Amino acid dipepetide frequency for Opitutaceae bacterium TAV5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.461AlaAla: 17.461 ± 0.148	1.191AlaCys: 1.191 ± 0.022	6.706AlaAsp: 6.706 ± 0.06	5.869AlaGlu: 5.869 ± 0.074	4.382AlaPhe: 4.382 ± 0.047	11.885AlaGly: 11.885 ± 0.096	2.195AlaHis: 2.195 ± 0.036	5.324AlaIle: 5.324 ± 0.056	2.914AlaLys: 2.914 ± 0.046	12.078AlaLeu: 12.078 ± 0.094	2.108AlaMet: 2.108 ± 0.033	3.051AlaAsn: 3.051 ± 0.048	6.395AlaPro: 6.395 ± 0.078	3.246AlaGln: 3.246 ± 0.041	9.293AlaArg: 9.293 ± 0.087	7.133AlaSer: 7.133 ± 0.069	7.483AlaThr: 7.483 ± 0.08	7.489AlaVal: 7.489 ± 0.067	2.361AlaTrp: 2.361 ± 0.035	2.172AlaTyr: 2.172 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.035CysAla: 1.035 ± 0.022	0.117CysCys: 0.117 ± 0.007	0.517CysAsp: 0.517 ± 0.018	0.468CysGlu: 0.468 ± 0.016	0.392CysPhe: 0.392 ± 0.013	0.831CysGly: 0.831 ± 0.021	0.28CysHis: 0.28 ± 0.011	0.432CysIle: 0.432 ± 0.016	0.209CysLys: 0.209 ± 0.012	0.923CysLeu: 0.923 ± 0.024	0.148CysMet: 0.148 ± 0.009	0.228CysAsn: 0.228 ± 0.01	0.578CysPro: 0.578 ± 0.019	0.242CysGln: 0.242 ± 0.01	0.707CysArg: 0.707 ± 0.02	0.475CysSer: 0.475 ± 0.014	0.417CysThr: 0.417 ± 0.014	0.641CysVal: 0.641 ± 0.02	0.147CysTrp: 0.147 ± 0.01	0.225CysTyr: 0.225 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.637AspAla: 6.637 ± 0.064	0.438AspCys: 0.438 ± 0.015	3.054AspAsp: 3.054 ± 0.038	2.828AspGlu: 2.828 ± 0.041	2.314AspPhe: 2.314 ± 0.038	5.309AspGly: 5.309 ± 0.062	1.146AspHis: 1.146 ± 0.024	2.709AspIle: 2.709 ± 0.047	1.458AspLys: 1.458 ± 0.028	5.047AspLeu: 5.047 ± 0.051	0.771AspMet: 0.771 ± 0.019	1.742AspAsn: 1.742 ± 0.034	3.418AspPro: 3.418 ± 0.04	1.317AspGln: 1.317 ± 0.028	3.521AspArg: 3.521 ± 0.044	2.704AspSer: 2.704 ± 0.038	3.342AspThr: 3.342 ± 0.044	3.308AspVal: 3.308 ± 0.041	1.11AspTrp: 1.11 ± 0.024	1.81AspTyr: 1.81 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	6.013GluAla: 6.013 ± 0.065	0.417GluCys: 0.417 ± 0.012	2.179GluAsp: 2.179 ± 0.034	2.607GluGlu: 2.607 ± 0.048	1.869GluPhe: 1.869 ± 0.032	3.589GluGly: 3.589 ± 0.049	1.171GluHis: 1.171 ± 0.026	3.097GluIle: 3.097 ± 0.04	2.617GluLys: 2.617 ± 0.046	5.085GluLeu: 5.085 ± 0.051	1.016GluMet: 1.016 ± 0.021	1.923GluAsn: 1.923 ± 0.034	2.657GluPro: 2.657 ± 0.041	1.859GluGln: 1.859 ± 0.033	3.886GluArg: 3.886 ± 0.053	2.643GluSer: 2.643 ± 0.035	3.481GluThr: 3.481 ± 0.044	3.152GluVal: 3.152 ± 0.039	0.835GluTrp: 0.835 ± 0.021	1.057GluTyr: 1.057 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.436PheAla: 4.436 ± 0.052	0.432PheCys: 0.432 ± 0.015	2.469PheAsp: 2.469 ± 0.039	1.83PheGlu: 1.83 ± 0.028	1.728PhePhe: 1.728 ± 0.029	3.261PheGly: 3.261 ± 0.045	0.849PheHis: 0.849 ± 0.025	1.611PheIle: 1.611 ± 0.028	0.84PheLys: 0.84 ± 0.02	3.55PheLeu: 3.55 ± 0.053	0.63PheMet: 0.63 ± 0.017	1.238PheAsn: 1.238 ± 0.026	2.083PhePro: 2.083 ± 0.036	0.99PheGln: 0.99 ± 0.021	2.876PheArg: 2.876 ± 0.046	2.819PheSer: 2.819 ± 0.04	2.684PheThr: 2.684 ± 0.04	2.67PheVal: 2.67 ± 0.036	0.637PheTrp: 0.637 ± 0.016	1.132PheTyr: 1.132 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	8.597GlyAla: 8.597 ± 0.092	0.855GlyCys: 0.855 ± 0.02	4.566GlyAsp: 4.566 ± 0.061	4.513GlyGlu: 4.513 ± 0.052	3.454GlyPhe: 3.454 ± 0.042	7.56GlyGly: 7.56 ± 0.105	1.896GlyHis: 1.896 ± 0.037	4.631GlyIle: 4.631 ± 0.051	3.373GlyLys: 3.373 ± 0.044	7.968GlyLeu: 7.968 ± 0.063	1.721GlyMet: 1.721 ± 0.032	2.984GlyAsn: 2.984 ± 0.05	3.175GlyPro: 3.175 ± 0.043	2.704GlyGln: 2.704 ± 0.035	5.975GlyArg: 5.975 ± 0.061	5.36GlySer: 5.36 ± 0.083	5.334GlyThr: 5.334 ± 0.089	5.798GlyVal: 5.798 ± 0.057	1.615GlyTrp: 1.615 ± 0.033	2.723GlyTyr: 2.723 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.656HisAla: 2.656 ± 0.041	0.213HisCys: 0.213 ± 0.01	1.233HisAsp: 1.233 ± 0.024	1.048HisGlu: 1.048 ± 0.026	1.003HisPhe: 1.003 ± 0.024	1.917HisGly: 1.917 ± 0.029	0.651HisHis: 0.651 ± 0.024	0.942HisIle: 0.942 ± 0.022	0.476HisLys: 0.476 ± 0.015	2.326HisLeu: 2.326 ± 0.038	0.328HisMet: 0.328 ± 0.013	0.622HisAsn: 0.622 ± 0.02	1.72HisPro: 1.72 ± 0.029	0.564HisGln: 0.564 ± 0.017	1.72HisArg: 1.72 ± 0.036	1.041HisSer: 1.041 ± 0.02	1.22HisThr: 1.22 ± 0.025	1.431HisVal: 1.431 ± 0.027	0.382HisTrp: 0.382 ± 0.014	0.705HisTyr: 0.705 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.725IleAla: 5.725 ± 0.057	0.449IleCys: 0.449 ± 0.017	3.099IleAsp: 3.099 ± 0.041	2.868IleGlu: 2.868 ± 0.035	1.576IlePhe: 1.576 ± 0.03	4.137IleGly: 4.137 ± 0.05	1.056IleHis: 1.056 ± 0.023	2.252IleIle: 2.252 ± 0.039	1.303IleLys: 1.303 ± 0.026	4.242IleLeu: 4.242 ± 0.043	0.713IleMet: 0.713 ± 0.017	1.641IleAsn: 1.641 ± 0.036	2.871IlePro: 2.871 ± 0.04	1.132IleGln: 1.132 ± 0.022	3.666IleArg: 3.666 ± 0.043	2.61IleSer: 2.61 ± 0.038	3.358IleThr: 3.358 ± 0.056	3.394IleVal: 3.394 ± 0.045	0.592IleTrp: 0.592 ± 0.017	1.117IleTyr: 1.117 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	3.215LysAla: 3.215 ± 0.05	0.179LysCys: 0.179 ± 0.009	1.451LysAsp: 1.451 ± 0.029	1.449LysGlu: 1.449 ± 0.032	0.967LysPhe: 0.967 ± 0.023	2.029LysGly: 2.029 ± 0.038	0.702LysHis: 0.702 ± 0.019	1.829LysIle: 1.829 ± 0.035	1.65LysLys: 1.65 ± 0.039	2.927LysLeu: 2.927 ± 0.047	0.625LysMet: 0.625 ± 0.017	1.331LysAsn: 1.331 ± 0.03	2.085LysPro: 2.085 ± 0.033	0.967LysGln: 0.967 ± 0.024	2.037LysArg: 2.037 ± 0.036	1.7LysSer: 1.7 ± 0.034	2.445LysThr: 2.445 ± 0.036	1.862LysVal: 1.862 ± 0.033	0.426LysTrp: 0.426 ± 0.015	0.654LysTyr: 0.654 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	13.868LeuAla: 13.868 ± 0.101	1.003LeuCys: 1.003 ± 0.025	5.523LeuAsp: 5.523 ± 0.061	4.686LeuGlu: 4.686 ± 0.057	3.753LeuPhe: 3.753 ± 0.052	7.499LeuGly: 7.499 ± 0.081	2.373LeuHis: 2.373 ± 0.033	3.92LeuIle: 3.92 ± 0.049	2.906LeuLys: 2.906 ± 0.04	10.318LeuLeu: 10.318 ± 0.095	1.561LeuMet: 1.561 ± 0.032	2.644LeuAsn: 2.644 ± 0.039	6.533LeuPro: 6.533 ± 0.06	2.755LeuGln: 2.755 ± 0.037	8.325LeuArg: 8.325 ± 0.075	5.802LeuSer: 5.802 ± 0.056	6.17LeuThr: 6.17 ± 0.065	7.383LeuVal: 7.383 ± 0.065	1.348LeuTrp: 1.348 ± 0.029	2.151LeuTyr: 2.151 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	1.848MetAla: 1.848 ± 0.032	0.134MetCys: 0.134 ± 0.008	0.749MetAsp: 0.749 ± 0.019	0.862MetGlu: 0.862 ± 0.018	0.559MetPhe: 0.559 ± 0.016	1.077MetGly: 1.077 ± 0.024	0.393MetHis: 0.393 ± 0.014	0.96MetIle: 0.96 ± 0.026	1.03MetLys: 1.03 ± 0.022	1.7MetLeu: 1.7 ± 0.034	0.374MetMet: 0.374 ± 0.015	0.742MetAsn: 0.742 ± 0.02	1.212MetPro: 1.212 ± 0.021	0.622MetGln: 0.622 ± 0.018	1.269MetArg: 1.269 ± 0.027	1.22MetSer: 1.22 ± 0.025	1.26MetThr: 1.26 ± 0.024	0.987MetVal: 0.987 ± 0.019	0.193MetTrp: 0.193 ± 0.01	0.228MetTyr: 0.228 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.216AsnAla: 3.216 ± 0.047	0.223AsnCys: 0.223 ± 0.012	1.554AsnAsp: 1.554 ± 0.03	1.346AsnGlu: 1.346 ± 0.023	1.112AsnPhe: 1.112 ± 0.022	2.688AsnGly: 2.688 ± 0.047	0.727AsnHis: 0.727 ± 0.017	1.542AsnIle: 1.542 ± 0.036	0.79AsnLys: 0.79 ± 0.021	3.124AsnLeu: 3.124 ± 0.042	0.452AsnMet: 0.452 ± 0.016	1.107AsnAsn: 1.107 ± 0.027	2.278AsnPro: 2.278 ± 0.039	0.842AsnGln: 0.842 ± 0.019	2.191AsnArg: 2.191 ± 0.036	1.556AsnSer: 1.556 ± 0.029	2.042AsnThr: 2.042 ± 0.037	1.873AsnVal: 1.873 ± 0.034	0.555AsnTrp: 0.555 ± 0.02	0.973AsnTyr: 0.973 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	9.084ProAla: 9.084 ± 0.098	0.41ProCys: 0.41 ± 0.015	4.288ProAsp: 4.288 ± 0.044	4.067ProGlu: 4.067 ± 0.048	2.042ProPhe: 2.042 ± 0.035	5.688ProGly: 5.688 ± 0.059	1.234ProHis: 1.234 ± 0.027	1.517ProIle: 1.517 ± 0.029	1.39ProLys: 1.39 ± 0.028	5.321ProLeu: 5.321 ± 0.051	0.961ProMet: 0.961 ± 0.023	1.16ProAsn: 1.16 ± 0.024	3.863ProPro: 3.863 ± 0.068	1.524ProGln: 1.524 ± 0.024	3.481ProArg: 3.481 ± 0.046	3.361ProSer: 3.361 ± 0.042	2.38ProThr: 2.38 ± 0.039	5.19ProVal: 5.19 ± 0.061	0.983ProTrp: 0.983 ± 0.023	1.119ProTyr: 1.119 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.412GlnAla: 3.412 ± 0.041	0.237GlnCys: 0.237 ± 0.012	1.239GlnAsp: 1.239 ± 0.021	1.359GlnGlu: 1.359 ± 0.029	1.063GlnPhe: 1.063 ± 0.025	2.061GlnGly: 2.061 ± 0.033	0.65GlnHis: 0.65 ± 0.018	1.678GlnIle: 1.678 ± 0.025	1.14GlnLys: 1.14 ± 0.025	2.981GlnLeu: 2.981 ± 0.044	0.592GlnMet: 0.592 ± 0.017	0.961GlnAsn: 0.961 ± 0.021	1.912GlnPro: 1.912 ± 0.031	1.129GlnGln: 1.129 ± 0.028	2.209GlnArg: 2.209 ± 0.042	1.611GlnSer: 1.611 ± 0.028	1.964GlnThr: 1.964 ± 0.03	1.965GlnVal: 1.965 ± 0.034	0.481GlnTrp: 0.481 ± 0.016	0.611GlnTyr: 0.611 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	7.709ArgAla: 7.709 ± 0.078	0.609ArgCys: 0.609 ± 0.018	3.818ArgAsp: 3.818 ± 0.045	4.694ArgGlu: 4.694 ± 0.057	3.107ArgPhe: 3.107 ± 0.043	4.79ArgGly: 4.79 ± 0.055	2.056ArgHis: 2.056 ± 0.029	4.319ArgIle: 4.319 ± 0.051	2.454ArgLys: 2.454 ± 0.042	8.143ArgLeu: 8.143 ± 0.078	1.593ArgMet: 1.593 ± 0.03	2.124ArgAsn: 2.124 ± 0.032	4.054ArgPro: 4.054 ± 0.047	2.782ArgGln: 2.782 ± 0.038	6.074ArgArg: 6.074 ± 0.075	3.833ArgSer: 3.833 ± 0.041	4.021ArgThr: 4.021 ± 0.049	4.861ArgVal: 4.861 ± 0.055	1.327ArgTrp: 1.327 ± 0.031	1.959ArgTyr: 1.959 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.825SerAla: 6.825 ± 0.071	0.451SerCys: 0.451 ± 0.016	2.899SerAsp: 2.899 ± 0.039	2.362SerGlu: 2.362 ± 0.032	2.244SerPhe: 2.244 ± 0.037	6.465SerGly: 6.465 ± 0.082	1.143SerHis: 1.143 ± 0.025	2.63SerIle: 2.63 ± 0.041	1.31SerLys: 1.31 ± 0.029	6.114SerLeu: 6.114 ± 0.062	1.018SerMet: 1.018 ± 0.022	1.513SerAsn: 1.513 ± 0.029	3.98SerPro: 3.98 ± 0.044	1.525SerGln: 1.525 ± 0.024	4.081SerArg: 4.081 ± 0.041	3.833SerSer: 3.833 ± 0.056	3.36SerThr: 3.36 ± 0.049	4.034SerVal: 4.034 ± 0.05	0.959SerTrp: 0.959 ± 0.024	1.4SerTyr: 1.4 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	7.144ThrAla: 7.144 ± 0.078	0.506ThrCys: 0.506 ± 0.016	3.163ThrAsp: 3.163 ± 0.044	2.54ThrGlu: 2.54 ± 0.037	2.484ThrPhe: 2.484 ± 0.035	6.547ThrGly: 6.547 ± 0.089	1.258ThrHis: 1.258 ± 0.024	2.9ThrIle: 2.9 ± 0.045	1.354ThrLys: 1.354 ± 0.026	7.605ThrLeu: 7.605 ± 0.086	0.831ThrMet: 0.831 ± 0.021	1.553ThrAsn: 1.553 ± 0.035	4.359ThrPro: 4.359 ± 0.04	1.54ThrGln: 1.54 ± 0.029	4.145ThrArg: 4.145 ± 0.042	3.347ThrSer: 3.347 ± 0.056	3.967ThrThr: 3.967 ± 0.078	4.821ThrVal: 4.821 ± 0.065	1.216ThrTrp: 1.216 ± 0.028	1.43ThrTyr: 1.43 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.966ValAla: 7.966 ± 0.069	0.759ValCys: 0.759 ± 0.022	3.2ValAsp: 3.2 ± 0.042	3.66ValGlu: 3.66 ± 0.043	2.959ValPhe: 2.959 ± 0.039	4.428ValGly: 4.428 ± 0.055	1.295ValHis: 1.295 ± 0.024	3.671ValIle: 3.671 ± 0.045	2.002ValLys: 2.002 ± 0.038	6.607ValLeu: 6.607 ± 0.057	1.239ValMet: 1.239 ± 0.025	2.133ValAsn: 2.133 ± 0.034	3.815ValPro: 3.815 ± 0.043	1.88ValGln: 1.88 ± 0.032	5.261ValArg: 5.261 ± 0.051	4.696ValSer: 4.696 ± 0.051	5.062ValThr: 5.062 ± 0.07	4.864ValVal: 4.864 ± 0.05	1.073ValTrp: 1.073 ± 0.025	1.553ValTyr: 1.553 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.328TrpAla: 1.328 ± 0.028	0.173TrpCys: 0.173 ± 0.01	0.816TrpAsp: 0.816 ± 0.022	0.842TrpGlu: 0.842 ± 0.022	0.705TrpPhe: 0.705 ± 0.02	1.015TrpGly: 1.015 ± 0.023	0.526TrpHis: 0.526 ± 0.018	0.859TrpIle: 0.859 ± 0.021	0.674TrpLys: 0.674 ± 0.017	2.062TrpLeu: 2.062 ± 0.036	0.401TrpMet: 0.401 ± 0.015	0.645TrpAsn: 0.645 ± 0.018	0.808TrpPro: 0.808 ± 0.022	0.832TrpGln: 0.832 ± 0.02	1.527TrpArg: 1.527 ± 0.032	1.088TrpSer: 1.088 ± 0.023	1.138TrpThr: 1.138 ± 0.031	0.868TrpVal: 0.868 ± 0.019	0.331TrpTrp: 0.331 ± 0.013	0.392TrpTyr: 0.392 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.563TyrAla: 2.563 ± 0.039	0.218TyrCys: 0.218 ± 0.01	1.458TyrAsp: 1.458 ± 0.035	1.258TyrGlu: 1.258 ± 0.026	1.052TyrPhe: 1.052 ± 0.021	2.028TyrGly: 2.028 ± 0.033	0.595TyrHis: 0.595 ± 0.018	0.976TyrIle: 0.976 ± 0.021	0.638TyrLys: 0.638 ± 0.02	2.395TyrLeu: 2.395 ± 0.034	0.34TyrMet: 0.34 ± 0.013	0.847TyrAsn: 0.847 ± 0.023	1.268TyrPro: 1.268 ± 0.023	0.802TyrGln: 0.802 ± 0.021	2.083TyrArg: 2.083 ± 0.034	1.318TyrSer: 1.318 ± 0.028	1.583TyrThr: 1.583 ± 0.037	1.532TyrVal: 1.532 ± 0.026	0.458TyrTrp: 0.458 ± 0.015	0.821TyrTyr: 0.821 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6011 proteins (2136471 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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