.73 ± 0.052	2.192ArgHis: 2.192 ± 0.031	3.174ArgIle: 3.174 ± 0.036	1.607ArgLys: 1.607 ± 0.031	8.881ArgLeu: 8.881 ± 0.061	1.651ArgMet: 1.651 ± 0.027	1.341ArgAsn: 1.341 ± 0.023	5.092ArgPro: 5.092 ± 0.061	2.371ArgGln: 2.371 ± 0.032	7.823ArgArg: 7.823 ± 0.074	4.001ArgSer: 4.001 ± 0.042	5.55ArgThr: 5.55 ± 0.05	5.916ArgVal: 5.916 ± 0.057	1.381ArgTrp: 1.381 ± 0.026	1.848ArgTyr: 1.848 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.954SerAla: 6.954 ± 0.058	0.43SerCys: 0.43 ± 0.015	2.733SerAsp: 2.733 ± 0.036	2.234SerGlu: 2.234 ± 0.029	1.545SerPhe: 1.545 ± 0.025	6.08SerGly: 6.08 ± 0.063	1.056SerHis: 1.056 ± 0.02	1.36SerIle: 1.36 ± 0.023	1.045SerLys: 1.045 ± 0.021	4.785SerLeu: 4.785 ± 0.041	1.093SerMet: 1.093 ± 0.022	0.938SerAsn: 0.938 ± 0.019	3.184SerPro: 3.184 ± 0.041	1.334SerGln: 1.334 ± 0.026	3.616SerArg: 3.616 ± 0.04	3.026SerSer: 3.026 ± 0.051	3.207SerThr: 3.207 ± 0.048	4.362SerVal: 4.362 ± 0.043	0.907SerTrp: 0.907 ± 0.021	1.335SerTyr: 1.335 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	9.399ThrAla: 9.399 ± 0.08	0.45ThrCys: 0.45 ± 0.014	3.795ThrAsp: 3.795 ± 0.043	3.254ThrGlu: 3.254 ± 0.038	1.672ThrPhe: 1.672 ± 0.03	7.142ThrGly: 7.142 ± 0.075	1.27ThrHis: 1.27 ± 0.02	1.648ThrIle: 1.648 ± 0.026	1.214ThrLys: 1.214 ± 0.028	5.806ThrLeu: 5.806 ± 0.049	0.941ThrMet: 0.941 ± 0.021	1.066ThrAsn: 1.066 ± 0.025	4.151ThrPro: 4.151 ± 0.042	1.381ThrGln: 1.381 ± 0.024	4.041ThrArg: 4.041 ± 0.042	3.344ThrSer: 3.344 ± 0.045	4.165ThrThr: 4.165 ± 0.066	6.426ThrVal: 6.426 ± 0.056	0.936ThrTrp: 0.936 ± 0.02	1.456ThrTyr: 1.456 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.831ValAla: 10.831 ± 0.073	0.773ValCys: 0.773 ± 0.017	4.993ValAsp: 4.993 ± 0.042	4.563ValGlu: 4.563 ± 0.044	2.463ValPhe: 2.463 ± 0.031	6.615ValGly: 6.615 ± 0.054	2.004ValHis: 2.004 ± 0.029	2.77ValIle: 2.77 ± 0.039	1.783ValLys: 1.783 ± 0.029	9.53ValLeu: 9.53 ± 0.076	1.366ValMet: 1.366 ± 0.021	1.742ValAsn: 1.742 ± 0.026	5.338ValPro: 5.338 ± 0.045	2.195ValGln: 2.195 ± 0.03	7.314ValArg: 7.314 ± 0.061	4.488ValSer: 4.488 ± 0.043	6.015ValThr: 6.015 ± 0.059	8.165ValVal: 8.165 ± 0.069	1.178ValTrp: 1.178 ± 0.02	1.691ValTyr: 1.691 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.735TrpAla: 1.735 ± 0.029	0.154TrpCys: 0.154 ± 0.007	0.83TrpAsp: 0.83 ± 0.019	0.726TrpGlu: 0.726 ± 0.019	0.529TrpPhe: 0.529 ± 0.015	1.076TrpGly: 1.076 ± 0.02	0.377TrpHis: 0.377 ± 0.012	0.561TrpIle: 0.561 ± 0.014	0.38TrpLys: 0.38 ± 0.012	1.785TrpLeu: 1.785 ± 0.03	0.282TrpMet: 0.282 ± 0.01	0.432TrpAsn: 0.432 ± 0.012	0.798TrpPro: 0.798 ± 0.017	0.643TrpGln: 0.643 ± 0.016	1.32TrpArg: 1.32 ± 0.023	0.978TrpSer: 0.978 ± 0.019	1.128TrpThr: 1.128 ± 0.02	0.989TrpVal: 0.989 ± 0.021	0.347TrpTrp: 0.347 ± 0.012	0.389TrpTyr: 0.389 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.819TyrAla: 2.819 ± 0.04	0.175TyrCys: 0.175 ± 0.008	1.712TyrAsp: 1.712 ± 0.033	1.233TyrGlu: 1.233 ± 0.024	0.689TyrPhe: 0.689 ± 0.019	2.362TyrGly: 2.362 ± 0.031	0.41TyrHis: 0.41 ± 0.012	0.503TyrIle: 0.503 ± 0.015	0.431TyrLys: 0.431 ± 0.014	2.125TyrLeu: 2.125 ± 0.032	0.234TyrMet: 0.234 ± 0.009	0.442TyrAsn: 0.442 ± 0.013	1.108TyrPro: 1.108 ± 0.024	0.648TyrGln: 0.648 ± 0.016	1.861TyrArg: 1.861 ± 0.027	1.042TyrSer: 1.042 ± 0.021	1.309TyrThr: 1.309 ± 0.026	1.76TyrVal: 1.76 ± 0.026	0.379TyrTrp: 0.379 ± 0.013	0.502TyrTyr: 0.502 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8132 proteins (2675155 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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