Amino acid dipepetide frequency for Hydnomerulius pinastri MD-312

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.928AlaAla: 7.928 ± 0.068	1.206AlaCys: 1.206 ± 0.023	4.069AlaAsp: 4.069 ± 0.038	4.776AlaGlu: 4.776 ± 0.045	3.334AlaPhe: 3.334 ± 0.038	5.409AlaGly: 5.409 ± 0.045	2.184AlaHis: 2.184 ± 0.026	4.252AlaIle: 4.252 ± 0.038	3.678AlaLys: 3.678 ± 0.048	8.564AlaLeu: 8.564 ± 0.057	1.913AlaMet: 1.913 ± 0.028	2.792AlaAsn: 2.792 ± 0.034	5.083AlaPro: 5.083 ± 0.046	3.459AlaGln: 3.459 ± 0.037	5.085AlaArg: 5.085 ± 0.052	7.628AlaSer: 7.628 ± 0.064	5.019AlaThr: 5.019 ± 0.043	5.443AlaVal: 5.443 ± 0.046	1.202AlaTrp: 1.202 ± 0.021	2.271AlaTyr: 2.271 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	1.097CysAla: 1.097 ± 0.02	0.299CysCys: 0.299 ± 0.009	0.69CysAsp: 0.69 ± 0.016	0.626CysGlu: 0.626 ± 0.016	0.559CysPhe: 0.559 ± 0.015	0.973CysGly: 0.973 ± 0.022	0.398CysHis: 0.398 ± 0.011	0.771CysIle: 0.771 ± 0.018	0.56CysLys: 0.56 ± 0.013	1.348CysLeu: 1.348 ± 0.024	0.293CysMet: 0.293 ± 0.011	0.471CysAsn: 0.471 ± 0.014	0.921CysPro: 0.921 ± 0.023	0.525CysGln: 0.525 ± 0.015	0.825CysArg: 0.825 ± 0.017	1.162CysSer: 1.162 ± 0.021	0.876CysThr: 0.876 ± 0.018	0.895CysVal: 0.895 ± 0.019	0.221CysTrp: 0.221 ± 0.009	0.381CysTyr: 0.381 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.745AspAla: 4.745 ± 0.041	0.659AspCys: 0.659 ± 0.015	4.068AspAsp: 4.068 ± 0.049	4.237AspGlu: 4.237 ± 0.051	2.034AspPhe: 2.034 ± 0.028	4.121AspGly: 4.121 ± 0.043	1.377AspHis: 1.377 ± 0.023	2.973AspIle: 2.973 ± 0.032	2.092AspLys: 2.092 ± 0.028	5.186AspLeu: 5.186 ± 0.046	1.197AspMet: 1.197 ± 0.022	1.66AspAsn: 1.66 ± 0.026	3.381AspPro: 3.381 ± 0.037	1.676AspGln: 1.676 ± 0.025	2.873AspArg: 2.873 ± 0.042	3.984AspSer: 3.984 ± 0.044	2.944AspThr: 2.944 ± 0.031	4.019AspVal: 4.019 ± 0.035	0.91AspTrp: 0.91 ± 0.018	1.411AspTyr: 1.411 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.007GluAla: 5.007 ± 0.055	0.695GluCys: 0.695 ± 0.015	4.116GluAsp: 4.116 ± 0.052	5.316GluGlu: 5.316 ± 0.07	1.878GluPhe: 1.878 ± 0.024	4.027GluGly: 4.027 ± 0.042	1.469GluHis: 1.469 ± 0.021	2.731GluIle: 2.731 ± 0.036	2.878GluLys: 2.878 ± 0.029	5.315GluLeu: 5.315 ± 0.05	1.36GluMet: 1.36 ± 0.022	1.862GluAsn: 1.862 ± 0.023	2.595GluPro: 2.595 ± 0.029	2.119GluGln: 2.119 ± 0.029	3.887GluArg: 3.887 ± 0.05	3.946GluSer: 3.946 ± 0.038	2.964GluThr: 2.964 ± 0.036	3.775GluVal: 3.775 ± 0.042	0.923GluTrp: 0.923 ± 0.018	1.518GluTyr: 1.518 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.156PheAla: 3.156 ± 0.037	0.595PheCys: 0.595 ± 0.015	2.184PheAsp: 2.184 ± 0.028	2.037PheGlu: 2.037 ± 0.029	1.548PhePhe: 1.548 ± 0.024	2.72PheGly: 2.72 ± 0.036	0.99PheHis: 0.99 ± 0.021	1.844PheIle: 1.844 ± 0.027	1.491PheLys: 1.491 ± 0.023	3.504PheLeu: 3.504 ± 0.04	0.8PheMet: 0.8 ± 0.017	1.34PheAsn: 1.34 ± 0.022	2.085PhePro: 2.085 ± 0.026	1.239PheGln: 1.239 ± 0.022	1.955PheArg: 1.955 ± 0.029	3.216PheSer: 3.216 ± 0.038	2.275PheThr: 2.275 ± 0.027	2.567PheVal: 2.567 ± 0.031	0.619PheTrp: 0.619 ± 0.015	1.122PheTyr: 1.122 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	5.073GlyAla: 5.073 ± 0.054	0.956GlyCys: 0.956 ± 0.018	3.658GlyAsp: 3.658 ± 0.041	3.789GlyGlu: 3.789 ± 0.044	2.497GlyPhe: 2.497 ± 0.032	5.416GlyGly: 5.416 ± 0.063	1.876GlyHis: 1.876 ± 0.027	3.233GlyIle: 3.233 ± 0.032	3.306GlyLys: 3.306 ± 0.04	5.578GlyLeu: 5.578 ± 0.054	1.498GlyMet: 1.498 ± 0.027	2.228GlyAsn: 2.228 ± 0.027	3.314GlyPro: 3.314 ± 0.038	2.34GlyGln: 2.34 ± 0.033	3.995GlyArg: 3.995 ± 0.046	5.75GlySer: 5.75 ± 0.045	3.954GlyThr: 3.954 ± 0.038	4.458GlyVal: 4.458 ± 0.048	1.158GlyTrp: 1.158 ± 0.022	1.89GlyTyr: 1.89 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	2.23HisAla: 2.23 ± 0.028	0.406HisCys: 0.406 ± 0.012	1.382HisAsp: 1.382 ± 0.022	1.326HisGlu: 1.326 ± 0.024	1.029HisPhe: 1.029 ± 0.023	1.689HisGly: 1.689 ± 0.025	1.023HisHis: 1.023 ± 0.023	1.388HisIle: 1.388 ± 0.022	0.944HisLys: 0.944 ± 0.019	2.655HisLeu: 2.655 ± 0.032	0.513HisMet: 0.513 ± 0.013	0.865HisAsn: 0.865 ± 0.018	2.156HisPro: 2.156 ± 0.039	1.028HisGln: 1.028 ± 0.021	1.646HisArg: 1.646 ± 0.028	2.198HisSer: 2.198 ± 0.034	1.59HisThr: 1.59 ± 0.026	1.662HisVal: 1.662 ± 0.024	0.408HisTrp: 0.408 ± 0.012	0.729HisTyr: 0.729 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.193IleAla: 4.193 ± 0.044	0.789IleCys: 0.789 ± 0.017	2.676IleAsp: 2.676 ± 0.032	2.611IleGlu: 2.611 ± 0.031	1.952IlePhe: 1.952 ± 0.029	2.981IleGly: 2.981 ± 0.04	1.35IleHis: 1.35 ± 0.021	2.472IleIle: 2.472 ± 0.034	1.946IleLys: 1.946 ± 0.028	4.56IleLeu: 4.56 ± 0.047	0.986IleMet: 0.986 ± 0.02	1.642IleAsn: 1.642 ± 0.024	3.265IlePro: 3.265 ± 0.033	1.78IleGln: 1.78 ± 0.023	2.827IleArg: 2.827 ± 0.03	4.021IleSer: 4.021 ± 0.04	2.899IleThr: 2.899 ± 0.033	3.157IleVal: 3.157 ± 0.036	0.848IleTrp: 0.848 ± 0.019	1.335IleTyr: 1.335 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.938LysAla: 3.938 ± 0.046	0.501LysCys: 0.501 ± 0.015	2.491LysAsp: 2.491 ± 0.03	2.941LysGlu: 2.941 ± 0.038	1.361LysPhe: 1.361 ± 0.023	2.839LysGly: 2.839 ± 0.036	1.122LysHis: 1.122 ± 0.02	1.913LysIle: 1.913 ± 0.027	2.733LysLys: 2.733 ± 0.046	3.899LysLeu: 3.899 ± 0.038	0.867LysMet: 0.867 ± 0.016	1.392LysAsn: 1.392 ± 0.023	2.356LysPro: 2.356 ± 0.034	1.62LysGln: 1.62 ± 0.024	3.186LysArg: 3.186 ± 0.039	3.176LysSer: 3.176 ± 0.041	2.437LysThr: 2.437 ± 0.034	2.749LysVal: 2.749 ± 0.033	0.655LysTrp: 0.655 ± 0.015	1.231LysTyr: 1.231 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	8.422LeuAla: 8.422 ± 0.058	1.375LeuCys: 1.375 ± 0.025	5.168LeuAsp: 5.168 ± 0.048	5.32LeuGlu: 5.32 ± 0.051	3.483LeuPhe: 3.483 ± 0.038	5.729LeuGly: 5.729 ± 0.046	2.562LeuHis: 2.562 ± 0.033	3.946LeuIle: 3.946 ± 0.041	4.043LeuLys: 4.043 ± 0.036	9.048LeuLeu: 9.048 ± 0.072	1.84LeuMet: 1.84 ± 0.027	3.088LeuAsn: 3.088 ± 0.032	6.291LeuPro: 6.291 ± 0.049	3.878LeuGln: 3.878 ± 0.038	5.975LeuArg: 5.975 ± 0.056	8.192LeuSer: 8.192 ± 0.06	5.353LeuThr: 5.353 ± 0.041	5.969LeuVal: 5.969 ± 0.056	1.394LeuTrp: 1.394 ± 0.023	2.468LeuTyr: 2.468 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	1.781MetAla: 1.781 ± 0.025	0.28MetCys: 0.28 ± 0.008	1.213MetAsp: 1.213 ± 0.021	1.183MetGlu: 1.183 ± 0.023	0.819MetPhe: 0.819 ± 0.016	1.308MetGly: 1.308 ± 0.025	0.586MetHis: 0.586 ± 0.014	0.955MetIle: 0.955 ± 0.018	0.941MetLys: 0.941 ± 0.02	1.965MetLeu: 1.965 ± 0.028	0.506MetMet: 0.506 ± 0.014	0.752MetAsn: 0.752 ± 0.019	1.212MetPro: 1.212 ± 0.022	0.82MetGln: 0.82 ± 0.016	1.264MetArg: 1.264 ± 0.021	2.012MetSer: 2.012 ± 0.026	1.233MetThr: 1.233 ± 0.023	1.27MetVal: 1.27 ± 0.021	0.298MetTrp: 0.298 ± 0.012	0.556MetTyr: 0.556 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.086AsnAla: 3.086 ± 0.033	0.435AsnCys: 0.435 ± 0.015	1.802AsnAsp: 1.802 ± 0.023	1.753AsnGlu: 1.753 ± 0.022	1.266AsnPhe: 1.266 ± 0.019	2.512AsnGly: 2.512 ± 0.036	0.846AsnHis: 0.846 ± 0.017	1.902AsnIle: 1.902 ± 0.024	1.285AsnLys: 1.285 ± 0.024	3.211AsnLeu: 3.211 ± 0.036	0.744AsnMet: 0.744 ± 0.017	1.289AsnAsn: 1.289 ± 0.024	2.273AsnPro: 2.273 ± 0.031	1.149AsnGln: 1.149 ± 0.022	1.623AsnArg: 1.623 ± 0.027	2.522AsnSer: 2.522 ± 0.031	2.069AsnThr: 2.069 ± 0.026	2.329AsnVal: 2.329 ± 0.024	0.515AsnTrp: 0.515 ± 0.013	0.946AsnTyr: 0.946 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	5.317ProAla: 5.317 ± 0.051	0.634ProCys: 0.634 ± 0.017	3.357ProAsp: 3.357 ± 0.034	3.569ProGlu: 3.569 ± 0.036	2.178ProPhe: 2.178 ± 0.032	3.776ProGly: 3.776 ± 0.043	1.694ProHis: 1.694 ± 0.028	2.659ProIle: 2.659 ± 0.032	2.395ProLys: 2.395 ± 0.031	5.394ProLeu: 5.394 ± 0.049	1.082ProMet: 1.082 ± 0.019	2.197ProAsn: 2.197 ± 0.025	6.347ProPro: 6.347 ± 0.1	2.465ProGln: 2.465 ± 0.034	3.546ProArg: 3.546 ± 0.042	7.404ProSer: 7.404 ± 0.075	4.385ProThr: 4.385 ± 0.051	3.733ProVal: 3.733 ± 0.039	0.771ProTrp: 0.771 ± 0.018	1.603ProTyr: 1.603 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.304GlnAla: 3.304 ± 0.035	0.525GlnCys: 0.525 ± 0.015	1.875GlnAsp: 1.875 ± 0.024	2.149GlnGlu: 2.149 ± 0.033	1.21GlnPhe: 1.21 ± 0.02	2.268GlnGly: 2.268 ± 0.034	1.14GlnHis: 1.14 ± 0.025	1.746GlnIle: 1.746 ± 0.026	1.626GlnLys: 1.626 ± 0.028	3.563GlnLeu: 3.563 ± 0.04	0.828GlnMet: 0.828 ± 0.017	1.336GlnAsn: 1.336 ± 0.022	2.49GlnPro: 2.49 ± 0.037	1.843GlnGln: 1.843 ± 0.041	2.499GlnArg: 2.499 ± 0.033	3.081GlnSer: 3.081 ± 0.034	2.262GlnThr: 2.262 ± 0.029	2.251GlnVal: 2.251 ± 0.028	0.629GlnTrp: 0.629 ± 0.013	1.07GlnTyr: 1.07 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	5.047ArgAla: 5.047 ± 0.046	0.858ArgCys: 0.858 ± 0.021	3.257ArgAsp: 3.257 ± 0.038	3.744ArgGlu: 3.744 ± 0.045	2.192ArgPhe: 2.192 ± 0.03	3.666ArgGly: 3.666 ± 0.042	1.589ArgHis: 1.589 ± 0.027	2.906ArgIle: 2.906 ± 0.036	3.132ArgLys: 3.132 ± 0.035	5.567ArgLeu: 5.567 ± 0.052	1.336ArgMet: 1.336 ± 0.023	1.933ArgAsn: 1.933 ± 0.025	3.491ArgPro: 3.491 ± 0.038	2.261ArgGln: 2.261 ± 0.026	4.818ArgArg: 4.818 ± 0.057	5.043ArgSer: 5.043 ± 0.055	3.426ArgThr: 3.426 ± 0.034	3.754ArgVal: 3.754 ± 0.042	1.032ArgTrp: 1.032 ± 0.021	1.611ArgTyr: 1.611 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	7.124SerAla: 7.124 ± 0.05	1.11SerCys: 1.11 ± 0.023	4.398SerAsp: 4.398 ± 0.046	4.164SerGlu: 4.164 ± 0.041	3.246SerPhe: 3.246 ± 0.035	5.877SerGly: 5.877 ± 0.046	2.316SerHis: 2.316 ± 0.032	4.1SerIle: 4.1 ± 0.044	3.38SerLys: 3.38 ± 0.038	8.092SerLeu: 8.092 ± 0.056	1.707SerMet: 1.707 ± 0.027	2.801SerAsn: 2.801 ± 0.032	6.404SerPro: 6.404 ± 0.078	3.341SerGln: 3.341 ± 0.043	5.134SerArg: 5.134 ± 0.057	9.904SerSer: 9.904 ± 0.109	6.014SerThr: 6.014 ± 0.058	5.19SerVal: 5.19 ± 0.046	1.096SerTrp: 1.096 ± 0.02	2.01SerTyr: 2.01 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	5.014ThrAla: 5.014 ± 0.048	0.918ThrCys: 0.918 ± 0.02	2.741ThrAsp: 2.741 ± 0.033	2.755ThrGlu: 2.755 ± 0.027	2.387ThrPhe: 2.387 ± 0.031	3.927ThrGly: 3.927 ± 0.037	1.558ThrHis: 1.558 ± 0.024	3.12ThrIle: 3.12 ± 0.034	2.375ThrLys: 2.375 ± 0.032	5.757ThrLeu: 5.757 ± 0.053	1.199ThrMet: 1.199 ± 0.019	2.008ThrAsn: 2.008 ± 0.025	4.677ThrPro: 4.677 ± 0.058	2.156ThrGln: 2.156 ± 0.027	3.305ThrArg: 3.305 ± 0.038	5.919ThrSer: 5.919 ± 0.057	4.25ThrThr: 4.25 ± 0.05	3.698ThrVal: 3.698 ± 0.036	0.854ThrTrp: 0.854 ± 0.018	1.659ThrTyr: 1.659 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	5.402ValAla: 5.402 ± 0.051	0.933ValCys: 0.933 ± 0.019	3.723ValAsp: 3.723 ± 0.032	3.776ValGlu: 3.776 ± 0.043	2.59ValPhe: 2.59 ± 0.029	3.998ValGly: 3.998 ± 0.041	1.667ValHis: 1.667 ± 0.024	3.249ValIle: 3.249 ± 0.036	2.765ValLys: 2.765 ± 0.036	6.317ValLeu: 6.317 ± 0.049	1.341ValMet: 1.341 ± 0.021	2.204ValAsn: 2.204 ± 0.027	3.989ValPro: 3.989 ± 0.036	2.464ValGln: 2.464 ± 0.03	3.599ValArg: 3.599 ± 0.033	4.965ValSer: 4.965 ± 0.047	3.699ValThr: 3.699 ± 0.041	4.695ValVal: 4.695 ± 0.052	1.054ValTrp: 1.054 ± 0.021	1.802ValTyr: 1.802 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.222TrpAla: 1.222 ± 0.024	0.265TrpCys: 0.265 ± 0.009	1.074TrpAsp: 1.074 ± 0.027	0.89TrpGlu: 0.89 ± 0.019	0.569TrpPhe: 0.569 ± 0.014	0.902TrpGly: 0.902 ± 0.019	0.374TrpHis: 0.374 ± 0.011	0.745TrpIle: 0.745 ± 0.016	0.806TrpLys: 0.806 ± 0.015	1.375TrpLeu: 1.375 ± 0.026	0.372TrpMet: 0.372 ± 0.01	0.665TrpAsn: 0.665 ± 0.016	0.655TrpPro: 0.655 ± 0.016	0.53TrpGln: 0.53 ± 0.013	1.049TrpArg: 1.049 ± 0.018	1.194TrpSer: 1.194 ± 0.022	0.967TrpThr: 0.967 ± 0.019	0.934TrpVal: 0.934 ± 0.02	0.311TrpTrp: 0.311 ± 0.009	0.435TrpTyr: 0.435 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.21TyrAla: 2.21 ± 0.028	0.452TyrCys: 0.452 ± 0.014	1.609TyrAsp: 1.609 ± 0.024	1.419TyrGlu: 1.419 ± 0.022	1.153TyrPhe: 1.153 ± 0.021	1.828TyrGly: 1.828 ± 0.028	0.745TyrHis: 0.745 ± 0.018	1.385TyrIle: 1.385 ± 0.019	1.033TyrLys: 1.033 ± 0.019	2.642TyrLeu: 2.642 ± 0.029	0.571TyrMet: 0.571 ± 0.015	1.033TyrAsn: 1.033 ± 0.022	1.522TyrPro: 1.522 ± 0.027	1.003TyrGln: 1.003 ± 0.019	1.572TyrArg: 1.572 ± 0.023	2.088TyrSer: 2.088 ± 0.031	1.66TyrThr: 1.66 ± 0.03	1.685TyrVal: 1.685 ± 0.026	0.437TyrTrp: 0.437 ± 0.013	0.847TyrTyr: 0.847 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7783 proteins (2994580 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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