Amino acid dipepetide frequency for Symbiodinium microadriaticum (Dinoflagellate) (Zooxanthella microadriatica)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.402AlaAla: 13.402 ± 0.052	2.076AlaCys: 2.076 ± 0.012	5.138AlaAsp: 5.138 ± 0.02	7.174AlaGlu: 7.174 ± 0.025	3.581AlaPhe: 3.581 ± 0.015	7.102AlaGly: 7.102 ± 0.029	1.897AlaHis: 1.897 ± 0.01	3.43AlaIle: 3.43 ± 0.047	4.776AlaLys: 4.776 ± 0.022	9.863AlaLeu: 9.863 ± 0.036	2.548AlaMet: 2.548 ± 0.009	2.273AlaAsn: 2.273 ± 0.009	5.295AlaPro: 5.295 ± 0.018	4.067AlaGln: 4.067 ± 0.016	6.233AlaArg: 6.233 ± 0.018	7.925AlaSer: 7.925 ± 0.023	5.273AlaThr: 5.273 ± 0.023	7.189AlaVal: 7.189 ± 0.04	1.804AlaTrp: 1.804 ± 0.012	1.81AlaTyr: 1.81 ± 0.013	0.008AlaXaa: 0.008 ± 0.0
Cys	1.76CysAla: 1.76 ± 0.01	0.627CysCys: 0.627 ± 0.007	1.013CysAsp: 1.013 ± 0.013	1.132CysGlu: 1.132 ± 0.008	0.871CysPhe: 0.871 ± 0.007	1.626CysGly: 1.626 ± 0.01	0.525CysHis: 0.525 ± 0.004	0.743CysIle: 0.743 ± 0.005	0.848CysLys: 0.848 ± 0.006	2.042CysLeu: 2.042 ± 0.009	0.426CysMet: 0.426 ± 0.005	0.533CysAsn: 0.533 ± 0.006	1.197CysPro: 1.197 ± 0.022	0.84CysGln: 0.84 ± 0.006	1.521CysArg: 1.521 ± 0.007	1.624CysSer: 1.624 ± 0.01	0.976CysThr: 0.976 ± 0.007	1.212CysVal: 1.212 ± 0.008	0.435CysTrp: 0.435 ± 0.007	0.427CysTyr: 0.427 ± 0.004	0.002CysXaa: 0.002 ± 0.0
Asp	5.409AspAla: 5.409 ± 0.016	1.034AspCys: 1.034 ± 0.013	4.193AspAsp: 4.193 ± 0.102	3.899AspGlu: 3.899 ± 0.018	2.16AspPhe: 2.16 ± 0.011	4.439AspGly: 4.439 ± 0.025	1.138AspHis: 1.138 ± 0.017	1.943AspIle: 1.943 ± 0.008	2.079AspLys: 2.079 ± 0.013	5.254AspLeu: 5.254 ± 0.017	1.222AspMet: 1.222 ± 0.007	1.192AspAsn: 1.192 ± 0.008	2.957AspPro: 2.957 ± 0.012	1.864AspGln: 1.864 ± 0.009	2.944AspArg: 2.944 ± 0.012	3.649AspSer: 3.649 ± 0.015	2.279AspThr: 2.279 ± 0.011	3.967AspVal: 3.967 ± 0.024	0.989AspTrp: 0.989 ± 0.006	1.303AspTyr: 1.303 ± 0.033	0.003AspXaa: 0.003 ± 0.0
Glu	7.767GluAla: 7.767 ± 0.024	0.952GluCys: 0.952 ± 0.009	4.194GluAsp: 4.194 ± 0.02	6.401GluGlu: 6.401 ± 0.034	1.823GluPhe: 1.823 ± 0.009	4.256GluGly: 4.256 ± 0.016	1.526GluHis: 1.526 ± 0.008	2.283GluIle: 2.283 ± 0.01	3.283GluLys: 3.283 ± 0.036	6.502GluLeu: 6.502 ± 0.019	1.539GluMet: 1.539 ± 0.016	1.526GluAsn: 1.526 ± 0.009	3.195GluPro: 3.195 ± 0.015	3.679GluGln: 3.679 ± 0.145	3.9GluArg: 3.9 ± 0.031	3.998GluSer: 3.998 ± 0.07	2.966GluThr: 2.966 ± 0.011	5.028GluVal: 5.028 ± 0.119	1.022GluTrp: 1.022 ± 0.011	1.122GluTyr: 1.122 ± 0.006	0.004GluXaa: 0.004 ± 0.0
Phe	3.501PheAla: 3.501 ± 0.014	0.846PheCys: 0.846 ± 0.006	1.907PheAsp: 1.907 ± 0.01	2.056PheGlu: 2.056 ± 0.009	1.384PhePhe: 1.384 ± 0.007	2.683PheGly: 2.683 ± 0.012	0.845PheHis: 0.845 ± 0.007	1.082PheIle: 1.082 ± 0.01	1.238PheLys: 1.238 ± 0.007	3.566PheLeu: 3.566 ± 0.015	0.732PheMet: 0.732 ± 0.006	0.931PheAsn: 0.931 ± 0.006	1.611PhePro: 1.611 ± 0.008	1.506PheGln: 1.506 ± 0.007	2.241PheArg: 2.241 ± 0.009	2.449PheSer: 2.449 ± 0.01	1.573PheThr: 1.573 ± 0.009	2.529PheVal: 2.529 ± 0.015	0.64PheTrp: 0.64 ± 0.005	1.05PheTyr: 1.05 ± 0.043	0.002PheXaa: 0.002 ± 0.0
Gly	6.3GlyAla: 6.3 ± 0.029	1.569GlyCys: 1.569 ± 0.009	4.175GlyAsp: 4.175 ± 0.019	4.082GlyGlu: 4.082 ± 0.016	2.584GlyPhe: 2.584 ± 0.012	5.967GlyGly: 5.967 ± 0.032	1.908GlyHis: 1.908 ± 0.011	2.515GlyIle: 2.515 ± 0.012	3.579GlyLys: 3.579 ± 0.02	6.363GlyLeu: 6.363 ± 0.02	1.58GlyMet: 1.58 ± 0.013	1.891GlyAsn: 1.891 ± 0.008	3.623GlyPro: 3.623 ± 0.013	2.891GlyGln: 2.891 ± 0.017	4.827GlyArg: 4.827 ± 0.014	5.771GlySer: 5.771 ± 0.019	3.531GlyThr: 3.531 ± 0.014	4.597GlyVal: 4.597 ± 0.058	1.511GlyTrp: 1.511 ± 0.035	1.606GlyTyr: 1.606 ± 0.009	0.007GlyXaa: 0.007 ± 0.0
His	2.217HisAla: 2.217 ± 0.009	0.563HisCys: 0.563 ± 0.005	1.185HisAsp: 1.185 ± 0.017	1.369HisGlu: 1.369 ± 0.008	0.99HisPhe: 0.99 ± 0.007	1.945HisGly: 1.945 ± 0.013	0.715HisHis: 0.715 ± 0.007	0.841HisIle: 0.841 ± 0.006	0.881HisLys: 0.881 ± 0.024	2.505HisLeu: 2.505 ± 0.012	0.507HisMet: 0.507 ± 0.004	0.575HisAsn: 0.575 ± 0.008	1.35HisPro: 1.35 ± 0.006	1.007HisGln: 1.007 ± 0.006	1.739HisArg: 1.739 ± 0.008	1.59HisSer: 1.59 ± 0.009	0.981HisThr: 0.981 ± 0.007	1.736HisVal: 1.736 ± 0.009	0.482HisTrp: 0.482 ± 0.004	0.56HisTyr: 0.56 ± 0.024	0.002HisXaa: 0.002 ± 0.0
Ile	3.207IleAla: 3.207 ± 0.046	0.771IleCys: 0.771 ± 0.005	1.798IleAsp: 1.798 ± 0.009	1.901IleGlu: 1.901 ± 0.008	1.378IlePhe: 1.378 ± 0.01	2.128IleGly: 2.128 ± 0.01	0.764IleHis: 0.764 ± 0.006	1.744IleIle: 1.744 ± 0.037	1.274IleLys: 1.274 ± 0.008	3.48IleLeu: 3.48 ± 0.012	0.729IleMet: 0.729 ± 0.005	0.864IleAsn: 0.864 ± 0.006	1.84IlePro: 1.84 ± 0.009	1.545IleGln: 1.545 ± 0.009	2.174IleArg: 2.174 ± 0.015	2.587IleSer: 2.587 ± 0.012	1.711IleThr: 1.711 ± 0.014	2.3IleVal: 2.3 ± 0.01	0.541IleTrp: 0.541 ± 0.004	0.787IleTyr: 0.787 ± 0.019	0.002IleXaa: 0.002 ± 0.0
Lys	5.074LysAla: 5.074 ± 0.02	0.674LysCys: 0.674 ± 0.005	2.506LysAsp: 2.506 ± 0.013	3.432LysGlu: 3.432 ± 0.035	1.203LysPhe: 1.203 ± 0.009	3.337LysGly: 3.337 ± 0.022	1.079LysHis: 1.079 ± 0.024	1.419LysIle: 1.419 ± 0.008	2.777LysLys: 2.777 ± 0.021	3.999LysLeu: 3.999 ± 0.014	0.976LysMet: 0.976 ± 0.006	1.164LysAsn: 1.164 ± 0.008	2.259LysPro: 2.259 ± 0.012	2.033LysGln: 2.033 ± 0.024	2.947LysArg: 2.947 ± 0.014	2.678LysSer: 2.678 ± 0.01	2.109LysThr: 2.109 ± 0.01	2.948LysVal: 2.948 ± 0.012	0.647LysTrp: 0.647 ± 0.005	0.833LysTyr: 0.833 ± 0.006	0.003LysXaa: 0.003 ± 0.0
Leu	9.742LeuAla: 9.742 ± 0.023	2.137LeuCys: 2.137 ± 0.01	4.983LeuAsp: 4.983 ± 0.017	6.484LeuGlu: 6.484 ± 0.021	3.089LeuPhe: 3.089 ± 0.013	6.479LeuGly: 6.479 ± 0.019	2.716LeuHis: 2.716 ± 0.013	2.696LeuIle: 2.696 ± 0.01	4.213LeuLys: 4.213 ± 0.016	11.775LeuLeu: 11.775 ± 0.17	2.018LeuMet: 2.018 ± 0.011	2.204LeuAsn: 2.204 ± 0.01	6.104LeuPro: 6.104 ± 0.036	5.753LeuGln: 5.753 ± 0.017	7.968LeuArg: 7.968 ± 0.02	6.918LeuSer: 6.918 ± 0.021	4.32LeuThr: 4.32 ± 0.013	7.276LeuVal: 7.276 ± 0.122	1.627LeuTrp: 1.627 ± 0.008	1.816LeuTyr: 1.816 ± 0.038	0.008LeuXaa: 0.008 ± 0.0
Met	2.307MetAla: 2.307 ± 0.014	0.382MetCys: 0.382 ± 0.004	1.212MetAsp: 1.212 ± 0.018	1.495MetGlu: 1.495 ± 0.015	0.672MetPhe: 0.672 ± 0.005	1.315MetGly: 1.315 ± 0.007	0.528MetHis: 0.528 ± 0.004	0.781MetIle: 0.781 ± 0.006	1.069MetLys: 1.069 ± 0.008	2.411MetLeu: 2.411 ± 0.011	0.817MetMet: 0.817 ± 0.012	0.588MetAsn: 0.588 ± 0.006	1.39MetPro: 1.39 ± 0.007	1.175MetGln: 1.175 ± 0.007	1.428MetArg: 1.428 ± 0.007	1.6MetSer: 1.6 ± 0.008	1.137MetThr: 1.137 ± 0.007	1.507MetVal: 1.507 ± 0.008	0.332MetTrp: 0.332 ± 0.004	0.383MetTyr: 0.383 ± 0.004	0.001MetXaa: 0.001 ± 0.0
Asn	2.334AsnAla: 2.334 ± 0.011	0.502AsnCys: 0.502 ± 0.004	1.216AsnAsp: 1.216 ± 0.008	1.375AsnGlu: 1.375 ± 0.007	1.01AsnPhe: 1.01 ± 0.014	1.812AsnGly: 1.812 ± 0.01	0.588AsnHis: 0.588 ± 0.008	0.966AsnIle: 0.966 ± 0.006	1.018AsnLys: 1.018 ± 0.006	2.423AsnLeu: 2.423 ± 0.011	0.619AsnMet: 0.619 ± 0.005	0.772AsnAsn: 0.772 ± 0.065	1.349AsnPro: 1.349 ± 0.008	0.969AsnGln: 0.969 ± 0.007	1.454AsnArg: 1.454 ± 0.007	1.738AsnSer: 1.738 ± 0.018	1.254AsnThr: 1.254 ± 0.044	1.729AsnVal: 1.729 ± 0.009	0.432AsnTrp: 0.432 ± 0.004	0.584AsnTyr: 0.584 ± 0.013	0.002AsnXaa: 0.002 ± 0.0
Pro	5.947ProAla: 5.947 ± 0.031	1.061ProCys: 1.061 ± 0.022	3.08ProAsp: 3.08 ± 0.012	4.067ProGlu: 4.067 ± 0.013	1.64ProPhe: 1.64 ± 0.009	4.306ProGly: 4.306 ± 0.016	1.121ProHis: 1.121 ± 0.006	1.482ProIle: 1.482 ± 0.01	2.454ProLys: 2.454 ± 0.012	4.758ProLeu: 4.758 ± 0.016	1.098ProMet: 1.098 ± 0.007	1.252ProAsn: 1.252 ± 0.007	4.519ProPro: 4.519 ± 0.022	2.274ProGln: 2.274 ± 0.01	3.449ProArg: 3.449 ± 0.011	4.692ProSer: 4.692 ± 0.017	2.994ProThr: 2.994 ± 0.029	3.643ProVal: 3.643 ± 0.014	0.996ProTrp: 0.996 ± 0.006	0.834ProTyr: 0.834 ± 0.006	0.006ProXaa: 0.006 ± 0.0
Gln	4.942GlnAla: 4.942 ± 0.027	0.756GlnCys: 0.756 ± 0.006	2.33GlnAsp: 2.33 ± 0.009	4.029GlnGlu: 4.029 ± 0.145	1.128GlnPhe: 1.128 ± 0.006	2.941GlnGly: 2.941 ± 0.011	1.269GlnHis: 1.269 ± 0.008	1.531GlnIle: 1.531 ± 0.009	2.075GlnLys: 2.075 ± 0.015	4.739GlnLeu: 4.739 ± 0.015	1.005GlnMet: 1.005 ± 0.007	1.07GlnAsn: 1.07 ± 0.013	2.385GlnPro: 2.385 ± 0.012	3.378GlnGln: 3.378 ± 0.292	3.303GlnArg: 3.303 ± 0.014	2.795GlnSer: 2.795 ± 0.015	1.976GlnThr: 1.976 ± 0.009	3.045GlnVal: 3.045 ± 0.016	0.817GlnTrp: 0.817 ± 0.006	0.739GlnTyr: 0.739 ± 0.008	0.003GlnXaa: 0.003 ± 0.0
Arg	6.402ArgAla: 6.402 ± 0.019	1.509ArgCys: 1.509 ± 0.007	3.204ArgAsp: 3.204 ± 0.014	3.957ArgGlu: 3.957 ± 0.03	2.257ArgPhe: 2.257 ± 0.009	4.502ArgGly: 4.502 ± 0.02	1.834ArgHis: 1.834 ± 0.009	2.271ArgIle: 2.271 ± 0.01	3.085ArgLys: 3.085 ± 0.012	7.077ArgLeu: 7.077 ± 0.018	1.416ArgMet: 1.416 ± 0.008	1.65ArgAsn: 1.65 ± 0.008	3.699ArgPro: 3.699 ± 0.016	3.22ArgGln: 3.22 ± 0.01	5.912ArgArg: 5.912 ± 0.022	5.072ArgSer: 5.072 ± 0.017	3.053ArgThr: 3.053 ± 0.011	3.872ArgVal: 3.872 ± 0.013	1.303ArgTrp: 1.303 ± 0.007	1.307ArgTyr: 1.307 ± 0.01	0.006ArgXaa: 0.006 ± 0.0
Ser	7.222SerAla: 7.222 ± 0.02	1.576SerCys: 1.576 ± 0.01	3.656SerAsp: 3.656 ± 0.015	4.63SerGlu: 4.63 ± 0.069	2.867SerPhe: 2.867 ± 0.018	5.415SerGly: 5.415 ± 0.019	1.595SerHis: 1.595 ± 0.008	2.424SerIle: 2.424 ± 0.01	3.093SerLys: 3.093 ± 0.011	7.08SerLeu: 7.08 ± 0.023	1.697SerMet: 1.697 ± 0.009	1.705SerAsn: 1.705 ± 0.019	4.1SerPro: 4.1 ± 0.015	3.01SerGln: 3.01 ± 0.011	4.782SerArg: 4.782 ± 0.018	6.998SerSer: 6.998 ± 0.035	3.909SerThr: 3.909 ± 0.019	4.575SerVal: 4.575 ± 0.015	1.524SerTrp: 1.524 ± 0.008	1.42SerTyr: 1.42 ± 0.028	0.004SerXaa: 0.004 ± 0.0
Thr	5.239ThrAla: 5.239 ± 0.017	1.082ThrCys: 1.082 ± 0.014	2.281ThrAsp: 2.281 ± 0.01	2.891ThrGlu: 2.891 ± 0.014	1.775ThrPhe: 1.775 ± 0.008	3.51ThrGly: 3.51 ± 0.013	0.934ThrHis: 0.934 ± 0.006	1.703ThrIle: 1.703 ± 0.014	2.027ThrLys: 2.027 ± 0.021	4.464ThrLeu: 4.464 ± 0.013	1.147ThrMet: 1.147 ± 0.008	1.203ThrAsn: 1.203 ± 0.043	2.955ThrPro: 2.955 ± 0.014	1.763ThrGln: 1.763 ± 0.009	2.814ThrArg: 2.814 ± 0.01	3.917ThrSer: 3.917 ± 0.019	2.903ThrThr: 2.903 ± 0.019	3.35ThrVal: 3.35 ± 0.014	1.177ThrTrp: 1.177 ± 0.009	1.108ThrTyr: 1.108 ± 0.035	0.003ThrXaa: 0.003 ± 0.0
Val	6.885ValAla: 6.885 ± 0.04	1.387ValCys: 1.387 ± 0.008	3.664ValAsp: 3.664 ± 0.018	4.457ValGlu: 4.457 ± 0.12	2.347ValPhe: 2.347 ± 0.01	4.435ValGly: 4.435 ± 0.065	1.637ValHis: 1.637 ± 0.008	2.273ValIle: 2.273 ± 0.016	2.664ValLys: 2.664 ± 0.012	7.999ValLeu: 7.999 ± 0.116	1.531ValMet: 1.531 ± 0.009	1.577ValAsn: 1.577 ± 0.008	4.091ValPro: 4.091 ± 0.016	3.455ValGln: 3.455 ± 0.02	4.27ValArg: 4.27 ± 0.015	4.59ValSer: 4.59 ± 0.014	3.305ValThr: 3.305 ± 0.013	6.265ValVal: 6.265 ± 0.121	1.052ValTrp: 1.052 ± 0.009	1.378ValTyr: 1.378 ± 0.045	0.006ValXaa: 0.006 ± 0.0
Trp	1.521TrpAla: 1.521 ± 0.009	0.439TrpCys: 0.439 ± 0.007	0.864TrpAsp: 0.864 ± 0.005	1.014TrpGlu: 1.014 ± 0.011	0.534TrpPhe: 0.534 ± 0.004	1.178TrpGly: 1.178 ± 0.011	0.537TrpHis: 0.537 ± 0.008	0.651TrpIle: 0.651 ± 0.004	0.89TrpLys: 0.89 ± 0.006	1.972TrpLeu: 1.972 ± 0.029	0.478TrpMet: 0.478 ± 0.017	0.56TrpAsn: 0.56 ± 0.005	0.896TrpPro: 0.896 ± 0.006	1.01TrpGln: 1.01 ± 0.008	1.408TrpArg: 1.408 ± 0.009	1.369TrpSer: 1.369 ± 0.009	0.973TrpThr: 0.973 ± 0.005	1.024TrpVal: 1.024 ± 0.008	0.407TrpTrp: 0.407 ± 0.013	0.362TrpTyr: 0.362 ± 0.003	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.678TyrAla: 1.678 ± 0.011	0.431TyrCys: 0.431 ± 0.005	1.312TyrAsp: 1.312 ± 0.033	1.117TyrGlu: 1.117 ± 0.008	1.076TyrPhe: 1.076 ± 0.04	1.492TyrGly: 1.492 ± 0.009	0.586TyrHis: 0.586 ± 0.025	0.746TyrIle: 0.746 ± 0.019	0.774TyrLys: 0.774 ± 0.006	2.049TyrLeu: 2.049 ± 0.041	0.446TyrMet: 0.446 ± 0.005	0.61TyrAsn: 0.61 ± 0.015	0.857TyrPro: 0.857 ± 0.007	0.813TyrGln: 0.813 ± 0.008	1.289TyrArg: 1.289 ± 0.013	1.318TyrSer: 1.318 ± 0.031	1.019TyrThr: 1.019 ± 0.028	1.469TyrVal: 1.469 ± 0.046	0.348TyrTrp: 0.348 ± 0.004	0.524TyrTyr: 0.524 ± 0.009	0.002TyrXaa: 0.002 ± 0.0
Xaa	0.007XaaAla: 0.007 ± 0.001	0.002XaaCys: 0.002 ± 0.0	0.003XaaAsp: 0.003 ± 0.0	0.004XaaGlu: 0.004 ± 0.0	0.002XaaPhe: 0.002 ± 0.0	0.007XaaGly: 0.007 ± 0.001	0.002XaaHis: 0.002 ± 0.0	0.002XaaIle: 0.002 ± 0.0	0.003XaaLys: 0.003 ± 0.0	0.008XaaLeu: 0.008 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.005XaaPro: 0.005 ± 0.0	0.003XaaGln: 0.003 ± 0.0	0.006XaaArg: 0.006 ± 0.0	0.005XaaSer: 0.005 ± 0.0	0.003XaaThr: 0.003 ± 0.0	0.006XaaVal: 0.006 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.002XaaTyr: 0.002 ± 0.0	4.813XaaXaa: 4.813 ± 0.319

Statistics based on 43269 proteins (32314097 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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