Amino acid dipepetide frequency for Psychroflexus halocasei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.748AlaAla: 3.748 ± 0.08
0.552AlaCys: 0.552 ± 0.026
3.488AlaAsp: 3.488 ± 0.076
4.461AlaGlu: 4.461 ± 0.069
3.2AlaPhe: 3.2 ± 0.071
3.704AlaGly: 3.704 ± 0.077
1.158AlaHis: 1.158 ± 0.04
5.057AlaIle: 5.057 ± 0.092
4.809AlaLys: 4.809 ± 0.082
5.87AlaLeu: 5.87 ± 0.103
1.573AlaMet: 1.573 ± 0.053
3.06AlaAsn: 3.06 ± 0.068
1.539AlaPro: 1.539 ± 0.046
2.584AlaGln: 2.584 ± 0.065
1.801AlaArg: 1.801 ± 0.054
4.071AlaSer: 4.071 ± 0.07
2.97AlaThr: 2.97 ± 0.069
3.735AlaVal: 3.735 ± 0.071
0.528AlaTrp: 0.528 ± 0.026
2.712AlaTyr: 2.712 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.395CysAla: 0.395 ± 0.024
0.082CysCys: 0.082 ± 0.01
0.439CysAsp: 0.439 ± 0.028
0.457CysGlu: 0.457 ± 0.024
0.387CysPhe: 0.387 ± 0.024
0.528CysGly: 0.528 ± 0.025
0.165CysHis: 0.165 ± 0.018
0.495CysIle: 0.495 ± 0.026
0.326CysLys: 0.326 ± 0.021
0.615CysLeu: 0.615 ± 0.026
0.119CysMet: 0.119 ± 0.011
0.301CysAsn: 0.301 ± 0.02
0.306CysPro: 0.306 ± 0.026
0.366CysGln: 0.366 ± 0.024
0.187CysArg: 0.187 ± 0.016
0.471CysSer: 0.471 ± 0.028
0.324CysThr: 0.324 ± 0.02
0.421CysVal: 0.421 ± 0.023
0.062CysTrp: 0.062 ± 0.009
0.233CysTyr: 0.233 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.745AspAla: 3.745 ± 0.078
0.414AspCys: 0.414 ± 0.025
3.509AspAsp: 3.509 ± 0.08
4.661AspGlu: 4.661 ± 0.091
4.191AspPhe: 4.191 ± 0.077
3.405AspGly: 3.405 ± 0.083
1.052AspHis: 1.052 ± 0.037
4.843AspIle: 4.843 ± 0.094
4.607AspLys: 4.607 ± 0.087
6.015AspLeu: 6.015 ± 0.1
1.138AspMet: 1.138 ± 0.037
2.956AspAsn: 2.956 ± 0.067
1.661AspPro: 1.661 ± 0.057
2.423AspGln: 2.423 ± 0.06
1.873AspArg: 1.873 ± 0.056
3.251AspSer: 3.251 ± 0.073
2.395AspThr: 2.395 ± 0.064
3.896AspVal: 3.896 ± 0.078
0.653AspTrp: 0.653 ± 0.034
3.063AspTyr: 3.063 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
4.491GluAla: 4.491 ± 0.092
0.312GluCys: 0.312 ± 0.02
4.177GluAsp: 4.177 ± 0.072
5.374GluGlu: 5.374 ± 0.114
3.318GluPhe: 3.318 ± 0.069
3.541GluGly: 3.541 ± 0.08
1.143GluHis: 1.143 ± 0.042
6.318GluIle: 6.318 ± 0.091
6.942GluLys: 6.942 ± 0.128
6.428GluLeu: 6.428 ± 0.089
1.772GluMet: 1.772 ± 0.043
5.392GluAsn: 5.392 ± 0.098
1.563GluPro: 1.563 ± 0.05
2.185GluGln: 2.185 ± 0.06
2.52GluArg: 2.52 ± 0.068
3.854GluSer: 3.854 ± 0.072
3.804GluThr: 3.804 ± 0.07
4.56GluVal: 4.56 ± 0.088
0.616GluTrp: 0.616 ± 0.028
2.258GluTyr: 2.258 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
2.944PheAla: 2.944 ± 0.051
0.402PheCys: 0.402 ± 0.024
3.582PheAsp: 3.582 ± 0.067
3.664PheGlu: 3.664 ± 0.07
2.785PhePhe: 2.785 ± 0.077
3.63PheGly: 3.63 ± 0.079
0.859PheHis: 0.859 ± 0.032
4.271PheIle: 4.271 ± 0.09
4.42PheLys: 4.42 ± 0.083
4.851PheLeu: 4.851 ± 0.087
1.134PheMet: 1.134 ± 0.037
3.104PheAsn: 3.104 ± 0.069
1.577PhePro: 1.577 ± 0.046
1.759PheGln: 1.759 ± 0.05
1.615PheArg: 1.615 ± 0.051
4.064PheSer: 4.064 ± 0.084
2.809PheThr: 2.809 ± 0.064
3.007PheVal: 3.007 ± 0.071
0.571PheTrp: 0.571 ± 0.032
2.343PheTyr: 2.343 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
3.655GlyAla: 3.655 ± 0.084
0.445GlyCys: 0.445 ± 0.03
3.342GlyAsp: 3.342 ± 0.075
3.836GlyGlu: 3.836 ± 0.076
3.519GlyPhe: 3.519 ± 0.074
4.073GlyGly: 4.073 ± 0.096
1.161GlyHis: 1.161 ± 0.041
4.9GlyIle: 4.9 ± 0.088
4.285GlyLys: 4.285 ± 0.087
5.64GlyLeu: 5.64 ± 0.1
1.439GlyMet: 1.439 ± 0.051
3.081GlyAsn: 3.081 ± 0.084
1.202GlyPro: 1.202 ± 0.039
2.246GlyGln: 2.246 ± 0.061
1.963GlyArg: 1.963 ± 0.052
3.742GlySer: 3.742 ± 0.091
3.283GlyThr: 3.283 ± 0.082
3.958GlyVal: 3.958 ± 0.081
0.575GlyTrp: 0.575 ± 0.028
2.433GlyTyr: 2.433 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
0.968HisAla: 0.968 ± 0.034
0.19HisCys: 0.19 ± 0.017
0.972HisAsp: 0.972 ± 0.034
1.149HisGlu: 1.149 ± 0.037
1.205HisPhe: 1.205 ± 0.039
0.948HisGly: 0.948 ± 0.036
0.524HisHis: 0.524 ± 0.024
1.504HisIle: 1.504 ± 0.048
1.351HisLys: 1.351 ± 0.042
2.056HisLeu: 2.056 ± 0.057
0.321HisMet: 0.321 ± 0.021
0.918HisAsn: 0.918 ± 0.032
0.868HisPro: 0.868 ± 0.039
1.113HisGln: 1.113 ± 0.036
0.683HisArg: 0.683 ± 0.029
1.065HisSer: 1.065 ± 0.039
0.868HisThr: 0.868 ± 0.035
1.021HisVal: 1.021 ± 0.036
0.191HisTrp: 0.191 ± 0.017
0.897HisTyr: 0.897 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.216IleAla: 5.216 ± 0.086
0.6IleCys: 0.6 ± 0.029
5.56IleAsp: 5.56 ± 0.094
5.782IleGlu: 5.782 ± 0.098
4.0IlePhe: 4.0 ± 0.087
5.167IleGly: 5.167 ± 0.081
1.375IleHis: 1.375 ± 0.045
6.185IleIle: 6.185 ± 0.119
6.489IleLys: 6.489 ± 0.103
7.349IleLeu: 7.349 ± 0.125
1.394IleMet: 1.394 ± 0.046
5.032IleAsn: 5.032 ± 0.082
2.983IlePro: 2.983 ± 0.071
2.693IleGln: 2.693 ± 0.064
2.498IleArg: 2.498 ± 0.054
6.062IleSer: 6.062 ± 0.1
4.297IleThr: 4.297 ± 0.091
4.415IleVal: 4.415 ± 0.077
0.669IleTrp: 0.669 ± 0.03
3.071IleTyr: 3.071 ± 0.076
0.0IleXaa: 0.0 ± 0.0
Lys
5.405LysAla: 5.405 ± 0.087
0.337LysCys: 0.337 ± 0.02
5.001LysAsp: 5.001 ± 0.101
6.474LysGlu: 6.474 ± 0.108
3.4LysPhe: 3.4 ± 0.067
4.057LysGly: 4.057 ± 0.083
1.598LysHis: 1.598 ± 0.046
6.842LysIle: 6.842 ± 0.105
7.777LysLys: 7.777 ± 0.132
7.216LysLeu: 7.216 ± 0.12
2.131LysMet: 2.131 ± 0.054
5.853LysAsn: 5.853 ± 0.086
2.64LysPro: 2.64 ± 0.068
2.898LysGln: 2.898 ± 0.07
3.15LysArg: 3.15 ± 0.068
5.524LysSer: 5.524 ± 0.095
4.672LysThr: 4.672 ± 0.08
4.649LysVal: 4.649 ± 0.088
0.679LysTrp: 0.679 ± 0.035
3.205LysTyr: 3.205 ± 0.071
0.0LysXaa: 0.0 ± 0.0
Leu
5.529LeuAla: 5.529 ± 0.093
0.583LeuCys: 0.583 ± 0.026
5.29LeuAsp: 5.29 ± 0.094
6.359LeuGlu: 6.359 ± 0.097
4.792LeuPhe: 4.792 ± 0.093
5.541LeuGly: 5.541 ± 0.101
1.606LeuHis: 1.606 ± 0.051
7.697LeuIle: 7.697 ± 0.149
8.931LeuLys: 8.931 ± 0.132
8.046LeuLeu: 8.046 ± 0.146
2.18LeuMet: 2.18 ± 0.056
5.994LeuAsn: 5.994 ± 0.1
3.29LeuPro: 3.29 ± 0.075
3.133LeuGln: 3.133 ± 0.063
3.131LeuArg: 3.131 ± 0.076
7.32LeuSer: 7.32 ± 0.107
4.89LeuThr: 4.89 ± 0.077
5.062LeuVal: 5.062 ± 0.087
0.725LeuTrp: 0.725 ± 0.032
3.184LeuTyr: 3.184 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
1.428MetAla: 1.428 ± 0.041
0.114MetCys: 0.114 ± 0.012
1.06MetAsp: 1.06 ± 0.038
1.201MetGlu: 1.201 ± 0.043
0.861MetPhe: 0.861 ± 0.04
1.275MetGly: 1.275 ± 0.043
0.434MetHis: 0.434 ± 0.026
1.791MetIle: 1.791 ± 0.05
2.335MetLys: 2.335 ± 0.053
2.081MetLeu: 2.081 ± 0.057
0.731MetMet: 0.731 ± 0.031
1.294MetAsn: 1.294 ± 0.036
0.822MetPro: 0.822 ± 0.038
0.916MetGln: 0.916 ± 0.032
0.938MetArg: 0.938 ± 0.034
1.65MetSer: 1.65 ± 0.049
1.335MetThr: 1.335 ± 0.042
1.094MetVal: 1.094 ± 0.041
0.152MetTrp: 0.152 ± 0.015
0.666MetTyr: 0.666 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.64AsnAla: 3.64 ± 0.063
0.425AsnCys: 0.425 ± 0.027
3.291AsnAsp: 3.291 ± 0.069
3.83AsnGlu: 3.83 ± 0.067
3.453AsnPhe: 3.453 ± 0.069
3.291AsnGly: 3.291 ± 0.099
1.178AsnHis: 1.178 ± 0.042
4.692AsnIle: 4.692 ± 0.082
4.523AsnLys: 4.523 ± 0.08
5.743AsnLeu: 5.743 ± 0.096
1.195AsnMet: 1.195 ± 0.041
3.44AsnAsn: 3.44 ± 0.096
2.613AsnPro: 2.613 ± 0.071
2.768AsnGln: 2.768 ± 0.073
2.177AsnArg: 2.177 ± 0.057
3.84AsnSer: 3.84 ± 0.087
3.121AsnThr: 3.121 ± 0.066
3.07AsnVal: 3.07 ± 0.066
0.764AsnTrp: 0.764 ± 0.031
2.981AsnTyr: 2.981 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
1.646ProAla: 1.646 ± 0.061
0.186ProCys: 0.186 ± 0.015
2.013ProAsp: 2.013 ± 0.056
2.879ProGlu: 2.879 ± 0.066
1.618ProPhe: 1.618 ± 0.044
1.797ProGly: 1.797 ± 0.053
0.671ProHis: 0.671 ± 0.03
2.532ProIle: 2.532 ± 0.056
2.504ProLys: 2.504 ± 0.057
2.679ProLeu: 2.679 ± 0.061
0.637ProMet: 0.637 ± 0.028
2.008ProAsn: 2.008 ± 0.06
0.755ProPro: 0.755 ± 0.035
1.346ProGln: 1.346 ± 0.043
0.879ProArg: 0.879 ± 0.034
2.012ProSer: 2.012 ± 0.048
1.681ProThr: 1.681 ± 0.066
2.115ProVal: 2.115 ± 0.056
0.274ProTrp: 0.274 ± 0.019
1.3ProTyr: 1.3 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
2.206GlnAla: 2.206 ± 0.058
0.15GlnCys: 0.15 ± 0.014
2.167GlnAsp: 2.167 ± 0.055
2.649GlnGlu: 2.649 ± 0.064
1.712GlnPhe: 1.712 ± 0.052
1.749GlnGly: 1.749 ± 0.046
0.747GlnHis: 0.747 ± 0.036
3.171GlnIle: 3.171 ± 0.071
3.906GlnLys: 3.906 ± 0.078
3.851GlnLeu: 3.851 ± 0.075
0.941GlnMet: 0.941 ± 0.033
2.829GlnAsn: 2.829 ± 0.055
1.156GlnPro: 1.156 ± 0.035
1.538GlnGln: 1.538 ± 0.043
1.295GlnArg: 1.295 ± 0.045
2.335GlnSer: 2.335 ± 0.062
2.153GlnThr: 2.153 ± 0.056
2.122GlnVal: 2.122 ± 0.05
0.364GlnTrp: 0.364 ± 0.021
1.253GlnTyr: 1.253 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
1.921ArgAla: 1.921 ± 0.053
0.174ArgCys: 0.174 ± 0.015
1.846ArgAsp: 1.846 ± 0.053
2.227ArgGlu: 2.227 ± 0.062
1.894ArgPhe: 1.894 ± 0.055
1.828ArgGly: 1.828 ± 0.05
0.671ArgHis: 0.671 ± 0.035
2.888ArgIle: 2.888 ± 0.057
2.877ArgLys: 2.877 ± 0.068
3.365ArgLeu: 3.365 ± 0.071
0.876ArgMet: 0.876 ± 0.03
1.924ArgAsn: 1.924 ± 0.048
1.025ArgPro: 1.025 ± 0.034
1.368ArgGln: 1.368 ± 0.039
1.33ArgArg: 1.33 ± 0.047
1.914ArgSer: 1.914 ± 0.059
1.621ArgThr: 1.621 ± 0.04
2.056ArgVal: 2.056 ± 0.054
0.34ArgTrp: 0.34 ± 0.02
1.515ArgTyr: 1.515 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
3.825SerAla: 3.825 ± 0.072
0.617SerCys: 0.617 ± 0.029
3.918SerAsp: 3.918 ± 0.066
4.704SerGlu: 4.704 ± 0.078
4.058SerPhe: 4.058 ± 0.071
4.213SerGly: 4.213 ± 0.092
1.263SerHis: 1.263 ± 0.035
5.238SerIle: 5.238 ± 0.088
5.146SerLys: 5.146 ± 0.089
6.476SerLeu: 6.476 ± 0.096
1.36SerMet: 1.36 ± 0.044
3.452SerAsn: 3.452 ± 0.079
2.087SerPro: 2.087 ± 0.061
2.825SerGln: 2.825 ± 0.06
2.096SerArg: 2.096 ± 0.057
4.693SerSer: 4.693 ± 0.093
3.385SerThr: 3.385 ± 0.083
4.083SerVal: 4.083 ± 0.076
0.638SerTrp: 0.638 ± 0.028
2.876SerTyr: 2.876 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
3.378ThrAla: 3.378 ± 0.07
0.319ThrCys: 0.319 ± 0.018
3.257ThrAsp: 3.257 ± 0.077
3.588ThrGlu: 3.588 ± 0.071
2.602ThrPhe: 2.602 ± 0.061
3.514ThrGly: 3.514 ± 0.082
1.071ThrHis: 1.071 ± 0.043
4.022ThrIle: 4.022 ± 0.078
3.766ThrLys: 3.766 ± 0.07
4.814ThrLeu: 4.814 ± 0.078
0.875ThrMet: 0.875 ± 0.036
2.851ThrAsn: 2.851 ± 0.079
1.984ThrPro: 1.984 ± 0.054
1.961ThrGln: 1.961 ± 0.057
1.626ThrArg: 1.626 ± 0.05
3.785ThrSer: 3.785 ± 0.072
2.832ThrThr: 2.832 ± 0.081
2.945ThrVal: 2.945 ± 0.073
0.461ThrTrp: 0.461 ± 0.025
2.423ThrTyr: 2.423 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
3.466ValAla: 3.466 ± 0.065
0.439ValCys: 0.439 ± 0.024
3.795ValAsp: 3.795 ± 0.079
4.121ValGlu: 4.121 ± 0.078
3.327ValPhe: 3.327 ± 0.069
3.525ValGly: 3.525 ± 0.071
0.971ValHis: 0.971 ± 0.039
4.884ValIle: 4.884 ± 0.08
4.579ValLys: 4.579 ± 0.074
5.339ValLeu: 5.339 ± 0.099
1.297ValMet: 1.297 ± 0.041
3.483ValAsn: 3.483 ± 0.082
1.825ValPro: 1.825 ± 0.051
1.836ValGln: 1.836 ± 0.051
1.868ValArg: 1.868 ± 0.05
4.139ValSer: 4.139 ± 0.089
3.057ValThr: 3.057 ± 0.079
3.756ValVal: 3.756 ± 0.079
0.524ValTrp: 0.524 ± 0.029
2.405ValTyr: 2.405 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
0.534TrpAla: 0.534 ± 0.026
0.079TrpCys: 0.079 ± 0.01
0.544TrpAsp: 0.544 ± 0.027
0.583TrpGlu: 0.583 ± 0.029
0.553TrpPhe: 0.553 ± 0.029
0.544TrpGly: 0.544 ± 0.028
0.211TrpHis: 0.211 ± 0.017
0.72TrpIle: 0.72 ± 0.032
0.643TrpLys: 0.643 ± 0.03
0.946TrpLeu: 0.946 ± 0.038
0.31TrpMet: 0.31 ± 0.02
0.581TrpAsn: 0.581 ± 0.027
0.238TrpPro: 0.238 ± 0.018
0.372TrpGln: 0.372 ± 0.023
0.398TrpArg: 0.398 ± 0.02
0.607TrpSer: 0.607 ± 0.026
0.476TrpThr: 0.476 ± 0.027
0.523TrpVal: 0.523 ± 0.024
0.123TrpTrp: 0.123 ± 0.015
0.373TrpTyr: 0.373 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.479TyrAla: 2.479 ± 0.062
0.26TyrCys: 0.26 ± 0.018
2.499TyrAsp: 2.499 ± 0.069
2.569TyrGlu: 2.569 ± 0.058
2.517TyrPhe: 2.517 ± 0.071
2.449TyrGly: 2.449 ± 0.06
0.956TyrHis: 0.956 ± 0.04
2.791TyrIle: 2.791 ± 0.064
3.293TyrLys: 3.293 ± 0.069
3.903TyrLeu: 3.903 ± 0.079
0.755TyrMet: 0.755 ± 0.031
2.479TyrAsn: 2.479 ± 0.062
1.396TyrPro: 1.396 ± 0.04
1.963TyrGln: 1.963 ± 0.058
1.632TyrArg: 1.632 ± 0.05
2.555TyrSer: 2.555 ± 0.064
2.103TyrThr: 2.103 ± 0.056
2.143TyrVal: 2.143 ± 0.051
0.447TyrTrp: 0.447 ± 0.025
1.859TyrTyr: 1.859 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2462 proteins (806779 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski