Amino acid dipepetide frequency for Candidatus Tremblaya phenacola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.677AlaAla: 2.677 ± 0.245
0.871AlaCys: 0.871 ± 0.12
1.889AlaAsp: 1.889 ± 0.176
1.938AlaGlu: 1.938 ± 0.191
2.644AlaPhe: 2.644 ± 0.218
3.252AlaGly: 3.252 ± 0.258
0.739AlaHis: 0.739 ± 0.108
5.617AlaIle: 5.617 ± 0.239
3.318AlaLys: 3.318 ± 0.237
4.977AlaLeu: 4.977 ± 0.304
1.002AlaMet: 1.002 ± 0.15
3.318AlaAsn: 3.318 ± 0.258
1.018AlaPro: 1.018 ± 0.135
1.248AlaGln: 1.248 ± 0.139
2.201AlaArg: 2.201 ± 0.194
4.796AlaSer: 4.796 ± 0.329
2.71AlaThr: 2.71 ± 0.207
4.5AlaVal: 4.5 ± 0.333
0.378AlaTrp: 0.378 ± 0.087
2.299AlaTyr: 2.299 ± 0.204
0.0AlaXaa: 0.0 ± 0.0
Cys
0.641CysAla: 0.641 ± 0.086
0.328CysCys: 0.328 ± 0.071
0.673CysAsp: 0.673 ± 0.11
0.361CysGlu: 0.361 ± 0.078
1.183CysPhe: 1.183 ± 0.139
1.281CysGly: 1.281 ± 0.171
0.312CysHis: 0.312 ± 0.079
2.02CysIle: 2.02 ± 0.193
0.788CysLys: 0.788 ± 0.105
2.119CysLeu: 2.119 ± 0.209
0.312CysMet: 0.312 ± 0.065
0.854CysAsn: 0.854 ± 0.106
0.394CysPro: 0.394 ± 0.083
0.263CysGln: 0.263 ± 0.078
0.706CysArg: 0.706 ± 0.116
1.922CysSer: 1.922 ± 0.211
0.657CysThr: 0.657 ± 0.099
1.084CysVal: 1.084 ± 0.142
0.279CysTrp: 0.279 ± 0.074
0.854CysTyr: 0.854 ± 0.112
0.0CysXaa: 0.0 ± 0.0
Asp
1.61AspAla: 1.61 ± 0.184
0.509AspCys: 0.509 ± 0.098
0.821AspAsp: 0.821 ± 0.116
1.363AspGlu: 1.363 ± 0.165
1.232AspPhe: 1.232 ± 0.15
1.987AspGly: 1.987 ± 0.192
0.673AspHis: 0.673 ± 0.106
5.305AspIle: 5.305 ± 0.331
2.792AspLys: 2.792 ± 0.217
3.893AspLeu: 3.893 ± 0.295
0.985AspMet: 0.985 ± 0.117
1.971AspAsn: 1.971 ± 0.205
0.985AspPro: 0.985 ± 0.156
0.772AspGln: 0.772 ± 0.128
1.757AspArg: 1.757 ± 0.181
3.154AspSer: 3.154 ± 0.231
1.84AspThr: 1.84 ± 0.188
2.776AspVal: 2.776 ± 0.182
0.361AspTrp: 0.361 ± 0.075
1.61AspTyr: 1.61 ± 0.159
0.0AspXaa: 0.0 ± 0.0
Glu
3.876GluAla: 3.876 ± 0.291
0.871GluCys: 0.871 ± 0.122
1.872GluAsp: 1.872 ± 0.206
2.677GluGlu: 2.677 ± 0.232
0.985GluPhe: 0.985 ± 0.137
2.316GluGly: 2.316 ± 0.216
1.215GluHis: 1.215 ± 0.13
2.398GluIle: 2.398 ± 0.206
2.874GluLys: 2.874 ± 0.205
5.65GluLeu: 5.65 ± 0.297
1.002GluMet: 1.002 ± 0.137
1.281GluAsn: 1.281 ± 0.156
2.102GluPro: 2.102 ± 0.159
1.856GluGln: 1.856 ± 0.176
2.792GluArg: 2.792 ± 0.2
3.811GluSer: 3.811 ± 0.259
3.039GluThr: 3.039 ± 0.215
4.533GluVal: 4.533 ± 0.32
0.411GluTrp: 0.411 ± 0.065
1.84GluTyr: 1.84 ± 0.17
0.0GluXaa: 0.0 ± 0.0
Phe
1.068PheAla: 1.068 ± 0.144
0.657PheCys: 0.657 ± 0.107
1.363PheAsp: 1.363 ± 0.13
1.79PheGlu: 1.79 ± 0.215
0.871PhePhe: 0.871 ± 0.131
2.283PheGly: 2.283 ± 0.18
0.788PheHis: 0.788 ± 0.103
3.301PheIle: 3.301 ± 0.238
3.482PheLys: 3.482 ± 0.211
2.924PheLeu: 2.924 ± 0.222
0.526PheMet: 0.526 ± 0.07
3.318PheAsn: 3.318 ± 0.21
1.33PhePro: 1.33 ± 0.159
0.871PheGln: 0.871 ± 0.131
2.086PheArg: 2.086 ± 0.169
2.792PheSer: 2.792 ± 0.185
1.347PheThr: 1.347 ± 0.134
1.807PheVal: 1.807 ± 0.196
0.279PheTrp: 0.279 ± 0.076
1.577PheTyr: 1.577 ± 0.177
0.0PheXaa: 0.0 ± 0.0
Gly
2.267GlyAla: 2.267 ± 0.233
1.413GlyCys: 1.413 ± 0.137
2.168GlyAsp: 2.168 ± 0.183
2.332GlyGlu: 2.332 ± 0.268
2.628GlyPhe: 2.628 ± 0.233
3.63GlyGly: 3.63 ± 0.292
1.314GlyHis: 1.314 ± 0.169
5.913GlyIle: 5.913 ± 0.323
4.353GlyLys: 4.353 ± 0.249
6.849GlyLeu: 6.849 ± 0.333
1.38GlyMet: 1.38 ± 0.161
2.497GlyAsn: 2.497 ± 0.244
1.265GlyPro: 1.265 ± 0.163
1.511GlyGln: 1.511 ± 0.174
2.644GlyArg: 2.644 ± 0.22
5.995GlySer: 5.995 ± 0.329
3.022GlyThr: 3.022 ± 0.247
4.09GlyVal: 4.09 ± 0.306
0.641GlyTrp: 0.641 ± 0.114
1.84GlyTyr: 1.84 ± 0.201
0.0GlyXaa: 0.0 ± 0.0
His
0.871HisAla: 0.871 ± 0.124
0.312HisCys: 0.312 ± 0.069
0.46HisAsp: 0.46 ± 0.095
0.608HisGlu: 0.608 ± 0.094
0.641HisPhe: 0.641 ± 0.106
1.429HisGly: 1.429 ± 0.155
0.443HisHis: 0.443 ± 0.078
3.499HisIle: 3.499 ± 0.247
1.79HisLys: 1.79 ± 0.186
2.414HisLeu: 2.414 ± 0.183
0.657HisMet: 0.657 ± 0.123
1.314HisAsn: 1.314 ± 0.142
1.018HisPro: 1.018 ± 0.161
0.673HisGln: 0.673 ± 0.105
1.215HisArg: 1.215 ± 0.142
1.905HisSer: 1.905 ± 0.196
1.265HisThr: 1.265 ± 0.168
1.117HisVal: 1.117 ± 0.147
0.131HisTrp: 0.131 ± 0.043
0.706HisTyr: 0.706 ± 0.093
0.0HisXaa: 0.0 ± 0.0
Ile
5.601IleAla: 5.601 ± 0.319
2.119IleCys: 2.119 ± 0.193
3.958IleAsp: 3.958 ± 0.246
5.667IleGlu: 5.667 ± 0.296
1.79IlePhe: 1.79 ± 0.182
5.88IleGly: 5.88 ± 0.379
2.431IleHis: 2.431 ± 0.181
7.243IleIle: 7.243 ± 0.482
9.543IleLys: 9.543 ± 0.437
8.59IleLeu: 8.59 ± 0.383
1.741IleMet: 1.741 ± 0.223
5.502IleAsn: 5.502 ± 0.304
3.466IlePro: 3.466 ± 0.232
2.776IleGln: 2.776 ± 0.226
5.322IleArg: 5.322 ± 0.298
7.309IleSer: 7.309 ± 0.402
5.519IleThr: 5.519 ± 0.323
6.554IleVal: 6.554 ± 0.312
0.805IleTrp: 0.805 ± 0.113
4.862IleTyr: 4.862 ± 0.354
0.0IleXaa: 0.0 ± 0.0
Lys
8.114LysAla: 8.114 ± 0.387
0.69LysCys: 0.69 ± 0.118
4.156LysAsp: 4.156 ± 0.272
5.946LysGlu: 5.946 ± 0.336
1.002LysPhe: 1.002 ± 0.126
4.451LysGly: 4.451 ± 0.276
2.825LysHis: 2.825 ± 0.224
4.172LysIle: 4.172 ± 0.349
5.01LysLys: 5.01 ± 0.307
9.806LysLeu: 9.806 ± 0.427
0.854LysMet: 0.854 ± 0.132
2.644LysAsn: 2.644 ± 0.212
3.351LysPro: 3.351 ± 0.236
2.743LysGln: 2.743 ± 0.214
5.831LysArg: 5.831 ± 0.251
5.502LysSer: 5.502 ± 0.263
5.437LysThr: 5.437 ± 0.306
5.01LysVal: 5.01 ± 0.306
0.476LysTrp: 0.476 ± 0.081
2.316LysTyr: 2.316 ± 0.197
0.0LysXaa: 0.0 ± 0.0
Leu
5.798LeuAla: 5.798 ± 0.285
1.495LeuCys: 1.495 ± 0.157
3.991LeuAsp: 3.991 ± 0.266
5.387LeuGlu: 5.387 ± 0.27
3.499LeuPhe: 3.499 ± 0.247
6.127LeuGly: 6.127 ± 0.316
2.037LeuHis: 2.037 ± 0.162
8.738LeuIle: 8.738 ± 0.374
9.773LeuLys: 9.773 ± 0.399
10.89LeuLeu: 10.89 ± 0.494
2.332LeuMet: 2.332 ± 0.197
7.243LeuAsn: 7.243 ± 0.438
3.384LeuPro: 3.384 ± 0.23
1.856LeuGln: 1.856 ± 0.188
5.716LeuArg: 5.716 ± 0.299
9.132LeuSer: 9.132 ± 0.39
6.603LeuThr: 6.603 ± 0.326
6.833LeuVal: 6.833 ± 0.313
0.739LeuTrp: 0.739 ± 0.121
4.353LeuTyr: 4.353 ± 0.358
0.0LeuXaa: 0.0 ± 0.0
Met
0.805MetAla: 0.805 ± 0.106
0.46MetCys: 0.46 ± 0.085
0.936MetAsp: 0.936 ± 0.133
1.002MetGlu: 1.002 ± 0.122
1.1MetPhe: 1.1 ± 0.14
0.887MetGly: 0.887 ± 0.13
0.772MetHis: 0.772 ± 0.117
1.018MetIle: 1.018 ± 0.124
1.544MetLys: 1.544 ± 0.151
2.94MetLeu: 2.94 ± 0.194
0.411MetMet: 0.411 ± 0.096
1.445MetAsn: 1.445 ± 0.158
0.903MetPro: 0.903 ± 0.133
0.641MetGln: 0.641 ± 0.098
0.657MetArg: 0.657 ± 0.095
1.462MetSer: 1.462 ± 0.156
0.69MetThr: 0.69 ± 0.116
1.774MetVal: 1.774 ± 0.159
0.115MetTrp: 0.115 ± 0.044
1.314MetTyr: 1.314 ± 0.146
0.0MetXaa: 0.0 ± 0.0
Asn
2.201AsnAla: 2.201 ± 0.177
0.575AsnCys: 0.575 ± 0.109
1.642AsnAsp: 1.642 ± 0.168
2.743AsnGlu: 2.743 ± 0.218
0.969AsnPhe: 0.969 ± 0.119
2.858AsnGly: 2.858 ± 0.215
1.413AsnHis: 1.413 ± 0.173
8.771AsnIle: 8.771 ± 0.447
5.979AsnLys: 5.979 ± 0.337
4.5AsnLeu: 4.5 ± 0.312
1.33AsnMet: 1.33 ± 0.138
4.583AsnAsn: 4.583 ± 0.287
2.776AsnPro: 2.776 ± 0.207
1.298AsnGln: 1.298 ± 0.138
3.285AsnArg: 3.285 ± 0.235
4.583AsnSer: 4.583 ± 0.269
3.269AsnThr: 3.269 ± 0.218
3.597AsnVal: 3.597 ± 0.231
0.263AsnTrp: 0.263 ± 0.071
2.579AsnTyr: 2.579 ± 0.216
0.0AsnXaa: 0.0 ± 0.0
Pro
1.133ProAla: 1.133 ± 0.149
0.542ProCys: 0.542 ± 0.092
1.002ProAsp: 1.002 ± 0.131
1.708ProGlu: 1.708 ± 0.185
1.528ProPhe: 1.528 ± 0.17
1.987ProGly: 1.987 ± 0.213
0.591ProHis: 0.591 ± 0.099
4.09ProIle: 4.09 ± 0.252
2.431ProLys: 2.431 ± 0.196
2.858ProLeu: 2.858 ± 0.223
0.821ProMet: 0.821 ± 0.102
2.316ProAsn: 2.316 ± 0.224
0.624ProPro: 0.624 ± 0.085
0.657ProGln: 0.657 ± 0.096
1.265ProArg: 1.265 ± 0.143
2.71ProSer: 2.71 ± 0.204
2.759ProThr: 2.759 ± 0.226
1.84ProVal: 1.84 ± 0.177
0.23ProTrp: 0.23 ± 0.06
1.232ProTyr: 1.232 ± 0.142
0.0ProXaa: 0.0 ± 0.0
Gln
1.725GlnAla: 1.725 ± 0.169
0.394GlnCys: 0.394 ± 0.072
0.953GlnAsp: 0.953 ± 0.113
1.15GlnGlu: 1.15 ± 0.153
0.756GlnPhe: 0.756 ± 0.124
1.347GlnGly: 1.347 ± 0.169
0.641GlnHis: 0.641 ± 0.111
1.265GlnIle: 1.265 ± 0.133
2.02GlnLys: 2.02 ± 0.186
3.597GlnLeu: 3.597 ± 0.269
0.509GlnMet: 0.509 ± 0.081
0.706GlnAsn: 0.706 ± 0.106
1.15GlnPro: 1.15 ± 0.167
0.558GlnGln: 0.558 ± 0.094
1.478GlnArg: 1.478 ± 0.136
1.955GlnSer: 1.955 ± 0.154
1.757GlnThr: 1.757 ± 0.197
1.626GlnVal: 1.626 ± 0.143
0.23GlnTrp: 0.23 ± 0.063
1.215GlnTyr: 1.215 ± 0.141
0.0GlnXaa: 0.0 ± 0.0
Arg
2.332ArgAla: 2.332 ± 0.168
0.821ArgCys: 0.821 ± 0.117
1.642ArgAsp: 1.642 ± 0.149
1.905ArgGlu: 1.905 ± 0.197
2.546ArgPhe: 2.546 ± 0.188
2.086ArgGly: 2.086 ± 0.215
0.854ArgHis: 0.854 ± 0.106
4.747ArgIle: 4.747 ± 0.304
3.991ArgLys: 3.991 ± 0.266
6.439ArgLeu: 6.439 ± 0.365
1.248ArgMet: 1.248 ± 0.146
2.842ArgAsn: 2.842 ± 0.204
1.166ArgPro: 1.166 ± 0.152
1.1ArgGln: 1.1 ± 0.134
2.004ArgArg: 2.004 ± 0.188
4.813ArgSer: 4.813 ± 0.267
4.254ArgThr: 4.254 ± 0.269
3.071ArgVal: 3.071 ± 0.24
0.443ArgTrp: 0.443 ± 0.089
2.612ArgTyr: 2.612 ± 0.228
0.0ArgXaa: 0.0 ± 0.0
Ser
2.628SerAla: 2.628 ± 0.241
1.675SerCys: 1.675 ± 0.201
2.546SerAsp: 2.546 ± 0.203
3.301SerGlu: 3.301 ± 0.25
5.141SerPhe: 5.141 ± 0.274
4.698SerGly: 4.698 ± 0.279
1.396SerHis: 1.396 ± 0.146
10.085SerIle: 10.085 ± 0.459
6.866SerLys: 6.866 ± 0.306
10.019SerLeu: 10.019 ± 0.43
1.889SerMet: 1.889 ± 0.172
5.798SerAsn: 5.798 ± 0.276
2.217SerPro: 2.217 ± 0.196
1.84SerGln: 1.84 ± 0.155
3.811SerArg: 3.811 ± 0.228
7.769SerSer: 7.769 ± 0.389
3.433SerThr: 3.433 ± 0.287
4.96SerVal: 4.96 ± 0.279
1.084SerTrp: 1.084 ± 0.167
4.303SerTyr: 4.303 ± 0.249
0.0SerXaa: 0.0 ± 0.0
Thr
3.318ThrAla: 3.318 ± 0.212
0.805ThrCys: 0.805 ± 0.12
2.267ThrAsp: 2.267 ± 0.206
2.316ThrGlu: 2.316 ± 0.216
1.642ThrPhe: 1.642 ± 0.138
3.318ThrGly: 3.318 ± 0.264
1.56ThrHis: 1.56 ± 0.16
6.586ThrIle: 6.586 ± 0.379
4.763ThrLys: 4.763 ± 0.265
5.108ThrLeu: 5.108 ± 0.282
1.183ThrMet: 1.183 ± 0.122
3.499ThrAsn: 3.499 ± 0.213
1.922ThrPro: 1.922 ± 0.164
1.774ThrGln: 1.774 ± 0.183
2.07ThrArg: 2.07 ± 0.187
4.73ThrSer: 4.73 ± 0.29
3.696ThrThr: 3.696 ± 0.268
3.219ThrVal: 3.219 ± 0.277
0.443ThrTrp: 0.443 ± 0.09
2.874ThrTyr: 2.874 ± 0.237
0.0ThrXaa: 0.0 ± 0.0
Val
3.039ValAla: 3.039 ± 0.275
1.314ValCys: 1.314 ± 0.137
2.398ValAsp: 2.398 ± 0.179
3.236ValGlu: 3.236 ± 0.265
2.267ValPhe: 2.267 ± 0.2
4.632ValGly: 4.632 ± 0.334
1.675ValHis: 1.675 ± 0.175
5.125ValIle: 5.125 ± 0.257
5.256ValLys: 5.256 ± 0.294
7.473ValLeu: 7.473 ± 0.31
1.199ValMet: 1.199 ± 0.158
4.796ValAsn: 4.796 ± 0.283
2.25ValPro: 2.25 ± 0.184
1.281ValGln: 1.281 ± 0.15
3.318ValArg: 3.318 ± 0.251
6.143ValSer: 6.143 ± 0.404
3.449ValThr: 3.449 ± 0.264
5.223ValVal: 5.223 ± 0.327
0.608ValTrp: 0.608 ± 0.122
2.792ValTyr: 2.792 ± 0.219
0.0ValXaa: 0.0 ± 0.0
Trp
0.115TrpAla: 0.115 ± 0.044
0.279TrpCys: 0.279 ± 0.072
0.312TrpAsp: 0.312 ± 0.067
0.263TrpGlu: 0.263 ± 0.07
0.657TrpPhe: 0.657 ± 0.121
0.394TrpGly: 0.394 ± 0.067
0.181TrpHis: 0.181 ± 0.07
0.46TrpIle: 0.46 ± 0.089
0.526TrpLys: 0.526 ± 0.083
1.183TrpLeu: 1.183 ± 0.151
0.197TrpMet: 0.197 ± 0.061
0.526TrpAsn: 0.526 ± 0.105
0.181TrpPro: 0.181 ± 0.058
0.23TrpGln: 0.23 ± 0.065
0.411TrpArg: 0.411 ± 0.074
0.936TrpSer: 0.936 ± 0.143
0.394TrpThr: 0.394 ± 0.071
0.723TrpVal: 0.723 ± 0.119
0.033TrpTrp: 0.033 ± 0.022
0.279TrpTyr: 0.279 ± 0.091
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.577TyrAla: 1.577 ± 0.154
0.903TyrCys: 0.903 ± 0.14
1.347TyrAsp: 1.347 ± 0.141
1.708TyrGlu: 1.708 ± 0.168
1.38TyrPhe: 1.38 ± 0.133
2.907TyrGly: 2.907 ± 0.192
0.608TyrHis: 0.608 ± 0.112
6.324TyrIle: 6.324 ± 0.45
3.236TyrLys: 3.236 ± 0.225
3.696TyrLeu: 3.696 ± 0.242
1.281TyrMet: 1.281 ± 0.141
2.759TyrAsn: 2.759 ± 0.241
0.821TyrPro: 0.821 ± 0.112
1.1TyrGln: 1.1 ± 0.133
2.349TyrArg: 2.349 ± 0.207
4.041TyrSer: 4.041 ± 0.32
1.955TyrThr: 1.955 ± 0.216
3.137TyrVal: 3.137 ± 0.275
0.328TyrTrp: 0.328 ± 0.099
2.037TyrTyr: 2.037 ± 0.227
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 194 proteins (60884 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski