Amino acid dipepetide frequency for Pseudomonas phage YMC11/02/R656

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.752AlaAla: 15.752 ± 1.384
1.345AlaCys: 1.345 ± 0.342
5.718AlaAsp: 5.718 ± 0.53
9.418AlaGlu: 9.418 ± 1.299
4.204AlaPhe: 4.204 ± 0.502
8.577AlaGly: 8.577 ± 0.743
1.345AlaHis: 1.345 ± 0.285
6.11AlaIle: 6.11 ± 0.585
6.166AlaLys: 6.166 ± 0.548
10.314AlaLeu: 10.314 ± 0.873
3.924AlaMet: 3.924 ± 0.391
4.204AlaAsn: 4.204 ± 0.399
3.251AlaPro: 3.251 ± 0.351
4.316AlaGln: 4.316 ± 0.587
8.689AlaArg: 8.689 ± 0.84
5.438AlaSer: 5.438 ± 0.618
4.485AlaThr: 4.485 ± 0.625
8.128AlaVal: 8.128 ± 0.712
2.074AlaTrp: 2.074 ± 0.417
2.467AlaTyr: 2.467 ± 0.402
0.0AlaXaa: 0.0 ± 0.0
Cys
1.233CysAla: 1.233 ± 0.291
0.168CysCys: 0.168 ± 0.128
0.505CysAsp: 0.505 ± 0.154
0.785CysGlu: 0.785 ± 0.232
0.561CysPhe: 0.561 ± 0.169
1.065CysGly: 1.065 ± 0.238
0.392CysHis: 0.392 ± 0.145
0.561CysIle: 0.561 ± 0.198
0.897CysLys: 0.897 ± 0.327
0.785CysLeu: 0.785 ± 0.226
0.28CysMet: 0.28 ± 0.132
0.617CysAsn: 0.617 ± 0.183
1.009CysPro: 1.009 ± 0.199
0.617CysGln: 0.617 ± 0.228
1.289CysArg: 1.289 ± 0.263
1.065CysSer: 1.065 ± 0.3
0.336CysThr: 0.336 ± 0.15
0.28CysVal: 0.28 ± 0.13
0.224CysTrp: 0.224 ± 0.117
0.112CysTyr: 0.112 ± 0.093
0.0CysXaa: 0.0 ± 0.0
Asp
7.119AspAla: 7.119 ± 0.587
0.617AspCys: 0.617 ± 0.175
3.195AspAsp: 3.195 ± 0.382
3.756AspGlu: 3.756 ± 0.429
1.626AspPhe: 1.626 ± 0.315
5.101AspGly: 5.101 ± 0.575
1.233AspHis: 1.233 ± 0.292
2.971AspIle: 2.971 ± 0.484
2.242AspLys: 2.242 ± 0.366
4.821AspLeu: 4.821 ± 0.468
0.953AspMet: 0.953 ± 0.217
1.289AspAsn: 1.289 ± 0.286
1.794AspPro: 1.794 ± 0.3
3.532AspGln: 3.532 ± 0.479
4.148AspArg: 4.148 ± 0.476
2.915AspSer: 2.915 ± 0.401
2.467AspThr: 2.467 ± 0.48
3.812AspVal: 3.812 ± 0.531
0.953AspTrp: 0.953 ± 0.241
2.298AspTyr: 2.298 ± 0.412
0.0AspXaa: 0.0 ± 0.0
Glu
8.296GluAla: 8.296 ± 1.179
1.514GluCys: 1.514 ± 0.367
3.195GluAsp: 3.195 ± 0.439
5.325GluGlu: 5.325 ± 0.686
2.747GluPhe: 2.747 ± 0.347
4.148GluGly: 4.148 ± 0.476
1.401GluHis: 1.401 ± 0.285
3.868GluIle: 3.868 ± 0.456
2.523GluLys: 2.523 ± 0.374
6.783GluLeu: 6.783 ± 0.755
2.186GluMet: 2.186 ± 0.376
1.906GluAsn: 1.906 ± 0.345
2.242GluPro: 2.242 ± 0.343
5.213GluGln: 5.213 ± 0.692
6.278GluArg: 6.278 ± 0.952
3.139GluSer: 3.139 ± 0.392
3.195GluThr: 3.195 ± 0.384
5.213GluVal: 5.213 ± 0.592
1.738GluTrp: 1.738 ± 0.346
1.738GluTyr: 1.738 ± 0.317
0.0GluXaa: 0.0 ± 0.0
Phe
3.251PheAla: 3.251 ± 0.496
0.28PheCys: 0.28 ± 0.128
2.354PheAsp: 2.354 ± 0.32
2.298PheGlu: 2.298 ± 0.339
0.729PhePhe: 0.729 ± 0.176
2.803PheGly: 2.803 ± 0.456
0.617PheHis: 0.617 ± 0.209
1.177PheIle: 1.177 ± 0.229
1.233PheLys: 1.233 ± 0.281
2.186PheLeu: 2.186 ± 0.323
0.673PheMet: 0.673 ± 0.196
1.233PheAsn: 1.233 ± 0.27
1.682PhePro: 1.682 ± 0.318
1.457PheGln: 1.457 ± 0.256
2.747PheArg: 2.747 ± 0.331
2.074PheSer: 2.074 ± 0.305
2.074PheThr: 2.074 ± 0.321
2.074PheVal: 2.074 ± 0.365
0.28PheTrp: 0.28 ± 0.129
0.673PheTyr: 0.673 ± 0.186
0.0PheXaa: 0.0 ± 0.0
Gly
6.11GlyAla: 6.11 ± 0.876
1.065GlyCys: 1.065 ± 0.277
4.148GlyAsp: 4.148 ± 0.496
5.886GlyGlu: 5.886 ± 0.531
2.747GlyPhe: 2.747 ± 0.366
6.727GlyGly: 6.727 ± 0.766
1.345GlyHis: 1.345 ± 0.267
3.924GlyIle: 3.924 ± 0.454
3.476GlyLys: 3.476 ± 0.416
5.886GlyLeu: 5.886 ± 0.647
2.13GlyMet: 2.13 ± 0.381
2.803GlyAsn: 2.803 ± 0.556
2.579GlyPro: 2.579 ± 0.437
3.195GlyGln: 3.195 ± 0.4
4.933GlyArg: 4.933 ± 0.589
4.821GlySer: 4.821 ± 0.488
3.419GlyThr: 3.419 ± 0.487
5.55GlyVal: 5.55 ± 0.518
1.738GlyTrp: 1.738 ± 0.375
3.083GlyTyr: 3.083 ± 0.408
0.0GlyXaa: 0.0 ± 0.0
His
1.962HisAla: 1.962 ± 0.357
0.336HisCys: 0.336 ± 0.139
1.009HisAsp: 1.009 ± 0.204
1.121HisGlu: 1.121 ± 0.264
0.505HisPhe: 0.505 ± 0.192
1.57HisGly: 1.57 ± 0.28
0.729HisHis: 0.729 ± 0.225
1.121HisIle: 1.121 ± 0.298
0.841HisLys: 0.841 ± 0.261
1.289HisLeu: 1.289 ± 0.266
0.448HisMet: 0.448 ± 0.151
0.392HisAsn: 0.392 ± 0.135
0.785HisPro: 0.785 ± 0.238
1.345HisGln: 1.345 ± 0.241
1.345HisArg: 1.345 ± 0.259
1.177HisSer: 1.177 ± 0.282
0.841HisThr: 0.841 ± 0.229
0.561HisVal: 0.561 ± 0.217
0.505HisTrp: 0.505 ± 0.159
0.673HisTyr: 0.673 ± 0.211
0.0HisXaa: 0.0 ± 0.0
Ile
6.727IleAla: 6.727 ± 0.645
0.505IleCys: 0.505 ± 0.181
3.98IleAsp: 3.98 ± 0.367
3.756IleGlu: 3.756 ± 0.45
0.953IlePhe: 0.953 ± 0.269
3.644IleGly: 3.644 ± 0.442
0.729IleHis: 0.729 ± 0.228
1.682IleIle: 1.682 ± 0.408
2.523IleLys: 2.523 ± 0.378
3.924IleLeu: 3.924 ± 0.512
0.673IleMet: 0.673 ± 0.205
1.906IleAsn: 1.906 ± 0.374
2.41IlePro: 2.41 ± 0.365
1.85IleGln: 1.85 ± 0.415
2.467IleArg: 2.467 ± 0.378
3.307IleSer: 3.307 ± 0.424
2.971IleThr: 2.971 ± 0.438
3.7IleVal: 3.7 ± 0.509
0.673IleTrp: 0.673 ± 0.217
1.514IleTyr: 1.514 ± 0.317
0.0IleXaa: 0.0 ± 0.0
Lys
6.39LysAla: 6.39 ± 0.686
0.505LysCys: 0.505 ± 0.208
2.41LysAsp: 2.41 ± 0.423
2.859LysGlu: 2.859 ± 0.445
1.233LysPhe: 1.233 ± 0.252
2.803LysGly: 2.803 ± 0.441
1.233LysHis: 1.233 ± 0.295
2.13LysIle: 2.13 ± 0.364
1.738LysLys: 1.738 ± 0.381
3.644LysLeu: 3.644 ± 0.493
1.177LysMet: 1.177 ± 0.29
1.121LysAsn: 1.121 ± 0.317
2.074LysPro: 2.074 ± 0.312
1.626LysGln: 1.626 ± 0.308
3.476LysArg: 3.476 ± 0.495
2.803LysSer: 2.803 ± 0.339
2.186LysThr: 2.186 ± 0.347
2.915LysVal: 2.915 ± 0.453
1.065LysTrp: 1.065 ± 0.253
0.785LysTyr: 0.785 ± 0.193
0.0LysXaa: 0.0 ± 0.0
Leu
8.689LeuAla: 8.689 ± 0.693
1.233LeuCys: 1.233 ± 0.245
4.653LeuAsp: 4.653 ± 0.472
5.83LeuGlu: 5.83 ± 0.725
2.242LeuPhe: 2.242 ± 0.349
6.783LeuGly: 6.783 ± 0.751
1.57LeuHis: 1.57 ± 0.331
4.709LeuIle: 4.709 ± 0.44
4.485LeuLys: 4.485 ± 0.539
5.942LeuLeu: 5.942 ± 0.481
1.457LeuMet: 1.457 ± 0.281
2.579LeuAsn: 2.579 ± 0.348
4.092LeuPro: 4.092 ± 0.464
3.195LeuGln: 3.195 ± 0.463
7.456LeuArg: 7.456 ± 0.612
5.774LeuSer: 5.774 ± 0.666
3.868LeuThr: 3.868 ± 0.452
5.606LeuVal: 5.606 ± 0.527
1.121LeuTrp: 1.121 ± 0.246
2.074LeuTyr: 2.074 ± 0.355
0.0LeuXaa: 0.0 ± 0.0
Met
3.083MetAla: 3.083 ± 0.412
0.168MetCys: 0.168 ± 0.098
1.289MetAsp: 1.289 ± 0.253
1.738MetGlu: 1.738 ± 0.309
0.673MetPhe: 0.673 ± 0.145
1.57MetGly: 1.57 ± 0.267
0.448MetHis: 0.448 ± 0.2
1.345MetIle: 1.345 ± 0.211
0.953MetLys: 0.953 ± 0.235
2.074MetLeu: 2.074 ± 0.336
0.448MetMet: 0.448 ± 0.145
0.897MetAsn: 0.897 ± 0.219
1.345MetPro: 1.345 ± 0.284
0.841MetGln: 0.841 ± 0.229
2.018MetArg: 2.018 ± 0.35
2.186MetSer: 2.186 ± 0.358
2.13MetThr: 2.13 ± 0.266
1.065MetVal: 1.065 ± 0.221
0.168MetTrp: 0.168 ± 0.094
0.28MetTyr: 0.28 ± 0.14
0.0MetXaa: 0.0 ± 0.0
Asn
3.812AsnAla: 3.812 ± 0.466
0.224AsnCys: 0.224 ± 0.114
2.074AsnAsp: 2.074 ± 0.33
2.186AsnGlu: 2.186 ± 0.31
0.953AsnPhe: 0.953 ± 0.195
3.363AsnGly: 3.363 ± 0.443
0.448AsnHis: 0.448 ± 0.265
1.626AsnIle: 1.626 ± 0.266
0.785AsnLys: 0.785 ± 0.206
2.691AsnLeu: 2.691 ± 0.361
0.392AsnMet: 0.392 ± 0.125
0.953AsnAsn: 0.953 ± 0.284
1.85AsnPro: 1.85 ± 0.329
1.345AsnGln: 1.345 ± 0.255
2.074AsnArg: 2.074 ± 0.243
2.074AsnSer: 2.074 ± 0.331
1.962AsnThr: 1.962 ± 0.397
1.794AsnVal: 1.794 ± 0.344
0.505AsnTrp: 0.505 ± 0.143
0.673AsnTyr: 0.673 ± 0.197
0.0AsnXaa: 0.0 ± 0.0
Pro
5.213ProAla: 5.213 ± 0.595
0.505ProCys: 0.505 ± 0.172
2.915ProAsp: 2.915 ± 0.38
3.7ProGlu: 3.7 ± 0.449
1.177ProPhe: 1.177 ± 0.259
2.971ProGly: 2.971 ± 0.391
0.561ProHis: 0.561 ± 0.158
1.906ProIle: 1.906 ± 0.249
1.682ProLys: 1.682 ± 0.347
3.419ProLeu: 3.419 ± 0.519
0.785ProMet: 0.785 ± 0.219
1.57ProAsn: 1.57 ± 0.249
2.074ProPro: 2.074 ± 0.411
1.514ProGln: 1.514 ± 0.315
2.018ProArg: 2.018 ± 0.359
2.467ProSer: 2.467 ± 0.388
1.906ProThr: 1.906 ± 0.352
3.756ProVal: 3.756 ± 0.456
1.289ProTrp: 1.289 ± 0.244
1.233ProTyr: 1.233 ± 0.264
0.0ProXaa: 0.0 ± 0.0
Gln
6.615GlnAla: 6.615 ± 0.725
0.505GlnCys: 0.505 ± 0.144
2.298GlnAsp: 2.298 ± 0.377
2.747GlnGlu: 2.747 ± 0.469
1.738GlnPhe: 1.738 ± 0.314
3.363GlnGly: 3.363 ± 0.417
0.841GlnHis: 0.841 ± 0.2
2.242GlnIle: 2.242 ± 0.338
1.962GlnLys: 1.962 ± 0.285
3.756GlnLeu: 3.756 ± 0.474
1.626GlnMet: 1.626 ± 0.299
1.289GlnAsn: 1.289 ± 0.265
1.514GlnPro: 1.514 ± 0.281
3.027GlnGln: 3.027 ± 0.506
3.307GlnArg: 3.307 ± 0.468
2.691GlnSer: 2.691 ± 0.479
1.85GlnThr: 1.85 ± 0.235
2.074GlnVal: 2.074 ± 0.311
0.617GlnTrp: 0.617 ± 0.183
1.626GlnTyr: 1.626 ± 0.314
0.0GlnXaa: 0.0 ± 0.0
Arg
7.904ArgAla: 7.904 ± 0.781
0.448ArgCys: 0.448 ± 0.18
4.541ArgAsp: 4.541 ± 0.531
6.222ArgGlu: 6.222 ± 0.804
2.579ArgPhe: 2.579 ± 0.374
4.26ArgGly: 4.26 ± 0.566
1.121ArgHis: 1.121 ± 0.256
3.812ArgIle: 3.812 ± 0.411
3.476ArgLys: 3.476 ± 0.468
7.68ArgLeu: 7.68 ± 0.57
1.794ArgMet: 1.794 ± 0.358
2.13ArgAsn: 2.13 ± 0.372
2.971ArgPro: 2.971 ± 0.599
2.971ArgGln: 2.971 ± 0.4
5.213ArgArg: 5.213 ± 0.557
3.363ArgSer: 3.363 ± 0.387
3.027ArgThr: 3.027 ± 0.373
4.709ArgVal: 4.709 ± 0.498
1.345ArgTrp: 1.345 ± 0.275
2.523ArgTyr: 2.523 ± 0.344
0.0ArgXaa: 0.0 ± 0.0
Ser
7.063SerAla: 7.063 ± 0.851
0.729SerCys: 0.729 ± 0.224
3.588SerAsp: 3.588 ± 0.508
3.868SerGlu: 3.868 ± 0.497
1.682SerPhe: 1.682 ± 0.343
5.494SerGly: 5.494 ± 0.521
1.738SerHis: 1.738 ± 0.284
3.027SerIle: 3.027 ± 0.347
2.354SerLys: 2.354 ± 0.384
5.101SerLeu: 5.101 ± 0.627
1.289SerMet: 1.289 ± 0.264
1.962SerAsn: 1.962 ± 0.354
2.298SerPro: 2.298 ± 0.386
2.691SerGln: 2.691 ± 0.514
4.148SerArg: 4.148 ± 0.465
3.7SerSer: 3.7 ± 0.479
3.251SerThr: 3.251 ± 0.495
4.485SerVal: 4.485 ± 0.627
0.673SerTrp: 0.673 ± 0.207
1.401SerTyr: 1.401 ± 0.271
0.0SerXaa: 0.0 ± 0.0
Thr
4.597ThrAla: 4.597 ± 0.542
0.673ThrCys: 0.673 ± 0.163
2.298ThrAsp: 2.298 ± 0.442
2.915ThrGlu: 2.915 ± 0.426
1.682ThrPhe: 1.682 ± 0.36
4.316ThrGly: 4.316 ± 0.621
0.841ThrHis: 0.841 ± 0.257
2.579ThrIle: 2.579 ± 0.403
2.13ThrLys: 2.13 ± 0.418
3.98ThrLeu: 3.98 ± 0.433
1.233ThrMet: 1.233 ± 0.334
1.906ThrAsn: 1.906 ± 0.285
3.307ThrPro: 3.307 ± 0.453
1.682ThrGln: 1.682 ± 0.257
2.242ThrArg: 2.242 ± 0.377
3.307ThrSer: 3.307 ± 0.489
2.803ThrThr: 2.803 ± 0.482
3.868ThrVal: 3.868 ± 0.559
0.617ThrTrp: 0.617 ± 0.212
1.738ThrTyr: 1.738 ± 0.401
0.0ThrXaa: 0.0 ± 0.0
Val
7.568ValAla: 7.568 ± 0.742
1.009ValCys: 1.009 ± 0.267
3.924ValAsp: 3.924 ± 0.566
5.269ValGlu: 5.269 ± 0.576
2.242ValPhe: 2.242 ± 0.41
4.933ValGly: 4.933 ± 0.466
1.177ValHis: 1.177 ± 0.261
3.532ValIle: 3.532 ± 0.494
3.083ValLys: 3.083 ± 0.441
4.485ValLeu: 4.485 ± 0.625
1.738ValMet: 1.738 ± 0.261
2.242ValAsn: 2.242 ± 0.345
3.419ValPro: 3.419 ± 0.546
2.859ValGln: 2.859 ± 0.422
4.148ValArg: 4.148 ± 0.426
5.381ValSer: 5.381 ± 0.459
3.139ValThr: 3.139 ± 0.61
4.428ValVal: 4.428 ± 0.552
0.953ValTrp: 0.953 ± 0.229
1.626ValTyr: 1.626 ± 0.317
0.0ValXaa: 0.0 ± 0.0
Trp
1.962TrpAla: 1.962 ± 0.337
0.28TrpCys: 0.28 ± 0.138
0.729TrpAsp: 0.729 ± 0.189
1.121TrpGlu: 1.121 ± 0.237
0.505TrpPhe: 0.505 ± 0.15
0.617TrpGly: 0.617 ± 0.199
0.448TrpHis: 0.448 ± 0.165
0.729TrpIle: 0.729 ± 0.192
0.841TrpLys: 0.841 ± 0.219
2.13TrpLeu: 2.13 ± 0.343
0.448TrpMet: 0.448 ± 0.164
0.336TrpAsn: 0.336 ± 0.139
0.841TrpPro: 0.841 ± 0.2
1.121TrpGln: 1.121 ± 0.248
1.233TrpArg: 1.233 ± 0.297
1.065TrpSer: 1.065 ± 0.242
0.673TrpThr: 0.673 ± 0.186
1.289TrpVal: 1.289 ± 0.238
0.336TrpTrp: 0.336 ± 0.125
0.505TrpTyr: 0.505 ± 0.206
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.579TyrAla: 2.579 ± 0.333
0.673TyrCys: 0.673 ± 0.201
2.018TyrAsp: 2.018 ± 0.341
1.906TyrGlu: 1.906 ± 0.291
1.121TyrPhe: 1.121 ± 0.254
1.457TyrGly: 1.457 ± 0.233
0.336TyrHis: 0.336 ± 0.145
0.841TyrIle: 0.841 ± 0.236
0.785TyrLys: 0.785 ± 0.224
2.467TyrLeu: 2.467 ± 0.503
1.009TyrMet: 1.009 ± 0.219
0.448TyrAsn: 0.448 ± 0.148
1.121TyrPro: 1.121 ± 0.228
1.289TyrGln: 1.289 ± 0.298
2.859TyrArg: 2.859 ± 0.378
1.794TyrSer: 1.794 ± 0.333
2.13TyrThr: 2.13 ± 0.354
1.85TyrVal: 1.85 ± 0.298
0.336TyrTrp: 0.336 ± 0.141
0.785TyrTyr: 0.785 ± 0.229
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 113 proteins (17840 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski