Amino acid dipepetide frequency for Janthinobacterium sp. 17J80-10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.593AlaAla: 16.593 ± 0.189	1.265AlaCys: 1.265 ± 0.037	6.258AlaAsp: 6.258 ± 0.087	6.63AlaGlu: 6.63 ± 0.102	4.027AlaPhe: 4.027 ± 0.076	10.611AlaGly: 10.611 ± 0.16	2.553AlaHis: 2.553 ± 0.047	6.21AlaIle: 6.21 ± 0.069	4.151AlaLys: 4.151 ± 0.093	13.351AlaLeu: 13.351 ± 0.165	3.319AlaMet: 3.319 ± 0.064	3.441AlaAsn: 3.441 ± 0.065	5.562AlaPro: 5.562 ± 0.087	5.421AlaGln: 5.421 ± 0.094	7.917AlaArg: 7.917 ± 0.114	7.011AlaSer: 7.011 ± 0.102	5.928AlaThr: 5.928 ± 0.127	8.058AlaVal: 8.058 ± 0.099	1.603AlaTrp: 1.603 ± 0.041	2.775AlaTyr: 2.775 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.128CysAla: 1.128 ± 0.032	0.117CysCys: 0.117 ± 0.01	0.519CysAsp: 0.519 ± 0.021	0.463CysGlu: 0.463 ± 0.022	0.312CysPhe: 0.312 ± 0.017	0.926CysGly: 0.926 ± 0.032	0.269CysHis: 0.269 ± 0.014	0.47CysIle: 0.47 ± 0.021	0.292CysLys: 0.292 ± 0.015	0.901CysLeu: 0.901 ± 0.029	0.21CysMet: 0.21 ± 0.013	0.284CysAsn: 0.284 ± 0.016	0.476CysPro: 0.476 ± 0.021	0.288CysGln: 0.288 ± 0.017	0.616CysArg: 0.616 ± 0.023	0.482CysSer: 0.482 ± 0.021	0.452CysThr: 0.452 ± 0.022	0.599CysVal: 0.599 ± 0.025	0.105CysTrp: 0.105 ± 0.008	0.239CysTyr: 0.239 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.795AspAla: 6.795 ± 0.093	0.463AspCys: 0.463 ± 0.019	2.868AspAsp: 2.868 ± 0.07	2.978AspGlu: 2.978 ± 0.055	2.254AspPhe: 2.254 ± 0.049	4.523AspGly: 4.523 ± 0.126	0.998AspHis: 0.998 ± 0.032	2.967AspIle: 2.967 ± 0.054	2.056AspLys: 2.056 ± 0.04	5.195AspLeu: 5.195 ± 0.081	1.325AspMet: 1.325 ± 0.033	1.548AspAsn: 1.548 ± 0.049	2.49AspPro: 2.49 ± 0.054	1.734AspGln: 1.734 ± 0.039	2.972AspArg: 2.972 ± 0.053	2.513AspSer: 2.513 ± 0.065	2.863AspThr: 2.863 ± 0.138	3.792AspVal: 3.792 ± 0.079	0.862AspTrp: 0.862 ± 0.029	1.614AspTyr: 1.614 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	6.315GluAla: 6.315 ± 0.097	0.427GluCys: 0.427 ± 0.022	2.264GluAsp: 2.264 ± 0.048	3.142GluGlu: 3.142 ± 0.067	2.056GluPhe: 2.056 ± 0.044	3.547GluGly: 3.547 ± 0.068	1.28GluHis: 1.28 ± 0.037	3.349GluIle: 3.349 ± 0.059	2.733GluLys: 2.733 ± 0.047	5.684GluLeu: 5.684 ± 0.081	1.435GluMet: 1.435 ± 0.038	1.792GluAsn: 1.792 ± 0.047	1.991GluPro: 1.991 ± 0.045	2.877GluGln: 2.877 ± 0.068	4.193GluArg: 4.193 ± 0.075	2.842GluSer: 2.842 ± 0.051	2.595GluThr: 2.595 ± 0.047	3.776GluVal: 3.776 ± 0.073	0.681GluTrp: 0.681 ± 0.025	1.307GluTyr: 1.307 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.318PheAla: 4.318 ± 0.071	0.418PheCys: 0.418 ± 0.02	2.366PheAsp: 2.366 ± 0.048	2.016PheGlu: 2.016 ± 0.042	1.515PhePhe: 1.515 ± 0.042	3.461PheGly: 3.461 ± 0.065	0.811PheHis: 0.811 ± 0.025	1.991PheIle: 1.991 ± 0.042	1.33PheLys: 1.33 ± 0.036	3.397PheLeu: 3.397 ± 0.064	0.883PheMet: 0.883 ± 0.03	1.268PheAsn: 1.268 ± 0.028	1.566PhePro: 1.566 ± 0.039	1.185PheGln: 1.185 ± 0.028	1.974PheArg: 1.974 ± 0.043	2.627PheSer: 2.627 ± 0.052	1.963PheThr: 1.963 ± 0.042	2.523PheVal: 2.523 ± 0.047	0.494PheTrp: 0.494 ± 0.025	1.038PheTyr: 1.038 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	8.803GlyAla: 8.803 ± 0.126	0.832GlyCys: 0.832 ± 0.03	4.1GlyAsp: 4.1 ± 0.106	4.212GlyGlu: 4.212 ± 0.07	3.162GlyPhe: 3.162 ± 0.059	6.652GlyGly: 6.652 ± 0.199	1.811GlyHis: 1.811 ± 0.044	4.656GlyIle: 4.656 ± 0.078	4.202GlyLys: 4.202 ± 0.061	7.917GlyLeu: 7.917 ± 0.105	2.486GlyMet: 2.486 ± 0.052	3.052GlyAsn: 3.052 ± 0.155	2.324GlyPro: 2.324 ± 0.047	3.045GlyGln: 3.045 ± 0.058	4.686GlyArg: 4.686 ± 0.075	4.654GlySer: 4.654 ± 0.112	4.453GlyThr: 4.453 ± 0.153	5.887GlyVal: 5.887 ± 0.086	1.213GlyTrp: 1.213 ± 0.038	2.337GlyTyr: 2.337 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.962HisAla: 2.962 ± 0.063	0.267HisCys: 0.267 ± 0.015	1.227HisAsp: 1.227 ± 0.034	1.155HisGlu: 1.155 ± 0.033	0.966HisPhe: 0.966 ± 0.028	2.014HisGly: 2.014 ± 0.049	0.655HisHis: 0.655 ± 0.027	1.083HisIle: 1.083 ± 0.031	0.676HisLys: 0.676 ± 0.023	2.174HisLeu: 2.174 ± 0.042	0.506HisMet: 0.506 ± 0.02	0.581HisAsn: 0.581 ± 0.021	1.377HisPro: 1.377 ± 0.035	0.781HisGln: 0.781 ± 0.027	1.307HisArg: 1.307 ± 0.031	1.086HisSer: 1.086 ± 0.032	0.976HisThr: 0.976 ± 0.031	1.52HisVal: 1.52 ± 0.037	0.328HisTrp: 0.328 ± 0.019	0.696HisTyr: 0.696 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.936IleAla: 6.936 ± 0.08	0.502IleCys: 0.502 ± 0.019	3.582IleAsp: 3.582 ± 0.07	3.422IleGlu: 3.422 ± 0.061	1.675IlePhe: 1.675 ± 0.044	4.812IleGly: 4.812 ± 0.084	1.022IleHis: 1.022 ± 0.029	2.244IleIle: 2.244 ± 0.057	1.928IleLys: 1.928 ± 0.047	4.653IleLeu: 4.653 ± 0.074	1.015IleMet: 1.015 ± 0.03	1.836IleAsn: 1.836 ± 0.049	2.256IlePro: 2.256 ± 0.045	1.509IleGln: 1.509 ± 0.035	2.935IleArg: 2.935 ± 0.051	3.131IleSer: 3.131 ± 0.054	2.856IleThr: 2.856 ± 0.069	3.911IleVal: 3.911 ± 0.056	0.555IleTrp: 0.555 ± 0.025	1.228IleTyr: 1.228 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.295LysAla: 4.295 ± 0.081	0.242LysCys: 0.242 ± 0.016	1.892LysAsp: 1.892 ± 0.044	2.029LysGlu: 2.029 ± 0.046	1.22LysPhe: 1.22 ± 0.032	2.483LysGly: 2.483 ± 0.061	0.786LysHis: 0.786 ± 0.025	2.263LysIle: 2.263 ± 0.05	2.008LysLys: 2.008 ± 0.057	4.249LysLeu: 4.249 ± 0.066	1.14LysMet: 1.14 ± 0.035	1.526LysAsn: 1.526 ± 0.046	2.293LysPro: 2.293 ± 0.051	1.577LysGln: 1.577 ± 0.041	2.362LysArg: 2.362 ± 0.044	2.269LysSer: 2.269 ± 0.043	2.117LysThr: 2.117 ± 0.045	2.718LysVal: 2.718 ± 0.056	0.455LysTrp: 0.455 ± 0.021	0.849LysTyr: 0.849 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	14.235LeuAla: 14.235 ± 0.163	0.976LeuCys: 0.976 ± 0.032	5.613LeuAsp: 5.613 ± 0.085	5.707LeuGlu: 5.707 ± 0.09	3.817LeuPhe: 3.817 ± 0.079	7.871LeuGly: 7.871 ± 0.081	2.342LeuHis: 2.342 ± 0.05	4.679LeuIle: 4.679 ± 0.074	4.125LeuLys: 4.125 ± 0.061	11.49LeuLeu: 11.49 ± 0.176	2.328LeuMet: 2.328 ± 0.051	3.112LeuAsn: 3.112 ± 0.049	5.797LeuPro: 5.797 ± 0.099	4.68LeuGln: 4.68 ± 0.085	6.807LeuArg: 6.807 ± 0.087	6.102LeuSer: 6.102 ± 0.078	5.363LeuThr: 5.363 ± 0.082	7.4LeuVal: 7.4 ± 0.091	1.136LeuTrp: 1.136 ± 0.036	2.289LeuTyr: 2.289 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.084MetAla: 3.084 ± 0.057	0.162MetCys: 0.162 ± 0.013	1.082MetAsp: 1.082 ± 0.03	1.204MetGlu: 1.204 ± 0.031	0.78MetPhe: 0.78 ± 0.025	1.658MetGly: 1.658 ± 0.041	0.592MetHis: 0.592 ± 0.022	1.107MetIle: 1.107 ± 0.034	1.176MetLys: 1.176 ± 0.037	2.921MetLeu: 2.921 ± 0.061	0.611MetMet: 0.611 ± 0.028	0.931MetAsn: 0.931 ± 0.031	1.483MetPro: 1.483 ± 0.041	1.301MetGln: 1.301 ± 0.032	1.735MetArg: 1.735 ± 0.039	1.546MetSer: 1.546 ± 0.032	1.452MetThr: 1.452 ± 0.035	1.704MetVal: 1.704 ± 0.041	0.198MetTrp: 0.198 ± 0.012	0.444MetTyr: 0.444 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.85AsnAla: 3.85 ± 0.07	0.353AsnCys: 0.353 ± 0.016	1.869AsnAsp: 1.869 ± 0.126	1.445AsnGlu: 1.445 ± 0.034	1.215AsnPhe: 1.215 ± 0.032	2.78AsnGly: 2.78 ± 0.081	0.593AsnHis: 0.593 ± 0.025	1.779AsnIle: 1.779 ± 0.048	1.065AsnLys: 1.065 ± 0.032	3.235AsnLeu: 3.235 ± 0.063	0.747AsnMet: 0.747 ± 0.025	1.137AsnAsn: 1.137 ± 0.041	1.984AsnPro: 1.984 ± 0.041	1.12AsnGln: 1.12 ± 0.032	1.92AsnArg: 1.92 ± 0.042	1.625AsnSer: 1.625 ± 0.041	1.603AsnThr: 1.603 ± 0.054	2.215AsnVal: 2.215 ± 0.044	0.489AsnTrp: 0.489 ± 0.021	0.877AsnTyr: 0.877 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.483ProAla: 6.483 ± 0.1	0.324ProCys: 0.324 ± 0.016	2.897ProAsp: 2.897 ± 0.052	3.012ProGlu: 3.012 ± 0.051	1.725ProPhe: 1.725 ± 0.041	3.916ProGly: 3.916 ± 0.059	1.093ProHis: 1.093 ± 0.032	2.009ProIle: 2.009 ± 0.043	1.583ProLys: 1.583 ± 0.043	4.884ProLeu: 4.884 ± 0.074	1.111ProMet: 1.111 ± 0.034	1.369ProAsn: 1.369 ± 0.037	2.134ProPro: 2.134 ± 0.052	2.174ProGln: 2.174 ± 0.048	2.38ProArg: 2.38 ± 0.051	2.307ProSer: 2.307 ± 0.045	2.005ProThr: 2.005 ± 0.039	4.019ProVal: 4.019 ± 0.063	0.6ProTrp: 0.6 ± 0.023	1.153ProTyr: 1.153 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	5.609GlnAla: 5.609 ± 0.099	0.319GlnCys: 0.319 ± 0.018	1.836GlnAsp: 1.836 ± 0.044	2.194GlnGlu: 2.194 ± 0.053	1.444GlnPhe: 1.444 ± 0.034	3.052GlnGly: 3.052 ± 0.049	0.969GlnHis: 0.969 ± 0.031	2.086GlnIle: 2.086 ± 0.047	1.545GlnLys: 1.545 ± 0.039	4.34GlnLeu: 4.34 ± 0.075	0.996GlnMet: 0.996 ± 0.029	1.136GlnAsn: 1.136 ± 0.03	2.015GlnPro: 2.015 ± 0.048	2.173GlnGln: 2.173 ± 0.06	2.837GlnArg: 2.837 ± 0.052	2.293GlnSer: 2.293 ± 0.043	2.009GlnThr: 2.009 ± 0.056	3.054GlnVal: 3.054 ± 0.064	0.537GlnTrp: 0.537 ± 0.022	0.938GlnTyr: 0.938 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	6.516ArgAla: 6.516 ± 0.097	0.454ArgCys: 0.454 ± 0.018	3.378ArgAsp: 3.378 ± 0.06	3.941ArgGlu: 3.941 ± 0.074	2.616ArgPhe: 2.616 ± 0.054	3.852ArgGly: 3.852 ± 0.063	1.857ArgHis: 1.857 ± 0.044	3.822ArgIle: 3.822 ± 0.063	2.418ArgLys: 2.418 ± 0.052	7.198ArgLeu: 7.198 ± 0.102	1.799ArgMet: 1.799 ± 0.036	2.177ArgAsn: 2.177 ± 0.04	2.578ArgPro: 2.578 ± 0.049	3.184ArgGln: 3.184 ± 0.063	4.145ArgArg: 4.145 ± 0.076	3.007ArgSer: 3.007 ± 0.05	2.892ArgThr: 2.892 ± 0.061	4.046ArgVal: 4.046 ± 0.069	0.844ArgTrp: 0.844 ± 0.026	1.836ArgTyr: 1.836 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.416SerAla: 6.416 ± 0.091	0.495SerCys: 0.495 ± 0.023	2.753SerAsp: 2.753 ± 0.056	2.602SerGlu: 2.602 ± 0.045	2.268SerPhe: 2.268 ± 0.044	5.529SerGly: 5.529 ± 0.097	1.264SerHis: 1.264 ± 0.039	2.867SerIle: 2.867 ± 0.054	1.906SerLys: 1.906 ± 0.046	6.091SerLeu: 6.091 ± 0.077	1.435SerMet: 1.435 ± 0.038	1.69SerAsn: 1.69 ± 0.047	2.537SerPro: 2.537 ± 0.048	2.094SerGln: 2.094 ± 0.048	3.481SerArg: 3.481 ± 0.054	3.339SerSer: 3.339 ± 0.068	2.917SerThr: 2.917 ± 0.081	3.892SerVal: 3.892 ± 0.063	0.786SerTrp: 0.786 ± 0.026	1.425SerTyr: 1.425 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.857ThrAla: 5.857 ± 0.096	0.421ThrCys: 0.421 ± 0.019	2.601ThrAsp: 2.601 ± 0.082	2.454ThrGlu: 2.454 ± 0.049	1.766ThrPhe: 1.766 ± 0.038	4.859ThrGly: 4.859 ± 0.134	1.085ThrHis: 1.085 ± 0.035	2.81ThrIle: 2.81 ± 0.078	1.382ThrLys: 1.382 ± 0.045	6.115ThrLeu: 6.115 ± 0.127	1.085ThrMet: 1.085 ± 0.031	1.395ThrAsn: 1.395 ± 0.052	3.032ThrPro: 3.032 ± 0.048	1.839ThrGln: 1.839 ± 0.062	3.003ThrArg: 3.003 ± 0.048	2.683ThrSer: 2.683 ± 0.049	2.816ThrThr: 2.816 ± 0.083	4.108ThrVal: 4.108 ± 0.083	0.614ThrTrp: 0.614 ± 0.027	1.293ThrTyr: 1.293 ± 0.068	0.0ThrXaa: 0.0 ± 0.0
Val	8.721ValAla: 8.721 ± 0.102	0.671ValCys: 0.671 ± 0.026	3.807ValAsp: 3.807 ± 0.076	3.944ValGlu: 3.944 ± 0.066	2.613ValPhe: 2.613 ± 0.053	4.989ValGly: 4.989 ± 0.066	1.438ValHis: 1.438 ± 0.037	3.818ValIle: 3.818 ± 0.061	2.833ValLys: 2.833 ± 0.053	7.523ValLeu: 7.523 ± 0.105	1.853ValMet: 1.853 ± 0.04	2.426ValAsn: 2.426 ± 0.055	3.475ValPro: 3.475 ± 0.061	2.568ValGln: 2.568 ± 0.053	4.451ValArg: 4.451 ± 0.063	4.097ValSer: 4.097 ± 0.07	4.055ValThr: 4.055 ± 0.105	5.513ValVal: 5.513 ± 0.08	0.83ValTrp: 0.83 ± 0.03	1.639ValTyr: 1.639 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.017TrpAla: 1.017 ± 0.027	0.137TrpCys: 0.137 ± 0.011	0.577TrpAsp: 0.577 ± 0.024	0.576TrpGlu: 0.576 ± 0.02	0.557TrpPhe: 0.557 ± 0.026	0.822TrpGly: 0.822 ± 0.028	0.376TrpHis: 0.376 ± 0.019	0.732TrpIle: 0.732 ± 0.027	0.511TrpLys: 0.511 ± 0.024	1.789TrpLeu: 1.789 ± 0.051	0.382TrpMet: 0.382 ± 0.017	0.467TrpAsn: 0.467 ± 0.022	0.557TrpPro: 0.557 ± 0.023	0.771TrpGln: 0.771 ± 0.029	0.996TrpArg: 0.996 ± 0.033	0.716TrpSer: 0.716 ± 0.028	0.642TrpThr: 0.642 ± 0.031	0.796TrpVal: 0.796 ± 0.025	0.212TrpTrp: 0.212 ± 0.015	0.3TrpTyr: 0.3 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.75TyrAla: 2.75 ± 0.045	0.303TyrCys: 0.303 ± 0.017	1.32TyrAsp: 1.32 ± 0.031	1.157TyrGlu: 1.157 ± 0.034	1.157TyrPhe: 1.157 ± 0.031	2.129TyrGly: 2.129 ± 0.049	0.544TyrHis: 0.544 ± 0.022	1.065TyrIle: 1.065 ± 0.031	0.854TyrLys: 0.854 ± 0.03	2.764TyrLeu: 2.764 ± 0.05	0.507TyrMet: 0.507 ± 0.02	0.735TyrAsn: 0.735 ± 0.03	1.25TyrPro: 1.25 ± 0.032	1.061TyrGln: 1.061 ± 0.033	1.845TyrArg: 1.845 ± 0.044	1.455TyrSer: 1.455 ± 0.042	1.26TyrThr: 1.26 ± 0.045	1.729TyrVal: 1.729 ± 0.05	0.391TyrTrp: 0.391 ± 0.018	0.778TyrTyr: 0.778 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3497 proteins (1200352 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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