Amino acid dipepetide frequency for Rutstroemia sp. NJR-2017a WRK4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.302AlaAla: 8.302 ± 0.056	0.985AlaCys: 0.985 ± 0.016	3.943AlaAsp: 3.943 ± 0.033	5.036AlaGlu: 5.036 ± 0.04	3.005AlaPhe: 3.005 ± 0.026	5.663AlaGly: 5.663 ± 0.04	1.628AlaHis: 1.628 ± 0.019	4.323AlaIle: 4.323 ± 0.035	4.212AlaLys: 4.212 ± 0.036	7.32AlaLeu: 7.32 ± 0.043	1.906AlaMet: 1.906 ± 0.019	3.057AlaAsn: 3.057 ± 0.029	4.484AlaPro: 4.484 ± 0.037	3.183AlaGln: 3.183 ± 0.029	4.357AlaArg: 4.357 ± 0.035	7.029AlaSer: 7.029 ± 0.047	5.117AlaThr: 5.117 ± 0.039	5.026AlaVal: 5.026 ± 0.038	1.082AlaTrp: 1.082 ± 0.019	2.139AlaTyr: 2.139 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.894CysAla: 0.894 ± 0.015	0.232CysCys: 0.232 ± 0.007	0.634CysAsp: 0.634 ± 0.01	0.598CysGlu: 0.598 ± 0.011	0.523CysPhe: 0.523 ± 0.01	0.915CysGly: 0.915 ± 0.015	0.287CysHis: 0.287 ± 0.008	0.734CysIle: 0.734 ± 0.013	0.544CysLys: 0.544 ± 0.013	1.194CysLeu: 1.194 ± 0.016	0.261CysMet: 0.261 ± 0.007	0.408CysAsn: 0.408 ± 0.008	0.617CysPro: 0.617 ± 0.014	0.409CysGln: 0.409 ± 0.01	0.649CysArg: 0.649 ± 0.013	0.904CysSer: 0.904 ± 0.016	0.698CysThr: 0.698 ± 0.014	0.755CysVal: 0.755 ± 0.012	0.202CysTrp: 0.202 ± 0.007	0.357CysTyr: 0.357 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.36AspAla: 4.36 ± 0.03	0.6AspCys: 0.6 ± 0.012	3.961AspAsp: 3.961 ± 0.04	4.47AspGlu: 4.47 ± 0.04	2.188AspPhe: 2.188 ± 0.021	3.969AspGly: 3.969 ± 0.031	1.155AspHis: 1.155 ± 0.016	3.231AspIle: 3.231 ± 0.025	2.363AspLys: 2.363 ± 0.023	4.942AspLeu: 4.942 ± 0.037	1.23AspMet: 1.23 ± 0.016	1.886AspAsn: 1.886 ± 0.022	3.077AspPro: 3.077 ± 0.026	1.692AspGln: 1.692 ± 0.02	2.833AspArg: 2.833 ± 0.03	4.135AspSer: 4.135 ± 0.033	2.939AspThr: 2.939 ± 0.027	3.505AspVal: 3.505 ± 0.026	0.861AspTrp: 0.861 ± 0.014	1.622AspTyr: 1.622 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.188GluAla: 5.188 ± 0.042	0.614GluCys: 0.614 ± 0.013	4.272GluAsp: 4.272 ± 0.039	6.016GluGlu: 6.016 ± 0.064	2.021GluPhe: 2.021 ± 0.017	4.168GluGly: 4.168 ± 0.035	1.319GluHis: 1.319 ± 0.015	3.388GluIle: 3.388 ± 0.029	4.28GluLys: 4.28 ± 0.037	5.171GluLeu: 5.171 ± 0.042	1.593GluMet: 1.593 ± 0.018	2.576GluAsn: 2.576 ± 0.021	2.617GluPro: 2.617 ± 0.035	2.339GluGln: 2.339 ± 0.023	4.03GluArg: 4.03 ± 0.038	4.378GluSer: 4.378 ± 0.04	3.412GluThr: 3.412 ± 0.03	3.827GluVal: 3.827 ± 0.029	0.939GluTrp: 0.939 ± 0.014	1.752GluTyr: 1.752 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	2.956PheAla: 2.956 ± 0.028	0.544PheCys: 0.544 ± 0.01	2.2PheAsp: 2.2 ± 0.022	2.239PheGlu: 2.239 ± 0.022	1.612PhePhe: 1.612 ± 0.02	2.925PheGly: 2.925 ± 0.028	0.857PheHis: 0.857 ± 0.011	1.917PheIle: 1.917 ± 0.025	1.621PheLys: 1.621 ± 0.016	3.507PheLeu: 3.507 ± 0.033	0.822PheMet: 0.822 ± 0.013	1.486PheAsn: 1.486 ± 0.018	1.925PhePro: 1.925 ± 0.021	1.378PheGln: 1.378 ± 0.017	1.858PheArg: 1.858 ± 0.02	3.077PheSer: 3.077 ± 0.024	2.246PheThr: 2.246 ± 0.022	2.347PheVal: 2.347 ± 0.023	0.637PheTrp: 0.637 ± 0.012	1.121PheTyr: 1.121 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.283GlyAla: 5.283 ± 0.035	0.872GlyCys: 0.872 ± 0.015	3.549GlyAsp: 3.549 ± 0.028	4.028GlyGlu: 4.028 ± 0.033	2.826GlyPhe: 2.826 ± 0.03	6.196GlyGly: 6.196 ± 0.054	1.624GlyHis: 1.624 ± 0.022	3.706GlyIle: 3.706 ± 0.027	3.928GlyLys: 3.928 ± 0.029	6.008GlyLeu: 6.008 ± 0.039	1.777GlyMet: 1.777 ± 0.02	2.768GlyAsn: 2.768 ± 0.027	3.044GlyPro: 3.044 ± 0.028	2.319GlyGln: 2.319 ± 0.023	4.096GlyArg: 4.096 ± 0.03	5.803GlySer: 5.803 ± 0.042	4.091GlyThr: 4.091 ± 0.04	4.5GlyVal: 4.5 ± 0.04	1.209GlyTrp: 1.209 ± 0.017	2.21GlyTyr: 2.21 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.625HisAla: 1.625 ± 0.019	0.308HisCys: 0.308 ± 0.008	1.228HisAsp: 1.228 ± 0.014	1.307HisGlu: 1.307 ± 0.016	0.896HisPhe: 0.896 ± 0.012	1.585HisGly: 1.585 ± 0.018	0.75HisHis: 0.75 ± 0.014	1.237HisIle: 1.237 ± 0.016	0.964HisLys: 0.964 ± 0.013	2.123HisLeu: 2.123 ± 0.022	0.456HisMet: 0.456 ± 0.01	0.908HisAsn: 0.908 ± 0.013	1.537HisPro: 1.537 ± 0.02	0.899HisGln: 0.899 ± 0.016	1.325HisArg: 1.325 ± 0.017	1.852HisSer: 1.852 ± 0.024	1.317HisThr: 1.317 ± 0.017	1.282HisVal: 1.282 ± 0.016	0.317HisTrp: 0.317 ± 0.007	0.69HisTyr: 0.69 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.273IleAla: 4.273 ± 0.033	0.809IleCys: 0.809 ± 0.014	3.0IleAsp: 3.0 ± 0.024	3.161IleGlu: 3.161 ± 0.026	2.157IlePhe: 2.157 ± 0.025	3.375IleGly: 3.375 ± 0.031	1.241IleHis: 1.241 ± 0.015	2.838IleIle: 2.838 ± 0.027	2.425IleLys: 2.425 ± 0.025	4.938IleLeu: 4.938 ± 0.039	1.076IleMet: 1.076 ± 0.014	2.033IleAsn: 2.033 ± 0.02	3.269IlePro: 3.269 ± 0.029	1.96IleGln: 1.96 ± 0.022	2.821IleArg: 2.821 ± 0.021	4.35IleSer: 4.35 ± 0.03	3.165IleThr: 3.165 ± 0.026	3.328IleVal: 3.328 ± 0.029	0.793IleTrp: 0.793 ± 0.012	1.594IleTyr: 1.594 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.365LysAla: 4.365 ± 0.036	0.517LysCys: 0.517 ± 0.009	3.069LysAsp: 3.069 ± 0.027	3.935LysGlu: 3.935 ± 0.033	1.632LysPhe: 1.632 ± 0.018	3.37LysGly: 3.37 ± 0.028	1.159LysHis: 1.159 ± 0.016	2.619LysIle: 2.619 ± 0.025	3.77LysLys: 3.77 ± 0.045	4.356LysLeu: 4.356 ± 0.034	1.134LysMet: 1.134 ± 0.015	2.051LysAsn: 2.051 ± 0.022	2.779LysPro: 2.779 ± 0.025	1.837LysGln: 1.837 ± 0.019	3.378LysArg: 3.378 ± 0.031	3.978LysSer: 3.978 ± 0.035	3.02LysThr: 3.02 ± 0.026	3.098LysVal: 3.098 ± 0.026	0.735LysTrp: 0.735 ± 0.014	1.531LysTyr: 1.531 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	7.298LeuAla: 7.298 ± 0.042	1.157LeuCys: 1.157 ± 0.019	4.936LeuAsp: 4.936 ± 0.037	5.545LeuGlu: 5.545 ± 0.04	3.281LeuPhe: 3.281 ± 0.031	5.957LeuGly: 5.957 ± 0.044	2.147LeuHis: 2.147 ± 0.022	4.186LeuIle: 4.186 ± 0.039	4.512LeuLys: 4.512 ± 0.035	8.428LeuLeu: 8.428 ± 0.063	1.835LeuMet: 1.835 ± 0.02	3.297LeuAsn: 3.297 ± 0.029	5.374LeuPro: 5.374 ± 0.036	3.736LeuGln: 3.736 ± 0.033	5.326LeuArg: 5.326 ± 0.039	7.414LeuSer: 7.414 ± 0.045	4.902LeuThr: 4.902 ± 0.037	5.229LeuVal: 5.229 ± 0.036	1.203LeuTrp: 1.203 ± 0.016	2.42LeuTyr: 2.42 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.106MetAla: 2.106 ± 0.022	0.231MetCys: 0.231 ± 0.006	1.274MetAsp: 1.274 ± 0.018	1.373MetGlu: 1.373 ± 0.018	0.776MetPhe: 0.776 ± 0.013	1.602MetGly: 1.602 ± 0.02	0.477MetHis: 0.477 ± 0.01	1.099MetIle: 1.099 ± 0.016	1.193MetLys: 1.193 ± 0.016	1.843MetLeu: 1.843 ± 0.019	0.603MetMet: 0.603 ± 0.012	0.896MetAsn: 0.896 ± 0.014	1.182MetPro: 1.182 ± 0.016	0.853MetGln: 0.853 ± 0.015	1.245MetArg: 1.245 ± 0.015	1.939MetSer: 1.939 ± 0.019	1.287MetThr: 1.287 ± 0.018	1.362MetVal: 1.362 ± 0.019	0.263MetTrp: 0.263 ± 0.009	0.542MetTyr: 0.542 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.272AsnAla: 3.272 ± 0.024	0.449AsnCys: 0.449 ± 0.009	2.064AsnAsp: 2.064 ± 0.019	2.199AsnGlu: 2.199 ± 0.021	1.525AsnPhe: 1.525 ± 0.019	3.31AsnGly: 3.31 ± 0.033	0.904AsnHis: 0.904 ± 0.013	2.325AsnIle: 2.325 ± 0.024	1.701AsnLys: 1.701 ± 0.018	3.495AsnLeu: 3.495 ± 0.031	0.873AsnMet: 0.873 ± 0.014	1.706AsnAsn: 1.706 ± 0.025	2.505AsnPro: 2.505 ± 0.026	1.359AsnGln: 1.359 ± 0.018	1.916AsnArg: 1.916 ± 0.023	3.204AsnSer: 3.204 ± 0.029	2.499AsnThr: 2.499 ± 0.023	2.353AsnVal: 2.353 ± 0.02	0.589AsnTrp: 0.589 ± 0.011	1.212AsnTyr: 1.212 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	4.732ProAla: 4.732 ± 0.036	0.439ProCys: 0.439 ± 0.01	2.838ProAsp: 2.838 ± 0.026	3.66ProGlu: 3.66 ± 0.035	1.97ProPhe: 1.97 ± 0.022	3.561ProGly: 3.561 ± 0.029	1.242ProHis: 1.242 ± 0.017	2.764ProIle: 2.764 ± 0.025	2.823ProLys: 2.823 ± 0.03	4.647ProLeu: 4.647 ± 0.03	1.055ProMet: 1.055 ± 0.016	2.333ProAsn: 2.333 ± 0.024	4.772ProPro: 4.772 ± 0.062	2.376ProGln: 2.376 ± 0.03	3.13ProArg: 3.13 ± 0.031	6.008ProSer: 6.008 ± 0.051	4.073ProThr: 4.073 ± 0.036	3.312ProVal: 3.312 ± 0.03	0.676ProTrp: 0.676 ± 0.011	1.532ProTyr: 1.532 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.155GlnAla: 3.155 ± 0.03	0.407GlnCys: 0.407 ± 0.009	1.903GlnAsp: 1.903 ± 0.02	2.344GlnGlu: 2.344 ± 0.025	1.259GlnPhe: 1.259 ± 0.017	2.255GlnGly: 2.255 ± 0.026	0.95GlnHis: 0.95 ± 0.014	1.958GlnIle: 1.958 ± 0.021	2.122GlnLys: 2.122 ± 0.021	3.212GlnLeu: 3.212 ± 0.027	0.857GlnMet: 0.857 ± 0.014	1.685GlnAsn: 1.685 ± 0.02	2.213GlnPro: 2.213 ± 0.028	2.08GlnGln: 2.08 ± 0.041	2.356GlnArg: 2.356 ± 0.025	3.075GlnSer: 3.075 ± 0.028	2.265GlnThr: 2.265 ± 0.025	2.052GlnVal: 2.052 ± 0.021	0.537GlnTrp: 0.537 ± 0.01	1.195GlnTyr: 1.195 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.204ArgAla: 4.204 ± 0.033	0.635ArgCys: 0.635 ± 0.013	3.119ArgAsp: 3.119 ± 0.033	3.905ArgGlu: 3.905 ± 0.037	1.968ArgPhe: 1.968 ± 0.02	3.742ArgGly: 3.742 ± 0.031	1.336ArgHis: 1.336 ± 0.018	2.885ArgIle: 2.885 ± 0.025	3.64ArgLys: 3.64 ± 0.031	4.959ArgLeu: 4.959 ± 0.038	1.304ArgMet: 1.304 ± 0.017	2.346ArgAsn: 2.346 ± 0.024	3.085ArgPro: 3.085 ± 0.032	2.26ArgGln: 2.26 ± 0.023	4.553ArgArg: 4.553 ± 0.044	4.603ArgSer: 4.603 ± 0.043	3.179ArgThr: 3.179 ± 0.025	3.096ArgVal: 3.096 ± 0.029	0.863ArgTrp: 0.863 ± 0.015	1.607ArgTyr: 1.607 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.649SerAla: 6.649 ± 0.046	0.874SerCys: 0.874 ± 0.015	4.12SerAsp: 4.12 ± 0.032	4.281SerGlu: 4.281 ± 0.04	3.12SerPhe: 3.12 ± 0.025	5.656SerGly: 5.656 ± 0.042	1.928SerHis: 1.928 ± 0.022	4.561SerIle: 4.561 ± 0.037	4.164SerLys: 4.164 ± 0.034	7.186SerLeu: 7.186 ± 0.036	1.797SerMet: 1.797 ± 0.021	3.455SerAsn: 3.455 ± 0.031	5.549SerPro: 5.549 ± 0.055	3.173SerGln: 3.173 ± 0.027	4.777SerArg: 4.777 ± 0.047	9.682SerSer: 9.682 ± 0.1	6.239SerThr: 6.239 ± 0.06	4.575SerVal: 4.575 ± 0.038	1.134SerTrp: 1.134 ± 0.015	2.289SerTyr: 2.289 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.014ThrAla: 5.014 ± 0.037	0.744ThrCys: 0.744 ± 0.014	2.805ThrAsp: 2.805 ± 0.022	3.146ThrGlu: 3.146 ± 0.025	2.354ThrPhe: 2.354 ± 0.022	4.216ThrGly: 4.216 ± 0.036	1.294ThrHis: 1.294 ± 0.016	3.442ThrIle: 3.442 ± 0.03	2.857ThrLys: 2.857 ± 0.021	5.338ThrLeu: 5.338 ± 0.032	1.196ThrMet: 1.196 ± 0.016	2.422ThrAsn: 2.422 ± 0.022	4.436ThrPro: 4.436 ± 0.039	2.117ThrGln: 2.117 ± 0.021	2.969ThrArg: 2.969 ± 0.023	5.996ThrSer: 5.996 ± 0.055	4.718ThrThr: 4.718 ± 0.055	3.63ThrVal: 3.63 ± 0.03	0.844ThrTrp: 0.844 ± 0.014	1.767ThrTyr: 1.767 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	4.896ValAla: 4.896 ± 0.034	0.765ValCys: 0.765 ± 0.012	3.556ValAsp: 3.556 ± 0.028	4.094ValGlu: 4.094 ± 0.033	2.387ValPhe: 2.387 ± 0.024	4.202ValGly: 4.202 ± 0.033	1.26ValHis: 1.26 ± 0.018	3.005ValIle: 3.005 ± 0.029	3.12ValLys: 3.12 ± 0.027	5.484ValLeu: 5.484 ± 0.04	1.362ValMet: 1.362 ± 0.013	2.27ValAsn: 2.27 ± 0.02	3.382ValPro: 3.382 ± 0.03	2.267ValGln: 2.267 ± 0.022	3.218ValArg: 3.218 ± 0.025	4.502ValSer: 4.502 ± 0.034	3.426ValThr: 3.426 ± 0.032	4.358ValVal: 4.358 ± 0.035	0.877ValTrp: 0.877 ± 0.014	1.74ValTyr: 1.74 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.059TrpAla: 1.059 ± 0.015	0.2TrpCys: 0.2 ± 0.006	0.883TrpAsp: 0.883 ± 0.014	0.913TrpGlu: 0.913 ± 0.017	0.534TrpPhe: 0.534 ± 0.011	1.018TrpGly: 1.018 ± 0.015	0.319TrpHis: 0.319 ± 0.009	0.826TrpIle: 0.826 ± 0.014	0.859TrpLys: 0.859 ± 0.014	1.307TrpLeu: 1.307 ± 0.02	0.375TrpMet: 0.375 ± 0.008	0.648TrpAsn: 0.648 ± 0.012	0.561TrpPro: 0.561 ± 0.011	0.531TrpGln: 0.531 ± 0.01	0.903TrpArg: 0.903 ± 0.016	1.04TrpSer: 1.04 ± 0.015	0.915TrpThr: 0.915 ± 0.014	0.911TrpVal: 0.911 ± 0.014	0.27TrpTrp: 0.27 ± 0.008	0.424TrpTyr: 0.424 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.167TyrAla: 2.167 ± 0.021	0.433TyrCys: 0.433 ± 0.01	1.668TyrAsp: 1.668 ± 0.02	1.652TyrGlu: 1.652 ± 0.018	1.24TyrPhe: 1.24 ± 0.016	2.15TyrGly: 2.15 ± 0.026	0.731TyrHis: 0.731 ± 0.011	1.561TyrIle: 1.561 ± 0.018	1.232TyrLys: 1.232 ± 0.014	2.722TyrLeu: 2.722 ± 0.027	0.633TyrMet: 0.633 ± 0.01	1.229TyrAsn: 1.229 ± 0.014	1.533TyrPro: 1.533 ± 0.018	1.115TyrGln: 1.115 ± 0.016	1.549TyrArg: 1.549 ± 0.016	2.239TyrSer: 2.239 ± 0.021	1.797TyrThr: 1.797 ± 0.021	1.624TyrVal: 1.624 ± 0.019	0.469TyrTrp: 0.469 ± 0.01	0.995TyrTyr: 0.995 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10520 proteins (5281618 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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