Amino acid dipepetide frequency for Mycobacterium phage Bxb1 (Mycobacteriophage Bxb1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.283AlaAla: 13.283 ± 1.483
0.793AlaCys: 0.793 ± 0.181
6.542AlaAsp: 6.542 ± 0.677
7.203AlaGlu: 7.203 ± 0.802
3.106AlaPhe: 3.106 ± 0.52
7.864AlaGly: 7.864 ± 0.866
1.256AlaHis: 1.256 ± 0.33
4.296AlaIle: 4.296 ± 0.747
4.229AlaLys: 4.229 ± 0.489
8.723AlaLeu: 8.723 ± 0.712
2.445AlaMet: 2.445 ± 0.469
2.709AlaAsn: 2.709 ± 0.426
4.956AlaPro: 4.956 ± 0.603
2.842AlaGln: 2.842 ± 0.434
6.278AlaArg: 6.278 ± 0.644
5.948AlaSer: 5.948 ± 0.731
5.617AlaThr: 5.617 ± 0.705
7.402AlaVal: 7.402 ± 0.901
1.652AlaTrp: 1.652 ± 0.278
3.37AlaTyr: 3.37 ± 0.43
0.0AlaXaa: 0.0 ± 0.0
Cys
0.727CysAla: 0.727 ± 0.253
0.066CysCys: 0.066 ± 0.069
0.529CysAsp: 0.529 ± 0.194
0.793CysGlu: 0.793 ± 0.207
0.132CysPhe: 0.132 ± 0.081
0.529CysGly: 0.529 ± 0.212
0.198CysHis: 0.198 ± 0.101
0.264CysIle: 0.264 ± 0.125
0.264CysLys: 0.264 ± 0.153
0.33CysLeu: 0.33 ± 0.175
0.066CysMet: 0.066 ± 0.066
0.33CysAsn: 0.33 ± 0.144
0.264CysPro: 0.264 ± 0.12
0.264CysGln: 0.264 ± 0.13
0.33CysArg: 0.33 ± 0.123
0.397CysSer: 0.397 ± 0.149
0.33CysThr: 0.33 ± 0.149
0.264CysVal: 0.264 ± 0.129
0.264CysTrp: 0.264 ± 0.131
0.132CysTyr: 0.132 ± 0.091
0.0CysXaa: 0.0 ± 0.0
Asp
6.609AspAla: 6.609 ± 0.85
0.397AspCys: 0.397 ± 0.145
3.899AspAsp: 3.899 ± 0.449
3.965AspGlu: 3.965 ± 0.666
2.643AspPhe: 2.643 ± 0.333
5.882AspGly: 5.882 ± 0.662
1.322AspHis: 1.322 ± 0.314
2.908AspIle: 2.908 ± 0.498
2.445AspLys: 2.445 ± 0.451
6.41AspLeu: 6.41 ± 0.737
1.454AspMet: 1.454 ± 0.275
1.85AspAsn: 1.85 ± 0.273
5.155AspPro: 5.155 ± 0.658
1.718AspGln: 1.718 ± 0.443
3.635AspArg: 3.635 ± 0.496
3.106AspSer: 3.106 ± 0.452
3.436AspThr: 3.436 ± 0.357
4.56AspVal: 4.56 ± 0.655
1.652AspTrp: 1.652 ± 0.286
1.983AspTyr: 1.983 ± 0.35
0.0AspXaa: 0.0 ± 0.0
Glu
6.014GluAla: 6.014 ± 0.739
0.33GluCys: 0.33 ± 0.176
5.221GluAsp: 5.221 ± 0.742
4.494GluGlu: 4.494 ± 0.713
1.85GluPhe: 1.85 ± 0.316
4.031GluGly: 4.031 ± 0.52
1.123GluHis: 1.123 ± 0.362
3.04GluIle: 3.04 ± 0.453
2.445GluLys: 2.445 ± 0.415
7.798GluLeu: 7.798 ± 0.719
1.586GluMet: 1.586 ± 0.287
1.586GluAsn: 1.586 ± 0.309
2.974GluPro: 2.974 ± 0.426
2.776GluGln: 2.776 ± 0.437
3.701GluArg: 3.701 ± 0.603
3.503GluSer: 3.503 ± 0.388
3.701GluThr: 3.701 ± 0.504
5.882GluVal: 5.882 ± 0.646
1.784GluTrp: 1.784 ± 0.349
2.643GluTyr: 2.643 ± 0.47
0.0GluXaa: 0.0 ± 0.0
Phe
2.577PheAla: 2.577 ± 0.391
0.397PheCys: 0.397 ± 0.215
2.908PheAsp: 2.908 ± 0.421
2.049PheGlu: 2.049 ± 0.359
0.463PhePhe: 0.463 ± 0.174
3.04PheGly: 3.04 ± 0.527
0.727PheHis: 0.727 ± 0.258
1.388PheIle: 1.388 ± 0.292
1.19PheLys: 1.19 ± 0.291
1.983PheLeu: 1.983 ± 0.366
0.463PheMet: 0.463 ± 0.177
1.256PheAsn: 1.256 ± 0.28
1.388PhePro: 1.388 ± 0.32
0.991PheGln: 0.991 ± 0.26
1.916PheArg: 1.916 ± 0.343
2.247PheSer: 2.247 ± 0.54
2.181PheThr: 2.181 ± 0.422
2.247PheVal: 2.247 ± 0.396
0.529PheTrp: 0.529 ± 0.182
0.925PheTyr: 0.925 ± 0.256
0.0PheXaa: 0.0 ± 0.0
Gly
7.6GlyAla: 7.6 ± 1.059
0.727GlyCys: 0.727 ± 0.217
5.948GlyAsp: 5.948 ± 0.544
4.89GlyGlu: 4.89 ± 0.604
2.842GlyPhe: 2.842 ± 0.499
9.648GlyGly: 9.648 ± 2.178
2.181GlyHis: 2.181 ± 0.408
4.494GlyIle: 4.494 ± 0.708
3.436GlyLys: 3.436 ± 0.482
7.6GlyLeu: 7.6 ± 1.061
2.181GlyMet: 2.181 ± 0.37
3.304GlyAsn: 3.304 ± 0.445
3.37GlyPro: 3.37 ± 0.618
2.776GlyGln: 2.776 ± 0.392
4.494GlyArg: 4.494 ± 0.521
6.278GlySer: 6.278 ± 0.953
5.221GlyThr: 5.221 ± 0.655
5.353GlyVal: 5.353 ± 0.69
2.247GlyTrp: 2.247 ± 0.373
3.04GlyTyr: 3.04 ± 0.414
0.0GlyXaa: 0.0 ± 0.0
His
1.652HisAla: 1.652 ± 0.374
0.264HisCys: 0.264 ± 0.166
1.057HisAsp: 1.057 ± 0.245
1.586HisGlu: 1.586 ± 0.361
0.793HisPhe: 0.793 ± 0.217
1.52HisGly: 1.52 ± 0.341
0.661HisHis: 0.661 ± 0.205
0.991HisIle: 0.991 ± 0.209
1.057HisLys: 1.057 ± 0.332
1.256HisLeu: 1.256 ± 0.333
0.066HisMet: 0.066 ± 0.059
0.264HisAsn: 0.264 ± 0.115
1.123HisPro: 1.123 ± 0.246
0.793HisGln: 0.793 ± 0.236
1.52HisArg: 1.52 ± 0.403
0.925HisSer: 0.925 ± 0.23
0.925HisThr: 0.925 ± 0.265
1.916HisVal: 1.916 ± 0.34
0.595HisTrp: 0.595 ± 0.187
0.793HisTyr: 0.793 ± 0.258
0.0HisXaa: 0.0 ± 0.0
Ile
6.08IleAla: 6.08 ± 0.752
0.33IleCys: 0.33 ± 0.141
3.436IleAsp: 3.436 ± 0.398
3.635IleGlu: 3.635 ± 0.516
0.925IlePhe: 0.925 ± 0.267
4.031IleGly: 4.031 ± 0.493
0.793IleHis: 0.793 ± 0.214
1.256IleIle: 1.256 ± 0.297
1.454IleLys: 1.454 ± 0.287
3.767IleLeu: 3.767 ± 0.468
0.793IleMet: 0.793 ± 0.231
2.049IleAsn: 2.049 ± 0.375
3.701IlePro: 3.701 ± 0.436
1.388IleGln: 1.388 ± 0.432
3.635IleArg: 3.635 ± 0.5
3.04IleSer: 3.04 ± 0.413
3.436IleThr: 3.436 ± 0.495
3.238IleVal: 3.238 ± 0.504
0.925IleTrp: 0.925 ± 0.196
1.916IleTyr: 1.916 ± 0.318
0.0IleXaa: 0.0 ± 0.0
Lys
3.635LysAla: 3.635 ± 0.487
0.264LysCys: 0.264 ± 0.127
2.577LysAsp: 2.577 ± 0.431
1.916LysGlu: 1.916 ± 0.428
1.454LysPhe: 1.454 ± 0.263
2.908LysGly: 2.908 ± 0.381
1.123LysHis: 1.123 ± 0.367
2.511LysIle: 2.511 ± 0.498
1.983LysLys: 1.983 ± 0.429
3.304LysLeu: 3.304 ± 0.504
0.991LysMet: 0.991 ± 0.219
1.718LysAsn: 1.718 ± 0.333
2.511LysPro: 2.511 ± 0.415
1.322LysGln: 1.322 ± 0.363
2.709LysArg: 2.709 ± 0.468
2.379LysSer: 2.379 ± 0.409
1.983LysThr: 1.983 ± 0.331
3.436LysVal: 3.436 ± 0.452
0.793LysTrp: 0.793 ± 0.192
0.859LysTyr: 0.859 ± 0.241
0.0LysXaa: 0.0 ± 0.0
Leu
9.318LeuAla: 9.318 ± 0.944
0.198LeuCys: 0.198 ± 0.107
5.551LeuAsp: 5.551 ± 0.707
5.683LeuGlu: 5.683 ± 0.652
1.784LeuPhe: 1.784 ± 0.373
7.798LeuGly: 7.798 ± 0.987
1.652LeuHis: 1.652 ± 0.345
5.617LeuIle: 5.617 ± 0.599
3.503LeuLys: 3.503 ± 0.539
5.683LeuLeu: 5.683 ± 0.633
1.916LeuMet: 1.916 ± 0.298
3.04LeuAsn: 3.04 ± 0.456
5.089LeuPro: 5.089 ± 0.671
2.247LeuGln: 2.247 ± 0.424
5.749LeuArg: 5.749 ± 0.6
5.683LeuSer: 5.683 ± 0.619
5.617LeuThr: 5.617 ± 0.628
4.89LeuVal: 4.89 ± 0.66
1.057LeuTrp: 1.057 ± 0.326
2.049LeuTyr: 2.049 ± 0.47
0.0LeuXaa: 0.0 ± 0.0
Met
2.577MetAla: 2.577 ± 0.356
0.0MetCys: 0.0 ± 0.0
1.322MetAsp: 1.322 ± 0.283
1.652MetGlu: 1.652 ± 0.287
0.661MetPhe: 0.661 ± 0.219
1.718MetGly: 1.718 ± 0.352
0.264MetHis: 0.264 ± 0.132
0.661MetIle: 0.661 ± 0.199
1.256MetLys: 1.256 ± 0.274
1.454MetLeu: 1.454 ± 0.318
0.066MetMet: 0.066 ± 0.059
0.925MetAsn: 0.925 ± 0.227
1.123MetPro: 1.123 ± 0.262
0.595MetGln: 0.595 ± 0.176
1.123MetArg: 1.123 ± 0.278
2.049MetSer: 2.049 ± 0.353
2.379MetThr: 2.379 ± 0.377
1.256MetVal: 1.256 ± 0.341
0.198MetTrp: 0.198 ± 0.124
0.264MetTyr: 0.264 ± 0.141
0.0MetXaa: 0.0 ± 0.0
Asn
3.37AsnAla: 3.37 ± 0.489
0.066AsnCys: 0.066 ± 0.068
1.784AsnAsp: 1.784 ± 0.343
1.916AsnGlu: 1.916 ± 0.369
0.991AsnPhe: 0.991 ± 0.219
3.767AsnGly: 3.767 ± 0.479
0.397AsnHis: 0.397 ± 0.136
1.652AsnIle: 1.652 ± 0.334
0.727AsnLys: 0.727 ± 0.225
2.313AsnLeu: 2.313 ± 0.342
0.727AsnMet: 0.727 ± 0.226
1.123AsnAsn: 1.123 ± 0.234
2.709AsnPro: 2.709 ± 0.401
1.256AsnGln: 1.256 ± 0.364
1.784AsnArg: 1.784 ± 0.348
1.85AsnSer: 1.85 ± 0.391
1.586AsnThr: 1.586 ± 0.304
2.115AsnVal: 2.115 ± 0.394
0.661AsnTrp: 0.661 ± 0.225
1.322AsnTyr: 1.322 ± 0.307
0.0AsnXaa: 0.0 ± 0.0
Pro
4.758ProAla: 4.758 ± 0.498
0.463ProCys: 0.463 ± 0.188
4.097ProAsp: 4.097 ± 0.528
4.692ProGlu: 4.692 ± 0.729
2.115ProPhe: 2.115 ± 0.392
4.494ProGly: 4.494 ± 0.61
1.123ProHis: 1.123 ± 0.241
2.379ProIle: 2.379 ± 0.414
1.784ProLys: 1.784 ± 0.272
3.767ProLeu: 3.767 ± 0.532
1.057ProMet: 1.057 ± 0.288
1.652ProAsn: 1.652 ± 0.38
2.842ProPro: 2.842 ± 0.477
1.454ProGln: 1.454 ± 0.319
2.643ProArg: 2.643 ± 0.515
3.899ProSer: 3.899 ± 0.574
4.229ProThr: 4.229 ± 0.584
4.031ProVal: 4.031 ± 0.451
0.859ProTrp: 0.859 ± 0.325
1.256ProTyr: 1.256 ± 0.331
0.0ProXaa: 0.0 ± 0.0
Gln
2.974GlnAla: 2.974 ± 0.463
0.132GlnCys: 0.132 ± 0.088
1.322GlnAsp: 1.322 ± 0.286
1.52GlnGlu: 1.52 ± 0.31
1.123GlnPhe: 1.123 ± 0.25
2.379GlnGly: 2.379 ± 0.362
0.661GlnHis: 0.661 ± 0.194
2.908GlnIle: 2.908 ± 0.521
1.19GlnLys: 1.19 ± 0.345
3.436GlnLeu: 3.436 ± 0.529
0.859GlnMet: 0.859 ± 0.254
0.529GlnAsn: 0.529 ± 0.2
1.718GlnPro: 1.718 ± 0.346
1.454GlnGln: 1.454 ± 0.373
1.916GlnArg: 1.916 ± 0.349
1.718GlnSer: 1.718 ± 0.385
1.784GlnThr: 1.784 ± 0.272
2.643GlnVal: 2.643 ± 0.384
0.793GlnTrp: 0.793 ± 0.193
0.463GlnTyr: 0.463 ± 0.149
0.0GlnXaa: 0.0 ± 0.0
Arg
5.551ArgAla: 5.551 ± 0.687
0.793ArgCys: 0.793 ± 0.26
2.974ArgAsp: 2.974 ± 0.405
4.692ArgGlu: 4.692 ± 0.605
1.652ArgPhe: 1.652 ± 0.319
5.089ArgGly: 5.089 ± 0.637
1.256ArgHis: 1.256 ± 0.298
2.776ArgIle: 2.776 ± 0.393
3.238ArgLys: 3.238 ± 0.525
5.221ArgLeu: 5.221 ± 0.699
1.586ArgMet: 1.586 ± 0.314
1.85ArgAsn: 1.85 ± 0.383
2.181ArgPro: 2.181 ± 0.346
1.916ArgGln: 1.916 ± 0.297
5.022ArgArg: 5.022 ± 0.748
4.362ArgSer: 4.362 ± 0.528
3.436ArgThr: 3.436 ± 0.596
5.287ArgVal: 5.287 ± 0.624
1.256ArgTrp: 1.256 ± 0.331
1.784ArgTyr: 1.784 ± 0.352
0.0ArgXaa: 0.0 ± 0.0
Ser
7.137SerAla: 7.137 ± 0.728
0.397SerCys: 0.397 ± 0.17
3.635SerAsp: 3.635 ± 0.454
3.172SerGlu: 3.172 ± 0.395
1.983SerPhe: 1.983 ± 0.433
7.137SerGly: 7.137 ± 0.9
1.388SerHis: 1.388 ± 0.309
3.238SerIle: 3.238 ± 0.478
2.577SerLys: 2.577 ± 0.444
4.758SerLeu: 4.758 ± 0.691
1.983SerMet: 1.983 ± 0.37
2.313SerAsn: 2.313 ± 0.445
3.04SerPro: 3.04 ± 0.499
1.85SerGln: 1.85 ± 0.334
2.908SerArg: 2.908 ± 0.415
3.635SerSer: 3.635 ± 0.685
3.965SerThr: 3.965 ± 0.517
4.163SerVal: 4.163 ± 0.488
1.19SerTrp: 1.19 ± 0.347
1.388SerTyr: 1.388 ± 0.349
0.0SerXaa: 0.0 ± 0.0
Thr
6.344ThrAla: 6.344 ± 0.709
0.132ThrCys: 0.132 ± 0.101
3.569ThrAsp: 3.569 ± 0.416
3.965ThrGlu: 3.965 ± 0.517
2.181ThrPhe: 2.181 ± 0.399
6.476ThrGly: 6.476 ± 0.647
0.925ThrHis: 0.925 ± 0.293
2.908ThrIle: 2.908 ± 0.502
2.908ThrLys: 2.908 ± 0.422
6.344ThrLeu: 6.344 ± 0.667
1.057ThrMet: 1.057 ± 0.208
1.322ThrAsn: 1.322 ± 0.313
3.635ThrPro: 3.635 ± 0.512
1.652ThrGln: 1.652 ± 0.351
2.776ThrArg: 2.776 ± 0.406
3.569ThrSer: 3.569 ± 0.506
3.965ThrThr: 3.965 ± 0.553
5.948ThrVal: 5.948 ± 0.677
1.388ThrTrp: 1.388 ± 0.311
1.983ThrTyr: 1.983 ± 0.394
0.0ThrXaa: 0.0 ± 0.0
Val
6.675ValAla: 6.675 ± 0.891
0.33ValCys: 0.33 ± 0.125
5.815ValAsp: 5.815 ± 0.62
4.956ValGlu: 4.956 ± 0.536
2.511ValPhe: 2.511 ± 0.346
5.089ValGly: 5.089 ± 0.668
1.718ValHis: 1.718 ± 0.312
3.635ValIle: 3.635 ± 0.525
3.106ValLys: 3.106 ± 0.411
5.485ValLeu: 5.485 ± 0.572
1.256ValMet: 1.256 ± 0.339
2.643ValAsn: 2.643 ± 0.438
3.899ValPro: 3.899 ± 0.502
2.313ValGln: 2.313 ± 0.413
5.882ValArg: 5.882 ± 0.822
5.089ValSer: 5.089 ± 0.459
4.956ValThr: 4.956 ± 0.519
4.956ValVal: 4.956 ± 0.733
1.256ValTrp: 1.256 ± 0.294
2.115ValTyr: 2.115 ± 0.401
0.0ValXaa: 0.0 ± 0.0
Trp
1.454TrpAla: 1.454 ± 0.367
0.264TrpCys: 0.264 ± 0.134
1.388TrpAsp: 1.388 ± 0.308
1.057TrpGlu: 1.057 ± 0.263
0.991TrpPhe: 0.991 ± 0.272
1.586TrpGly: 1.586 ± 0.268
0.529TrpHis: 0.529 ± 0.182
1.256TrpIle: 1.256 ± 0.248
0.264TrpLys: 0.264 ± 0.122
1.916TrpLeu: 1.916 ± 0.343
0.397TrpMet: 0.397 ± 0.158
0.529TrpAsn: 0.529 ± 0.155
0.661TrpPro: 0.661 ± 0.218
0.793TrpGln: 0.793 ± 0.186
1.256TrpArg: 1.256 ± 0.303
0.925TrpSer: 0.925 ± 0.296
1.983TrpThr: 1.983 ± 0.368
2.115TrpVal: 2.115 ± 0.377
0.595TrpTrp: 0.595 ± 0.219
0.33TrpTyr: 0.33 ± 0.141
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.181TyrAla: 2.181 ± 0.404
0.132TyrCys: 0.132 ± 0.084
1.454TyrAsp: 1.454 ± 0.289
2.643TyrGlu: 2.643 ± 0.408
0.661TyrPhe: 0.661 ± 0.183
2.643TyrGly: 2.643 ± 0.449
0.463TyrHis: 0.463 ± 0.168
1.652TyrIle: 1.652 ± 0.335
1.322TyrLys: 1.322 ± 0.273
2.577TyrLeu: 2.577 ± 0.468
0.529TyrMet: 0.529 ± 0.159
1.19TyrAsn: 1.19 ± 0.287
1.256TyrPro: 1.256 ± 0.284
1.123TyrGln: 1.123 ± 0.248
2.643TyrArg: 2.643 ± 0.387
1.256TyrSer: 1.256 ± 0.251
2.313TyrThr: 2.313 ± 0.401
1.983TyrVal: 1.983 ± 0.321
0.595TyrTrp: 0.595 ± 0.209
0.727TyrTyr: 0.727 ± 0.254
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 85 proteins (15133 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski