Amino acid dipepetide frequency for Mycobacterium phage LilhomieP

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.357AlaAla: 11.357 ± 1.425
0.777AlaCys: 0.777 ± 0.178
6.693AlaAsp: 6.693 ± 0.52
7.903AlaGlu: 7.903 ± 0.628
2.591AlaPhe: 2.591 ± 0.317
6.909AlaGly: 6.909 ± 0.715
2.202AlaHis: 2.202 ± 0.467
5.009AlaIle: 5.009 ± 0.421
5.441AlaLys: 5.441 ± 0.561
10.105AlaLeu: 10.105 ± 0.943
2.677AlaMet: 2.677 ± 0.314
3.757AlaAsn: 3.757 ± 0.595
4.275AlaPro: 4.275 ± 0.632
4.362AlaGln: 4.362 ± 0.472
6.089AlaArg: 6.089 ± 0.448
5.009AlaSer: 5.009 ± 0.44
5.787AlaThr: 5.787 ± 0.624
7.384AlaVal: 7.384 ± 0.539
2.375AlaTrp: 2.375 ± 0.299
2.634AlaTyr: 2.634 ± 0.283
0.0AlaXaa: 0.0 ± 0.0
Cys
1.08CysAla: 1.08 ± 0.19
0.043CysCys: 0.043 ± 0.04
0.561CysAsp: 0.561 ± 0.163
0.432CysGlu: 0.432 ± 0.149
0.173CysPhe: 0.173 ± 0.086
1.209CysGly: 1.209 ± 0.259
0.345CysHis: 0.345 ± 0.12
0.475CysIle: 0.475 ± 0.128
0.259CysLys: 0.259 ± 0.096
0.475CysLeu: 0.475 ± 0.158
0.259CysMet: 0.259 ± 0.12
0.475CysAsn: 0.475 ± 0.138
0.648CysPro: 0.648 ± 0.179
0.302CysGln: 0.302 ± 0.113
0.648CysArg: 0.648 ± 0.18
0.561CysSer: 0.561 ± 0.17
0.432CysThr: 0.432 ± 0.112
0.907CysVal: 0.907 ± 0.206
0.302CysTrp: 0.302 ± 0.119
0.302CysTyr: 0.302 ± 0.105
0.0CysXaa: 0.0 ± 0.0
Asp
6.478AspAla: 6.478 ± 0.474
0.864AspCys: 0.864 ± 0.208
4.88AspAsp: 4.88 ± 0.486
4.664AspGlu: 4.664 ± 0.489
1.986AspPhe: 1.986 ± 0.3
6.65AspGly: 6.65 ± 0.533
1.684AspHis: 1.684 ± 0.264
2.764AspIle: 2.764 ± 0.352
2.375AspLys: 2.375 ± 0.335
5.7AspLeu: 5.7 ± 0.49
1.943AspMet: 1.943 ± 0.345
1.857AspAsn: 1.857 ± 0.241
4.621AspPro: 4.621 ± 0.381
1.986AspGln: 1.986 ± 0.297
4.534AspArg: 4.534 ± 0.482
2.893AspSer: 2.893 ± 0.425
3.282AspThr: 3.282 ± 0.319
3.8AspVal: 3.8 ± 0.41
1.511AspTrp: 1.511 ± 0.313
2.202AspTyr: 2.202 ± 0.307
0.0AspXaa: 0.0 ± 0.0
Glu
6.737GluAla: 6.737 ± 0.563
0.518GluCys: 0.518 ± 0.174
3.973GluAsp: 3.973 ± 0.487
3.584GluGlu: 3.584 ± 0.511
2.418GluPhe: 2.418 ± 0.349
4.966GluGly: 4.966 ± 0.503
1.555GluHis: 1.555 ± 0.235
3.282GluIle: 3.282 ± 0.387
2.807GluLys: 2.807 ± 0.304
5.7GluLeu: 5.7 ± 0.552
2.289GluMet: 2.289 ± 0.356
2.03GluAsn: 2.03 ± 0.281
1.986GluPro: 1.986 ± 0.28
2.807GluGln: 2.807 ± 0.308
4.491GluArg: 4.491 ± 0.44
2.893GluSer: 2.893 ± 0.298
3.023GluThr: 3.023 ± 0.436
4.75GluVal: 4.75 ± 0.533
1.943GluTrp: 1.943 ± 0.298
2.116GluTyr: 2.116 ± 0.372
0.0GluXaa: 0.0 ± 0.0
Phe
2.677PheAla: 2.677 ± 0.407
0.216PheCys: 0.216 ± 0.095
3.109PheAsp: 3.109 ± 0.39
1.943PheGlu: 1.943 ± 0.26
1.036PhePhe: 1.036 ± 0.213
2.332PheGly: 2.332 ± 0.301
0.561PheHis: 0.561 ± 0.175
1.598PheIle: 1.598 ± 0.243
1.555PheLys: 1.555 ± 0.344
2.332PheLeu: 2.332 ± 0.305
0.648PheMet: 0.648 ± 0.213
1.166PheAsn: 1.166 ± 0.217
1.511PhePro: 1.511 ± 0.227
1.339PheGln: 1.339 ± 0.273
1.684PheArg: 1.684 ± 0.21
1.641PheSer: 1.641 ± 0.272
1.986PheThr: 1.986 ± 0.277
2.461PheVal: 2.461 ± 0.381
0.475PheTrp: 0.475 ± 0.162
0.734PheTyr: 0.734 ± 0.192
0.0PheXaa: 0.0 ± 0.0
Gly
7.471GlyAla: 7.471 ± 0.926
0.734GlyCys: 0.734 ± 0.173
5.225GlyAsp: 5.225 ± 0.598
5.009GlyGlu: 5.009 ± 0.429
2.634GlyPhe: 2.634 ± 0.331
8.507GlyGly: 8.507 ± 1.101
0.993GlyHis: 0.993 ± 0.249
3.93GlyIle: 3.93 ± 0.528
3.757GlyLys: 3.757 ± 0.405
6.175GlyLeu: 6.175 ± 0.778
1.727GlyMet: 1.727 ± 0.313
3.239GlyAsn: 3.239 ± 0.456
3.411GlyPro: 3.411 ± 0.668
2.893GlyGln: 2.893 ± 0.444
4.146GlyArg: 4.146 ± 0.451
5.571GlySer: 5.571 ± 0.566
5.7GlyThr: 5.7 ± 0.462
6.046GlyVal: 6.046 ± 0.552
2.461GlyTrp: 2.461 ± 0.398
2.936GlyTyr: 2.936 ± 0.359
0.0GlyXaa: 0.0 ± 0.0
His
1.425HisAla: 1.425 ± 0.293
0.302HisCys: 0.302 ± 0.102
1.382HisAsp: 1.382 ± 0.284
1.771HisGlu: 1.771 ± 0.289
0.777HisPhe: 0.777 ± 0.159
1.814HisGly: 1.814 ± 0.296
0.691HisHis: 0.691 ± 0.171
1.296HisIle: 1.296 ± 0.226
0.864HisLys: 0.864 ± 0.173
1.857HisLeu: 1.857 ± 0.357
0.389HisMet: 0.389 ± 0.127
0.95HisAsn: 0.95 ± 0.197
0.993HisPro: 0.993 ± 0.283
0.432HisGln: 0.432 ± 0.146
1.727HisArg: 1.727 ± 0.296
0.993HisSer: 0.993 ± 0.281
1.555HisThr: 1.555 ± 0.288
1.339HisVal: 1.339 ± 0.226
0.345HisTrp: 0.345 ± 0.138
0.648HisTyr: 0.648 ± 0.195
0.0HisXaa: 0.0 ± 0.0
Ile
4.621IleAla: 4.621 ± 0.407
0.432IleCys: 0.432 ± 0.141
4.189IleAsp: 4.189 ± 0.384
3.584IleGlu: 3.584 ± 0.362
1.123IlePhe: 1.123 ± 0.241
4.102IleGly: 4.102 ± 0.425
0.95IleHis: 0.95 ± 0.224
2.116IleIle: 2.116 ± 0.298
2.289IleLys: 2.289 ± 0.293
3.757IleLeu: 3.757 ± 0.349
1.036IleMet: 1.036 ± 0.203
1.684IleAsn: 1.684 ± 0.272
3.368IlePro: 3.368 ± 0.431
1.382IleGln: 1.382 ± 0.243
3.498IleArg: 3.498 ± 0.343
1.555IleSer: 1.555 ± 0.233
3.455IleThr: 3.455 ± 0.37
2.591IleVal: 2.591 ± 0.279
0.82IleTrp: 0.82 ± 0.153
1.339IleTyr: 1.339 ± 0.311
0.0IleXaa: 0.0 ± 0.0
Lys
5.268LysAla: 5.268 ± 0.648
0.432LysCys: 0.432 ± 0.149
2.461LysAsp: 2.461 ± 0.347
1.857LysGlu: 1.857 ± 0.307
1.425LysPhe: 1.425 ± 0.319
3.368LysGly: 3.368 ± 0.434
0.907LysHis: 0.907 ± 0.193
2.03LysIle: 2.03 ± 0.267
2.116LysLys: 2.116 ± 0.32
3.541LysLeu: 3.541 ± 0.36
1.166LysMet: 1.166 ± 0.272
1.727LysAsn: 1.727 ± 0.281
2.202LysPro: 2.202 ± 0.304
1.771LysGln: 1.771 ± 0.215
2.677LysArg: 2.677 ± 0.341
2.461LysSer: 2.461 ± 0.319
2.893LysThr: 2.893 ± 0.402
3.325LysVal: 3.325 ± 0.39
1.555LysTrp: 1.555 ± 0.278
1.598LysTyr: 1.598 ± 0.287
0.0LysXaa: 0.0 ± 0.0
Leu
9.457LeuAla: 9.457 ± 0.468
0.691LeuCys: 0.691 ± 0.18
5.873LeuAsp: 5.873 ± 0.587
5.355LeuGlu: 5.355 ± 0.51
2.505LeuPhe: 2.505 ± 0.36
6.348LeuGly: 6.348 ± 0.722
1.339LeuHis: 1.339 ± 0.3
3.757LeuIle: 3.757 ± 0.436
3.152LeuLys: 3.152 ± 0.385
5.268LeuLeu: 5.268 ± 0.545
1.814LeuMet: 1.814 ± 0.257
2.936LeuAsn: 2.936 ± 0.488
4.405LeuPro: 4.405 ± 0.508
2.591LeuGln: 2.591 ± 0.333
5.096LeuArg: 5.096 ± 0.444
4.664LeuSer: 4.664 ± 0.451
4.966LeuThr: 4.966 ± 0.536
5.571LeuVal: 5.571 ± 0.625
1.468LeuTrp: 1.468 ± 0.294
2.461LeuTyr: 2.461 ± 0.389
0.0LeuXaa: 0.0 ± 0.0
Met
3.541MetAla: 3.541 ± 0.297
0.302MetCys: 0.302 ± 0.121
1.166MetAsp: 1.166 ± 0.211
1.209MetGlu: 1.209 ± 0.224
0.648MetPhe: 0.648 ± 0.183
1.555MetGly: 1.555 ± 0.279
0.475MetHis: 0.475 ± 0.163
0.864MetIle: 0.864 ± 0.183
0.907MetLys: 0.907 ± 0.167
1.641MetLeu: 1.641 ± 0.305
0.302MetMet: 0.302 ± 0.107
0.691MetAsn: 0.691 ± 0.127
1.598MetPro: 1.598 ± 0.251
1.036MetGln: 1.036 ± 0.218
1.814MetArg: 1.814 ± 0.323
3.282MetSer: 3.282 ± 0.395
1.857MetThr: 1.857 ± 0.293
1.166MetVal: 1.166 ± 0.213
0.475MetTrp: 0.475 ± 0.184
0.691MetTyr: 0.691 ± 0.163
0.0MetXaa: 0.0 ± 0.0
Asn
3.757AsnAla: 3.757 ± 0.492
0.389AsnCys: 0.389 ± 0.124
1.727AsnAsp: 1.727 ± 0.34
2.159AsnGlu: 2.159 ± 0.331
1.166AsnPhe: 1.166 ± 0.232
3.411AsnGly: 3.411 ± 0.427
1.036AsnHis: 1.036 ± 0.174
1.339AsnIle: 1.339 ± 0.186
1.511AsnLys: 1.511 ± 0.204
2.505AsnLeu: 2.505 ± 0.302
0.82AsnMet: 0.82 ± 0.177
1.08AsnAsn: 1.08 ± 0.243
2.634AsnPro: 2.634 ± 0.333
1.296AsnGln: 1.296 ± 0.282
2.98AsnArg: 2.98 ± 0.36
1.986AsnSer: 1.986 ± 0.224
2.116AsnThr: 2.116 ± 0.283
2.116AsnVal: 2.116 ± 0.267
0.605AsnTrp: 0.605 ± 0.168
0.82AsnTyr: 0.82 ± 0.187
0.0AsnXaa: 0.0 ± 0.0
Pro
5.614ProAla: 5.614 ± 0.728
0.518ProCys: 0.518 ± 0.16
3.627ProAsp: 3.627 ± 0.333
3.584ProGlu: 3.584 ± 0.44
1.684ProPhe: 1.684 ± 0.237
4.405ProGly: 4.405 ± 0.809
1.036ProHis: 1.036 ± 0.201
1.727ProIle: 1.727 ± 0.272
2.073ProLys: 2.073 ± 0.359
3.93ProLeu: 3.93 ± 0.497
1.727ProMet: 1.727 ± 0.255
1.684ProAsn: 1.684 ± 0.327
2.116ProPro: 2.116 ± 0.388
1.727ProGln: 1.727 ± 0.309
2.634ProArg: 2.634 ± 0.319
2.332ProSer: 2.332 ± 0.289
2.893ProThr: 2.893 ± 0.347
3.843ProVal: 3.843 ± 0.411
0.95ProTrp: 0.95 ± 0.216
1.382ProTyr: 1.382 ± 0.229
0.0ProXaa: 0.0 ± 0.0
Gln
3.973GlnAla: 3.973 ± 0.539
0.691GlnCys: 0.691 ± 0.186
1.771GlnAsp: 1.771 ± 0.277
1.727GlnGlu: 1.727 ± 0.263
0.907GlnPhe: 0.907 ± 0.196
2.764GlnGly: 2.764 ± 0.342
0.82GlnHis: 0.82 ± 0.202
2.764GlnIle: 2.764 ± 0.323
1.382GlnLys: 1.382 ± 0.219
2.807GlnLeu: 2.807 ± 0.329
0.993GlnMet: 0.993 ± 0.188
0.95GlnAsn: 0.95 ± 0.168
1.598GlnPro: 1.598 ± 0.247
1.9GlnGln: 1.9 ± 0.315
2.936GlnArg: 2.936 ± 0.328
1.555GlnSer: 1.555 ± 0.273
1.943GlnThr: 1.943 ± 0.303
2.591GlnVal: 2.591 ± 0.301
1.209GlnTrp: 1.209 ± 0.212
0.907GlnTyr: 0.907 ± 0.19
0.0GlnXaa: 0.0 ± 0.0
Arg
6.607ArgAla: 6.607 ± 0.48
0.691ArgCys: 0.691 ± 0.176
3.584ArgAsp: 3.584 ± 0.392
4.146ArgGlu: 4.146 ± 0.402
2.375ArgPhe: 2.375 ± 0.309
4.577ArgGly: 4.577 ± 0.433
1.123ArgHis: 1.123 ± 0.232
3.714ArgIle: 3.714 ± 0.379
3.93ArgLys: 3.93 ± 0.452
4.448ArgLeu: 4.448 ± 0.42
2.289ArgMet: 2.289 ± 0.374
2.634ArgAsn: 2.634 ± 0.324
2.807ArgPro: 2.807 ± 0.407
3.023ArgGln: 3.023 ± 0.355
4.275ArgArg: 4.275 ± 0.451
2.721ArgSer: 2.721 ± 0.334
3.455ArgThr: 3.455 ± 0.335
4.534ArgVal: 4.534 ± 0.436
1.425ArgTrp: 1.425 ± 0.259
1.9ArgTyr: 1.9 ± 0.303
0.0ArgXaa: 0.0 ± 0.0
Ser
5.182SerAla: 5.182 ± 0.543
0.475SerCys: 0.475 ± 0.149
3.541SerAsp: 3.541 ± 0.35
2.375SerGlu: 2.375 ± 0.354
1.943SerPhe: 1.943 ± 0.267
4.88SerGly: 4.88 ± 0.523
1.166SerHis: 1.166 ± 0.231
2.332SerIle: 2.332 ± 0.334
1.943SerLys: 1.943 ± 0.242
3.843SerLeu: 3.843 ± 0.302
1.123SerMet: 1.123 ± 0.229
2.548SerAsn: 2.548 ± 0.34
2.03SerPro: 2.03 ± 0.314
1.296SerGln: 1.296 ± 0.233
3.023SerArg: 3.023 ± 0.384
3.627SerSer: 3.627 ± 0.438
4.318SerThr: 4.318 ± 0.501
4.232SerVal: 4.232 ± 0.455
1.511SerTrp: 1.511 ± 0.329
1.986SerTyr: 1.986 ± 0.306
0.0SerXaa: 0.0 ± 0.0
Thr
6.132ThrAla: 6.132 ± 0.59
0.475ThrCys: 0.475 ± 0.153
3.93ThrAsp: 3.93 ± 0.465
3.93ThrGlu: 3.93 ± 0.357
1.943ThrPhe: 1.943 ± 0.283
5.355ThrGly: 5.355 ± 0.497
1.252ThrHis: 1.252 ± 0.246
3.282ThrIle: 3.282 ± 0.427
2.591ThrLys: 2.591 ± 0.317
5.139ThrLeu: 5.139 ± 0.491
0.993ThrMet: 0.993 ± 0.188
1.9ThrAsn: 1.9 ± 0.319
3.714ThrPro: 3.714 ± 0.485
1.857ThrGln: 1.857 ± 0.268
3.282ThrArg: 3.282 ± 0.388
2.721ThrSer: 2.721 ± 0.43
3.8ThrThr: 3.8 ± 0.4
5.182ThrVal: 5.182 ± 0.549
1.209ThrTrp: 1.209 ± 0.23
2.289ThrTyr: 2.289 ± 0.321
0.0ThrXaa: 0.0 ± 0.0
Val
6.391ValAla: 6.391 ± 0.572
0.691ValCys: 0.691 ± 0.169
5.355ValAsp: 5.355 ± 0.523
4.75ValGlu: 4.75 ± 0.552
1.943ValPhe: 1.943 ± 0.238
5.312ValGly: 5.312 ± 0.547
1.943ValHis: 1.943 ± 0.318
3.627ValIle: 3.627 ± 0.475
3.368ValLys: 3.368 ± 0.329
5.614ValLeu: 5.614 ± 0.513
1.555ValMet: 1.555 ± 0.307
2.548ValAsn: 2.548 ± 0.306
3.325ValPro: 3.325 ± 0.421
2.505ValGln: 2.505 ± 0.379
4.318ValArg: 4.318 ± 0.375
4.448ValSer: 4.448 ± 0.44
4.577ValThr: 4.577 ± 0.578
4.793ValVal: 4.793 ± 0.452
1.339ValTrp: 1.339 ± 0.238
1.684ValTyr: 1.684 ± 0.271
0.0ValXaa: 0.0 ± 0.0
Trp
2.505TrpAla: 2.505 ± 0.328
0.302TrpCys: 0.302 ± 0.154
1.382TrpAsp: 1.382 ± 0.258
1.943TrpGlu: 1.943 ± 0.281
0.734TrpPhe: 0.734 ± 0.205
1.382TrpGly: 1.382 ± 0.275
0.691TrpHis: 0.691 ± 0.212
0.95TrpIle: 0.95 ± 0.187
0.993TrpLys: 0.993 ± 0.191
2.591TrpLeu: 2.591 ± 0.356
0.605TrpMet: 0.605 ± 0.165
0.648TrpAsn: 0.648 ± 0.16
0.777TrpPro: 0.777 ± 0.169
0.691TrpGln: 0.691 ± 0.173
1.641TrpArg: 1.641 ± 0.256
0.993TrpSer: 0.993 ± 0.235
1.296TrpThr: 1.296 ± 0.242
1.641TrpVal: 1.641 ± 0.219
0.777TrpTrp: 0.777 ± 0.189
0.648TrpTyr: 0.648 ± 0.202
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.066TyrAla: 3.066 ± 0.412
0.345TyrCys: 0.345 ± 0.103
2.246TyrAsp: 2.246 ± 0.328
1.943TyrGlu: 1.943 ± 0.353
0.993TyrPhe: 0.993 ± 0.174
2.721TyrGly: 2.721 ± 0.325
0.777TyrHis: 0.777 ± 0.17
1.08TyrIle: 1.08 ± 0.209
1.468TyrLys: 1.468 ± 0.271
2.289TyrLeu: 2.289 ± 0.314
0.82TyrMet: 0.82 ± 0.207
0.95TyrAsn: 0.95 ± 0.215
1.468TyrPro: 1.468 ± 0.329
0.993TyrGln: 0.993 ± 0.239
2.764TyrArg: 2.764 ± 0.311
1.468TyrSer: 1.468 ± 0.3
1.641TyrThr: 1.641 ± 0.311
1.814TyrVal: 1.814 ± 0.234
0.432TyrTrp: 0.432 ± 0.132
1.209TyrTyr: 1.209 ± 0.252
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 137 proteins (23158 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski