Amino acid dipepetide frequency for Yersinia pestis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.32AlaAla: 9.32 ± 0.121	1.032AlaCys: 1.032 ± 0.036	4.892AlaAsp: 4.892 ± 0.069	5.729AlaGlu: 5.729 ± 0.091	3.311AlaPhe: 3.311 ± 0.061	7.066AlaGly: 7.066 ± 0.1	1.744AlaHis: 1.744 ± 0.042	5.969AlaIle: 5.969 ± 0.083	4.102AlaLys: 4.102 ± 0.06	11.065AlaLeu: 11.065 ± 0.119	2.732AlaMet: 2.732 ± 0.05	3.449AlaAsn: 3.449 ± 0.074	3.294AlaPro: 3.294 ± 0.059	4.248AlaGln: 4.248 ± 0.076	4.625AlaArg: 4.625 ± 0.068	5.234AlaSer: 5.234 ± 0.077	4.718AlaThr: 4.718 ± 0.077	6.43AlaVal: 6.43 ± 0.07	1.138AlaTrp: 1.138 ± 0.037	2.347AlaTyr: 2.347 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.86CysAla: 0.86 ± 0.029	0.184CysCys: 0.184 ± 0.013	0.557CysAsp: 0.557 ± 0.023	0.536CysGlu: 0.536 ± 0.021	0.419CysPhe: 0.419 ± 0.018	0.969CysGly: 0.969 ± 0.03	0.382CysHis: 0.382 ± 0.02	0.622CysIle: 0.622 ± 0.022	0.326CysLys: 0.326 ± 0.017	1.047CysLeu: 1.047 ± 0.029	0.236CysMet: 0.236 ± 0.017	0.339CysAsn: 0.339 ± 0.017	0.46CysPro: 0.46 ± 0.024	0.529CysGln: 0.529 ± 0.023	0.615CysArg: 0.615 ± 0.02	0.645CysSer: 0.645 ± 0.023	0.464CysThr: 0.464 ± 0.023	0.648CysVal: 0.648 ± 0.024	0.195CysTrp: 0.195 ± 0.014	0.35CysTyr: 0.35 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.665AspAla: 4.665 ± 0.066	0.514AspCys: 0.514 ± 0.02	2.768AspAsp: 2.768 ± 0.055	3.308AspGlu: 3.308 ± 0.062	2.164AspPhe: 2.164 ± 0.042	3.717AspGly: 3.717 ± 0.064	1.041AspHis: 1.041 ± 0.028	3.815AspIle: 3.815 ± 0.063	2.625AspLys: 2.625 ± 0.06	4.78AspLeu: 4.78 ± 0.068	1.313AspMet: 1.313 ± 0.029	2.432AspAsn: 2.432 ± 0.049	2.174AspPro: 2.174 ± 0.044	1.851AspGln: 1.851 ± 0.035	2.55AspArg: 2.55 ± 0.053	3.05AspSer: 3.05 ± 0.058	2.6AspThr: 2.6 ± 0.048	3.677AspVal: 3.677 ± 0.056	0.784AspTrp: 0.784 ± 0.03	1.829AspTyr: 1.829 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.633GluAla: 4.633 ± 0.077	0.444GluCys: 0.444 ± 0.024	2.297GluAsp: 2.297 ± 0.057	3.033GluGlu: 3.033 ± 0.069	1.891GluPhe: 1.891 ± 0.039	3.483GluGly: 3.483 ± 0.059	1.465GluHis: 1.465 ± 0.038	3.449GluIle: 3.449 ± 0.059	3.171GluLys: 3.171 ± 0.053	5.999GluLeu: 5.999 ± 0.089	1.67GluMet: 1.67 ± 0.032	2.404GluAsn: 2.404 ± 0.046	2.013GluPro: 2.013 ± 0.043	3.707GluGln: 3.707 ± 0.059	3.485GluArg: 3.485 ± 0.067	3.112GluSer: 3.112 ± 0.052	2.8GluThr: 2.8 ± 0.055	3.656GluVal: 3.656 ± 0.057	0.706GluTrp: 0.706 ± 0.025	1.513GluTyr: 1.513 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.317PheAla: 3.317 ± 0.057	0.515PheCys: 0.515 ± 0.022	2.311PheAsp: 2.311 ± 0.046	1.769PheGlu: 1.769 ± 0.04	1.643PhePhe: 1.643 ± 0.046	3.057PheGly: 3.057 ± 0.061	0.753PheHis: 0.753 ± 0.025	2.748PheIle: 2.748 ± 0.055	1.356PheLys: 1.356 ± 0.036	3.223PheLeu: 3.223 ± 0.063	0.974PheMet: 0.974 ± 0.032	1.898PheAsn: 1.898 ± 0.037	1.476PhePro: 1.476 ± 0.038	1.164PheGln: 1.164 ± 0.033	1.766PheArg: 1.766 ± 0.04	3.319PheSer: 3.319 ± 0.055	2.444PheThr: 2.444 ± 0.048	2.41PheVal: 2.41 ± 0.045	0.548PheTrp: 0.548 ± 0.023	1.291PheTyr: 1.291 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	5.936GlyAla: 5.936 ± 0.103	0.919GlyCys: 0.919 ± 0.028	3.606GlyAsp: 3.606 ± 0.059	4.314GlyGlu: 4.314 ± 0.066	3.08GlyPhe: 3.08 ± 0.061	5.323GlyGly: 5.323 ± 0.102	1.624GlyHis: 1.624 ± 0.035	5.1GlyIle: 5.1 ± 0.072	3.859GlyLys: 3.859 ± 0.066	7.328GlyLeu: 7.328 ± 0.09	2.186GlyMet: 2.186 ± 0.043	2.895GlyAsn: 2.895 ± 0.076	1.975GlyPro: 1.975 ± 0.047	3.128GlyGln: 3.128 ± 0.052	3.737GlyArg: 3.737 ± 0.064	4.492GlySer: 4.492 ± 0.092	3.676GlyThr: 3.676 ± 0.088	5.663GlyVal: 5.663 ± 0.086	1.123GlyTrp: 1.123 ± 0.031	2.652GlyTyr: 2.652 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.742HisAla: 1.742 ± 0.041	0.36HisCys: 0.36 ± 0.019	1.117HisAsp: 1.117 ± 0.03	1.091HisGlu: 1.091 ± 0.033	1.065HisPhe: 1.065 ± 0.032	1.637HisGly: 1.637 ± 0.04	0.774HisHis: 0.774 ± 0.031	1.433HisIle: 1.433 ± 0.042	0.8HisLys: 0.8 ± 0.027	2.301HisLeu: 2.301 ± 0.039	0.537HisMet: 0.537 ± 0.022	0.868HisAsn: 0.868 ± 0.029	1.266HisPro: 1.266 ± 0.034	1.354HisGln: 1.354 ± 0.04	1.2HisArg: 1.2 ± 0.039	1.333HisSer: 1.333 ± 0.035	1.107HisThr: 1.107 ± 0.031	1.244HisVal: 1.244 ± 0.038	0.421HisTrp: 0.421 ± 0.022	0.911HisTyr: 0.911 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.496IleAla: 6.496 ± 0.08	0.664IleCys: 0.664 ± 0.025	3.885IleAsp: 3.885 ± 0.067	3.652IleGlu: 3.652 ± 0.062	2.223IlePhe: 2.223 ± 0.043	4.752IleGly: 4.752 ± 0.069	1.253IleHis: 1.253 ± 0.031	3.81IleIle: 3.81 ± 0.072	2.85IleLys: 2.85 ± 0.051	5.527IleLeu: 5.527 ± 0.074	1.352IleMet: 1.352 ± 0.034	3.151IleAsn: 3.151 ± 0.062	2.927IlePro: 2.927 ± 0.053	2.206IleGln: 2.206 ± 0.043	3.042IleArg: 3.042 ± 0.054	4.452IleSer: 4.452 ± 0.066	3.894IleThr: 3.894 ± 0.063	3.765IleVal: 3.765 ± 0.055	0.66IleTrp: 0.66 ± 0.028	1.728IleTyr: 1.728 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.995LysAla: 3.995 ± 0.065	0.249LysCys: 0.249 ± 0.014	2.111LysAsp: 2.111 ± 0.051	2.481LysGlu: 2.481 ± 0.047	1.205LysPhe: 1.205 ± 0.032	2.877LysGly: 2.877 ± 0.05	0.916LysHis: 0.916 ± 0.028	2.651LysIle: 2.651 ± 0.052	2.34LysLys: 2.34 ± 0.055	4.57LysLeu: 4.57 ± 0.067	1.316LysMet: 1.316 ± 0.034	2.125LysAsn: 2.125 ± 0.053	2.121LysPro: 2.121 ± 0.041	2.238LysGln: 2.238 ± 0.049	2.473LysArg: 2.473 ± 0.049	2.539LysSer: 2.539 ± 0.051	2.552LysThr: 2.552 ± 0.044	3.065LysVal: 3.065 ± 0.059	0.445LysTrp: 0.445 ± 0.021	1.215LysTyr: 1.215 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	11.247LeuAla: 11.247 ± 0.129	1.225LeuCys: 1.225 ± 0.032	5.574LeuAsp: 5.574 ± 0.077	5.207LeuGlu: 5.207 ± 0.072	4.159LeuPhe: 4.159 ± 0.066	7.257LeuGly: 7.257 ± 0.085	2.23LeuHis: 2.23 ± 0.051	6.265LeuIle: 6.265 ± 0.077	4.532LeuLys: 4.532 ± 0.062	12.213LeuLeu: 12.213 ± 0.181	2.9LeuMet: 2.9 ± 0.052	4.543LeuAsn: 4.543 ± 0.072	5.819LeuPro: 5.819 ± 0.085	4.681LeuGln: 4.681 ± 0.069	5.788LeuArg: 5.788 ± 0.084	8.052LeuSer: 8.052 ± 0.091	6.446LeuThr: 6.446 ± 0.101	7.152LeuVal: 7.152 ± 0.086	1.353LeuTrp: 1.353 ± 0.039	2.686LeuTyr: 2.686 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.818MetAla: 2.818 ± 0.054	0.207MetCys: 0.207 ± 0.014	1.171MetAsp: 1.171 ± 0.034	1.189MetGlu: 1.189 ± 0.032	0.854MetPhe: 0.854 ± 0.03	1.816MetGly: 1.816 ± 0.036	0.48MetHis: 0.48 ± 0.019	1.52MetIle: 1.52 ± 0.041	1.319MetLys: 1.319 ± 0.034	3.01MetLeu: 3.01 ± 0.059	0.918MetMet: 0.918 ± 0.028	1.105MetAsn: 1.105 ± 0.034	1.239MetPro: 1.239 ± 0.031	1.14MetGln: 1.14 ± 0.031	1.423MetArg: 1.423 ± 0.03	1.886MetSer: 1.886 ± 0.04	1.706MetThr: 1.706 ± 0.033	1.96MetVal: 1.96 ± 0.041	0.215MetTrp: 0.215 ± 0.014	0.538MetTyr: 0.538 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.589AsnAla: 3.589 ± 0.064	0.358AsnCys: 0.358 ± 0.017	2.124AsnAsp: 2.124 ± 0.049	2.043AsnGlu: 2.043 ± 0.045	1.435AsnPhe: 1.435 ± 0.038	3.2AsnGly: 3.2 ± 0.085	0.91AsnHis: 0.91 ± 0.028	2.857AsnIle: 2.857 ± 0.066	1.874AsnLys: 1.874 ± 0.052	3.836AsnLeu: 3.836 ± 0.069	0.99AsnMet: 0.99 ± 0.028	2.162AsnAsn: 2.162 ± 0.064	2.095AsnPro: 2.095 ± 0.041	1.907AsnGln: 1.907 ± 0.041	2.122AsnArg: 2.122 ± 0.042	2.536AsnSer: 2.536 ± 0.062	2.407AsnThr: 2.407 ± 0.058	2.632AsnVal: 2.632 ± 0.059	0.582AsnTrp: 0.582 ± 0.022	1.295AsnTyr: 1.295 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	4.114ProAla: 4.114 ± 0.064	0.351ProCys: 0.351 ± 0.017	2.629ProAsp: 2.629 ± 0.05	3.277ProGlu: 3.277 ± 0.055	1.712ProPhe: 1.712 ± 0.041	2.914ProGly: 2.914 ± 0.048	1.046ProHis: 1.046 ± 0.03	2.332ProIle: 2.332 ± 0.048	1.633ProLys: 1.633 ± 0.036	5.216ProLeu: 5.216 ± 0.079	1.069ProMet: 1.069 ± 0.03	1.471ProAsn: 1.471 ± 0.033	1.742ProPro: 1.742 ± 0.051	2.219ProGln: 2.219 ± 0.044	1.759ProArg: 1.759 ± 0.047	2.457ProSer: 2.457 ± 0.044	2.279ProThr: 2.279 ± 0.041	3.536ProVal: 3.536 ± 0.055	0.646ProTrp: 0.646 ± 0.024	1.344ProTyr: 1.344 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.721GlnAla: 4.721 ± 0.075	0.409GlnCys: 0.409 ± 0.017	1.997GlnAsp: 1.997 ± 0.043	2.277GlnGlu: 2.277 ± 0.042	1.539GlnPhe: 1.539 ± 0.038	3.417GlnGly: 3.417 ± 0.062	1.303GlnHis: 1.303 ± 0.036	2.568GlnIle: 2.568 ± 0.049	1.849GlnLys: 1.849 ± 0.041	5.677GlnLeu: 5.677 ± 0.08	1.242GlnMet: 1.242 ± 0.031	1.566GlnAsn: 1.566 ± 0.037	2.349GlnPro: 2.349 ± 0.05	4.066GlnGln: 4.066 ± 0.094	3.247GlnArg: 3.247 ± 0.066	2.626GlnSer: 2.626 ± 0.049	2.229GlnThr: 2.229 ± 0.05	3.33GlnVal: 3.33 ± 0.055	0.753GlnTrp: 0.753 ± 0.028	1.291GlnTyr: 1.291 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	4.22ArgAla: 4.22 ± 0.056	0.572ArgCys: 0.572 ± 0.024	2.783ArgAsp: 2.783 ± 0.059	3.31ArgGlu: 3.31 ± 0.057	2.395ArgPhe: 2.395 ± 0.046	3.312ArgGly: 3.312 ± 0.059	1.475ArgHis: 1.475 ± 0.041	3.451ArgIle: 3.451 ± 0.058	2.186ArgLys: 2.186 ± 0.05	6.252ArgLeu: 6.252 ± 0.089	1.434ArgMet: 1.434 ± 0.037	1.936ArgAsn: 1.936 ± 0.038	2.097ArgPro: 2.097 ± 0.041	3.027ArgGln: 3.027 ± 0.057	3.183ArgArg: 3.183 ± 0.067	2.735ArgSer: 2.735 ± 0.047	2.405ArgThr: 2.405 ± 0.042	3.556ArgVal: 3.556 ± 0.058	0.924ArgTrp: 0.924 ± 0.034	2.174ArgTyr: 2.174 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.772SerAla: 5.772 ± 0.075	0.59SerCys: 0.59 ± 0.021	3.265SerAsp: 3.265 ± 0.061	3.298SerGlu: 3.298 ± 0.058	2.466SerPhe: 2.466 ± 0.047	5.591SerGly: 5.591 ± 0.1	1.537SerHis: 1.537 ± 0.037	3.599SerIle: 3.599 ± 0.061	2.266SerLys: 2.266 ± 0.052	7.164SerLeu: 7.164 ± 0.074	1.522SerMet: 1.522 ± 0.033	2.321SerAsn: 2.321 ± 0.057	2.753SerPro: 2.753 ± 0.045	2.968SerGln: 2.968 ± 0.055	3.264SerArg: 3.264 ± 0.052	4.123SerSer: 4.123 ± 0.085	3.31SerThr: 3.31 ± 0.066	4.429SerVal: 4.429 ± 0.064	0.898SerTrp: 0.898 ± 0.027	1.835SerTyr: 1.835 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.116ThrAla: 5.116 ± 0.088	0.486ThrCys: 0.486 ± 0.02	2.791ThrAsp: 2.791 ± 0.056	2.889ThrGlu: 2.889 ± 0.051	1.985ThrPhe: 1.985 ± 0.04	4.29ThrGly: 4.29 ± 0.087	1.262ThrHis: 1.262 ± 0.034	3.015ThrIle: 3.015 ± 0.053	1.764ThrLys: 1.764 ± 0.044	7.374ThrLeu: 7.374 ± 0.102	1.066ThrMet: 1.066 ± 0.028	1.767ThrAsn: 1.767 ± 0.051	3.134ThrPro: 3.134 ± 0.052	2.473ThrGln: 2.473 ± 0.049	2.762ThrArg: 2.762 ± 0.054	3.109ThrSer: 3.109 ± 0.06	3.032ThrThr: 3.032 ± 0.074	3.907ThrVal: 3.907 ± 0.073	0.635ThrTrp: 0.635 ± 0.022	1.344ThrTyr: 1.344 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.655ValAla: 6.655 ± 0.078	0.728ValCys: 0.728 ± 0.029	3.62ValAsp: 3.62 ± 0.056	3.791ValGlu: 3.791 ± 0.064	2.562ValPhe: 2.562 ± 0.05	4.851ValGly: 4.851 ± 0.074	1.16ValHis: 1.16 ± 0.029	4.793ValIle: 4.793 ± 0.071	3.136ValLys: 3.136 ± 0.049	7.226ValLeu: 7.226 ± 0.091	2.08ValMet: 2.08 ± 0.046	2.953ValAsn: 2.953 ± 0.063	2.784ValPro: 2.784 ± 0.052	2.415ValGln: 2.415 ± 0.052	3.443ValArg: 3.443 ± 0.061	4.652ValSer: 4.652 ± 0.069	4.211ValThr: 4.211 ± 0.082	5.351ValVal: 5.351 ± 0.074	0.827ValTrp: 0.827 ± 0.025	1.755ValTyr: 1.755 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.926TrpAla: 0.926 ± 0.029	0.161TrpCys: 0.161 ± 0.011	0.602TrpAsp: 0.602 ± 0.022	0.524TrpGlu: 0.524 ± 0.021	0.588TrpPhe: 0.588 ± 0.024	0.853TrpGly: 0.853 ± 0.027	0.404TrpHis: 0.404 ± 0.018	0.702TrpIle: 0.702 ± 0.025	0.45TrpLys: 0.45 ± 0.02	2.119TrpLeu: 2.119 ± 0.055	0.365TrpMet: 0.365 ± 0.014	0.43TrpAsn: 0.43 ± 0.019	0.601TrpPro: 0.601 ± 0.026	1.184TrpGln: 1.184 ± 0.031	0.939TrpArg: 0.939 ± 0.029	0.757TrpSer: 0.757 ± 0.029	0.435TrpThr: 0.435 ± 0.02	0.918TrpVal: 0.918 ± 0.028	0.228TrpTrp: 0.228 ± 0.013	0.386TrpTyr: 0.386 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.305TyrAla: 2.305 ± 0.04	0.416TyrCys: 0.416 ± 0.021	1.558TyrAsp: 1.558 ± 0.033	1.212TyrGlu: 1.212 ± 0.028	1.286TyrPhe: 1.286 ± 0.035	2.232TyrGly: 2.232 ± 0.055	0.802TyrHis: 0.802 ± 0.025	1.591TyrIle: 1.591 ± 0.036	1.046TyrLys: 1.046 ± 0.032	3.401TyrLeu: 3.401 ± 0.047	0.613TyrMet: 0.613 ± 0.024	1.139TyrAsn: 1.139 ± 0.037	1.427TyrPro: 1.427 ± 0.034	1.952TyrGln: 1.952 ± 0.046	2.003TyrArg: 2.003 ± 0.04	1.864TyrSer: 1.864 ± 0.048	1.486TyrThr: 1.486 ± 0.04	1.662TyrVal: 1.662 ± 0.041	0.487TyrTrp: 0.487 ± 0.02	1.011TyrTyr: 1.011 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3910 proteins (1243634 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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