Amino acid dipepetide frequency for [Clostridium] aminophilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.049AlaAla: 10.049 ± 0.169
1.089AlaCys: 1.089 ± 0.036
5.442AlaAsp: 5.442 ± 0.085
7.466AlaGlu: 7.466 ± 0.139
3.295AlaPhe: 3.295 ± 0.06
7.224AlaGly: 7.224 ± 0.104
1.183AlaHis: 1.183 ± 0.043
4.916AlaIle: 4.916 ± 0.083
4.913AlaLys: 4.913 ± 0.086
7.055AlaLeu: 7.055 ± 0.101
2.844AlaMet: 2.844 ± 0.056
2.592AlaAsn: 2.592 ± 0.052
2.487AlaPro: 2.487 ± 0.062
2.427AlaGln: 2.427 ± 0.065
3.4AlaArg: 3.4 ± 0.063
4.6AlaSer: 4.6 ± 0.088
3.097AlaThr: 3.097 ± 0.062
7.244AlaVal: 7.244 ± 0.12
0.623AlaTrp: 0.623 ± 0.026
2.484AlaTyr: 2.484 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
1.251CysAla: 1.251 ± 0.037
0.241CysCys: 0.241 ± 0.017
0.83CysAsp: 0.83 ± 0.029
0.884CysGlu: 0.884 ± 0.035
0.639CysPhe: 0.639 ± 0.034
1.526CysGly: 1.526 ± 0.051
0.283CysHis: 0.283 ± 0.018
0.984CysIle: 0.984 ± 0.038
0.505CysLys: 0.505 ± 0.025
1.135CysLeu: 1.135 ± 0.039
0.433CysMet: 0.433 ± 0.023
0.423CysAsn: 0.423 ± 0.02
0.65CysPro: 0.65 ± 0.029
0.264CysGln: 0.264 ± 0.017
0.897CysArg: 0.897 ± 0.031
0.876CysSer: 0.876 ± 0.032
0.682CysThr: 0.682 ± 0.027
0.935CysVal: 0.935 ± 0.031
0.108CysTrp: 0.108 ± 0.011
0.453CysTyr: 0.453 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
4.711AspAla: 4.711 ± 0.075
0.782AspCys: 0.782 ± 0.028
3.357AspAsp: 3.357 ± 0.094
4.966AspGlu: 4.966 ± 0.087
2.553AspPhe: 2.553 ± 0.054
5.302AspGly: 5.302 ± 0.123
1.166AspHis: 1.166 ± 0.041
4.06AspIle: 4.06 ± 0.072
2.768AspLys: 2.768 ± 0.066
5.161AspLeu: 5.161 ± 0.075
1.841AspMet: 1.841 ± 0.044
1.999AspAsn: 1.999 ± 0.05
2.549AspPro: 2.549 ± 0.049
1.605AspGln: 1.605 ± 0.05
3.638AspArg: 3.638 ± 0.069
3.454AspSer: 3.454 ± 0.066
3.057AspThr: 3.057 ± 0.065
3.929AspVal: 3.929 ± 0.067
0.564AspTrp: 0.564 ± 0.029
2.588AspTyr: 2.588 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
6.047GluAla: 6.047 ± 0.094
0.787GluCys: 0.787 ± 0.029
4.56GluAsp: 4.56 ± 0.092
6.993GluGlu: 6.993 ± 0.117
2.545GluPhe: 2.545 ± 0.054
4.282GluGly: 4.282 ± 0.076
1.515GluHis: 1.515 ± 0.044
5.583GluIle: 5.583 ± 0.084
6.66GluLys: 6.66 ± 0.109
6.258GluLeu: 6.258 ± 0.092
2.653GluMet: 2.653 ± 0.055
3.993GluAsn: 3.993 ± 0.079
2.051GluPro: 2.051 ± 0.053
2.512GluGln: 2.512 ± 0.063
3.763GluArg: 3.763 ± 0.087
3.628GluSer: 3.628 ± 0.074
4.198GluThr: 4.198 ± 0.082
4.193GluVal: 4.193 ± 0.076
0.639GluTrp: 0.639 ± 0.027
2.867GluTyr: 2.867 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
3.272PheAla: 3.272 ± 0.074
0.756PheCys: 0.756 ± 0.035
2.608PheAsp: 2.608 ± 0.055
2.461PheGlu: 2.461 ± 0.061
1.843PhePhe: 1.843 ± 0.06
3.399PheGly: 3.399 ± 0.069
0.881PheHis: 0.881 ± 0.029
2.401PheIle: 2.401 ± 0.05
1.476PheLys: 1.476 ± 0.044
3.871PheLeu: 3.871 ± 0.085
1.109PheMet: 1.109 ± 0.037
1.336PheAsn: 1.336 ± 0.04
1.465PhePro: 1.465 ± 0.04
1.03PheGln: 1.03 ± 0.036
2.595PheArg: 2.595 ± 0.061
2.837PheSer: 2.837 ± 0.057
2.152PheThr: 2.152 ± 0.046
2.645PheVal: 2.645 ± 0.061
0.434PheTrp: 0.434 ± 0.019
1.565PheTyr: 1.565 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
5.896GlyAla: 5.896 ± 0.104
1.177GlyCys: 1.177 ± 0.04
4.076GlyAsp: 4.076 ± 0.077
5.099GlyGlu: 5.099 ± 0.092
3.345GlyPhe: 3.345 ± 0.062
5.427GlyGly: 5.427 ± 0.112
1.382GlyHis: 1.382 ± 0.043
6.174GlyIle: 6.174 ± 0.106
5.475GlyLys: 5.475 ± 0.076
5.895GlyLeu: 5.895 ± 0.088
2.685GlyMet: 2.685 ± 0.06
2.968GlyAsn: 2.968 ± 0.068
1.689GlyPro: 1.689 ± 0.05
1.995GlyGln: 1.995 ± 0.047
3.786GlyArg: 3.786 ± 0.071
4.671GlySer: 4.671 ± 0.092
4.767GlyThr: 4.767 ± 0.072
5.187GlyVal: 5.187 ± 0.083
0.777GlyTrp: 0.777 ± 0.038
3.106GlyTyr: 3.106 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.223HisAla: 1.223 ± 0.041
0.292HisCys: 0.292 ± 0.019
0.935HisAsp: 0.935 ± 0.031
1.134HisGlu: 1.134 ± 0.036
0.904HisPhe: 0.904 ± 0.029
1.382HisGly: 1.382 ± 0.04
0.403HisHis: 0.403 ± 0.026
1.353HisIle: 1.353 ± 0.039
0.765HisLys: 0.765 ± 0.033
1.561HisLeu: 1.561 ± 0.044
0.576HisMet: 0.576 ± 0.025
0.649HisAsn: 0.649 ± 0.025
0.969HisPro: 0.969 ± 0.032
0.498HisGln: 0.498 ± 0.023
1.02HisArg: 1.02 ± 0.034
1.001HisSer: 1.001 ± 0.037
0.958HisThr: 0.958 ± 0.029
1.258HisVal: 1.258 ± 0.042
0.161HisTrp: 0.161 ± 0.015
0.779HisTyr: 0.779 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.049IleAla: 6.049 ± 0.091
1.24IleCys: 1.24 ± 0.04
4.142IleAsp: 4.142 ± 0.067
4.156IleGlu: 4.156 ± 0.082
2.535IlePhe: 2.535 ± 0.055
5.279IleGly: 5.279 ± 0.097
1.346IleHis: 1.346 ± 0.041
4.128IleIle: 4.128 ± 0.08
2.644IleLys: 2.644 ± 0.061
6.904IleLeu: 6.904 ± 0.12
1.825IleMet: 1.825 ± 0.046
2.48IleAsn: 2.48 ± 0.053
3.326IlePro: 3.326 ± 0.055
1.861IleGln: 1.861 ± 0.047
5.097IleArg: 5.097 ± 0.085
4.597IleSer: 4.597 ± 0.07
3.868IleThr: 3.868 ± 0.065
4.554IleVal: 4.554 ± 0.079
0.56IleTrp: 0.56 ± 0.026
2.364IleTyr: 2.364 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
4.892LysAla: 4.892 ± 0.083
0.696LysCys: 0.696 ± 0.032
3.585LysAsp: 3.585 ± 0.068
5.175LysGlu: 5.175 ± 0.104
1.614LysPhe: 1.614 ± 0.042
3.665LysGly: 3.665 ± 0.069
0.934LysHis: 0.934 ± 0.03
4.135LysIle: 4.135 ± 0.068
5.199LysLys: 5.199 ± 0.096
4.789LysLeu: 4.789 ± 0.065
2.002LysMet: 2.002 ± 0.051
3.238LysAsn: 3.238 ± 0.058
2.017LysPro: 2.017 ± 0.044
1.735LysGln: 1.735 ± 0.046
2.912LysArg: 2.912 ± 0.057
2.944LysSer: 2.944 ± 0.068
3.915LysThr: 3.915 ± 0.076
3.562LysVal: 3.562 ± 0.071
0.508LysTrp: 0.508 ± 0.026
2.34LysTyr: 2.34 ± 0.052
0.0LysXaa: 0.0 ± 0.0
Leu
7.104LeuAla: 7.104 ± 0.081
1.338LeuCys: 1.338 ± 0.041
5.019LeuAsp: 5.019 ± 0.076
5.704LeuGlu: 5.704 ± 0.086
3.578LeuPhe: 3.578 ± 0.082
5.876LeuGly: 5.876 ± 0.086
1.577LeuHis: 1.577 ± 0.043
5.961LeuIle: 5.961 ± 0.116
5.145LeuLys: 5.145 ± 0.077
7.667LeuLeu: 7.667 ± 0.111
2.634LeuMet: 2.634 ± 0.059
3.635LeuAsn: 3.635 ± 0.065
3.544LeuPro: 3.544 ± 0.068
2.5LeuGln: 2.5 ± 0.058
4.736LeuArg: 4.736 ± 0.085
6.127LeuSer: 6.127 ± 0.083
5.06LeuThr: 5.06 ± 0.082
5.111LeuVal: 5.111 ± 0.075
0.717LeuTrp: 0.717 ± 0.034
2.925LeuTyr: 2.925 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
2.644MetAla: 2.644 ± 0.054
0.34MetCys: 0.34 ± 0.022
1.974MetAsp: 1.974 ± 0.048
2.388MetGlu: 2.388 ± 0.056
1.103MetPhe: 1.103 ± 0.033
2.089MetGly: 2.089 ± 0.054
0.473MetHis: 0.473 ± 0.023
2.448MetIle: 2.448 ± 0.062
2.378MetLys: 2.378 ± 0.053
2.697MetLeu: 2.697 ± 0.055
1.149MetMet: 1.149 ± 0.038
1.664MetAsn: 1.664 ± 0.042
1.194MetPro: 1.194 ± 0.038
0.968MetGln: 0.968 ± 0.028
1.537MetArg: 1.537 ± 0.039
1.85MetSer: 1.85 ± 0.049
2.071MetThr: 2.071 ± 0.05
1.969MetVal: 1.969 ± 0.049
0.199MetTrp: 0.199 ± 0.017
0.863MetTyr: 0.863 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.416AsnAla: 3.416 ± 0.064
0.529AsnCys: 0.529 ± 0.029
2.208AsnAsp: 2.208 ± 0.054
2.555AsnGlu: 2.555 ± 0.055
1.382AsnPhe: 1.382 ± 0.039
3.602AsnGly: 3.602 ± 0.074
0.801AsnHis: 0.801 ± 0.031
2.84AsnIle: 2.84 ± 0.069
1.823AsnLys: 1.823 ± 0.049
3.425AsnLeu: 3.425 ± 0.058
1.268AsnMet: 1.268 ± 0.038
1.432AsnAsn: 1.432 ± 0.049
2.012AsnPro: 2.012 ± 0.043
1.087AsnGln: 1.087 ± 0.037
2.401AsnArg: 2.401 ± 0.049
2.305AsnSer: 2.305 ± 0.055
2.158AsnThr: 2.158 ± 0.048
2.86AsnVal: 2.86 ± 0.064
0.342AsnTrp: 0.342 ± 0.02
1.581AsnTyr: 1.581 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
3.294ProAla: 3.294 ± 0.076
0.42ProCys: 0.42 ± 0.022
2.853ProAsp: 2.853 ± 0.062
4.179ProGlu: 4.179 ± 0.083
1.546ProPhe: 1.546 ± 0.039
2.628ProGly: 2.628 ± 0.057
0.601ProHis: 0.601 ± 0.026
2.012ProIle: 2.012 ± 0.049
1.851ProLys: 1.851 ± 0.044
2.716ProLeu: 2.716 ± 0.05
1.024ProMet: 1.024 ± 0.035
1.248ProAsn: 1.248 ± 0.04
0.695ProPro: 0.695 ± 0.034
1.059ProGln: 1.059 ± 0.034
1.141ProArg: 1.141 ± 0.031
1.857ProSer: 1.857 ± 0.056
1.654ProThr: 1.654 ± 0.044
3.247ProVal: 3.247 ± 0.063
0.324ProTrp: 0.324 ± 0.021
1.382ProTyr: 1.382 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
2.314GlnAla: 2.314 ± 0.059
0.34GlnCys: 0.34 ± 0.019
1.459GlnAsp: 1.459 ± 0.037
2.165GlnGlu: 2.165 ± 0.051
1.096GlnPhe: 1.096 ± 0.033
1.793GlnGly: 1.793 ± 0.048
0.467GlnHis: 0.467 ± 0.022
2.09GlnIle: 2.09 ± 0.047
2.336GlnLys: 2.336 ± 0.053
2.277GlnLeu: 2.277 ± 0.055
1.059GlnMet: 1.059 ± 0.033
1.487GlnAsn: 1.487 ± 0.045
0.839GlnPro: 0.839 ± 0.031
0.921GlnGln: 0.921 ± 0.044
1.301GlnArg: 1.301 ± 0.04
1.495GlnSer: 1.495 ± 0.036
1.644GlnThr: 1.644 ± 0.046
1.726GlnVal: 1.726 ± 0.047
0.295GlnTrp: 0.295 ± 0.017
1.174GlnTyr: 1.174 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
3.631ArgAla: 3.631 ± 0.078
0.663ArgCys: 0.663 ± 0.03
3.121ArgAsp: 3.121 ± 0.064
4.699ArgGlu: 4.699 ± 0.093
2.248ArgPhe: 2.248 ± 0.049
3.141ArgGly: 3.141 ± 0.062
0.931ArgHis: 0.931 ± 0.033
4.468ArgIle: 4.468 ± 0.072
3.993ArgLys: 3.993 ± 0.071
4.305ArgLeu: 4.305 ± 0.071
2.02ArgMet: 2.02 ± 0.052
2.443ArgAsn: 2.443 ± 0.054
1.622ArgPro: 1.622 ± 0.042
1.764ArgGln: 1.764 ± 0.043
3.326ArgArg: 3.326 ± 0.081
2.831ArgSer: 2.831 ± 0.06
2.836ArgThr: 2.836 ± 0.063
3.16ArgVal: 3.16 ± 0.066
0.415ArgTrp: 0.415 ± 0.022
2.162ArgTyr: 2.162 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
5.304SerAla: 5.304 ± 0.094
0.816SerCys: 0.816 ± 0.033
3.611SerAsp: 3.611 ± 0.066
4.248SerGlu: 4.248 ± 0.075
2.634SerPhe: 2.634 ± 0.055
5.882SerGly: 5.882 ± 0.085
0.948SerHis: 0.948 ± 0.033
3.809SerIle: 3.809 ± 0.068
2.802SerLys: 2.802 ± 0.056
5.05SerLeu: 5.05 ± 0.08
1.862SerMet: 1.862 ± 0.051
1.945SerAsn: 1.945 ± 0.052
1.886SerPro: 1.886 ± 0.043
1.476SerGln: 1.476 ± 0.047
3.138SerArg: 3.138 ± 0.067
3.797SerSer: 3.797 ± 0.086
2.817SerThr: 2.817 ± 0.063
4.448SerVal: 4.448 ± 0.063
0.551SerTrp: 0.551 ± 0.026
2.112SerTyr: 2.112 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
5.356ThrAla: 5.356 ± 0.097
0.648ThrCys: 0.648 ± 0.026
3.39ThrAsp: 3.39 ± 0.068
4.217ThrGlu: 4.217 ± 0.09
2.103ThrPhe: 2.103 ± 0.052
5.315ThrGly: 5.315 ± 0.093
0.813ThrHis: 0.813 ± 0.031
3.529ThrIle: 3.529 ± 0.067
2.691ThrLys: 2.691 ± 0.054
4.462ThrLeu: 4.462 ± 0.078
1.502ThrMet: 1.502 ± 0.046
1.882ThrAsn: 1.882 ± 0.045
2.229ThrPro: 2.229 ± 0.049
1.29ThrGln: 1.29 ± 0.04
2.183ThrArg: 2.183 ± 0.045
2.884ThrSer: 2.884 ± 0.055
2.695ThrThr: 2.695 ± 0.061
4.756ThrVal: 4.756 ± 0.081
0.488ThrTrp: 0.488 ± 0.025
1.839ThrTyr: 1.839 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
4.644ValAla: 4.644 ± 0.079
1.178ValCys: 1.178 ± 0.038
3.814ValAsp: 3.814 ± 0.066
4.097ValGlu: 4.097 ± 0.084
3.152ValPhe: 3.152 ± 0.064
4.365ValGly: 4.365 ± 0.084
1.115ValHis: 1.115 ± 0.036
5.132ValIle: 5.132 ± 0.079
3.966ValLys: 3.966 ± 0.072
6.564ValLeu: 6.564 ± 0.082
2.144ValMet: 2.144 ± 0.054
2.707ValAsn: 2.707 ± 0.056
2.859ValPro: 2.859 ± 0.053
1.832ValGln: 1.832 ± 0.041
3.946ValArg: 3.946 ± 0.075
4.672ValSer: 4.672 ± 0.066
4.314ValThr: 4.314 ± 0.084
4.406ValVal: 4.406 ± 0.077
0.668ValTrp: 0.668 ± 0.028
2.565ValTyr: 2.565 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.547TrpAla: 0.547 ± 0.028
0.128TrpCys: 0.128 ± 0.013
0.523TrpAsp: 0.523 ± 0.025
0.586TrpGlu: 0.586 ± 0.027
0.405TrpPhe: 0.405 ± 0.021
0.547TrpGly: 0.547 ± 0.027
0.168TrpHis: 0.168 ± 0.013
0.686TrpIle: 0.686 ± 0.03
0.789TrpLys: 0.789 ± 0.033
0.805TrpLeu: 0.805 ± 0.029
0.332TrpMet: 0.332 ± 0.018
0.489TrpAsn: 0.489 ± 0.023
0.221TrpPro: 0.221 ± 0.016
0.282TrpGln: 0.282 ± 0.018
0.38TrpArg: 0.38 ± 0.019
0.441TrpSer: 0.441 ± 0.024
0.432TrpThr: 0.432 ± 0.024
0.481TrpVal: 0.481 ± 0.024
0.091TrpTrp: 0.091 ± 0.011
0.453TrpTyr: 0.453 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.784TyrAla: 2.784 ± 0.059
0.542TyrCys: 0.542 ± 0.023
2.542TyrAsp: 2.542 ± 0.055
2.552TyrGlu: 2.552 ± 0.05
1.616TyrPhe: 1.616 ± 0.042
2.854TyrGly: 2.854 ± 0.056
0.833TyrHis: 0.833 ± 0.029
2.245TyrIle: 2.245 ± 0.055
1.677TyrLys: 1.677 ± 0.052
3.36TyrLeu: 3.36 ± 0.066
1.039TyrMet: 1.039 ± 0.037
1.418TyrAsn: 1.418 ± 0.039
1.426TyrPro: 1.426 ± 0.046
1.171TyrGln: 1.171 ± 0.036
2.584TyrArg: 2.584 ± 0.064
2.267TyrSer: 2.267 ± 0.05
1.899TyrThr: 1.899 ± 0.049
2.471TyrVal: 2.471 ± 0.049
0.324TyrTrp: 0.324 ± 0.02
1.738TyrTyr: 1.738 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2701 proteins (915300 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski