Amino acid dipepetide frequency for Thalassorhabdomicrobium marinisediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.402AlaAla: 16.402 ± 0.2	1.119AlaCys: 1.119 ± 0.036	7.272AlaAsp: 7.272 ± 0.092	8.209AlaGlu: 8.209 ± 0.1	4.419AlaPhe: 4.419 ± 0.066	10.142AlaGly: 10.142 ± 0.127	2.333AlaHis: 2.333 ± 0.052	5.719AlaIle: 5.719 ± 0.075	3.834AlaLys: 3.834 ± 0.09	13.631AlaLeu: 13.631 ± 0.146	3.705AlaMet: 3.705 ± 0.07	2.694AlaAsn: 2.694 ± 0.053	6.156AlaPro: 6.156 ± 0.112	5.007AlaGln: 5.007 ± 0.085	8.903AlaArg: 8.903 ± 0.119	5.349AlaSer: 5.349 ± 0.089	6.454AlaThr: 6.454 ± 0.093	8.434AlaVal: 8.434 ± 0.097	1.337AlaTrp: 1.337 ± 0.042	2.474AlaTyr: 2.474 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.078CysAla: 1.078 ± 0.038	0.102CysCys: 0.102 ± 0.01	0.699CysAsp: 0.699 ± 0.028	0.465CysGlu: 0.465 ± 0.022	0.323CysPhe: 0.323 ± 0.018	0.943CysGly: 0.943 ± 0.03	0.267CysHis: 0.267 ± 0.014	0.401CysIle: 0.401 ± 0.022	0.226CysLys: 0.226 ± 0.015	0.863CysLeu: 0.863 ± 0.032	0.15CysMet: 0.15 ± 0.014	0.23CysAsn: 0.23 ± 0.014	0.462CysPro: 0.462 ± 0.021	0.203CysGln: 0.203 ± 0.014	0.538CysArg: 0.538 ± 0.022	0.421CysSer: 0.421 ± 0.024	0.462CysThr: 0.462 ± 0.02	0.61CysVal: 0.61 ± 0.027	0.112CysTrp: 0.112 ± 0.011	0.209CysTyr: 0.209 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.18AspAla: 8.18 ± 0.107	0.517AspCys: 0.517 ± 0.021	3.783AspAsp: 3.783 ± 0.074	3.917AspGlu: 3.917 ± 0.061	2.248AspPhe: 2.248 ± 0.045	5.822AspGly: 5.822 ± 0.097	1.518AspHis: 1.518 ± 0.046	3.152AspIle: 3.152 ± 0.057	1.71AspLys: 1.71 ± 0.05	6.711AspLeu: 6.711 ± 0.094	1.769AspMet: 1.769 ± 0.047	1.38AspAsn: 1.38 ± 0.039	3.704AspPro: 3.704 ± 0.062	1.961AspGln: 1.961 ± 0.048	4.624AspArg: 4.624 ± 0.07	2.309AspSer: 2.309 ± 0.051	3.327AspThr: 3.327 ± 0.064	4.616AspVal: 4.616 ± 0.071	1.267AspTrp: 1.267 ± 0.035	1.599AspTyr: 1.599 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	8.432GluAla: 8.432 ± 0.119	0.398GluCys: 0.398 ± 0.021	3.599GluAsp: 3.599 ± 0.067	3.716GluGlu: 3.716 ± 0.076	1.714GluPhe: 1.714 ± 0.044	4.98GluGly: 4.98 ± 0.078	1.166GluHis: 1.166 ± 0.04	3.459GluIle: 3.459 ± 0.065	2.063GluLys: 2.063 ± 0.055	5.05GluLeu: 5.05 ± 0.068	1.791GluMet: 1.791 ± 0.037	1.672GluAsn: 1.672 ± 0.042	2.454GluPro: 2.454 ± 0.05	2.108GluGln: 2.108 ± 0.056	4.178GluArg: 4.178 ± 0.072	2.171GluSer: 2.171 ± 0.053	3.834GluThr: 3.834 ± 0.062	5.017GluVal: 5.017 ± 0.077	0.668GluTrp: 0.668 ± 0.027	1.03GluTyr: 1.03 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.312PheAla: 4.312 ± 0.069	0.417PheCys: 0.417 ± 0.019	2.972PheAsp: 2.972 ± 0.054	2.251PheGlu: 2.251 ± 0.051	1.331PhePhe: 1.331 ± 0.045	3.616PheGly: 3.616 ± 0.06	0.745PheHis: 0.745 ± 0.026	1.66PheIle: 1.66 ± 0.04	0.954PheLys: 0.954 ± 0.031	3.328PheLeu: 3.328 ± 0.069	0.85PheMet: 0.85 ± 0.034	1.074PheAsn: 1.074 ± 0.039	1.542PhePro: 1.542 ± 0.043	1.036PheGln: 1.036 ± 0.031	2.166PheArg: 2.166 ± 0.046	1.951PheSer: 1.951 ± 0.046	2.113PheThr: 2.113 ± 0.048	2.726PheVal: 2.726 ± 0.051	0.538PheTrp: 0.538 ± 0.024	0.937PheTyr: 0.937 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.867GlyAla: 9.867 ± 0.116	0.81GlyCys: 0.81 ± 0.028	4.823GlyAsp: 4.823 ± 0.083	4.777GlyGlu: 4.777 ± 0.083	3.505GlyPhe: 3.505 ± 0.059	7.328GlyGly: 7.328 ± 0.108	1.911GlyHis: 1.911 ± 0.047	4.292GlyIle: 4.292 ± 0.075	3.022GlyLys: 3.022 ± 0.064	8.883GlyLeu: 8.883 ± 0.117	2.449GlyMet: 2.449 ± 0.048	1.923GlyAsn: 1.923 ± 0.049	3.668GlyPro: 3.668 ± 0.062	3.13GlyGln: 3.13 ± 0.054	5.615GlyArg: 5.615 ± 0.073	3.91GlySer: 3.91 ± 0.06	4.941GlyThr: 4.941 ± 0.072	6.423GlyVal: 6.423 ± 0.079	1.376GlyTrp: 1.376 ± 0.038	2.212GlyTyr: 2.212 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.282HisAla: 2.282 ± 0.054	0.22HisCys: 0.22 ± 0.015	1.348HisAsp: 1.348 ± 0.039	1.105HisGlu: 1.105 ± 0.035	0.811HisPhe: 0.811 ± 0.03	1.882HisGly: 1.882 ± 0.048	0.55HisHis: 0.55 ± 0.033	0.998HisIle: 0.998 ± 0.035	0.566HisLys: 0.566 ± 0.021	2.14HisLeu: 2.14 ± 0.052	0.537HisMet: 0.537 ± 0.023	0.452HisAsn: 0.452 ± 0.023	1.366HisPro: 1.366 ± 0.033	0.603HisGln: 0.603 ± 0.026	1.455HisArg: 1.455 ± 0.044	0.888HisSer: 0.888 ± 0.031	0.883HisThr: 0.883 ± 0.035	1.589HisVal: 1.589 ± 0.042	0.33HisTrp: 0.33 ± 0.019	0.576HisTyr: 0.576 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.864IleAla: 6.864 ± 0.078	0.602IleCys: 0.602 ± 0.028	3.734IleAsp: 3.734 ± 0.059	3.543IleGlu: 3.543 ± 0.056	1.699IlePhe: 1.699 ± 0.044	4.654IleGly: 4.654 ± 0.077	0.926IleHis: 0.926 ± 0.031	2.28IleIle: 2.28 ± 0.055	1.467IleLys: 1.467 ± 0.038	4.688IleLeu: 4.688 ± 0.072	1.018IleMet: 1.018 ± 0.033	1.425IleAsn: 1.425 ± 0.039	2.276IlePro: 2.276 ± 0.055	1.156IleGln: 1.156 ± 0.034	3.015IleArg: 3.015 ± 0.055	2.72IleSer: 2.72 ± 0.058	3.026IleThr: 3.026 ± 0.058	3.973IleVal: 3.973 ± 0.078	0.649IleTrp: 0.649 ± 0.027	1.162IleTyr: 1.162 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.917LysAla: 3.917 ± 0.08	0.171LysCys: 0.171 ± 0.013	1.814LysAsp: 1.814 ± 0.05	1.489LysGlu: 1.489 ± 0.04	0.885LysPhe: 0.885 ± 0.031	2.542LysGly: 2.542 ± 0.063	0.642LysHis: 0.642 ± 0.025	1.691LysIle: 1.691 ± 0.039	1.147LysLys: 1.147 ± 0.047	2.936LysLeu: 2.936 ± 0.058	0.87LysMet: 0.87 ± 0.032	0.763LysAsn: 0.763 ± 0.027	1.772LysPro: 1.772 ± 0.049	0.967LysGln: 0.967 ± 0.032	2.28LysArg: 2.28 ± 0.056	1.783LysSer: 1.783 ± 0.045	2.021LysThr: 2.021 ± 0.046	2.216LysVal: 2.216 ± 0.058	0.329LysTrp: 0.329 ± 0.018	0.608LysTyr: 0.608 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	12.557LeuAla: 12.557 ± 0.15	0.904LeuCys: 0.904 ± 0.034	6.363LeuAsp: 6.363 ± 0.091	5.357LeuGlu: 5.357 ± 0.078	3.501LeuPhe: 3.501 ± 0.062	8.217LeuGly: 8.217 ± 0.103	1.925LeuHis: 1.925 ± 0.052	5.111LeuIle: 5.111 ± 0.08	3.055LeuLys: 3.055 ± 0.064	8.928LeuLeu: 8.928 ± 0.148	2.563LeuMet: 2.563 ± 0.051	2.688LeuAsn: 2.688 ± 0.052	5.353LeuPro: 5.353 ± 0.073	2.983LeuGln: 2.983 ± 0.057	7.149LeuArg: 7.149 ± 0.088	6.43LeuSer: 6.43 ± 0.086	6.326LeuThr: 6.326 ± 0.081	6.748LeuVal: 6.748 ± 0.092	1.296LeuTrp: 1.296 ± 0.043	1.988LeuTyr: 1.988 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.407MetAla: 3.407 ± 0.056	0.199MetCys: 0.199 ± 0.014	1.461MetAsp: 1.461 ± 0.038	1.363MetGlu: 1.363 ± 0.038	0.851MetPhe: 0.851 ± 0.032	2.219MetGly: 2.219 ± 0.048	0.44MetHis: 0.44 ± 0.023	1.543MetIle: 1.543 ± 0.043	0.992MetLys: 0.992 ± 0.033	2.54MetLeu: 2.54 ± 0.054	0.744MetMet: 0.744 ± 0.03	0.791MetAsn: 0.791 ± 0.03	1.464MetPro: 1.464 ± 0.043	0.992MetGln: 0.992 ± 0.033	1.849MetArg: 1.849 ± 0.043	1.703MetSer: 1.703 ± 0.041	2.21MetThr: 2.21 ± 0.05	1.814MetVal: 1.814 ± 0.045	0.226MetTrp: 0.226 ± 0.016	0.33MetTyr: 0.33 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.116AsnAla: 3.116 ± 0.058	0.253AsnCys: 0.253 ± 0.016	1.507AsnAsp: 1.507 ± 0.041	1.296AsnGlu: 1.296 ± 0.03	0.979AsnPhe: 0.979 ± 0.035	2.324AsnGly: 2.324 ± 0.051	0.49AsnHis: 0.49 ± 0.026	1.343AsnIle: 1.343 ± 0.043	0.652AsnLys: 0.652 ± 0.027	2.48AsnLeu: 2.48 ± 0.044	0.666AsnMet: 0.666 ± 0.024	0.669AsnAsn: 0.669 ± 0.03	1.784AsnPro: 1.784 ± 0.048	0.748AsnGln: 0.748 ± 0.027	1.746AsnArg: 1.746 ± 0.042	1.132AsnSer: 1.132 ± 0.037	1.393AsnThr: 1.393 ± 0.04	1.838AsnVal: 1.838 ± 0.046	0.42AsnTrp: 0.42 ± 0.022	0.599AsnTyr: 0.599 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.893ProAla: 5.893 ± 0.11	0.367ProCys: 0.367 ± 0.022	4.231ProAsp: 4.231 ± 0.07	4.094ProGlu: 4.094 ± 0.075	1.944ProPhe: 1.944 ± 0.05	3.794ProGly: 3.794 ± 0.061	1.098ProHis: 1.098 ± 0.03	2.15ProIle: 2.15 ± 0.046	1.644ProLys: 1.644 ± 0.05	4.657ProLeu: 4.657 ± 0.072	1.318ProMet: 1.318 ± 0.034	1.336ProAsn: 1.336 ± 0.039	2.345ProPro: 2.345 ± 0.061	1.877ProGln: 1.877 ± 0.048	2.911ProArg: 2.911 ± 0.065	2.482ProSer: 2.482 ± 0.052	2.646ProThr: 2.646 ± 0.058	4.22ProVal: 4.22 ± 0.067	0.674ProTrp: 0.674 ± 0.024	1.154ProTyr: 1.154 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.198GlnAla: 4.198 ± 0.063	0.184GlnCys: 0.184 ± 0.012	1.965GlnAsp: 1.965 ± 0.048	1.7GlnGlu: 1.7 ± 0.048	1.073GlnPhe: 1.073 ± 0.032	2.688GlnGly: 2.688 ± 0.061	0.661GlnHis: 0.661 ± 0.025	2.092GlnIle: 2.092 ± 0.042	1.06GlnLys: 1.06 ± 0.033	2.864GlnLeu: 2.864 ± 0.055	1.111GlnMet: 1.111 ± 0.036	0.938GlnAsn: 0.938 ± 0.028	1.693GlnPro: 1.693 ± 0.041	1.179GlnGln: 1.179 ± 0.042	2.292GlnArg: 2.292 ± 0.051	1.82GlnSer: 1.82 ± 0.04	2.181GlnThr: 2.181 ± 0.044	2.533GlnVal: 2.533 ± 0.047	0.432GlnTrp: 0.432 ± 0.024	0.552GlnTyr: 0.552 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.227ArgAla: 8.227 ± 0.099	0.532ArgCys: 0.532 ± 0.024	4.701ArgAsp: 4.701 ± 0.075	3.671ArgGlu: 3.671 ± 0.063	2.656ArgPhe: 2.656 ± 0.054	4.632ArgGly: 4.632 ± 0.072	1.562ArgHis: 1.562 ± 0.046	3.814ArgIle: 3.814 ± 0.059	2.408ArgLys: 2.408 ± 0.06	6.959ArgLeu: 6.959 ± 0.095	1.978ArgMet: 1.978 ± 0.045	1.814ArgAsn: 1.814 ± 0.044	3.344ArgPro: 3.344 ± 0.061	2.32ArgGln: 2.32 ± 0.048	5.005ArgArg: 5.005 ± 0.09	3.3ArgSer: 3.3 ± 0.064	3.359ArgThr: 3.359 ± 0.06	4.799ArgVal: 4.799 ± 0.073	0.967ArgTrp: 0.967 ± 0.035	1.584ArgTyr: 1.584 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.534SerAla: 5.534 ± 0.078	0.416SerCys: 0.416 ± 0.021	3.506SerAsp: 3.506 ± 0.063	2.824SerGlu: 2.824 ± 0.058	2.155SerPhe: 2.155 ± 0.045	5.088SerGly: 5.088 ± 0.086	1.092SerHis: 1.092 ± 0.031	2.447SerIle: 2.447 ± 0.052	1.47SerLys: 1.47 ± 0.044	4.832SerLeu: 4.832 ± 0.076	1.3SerMet: 1.3 ± 0.035	1.392SerAsn: 1.392 ± 0.043	2.281SerPro: 2.281 ± 0.059	1.544SerGln: 1.544 ± 0.039	3.105SerArg: 3.105 ± 0.053	2.449SerSer: 2.449 ± 0.056	2.608SerThr: 2.608 ± 0.057	3.667SerVal: 3.667 ± 0.064	0.636SerTrp: 0.636 ± 0.027	1.286SerTyr: 1.286 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.572ThrAla: 6.572 ± 0.075	0.531ThrCys: 0.531 ± 0.021	3.544ThrAsp: 3.544 ± 0.066	3.079ThrGlu: 3.079 ± 0.05	2.205ThrPhe: 2.205 ± 0.049	5.548ThrGly: 5.548 ± 0.077	1.135ThrHis: 1.135 ± 0.038	2.748ThrIle: 2.748 ± 0.055	1.5ThrLys: 1.5 ± 0.044	6.536ThrLeu: 6.536 ± 0.09	1.356ThrMet: 1.356 ± 0.033	1.256ThrAsn: 1.256 ± 0.038	3.762ThrPro: 3.762 ± 0.083	1.76ThrGln: 1.76 ± 0.045	3.691ThrArg: 3.691 ± 0.064	2.85ThrSer: 2.85 ± 0.059	3.069ThrThr: 3.069 ± 0.06	4.573ThrVal: 4.573 ± 0.067	0.649ThrTrp: 0.649 ± 0.023	1.402ThrTyr: 1.402 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.791ValAla: 8.791 ± 0.095	0.679ValCys: 0.679 ± 0.028	4.288ValAsp: 4.288 ± 0.067	4.758ValGlu: 4.758 ± 0.076	2.825ValPhe: 2.825 ± 0.056	5.413ValGly: 5.413 ± 0.079	1.299ValHis: 1.299 ± 0.033	4.306ValIle: 4.306 ± 0.06	2.116ValLys: 2.116 ± 0.051	7.573ValLeu: 7.573 ± 0.103	2.087ValMet: 2.087 ± 0.049	1.98ValAsn: 1.98 ± 0.046	3.693ValPro: 3.693 ± 0.062	2.366ValGln: 2.366 ± 0.054	4.515ValArg: 4.515 ± 0.08	4.085ValSer: 4.085 ± 0.064	5.027ValThr: 5.027 ± 0.078	5.724ValVal: 5.724 ± 0.087	0.96ValTrp: 0.96 ± 0.035	1.418ValTyr: 1.418 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.416TrpAla: 1.416 ± 0.042	0.137TrpCys: 0.137 ± 0.011	0.781TrpAsp: 0.781 ± 0.029	0.63TrpGlu: 0.63 ± 0.027	0.526TrpPhe: 0.526 ± 0.023	0.956TrpGly: 0.956 ± 0.03	0.306TrpHis: 0.306 ± 0.02	0.71TrpIle: 0.71 ± 0.03	0.411TrpLys: 0.411 ± 0.019	1.568TrpLeu: 1.568 ± 0.048	0.404TrpMet: 0.404 ± 0.02	0.346TrpAsn: 0.346 ± 0.019	0.68TrpPro: 0.68 ± 0.025	0.561TrpGln: 0.561 ± 0.024	1.042TrpArg: 1.042 ± 0.029	0.77TrpSer: 0.77 ± 0.03	0.81TrpThr: 0.81 ± 0.025	0.89TrpVal: 0.89 ± 0.027	0.21TrpTrp: 0.21 ± 0.014	0.248TrpTyr: 0.248 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.548TyrAla: 2.548 ± 0.051	0.204TyrCys: 0.204 ± 0.016	1.723TyrAsp: 1.723 ± 0.046	1.255TyrGlu: 1.255 ± 0.041	0.868TyrPhe: 0.868 ± 0.027	2.074TyrGly: 2.074 ± 0.047	0.514TyrHis: 0.514 ± 0.022	0.962TyrIle: 0.962 ± 0.033	0.55TyrLys: 0.55 ± 0.025	2.272TyrLeu: 2.272 ± 0.053	0.473TyrMet: 0.473 ± 0.021	0.611TyrAsn: 0.611 ± 0.027	1.035TyrPro: 1.035 ± 0.032	0.716TyrGln: 0.716 ± 0.025	1.556TyrArg: 1.556 ± 0.038	1.11TyrSer: 1.11 ± 0.033	1.077TyrThr: 1.077 ± 0.036	1.493TyrVal: 1.493 ± 0.043	0.326TyrTrp: 0.326 ± 0.019	0.576TyrTyr: 0.576 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3212 proteins (1015165 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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