Amino acid dipepetide frequency for Hyphomonas jannaschiana VP2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.032AlaAla: 16.032 ± 0.182	1.314AlaCys: 1.314 ± 0.041	7.428AlaAsp: 7.428 ± 0.103	8.31AlaGlu: 8.31 ± 0.119	4.628AlaPhe: 4.628 ± 0.075	10.598AlaGly: 10.598 ± 0.104	2.103AlaHis: 2.103 ± 0.045	5.975AlaIle: 5.975 ± 0.082	4.176AlaLys: 4.176 ± 0.071	12.261AlaLeu: 12.261 ± 0.142	3.623AlaMet: 3.623 ± 0.061	3.024AlaAsn: 3.024 ± 0.049	5.821AlaPro: 5.821 ± 0.087	3.486AlaGln: 3.486 ± 0.052	7.946AlaArg: 7.946 ± 0.109	6.503AlaSer: 6.503 ± 0.081	5.273AlaThr: 5.273 ± 0.078	7.637AlaVal: 7.637 ± 0.087	1.655AlaTrp: 1.655 ± 0.04	2.799AlaTyr: 2.799 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.015CysAla: 1.015 ± 0.034	0.098CysCys: 0.098 ± 0.01	0.553CysAsp: 0.553 ± 0.022	0.46CysGlu: 0.46 ± 0.021	0.346CysPhe: 0.346 ± 0.015	0.858CysGly: 0.858 ± 0.031	0.205CysHis: 0.205 ± 0.014	0.37CysIle: 0.37 ± 0.021	0.236CysLys: 0.236 ± 0.015	0.822CysLeu: 0.822 ± 0.031	0.155CysMet: 0.155 ± 0.012	0.228CysAsn: 0.228 ± 0.014	0.502CysPro: 0.502 ± 0.025	0.247CysGln: 0.247 ± 0.014	0.503CysArg: 0.503 ± 0.023	0.47CysSer: 0.47 ± 0.022	0.415CysThr: 0.415 ± 0.02	0.646CysVal: 0.646 ± 0.025	0.086CysTrp: 0.086 ± 0.009	0.215CysTyr: 0.215 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.303AspAla: 7.303 ± 0.096	0.432AspCys: 0.432 ± 0.021	3.586AspAsp: 3.586 ± 0.092	3.991AspGlu: 3.991 ± 0.079	2.472AspPhe: 2.472 ± 0.058	5.684AspGly: 5.684 ± 0.088	1.218AspHis: 1.218 ± 0.033	3.225AspIle: 3.225 ± 0.059	2.107AspLys: 2.107 ± 0.047	6.205AspLeu: 6.205 ± 0.079	1.708AspMet: 1.708 ± 0.04	1.452AspAsn: 1.452 ± 0.04	3.613AspPro: 3.613 ± 0.056	1.86AspGln: 1.86 ± 0.043	3.845AspArg: 3.845 ± 0.062	2.504AspSer: 2.504 ± 0.053	3.253AspThr: 3.253 ± 0.068	4.549AspVal: 4.549 ± 0.068	1.181AspTrp: 1.181 ± 0.028	1.866AspTyr: 1.866 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	8.855GluAla: 8.855 ± 0.126	0.375GluCys: 0.375 ± 0.02	3.991GluAsp: 3.991 ± 0.071	4.085GluGlu: 4.085 ± 0.08	1.994GluPhe: 1.994 ± 0.039	5.018GluGly: 5.018 ± 0.069	1.169GluHis: 1.169 ± 0.037	3.554GluIle: 3.554 ± 0.061	2.624GluLys: 2.624 ± 0.054	5.405GluLeu: 5.405 ± 0.078	1.805GluMet: 1.805 ± 0.043	1.815GluAsn: 1.815 ± 0.04	2.759GluPro: 2.759 ± 0.064	2.291GluGln: 2.291 ± 0.042	4.376GluArg: 4.376 ± 0.073	2.757GluSer: 2.757 ± 0.051	4.48GluThr: 4.48 ± 0.071	4.03GluVal: 4.03 ± 0.064	0.855GluTrp: 0.855 ± 0.027	1.256GluTyr: 1.256 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.445PheAla: 4.445 ± 0.07	0.402PheCys: 0.402 ± 0.018	2.804PheAsp: 2.804 ± 0.054	2.514PheGlu: 2.514 ± 0.05	1.451PhePhe: 1.451 ± 0.049	3.858PheGly: 3.858 ± 0.068	0.773PheHis: 0.773 ± 0.025	1.804PheIle: 1.804 ± 0.044	1.008PheLys: 1.008 ± 0.034	3.554PheLeu: 3.554 ± 0.071	0.905PheMet: 0.905 ± 0.029	1.215PheAsn: 1.215 ± 0.039	1.577PhePro: 1.577 ± 0.037	1.035PheGln: 1.035 ± 0.035	2.254PheArg: 2.254 ± 0.043	2.359PheSer: 2.359 ± 0.053	2.134PheThr: 2.134 ± 0.046	2.666PheVal: 2.666 ± 0.06	0.534PheTrp: 0.534 ± 0.024	0.971PheTyr: 0.971 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.418GlyAla: 9.418 ± 0.105	0.782GlyCys: 0.782 ± 0.027	4.921GlyAsp: 4.921 ± 0.084	5.399GlyGlu: 5.399 ± 0.067	3.617GlyPhe: 3.617 ± 0.059	7.447GlyGly: 7.447 ± 0.093	1.845GlyHis: 1.845 ± 0.048	4.358GlyIle: 4.358 ± 0.067	3.618GlyLys: 3.618 ± 0.062	8.879GlyLeu: 8.879 ± 0.115	2.384GlyMet: 2.384 ± 0.046	2.321GlyAsn: 2.321 ± 0.053	3.677GlyPro: 3.677 ± 0.061	2.872GlyGln: 2.872 ± 0.055	5.465GlyArg: 5.465 ± 0.065	4.355GlySer: 4.355 ± 0.065	4.525GlyThr: 4.525 ± 0.07	6.191GlyVal: 6.191 ± 0.082	1.523GlyTrp: 1.523 ± 0.036	2.35GlyTyr: 2.35 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.096HisAla: 2.096 ± 0.043	0.215HisCys: 0.215 ± 0.014	1.151HisAsp: 1.151 ± 0.035	1.107HisGlu: 1.107 ± 0.033	0.8HisPhe: 0.8 ± 0.027	1.803HisGly: 1.803 ± 0.041	0.481HisHis: 0.481 ± 0.024	1.005HisIle: 1.005 ± 0.035	0.559HisLys: 0.559 ± 0.023	1.877HisLeu: 1.877 ± 0.041	0.519HisMet: 0.519 ± 0.021	0.477HisAsn: 0.477 ± 0.019	1.246HisPro: 1.246 ± 0.034	0.532HisGln: 0.532 ± 0.023	1.157HisArg: 1.157 ± 0.035	0.875HisSer: 0.875 ± 0.029	0.903HisThr: 0.903 ± 0.032	1.402HisVal: 1.402 ± 0.036	0.323HisTrp: 0.323 ± 0.016	0.552HisTyr: 0.552 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.701IleAla: 6.701 ± 0.087	0.524IleCys: 0.524 ± 0.022	3.531IleAsp: 3.531 ± 0.06	3.621IleGlu: 3.621 ± 0.062	1.666IlePhe: 1.666 ± 0.044	4.63IleGly: 4.63 ± 0.066	0.924IleHis: 0.924 ± 0.031	2.306IleIle: 2.306 ± 0.043	1.402IleLys: 1.402 ± 0.038	4.688IleLeu: 4.688 ± 0.082	1.081IleMet: 1.081 ± 0.033	1.416IleAsn: 1.416 ± 0.039	2.29IlePro: 2.29 ± 0.044	1.347IleGln: 1.347 ± 0.038	3.275IleArg: 3.275 ± 0.054	3.103IleSer: 3.103 ± 0.048	2.715IleThr: 2.715 ± 0.048	3.821IleVal: 3.821 ± 0.069	0.665IleTrp: 0.665 ± 0.026	1.201IleTyr: 1.201 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.811LysAla: 4.811 ± 0.088	0.195LysCys: 0.195 ± 0.013	2.239LysAsp: 2.239 ± 0.054	1.992LysGlu: 1.992 ± 0.045	1.113LysPhe: 1.113 ± 0.032	2.914LysGly: 2.914 ± 0.057	0.676LysHis: 0.676 ± 0.028	1.705LysIle: 1.705 ± 0.041	1.55LysLys: 1.55 ± 0.053	3.449LysLeu: 3.449 ± 0.061	0.887LysMet: 0.887 ± 0.031	0.885LysAsn: 0.885 ± 0.029	2.322LysPro: 2.322 ± 0.042	1.149LysGln: 1.149 ± 0.036	2.551LysArg: 2.551 ± 0.052	2.029LysSer: 2.029 ± 0.044	2.189LysThr: 2.189 ± 0.05	2.453LysVal: 2.453 ± 0.051	0.455LysTrp: 0.455 ± 0.02	0.781LysTyr: 0.781 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	12.235LeuAla: 12.235 ± 0.141	0.784LeuCys: 0.784 ± 0.025	5.835LeuAsp: 5.835 ± 0.069	5.781LeuGlu: 5.781 ± 0.095	3.766LeuPhe: 3.766 ± 0.066	7.787LeuGly: 7.787 ± 0.097	1.691LeuHis: 1.691 ± 0.039	5.113LeuIle: 5.113 ± 0.077	4.16LeuLys: 4.16 ± 0.064	8.102LeuLeu: 8.102 ± 0.123	2.534LeuMet: 2.534 ± 0.054	2.728LeuAsn: 2.728 ± 0.053	5.301LeuPro: 5.301 ± 0.078	2.845LeuGln: 2.845 ± 0.053	5.759LeuArg: 5.759 ± 0.078	6.74LeuSer: 6.74 ± 0.094	5.736LeuThr: 5.736 ± 0.082	6.7LeuVal: 6.7 ± 0.099	1.084LeuTrp: 1.084 ± 0.034	2.054LeuTyr: 2.054 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.204MetAla: 3.204 ± 0.057	0.189MetCys: 0.189 ± 0.013	1.476MetAsp: 1.476 ± 0.038	1.551MetGlu: 1.551 ± 0.039	0.864MetPhe: 0.864 ± 0.025	2.013MetGly: 2.013 ± 0.045	0.45MetHis: 0.45 ± 0.021	1.457MetIle: 1.457 ± 0.034	1.243MetLys: 1.243 ± 0.033	2.427MetLeu: 2.427 ± 0.047	0.793MetMet: 0.793 ± 0.03	0.823MetAsn: 0.823 ± 0.026	1.493MetPro: 1.493 ± 0.037	0.832MetGln: 0.832 ± 0.025	1.739MetArg: 1.739 ± 0.048	1.822MetSer: 1.822 ± 0.042	1.986MetThr: 1.986 ± 0.043	1.644MetVal: 1.644 ± 0.038	0.234MetTrp: 0.234 ± 0.016	0.35MetTyr: 0.35 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.161AsnAla: 3.161 ± 0.063	0.253AsnCys: 0.253 ± 0.017	1.506AsnAsp: 1.506 ± 0.045	1.469AsnGlu: 1.469 ± 0.036	1.072AsnPhe: 1.072 ± 0.034	2.517AsnGly: 2.517 ± 0.055	0.45AsnHis: 0.45 ± 0.022	1.409AsnIle: 1.409 ± 0.038	0.845AsnLys: 0.845 ± 0.033	2.639AsnLeu: 2.639 ± 0.047	0.742AsnMet: 0.742 ± 0.025	0.674AsnAsn: 0.674 ± 0.028	1.86AsnPro: 1.86 ± 0.04	0.821AsnGln: 0.821 ± 0.029	1.753AsnArg: 1.753 ± 0.044	1.318AsnSer: 1.318 ± 0.037	1.404AsnThr: 1.404 ± 0.038	1.963AsnVal: 1.963 ± 0.044	0.511AsnTrp: 0.511 ± 0.021	0.755AsnTyr: 0.755 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	6.24ProAla: 6.24 ± 0.09	0.298ProCys: 0.298 ± 0.018	4.228ProAsp: 4.228 ± 0.07	4.543ProGlu: 4.543 ± 0.063	1.92ProPhe: 1.92 ± 0.042	4.683ProGly: 4.683 ± 0.068	1.007ProHis: 1.007 ± 0.031	2.13ProIle: 2.13 ± 0.047	1.842ProLys: 1.842 ± 0.043	4.499ProLeu: 4.499 ± 0.065	1.282ProMet: 1.282 ± 0.034	1.343ProAsn: 1.343 ± 0.037	2.651ProPro: 2.651 ± 0.076	1.544ProGln: 1.544 ± 0.038	2.485ProArg: 2.485 ± 0.053	2.636ProSer: 2.636 ± 0.054	2.141ProThr: 2.141 ± 0.046	4.527ProVal: 4.527 ± 0.066	0.626ProTrp: 0.626 ± 0.026	1.279ProTyr: 1.279 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.973GlnAla: 3.973 ± 0.069	0.185GlnCys: 0.185 ± 0.014	1.684GlnAsp: 1.684 ± 0.04	1.702GlnGlu: 1.702 ± 0.04	1.09GlnPhe: 1.09 ± 0.036	2.321GlnGly: 2.321 ± 0.047	0.565GlnHis: 0.565 ± 0.025	1.769GlnIle: 1.769 ± 0.042	1.234GlnLys: 1.234 ± 0.033	2.864GlnLeu: 2.864 ± 0.047	0.915GlnMet: 0.915 ± 0.03	0.859GlnAsn: 0.859 ± 0.029	1.669GlnPro: 1.669 ± 0.037	1.085GlnGln: 1.085 ± 0.035	2.046GlnArg: 2.046 ± 0.048	1.735GlnSer: 1.735 ± 0.042	1.814GlnThr: 1.814 ± 0.039	2.264GlnVal: 2.264 ± 0.048	0.368GlnTrp: 0.368 ± 0.016	0.66GlnTyr: 0.66 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.022ArgAla: 7.022 ± 0.091	0.447ArgCys: 0.447 ± 0.017	3.724ArgAsp: 3.724 ± 0.06	3.948ArgGlu: 3.948 ± 0.074	2.67ArgPhe: 2.67 ± 0.052	4.355ArgGly: 4.355 ± 0.073	1.306ArgHis: 1.306 ± 0.035	3.602ArgIle: 3.602 ± 0.06	2.574ArgLys: 2.574 ± 0.054	7.083ArgLeu: 7.083 ± 0.098	1.824ArgMet: 1.824 ± 0.042	1.816ArgAsn: 1.816 ± 0.046	3.227ArgPro: 3.227 ± 0.062	2.299ArgGln: 2.299 ± 0.055	4.704ArgArg: 4.704 ± 0.076	3.257ArgSer: 3.257 ± 0.055	3.398ArgThr: 3.398 ± 0.059	4.26ArgVal: 4.26 ± 0.068	0.924ArgTrp: 0.924 ± 0.03	1.627ArgTyr: 1.627 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.364SerAla: 6.364 ± 0.09	0.39SerCys: 0.39 ± 0.02	3.449SerAsp: 3.449 ± 0.056	3.255SerGlu: 3.255 ± 0.058	2.244SerPhe: 2.244 ± 0.051	5.783SerGly: 5.783 ± 0.066	1.046SerHis: 1.046 ± 0.029	2.742SerIle: 2.742 ± 0.052	1.763SerLys: 1.763 ± 0.042	5.674SerLeu: 5.674 ± 0.077	1.435SerMet: 1.435 ± 0.032	1.434SerAsn: 1.434 ± 0.04	3.043SerPro: 3.043 ± 0.051	1.683SerGln: 1.683 ± 0.043	3.474SerArg: 3.474 ± 0.058	2.896SerSer: 2.896 ± 0.053	2.599SerThr: 2.599 ± 0.053	3.974SerVal: 3.974 ± 0.057	0.78SerTrp: 0.78 ± 0.028	1.307SerTyr: 1.307 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.043ThrAla: 6.043 ± 0.083	0.496ThrCys: 0.496 ± 0.021	3.377ThrAsp: 3.377 ± 0.055	3.174ThrGlu: 3.174 ± 0.06	1.998ThrPhe: 1.998 ± 0.046	5.638ThrGly: 5.638 ± 0.076	1.075ThrHis: 1.075 ± 0.038	2.68ThrIle: 2.68 ± 0.049	1.591ThrLys: 1.591 ± 0.038	5.741ThrLeu: 5.741 ± 0.074	1.092ThrMet: 1.092 ± 0.031	1.347ThrAsn: 1.347 ± 0.035	3.447ThrPro: 3.447 ± 0.054	1.525ThrGln: 1.525 ± 0.038	3.175ThrArg: 3.175 ± 0.06	2.967ThrSer: 2.967 ± 0.057	2.482ThrThr: 2.482 ± 0.044	3.994ThrVal: 3.994 ± 0.075	0.685ThrTrp: 0.685 ± 0.023	1.469ThrTyr: 1.469 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	7.688ValAla: 7.688 ± 0.083	0.665ValCys: 0.665 ± 0.026	4.11ValAsp: 4.11 ± 0.067	4.381ValGlu: 4.381 ± 0.078	2.914ValPhe: 2.914 ± 0.057	4.853ValGly: 4.853 ± 0.066	1.292ValHis: 1.292 ± 0.037	3.899ValIle: 3.899 ± 0.064	2.472ValLys: 2.472 ± 0.054	6.714ValLeu: 6.714 ± 0.077	1.971ValMet: 1.971 ± 0.047	2.04ValAsn: 2.04 ± 0.053	3.676ValPro: 3.676 ± 0.057	2.009ValGln: 2.009 ± 0.05	4.742ValArg: 4.742 ± 0.069	4.743ValSer: 4.743 ± 0.06	4.427ValThr: 4.427 ± 0.07	4.683ValVal: 4.683 ± 0.078	1.065ValTrp: 1.065 ± 0.034	1.647ValTyr: 1.647 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.369TrpAla: 1.369 ± 0.041	0.156TrpCys: 0.156 ± 0.012	0.772TrpAsp: 0.772 ± 0.028	0.677TrpGlu: 0.677 ± 0.023	0.572TrpPhe: 0.572 ± 0.025	0.983TrpGly: 0.983 ± 0.03	0.325TrpHis: 0.325 ± 0.018	0.731TrpIle: 0.731 ± 0.026	0.572TrpLys: 0.572 ± 0.023	1.583TrpLeu: 1.583 ± 0.043	0.426TrpMet: 0.426 ± 0.02	0.502TrpAsn: 0.502 ± 0.02	0.685TrpPro: 0.685 ± 0.026	0.541TrpGln: 0.541 ± 0.021	1.126TrpArg: 1.126 ± 0.031	0.9TrpSer: 0.9 ± 0.031	0.823TrpThr: 0.823 ± 0.027	0.903TrpVal: 0.903 ± 0.028	0.221TrpTrp: 0.221 ± 0.017	0.321TrpTyr: 0.321 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.618TyrAla: 2.618 ± 0.049	0.232TyrCys: 0.232 ± 0.013	1.692TyrAsp: 1.692 ± 0.044	1.535TyrGlu: 1.535 ± 0.033	1.064TyrPhe: 1.064 ± 0.031	2.204TyrGly: 2.204 ± 0.053	0.477TyrHis: 0.477 ± 0.02	1.072TyrIle: 1.072 ± 0.035	0.766TyrLys: 0.766 ± 0.029	2.268TyrLeu: 2.268 ± 0.045	0.504TyrMet: 0.504 ± 0.021	0.724TyrAsn: 0.724 ± 0.03	1.047TyrPro: 1.047 ± 0.03	0.8TyrGln: 0.8 ± 0.028	1.692TyrArg: 1.692 ± 0.041	1.365TyrSer: 1.365 ± 0.045	1.299TyrThr: 1.299 ± 0.038	1.687TyrVal: 1.687 ± 0.036	0.415TyrTrp: 0.415 ± 0.017	0.7TyrTyr: 0.7 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3505 proteins (1100037 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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