Amino acid dipepetide frequency for Curtobacterium sp. Leaf261

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.554AlaAla: 20.554 ± 0.222	0.579AlaCys: 0.579 ± 0.024	8.859AlaAsp: 8.859 ± 0.111	7.044AlaGlu: 7.044 ± 0.103	3.884AlaPhe: 3.884 ± 0.064	12.421AlaGly: 12.421 ± 0.121	2.328AlaHis: 2.328 ± 0.05	5.627AlaIle: 5.627 ± 0.075	2.577AlaLys: 2.577 ± 0.07	12.903AlaLeu: 12.903 ± 0.131	2.8AlaMet: 2.8 ± 0.056	2.389AlaAsn: 2.389 ± 0.056	6.718AlaPro: 6.718 ± 0.109	3.27AlaGln: 3.27 ± 0.057	8.857AlaArg: 8.857 ± 0.116	7.846AlaSer: 7.846 ± 0.104	8.799AlaThr: 8.799 ± 0.131	12.477AlaVal: 12.477 ± 0.134	1.878AlaTrp: 1.878 ± 0.043	2.169AlaTyr: 2.169 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.559CysAla: 0.559 ± 0.026	0.04CysCys: 0.04 ± 0.007	0.277CysAsp: 0.277 ± 0.019	0.183CysGlu: 0.183 ± 0.015	0.139CysPhe: 0.139 ± 0.012	0.496CysGly: 0.496 ± 0.023	0.095CysHis: 0.095 ± 0.011	0.181CysIle: 0.181 ± 0.013	0.057CysLys: 0.057 ± 0.008	0.403CysLeu: 0.403 ± 0.019	0.082CysMet: 0.082 ± 0.008	0.101CysAsn: 0.101 ± 0.011	0.225CysPro: 0.225 ± 0.017	0.094CysGln: 0.094 ± 0.009	0.264CysArg: 0.264 ± 0.016	0.377CysSer: 0.377 ± 0.018	0.345CysThr: 0.345 ± 0.021	0.401CysVal: 0.401 ± 0.02	0.06CysTrp: 0.06 ± 0.007	0.098CysTyr: 0.098 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	9.553AspAla: 9.553 ± 0.131	0.23AspCys: 0.23 ± 0.014	5.096AspAsp: 5.096 ± 0.094	3.959AspGlu: 3.959 ± 0.075	1.595AspPhe: 1.595 ± 0.043	7.017AspGly: 7.017 ± 0.109	1.428AspHis: 1.428 ± 0.04	2.166AspIle: 2.166 ± 0.051	0.963AspLys: 0.963 ± 0.034	6.39AspLeu: 6.39 ± 0.089	0.877AspMet: 0.877 ± 0.026	0.866AspAsn: 0.866 ± 0.033	4.336AspPro: 4.336 ± 0.072	1.813AspGln: 1.813 ± 0.047	5.366AspArg: 5.366 ± 0.093	2.7AspSer: 2.7 ± 0.052	3.819AspThr: 3.819 ± 0.074	6.466AspVal: 6.466 ± 0.073	0.964AspTrp: 0.964 ± 0.03	1.057AspTyr: 1.057 ± 0.037	0.002AspXaa: 0.002 ± 0.002
Glu	5.726GluAla: 5.726 ± 0.082	0.19GluCys: 0.19 ± 0.014	2.85GluAsp: 2.85 ± 0.052	2.17GluGlu: 2.17 ± 0.052	1.521GluPhe: 1.521 ± 0.041	3.086GluGly: 3.086 ± 0.062	1.638GluHis: 1.638 ± 0.043	2.14GluIle: 2.14 ± 0.044	0.884GluLys: 0.884 ± 0.032	5.392GluLeu: 5.392 ± 0.086	0.778GluMet: 0.778 ± 0.028	0.957GluAsn: 0.957 ± 0.032	2.87GluPro: 2.87 ± 0.059	2.127GluGln: 2.127 ± 0.048	4.931GluArg: 4.931 ± 0.079	2.745GluSer: 2.745 ± 0.049	2.771GluThr: 2.771 ± 0.051	4.118GluVal: 4.118 ± 0.073	0.704GluTrp: 0.704 ± 0.025	0.98GluTyr: 0.98 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.114PheAla: 4.114 ± 0.064	0.178PheCys: 0.178 ± 0.014	2.296PheAsp: 2.296 ± 0.055	1.402PheGlu: 1.402 ± 0.045	1.025PhePhe: 1.025 ± 0.039	3.28PheGly: 3.28 ± 0.06	0.568PheHis: 0.568 ± 0.025	1.086PheIle: 1.086 ± 0.033	0.408PheLys: 0.408 ± 0.02	2.73PheLeu: 2.73 ± 0.055	0.451PheMet: 0.451 ± 0.021	0.564PheAsn: 0.564 ± 0.021	1.442PhePro: 1.442 ± 0.034	0.748PheGln: 0.748 ± 0.027	2.056PheArg: 2.056 ± 0.043	1.741PheSer: 1.741 ± 0.046	2.119PheThr: 2.119 ± 0.051	3.062PheVal: 3.062 ± 0.061	0.455PheTrp: 0.455 ± 0.02	0.566PheTyr: 0.566 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	11.487GlyAla: 11.487 ± 0.139	0.502GlyCys: 0.502 ± 0.023	5.292GlyAsp: 5.292 ± 0.083	3.802GlyGlu: 3.802 ± 0.07	3.245GlyPhe: 3.245 ± 0.062	8.184GlyGly: 8.184 ± 0.126	2.009GlyHis: 2.009 ± 0.044	4.577GlyIle: 4.577 ± 0.076	1.959GlyLys: 1.959 ± 0.056	8.641GlyLeu: 8.641 ± 0.096	1.805GlyMet: 1.805 ± 0.035	1.872GlyAsn: 1.872 ± 0.051	4.256GlyPro: 4.256 ± 0.072	2.678GlyGln: 2.678 ± 0.067	6.652GlyArg: 6.652 ± 0.084	6.609GlySer: 6.609 ± 0.093	6.955GlyThr: 6.955 ± 0.125	8.513GlyVal: 8.513 ± 0.092	1.616GlyTrp: 1.616 ± 0.043	2.153GlyTyr: 2.153 ± 0.052	0.002GlyXaa: 0.002 ± 0.001
His	2.463HisAla: 2.463 ± 0.055	0.105HisCys: 0.105 ± 0.01	1.574HisAsp: 1.574 ± 0.038	1.147HisGlu: 1.147 ± 0.035	0.534HisPhe: 0.534 ± 0.024	2.162HisGly: 2.162 ± 0.055	0.57HisHis: 0.57 ± 0.022	0.649HisIle: 0.649 ± 0.026	0.213HisLys: 0.213 ± 0.016	1.968HisLeu: 1.968 ± 0.046	0.334HisMet: 0.334 ± 0.019	0.291HisAsn: 0.291 ± 0.014	1.427HisPro: 1.427 ± 0.038	0.535HisGln: 0.535 ± 0.019	1.799HisArg: 1.799 ± 0.043	0.891HisSer: 0.891 ± 0.028	1.078HisThr: 1.078 ± 0.036	1.862HisVal: 1.862 ± 0.051	0.293HisTrp: 0.293 ± 0.017	0.332HisTyr: 0.332 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.685IleAla: 6.685 ± 0.09	0.203IleCys: 0.203 ± 0.014	3.343IleAsp: 3.343 ± 0.058	2.275IleGlu: 2.275 ± 0.049	0.768IlePhe: 0.768 ± 0.036	4.789IleGly: 4.789 ± 0.075	0.628IleHis: 0.628 ± 0.024	1.474IleIle: 1.474 ± 0.048	0.714IleLys: 0.714 ± 0.027	3.023IleLeu: 3.023 ± 0.062	0.543IleMet: 0.543 ± 0.024	0.757IleAsn: 0.757 ± 0.028	2.122IlePro: 2.122 ± 0.06	0.92IleGln: 0.92 ± 0.033	2.678IleArg: 2.678 ± 0.051	2.023IleSer: 2.023 ± 0.045	2.927IleThr: 2.927 ± 0.061	4.669IleVal: 4.669 ± 0.08	0.477IleTrp: 0.477 ± 0.023	0.575IleTyr: 0.575 ± 0.023	0.001IleXaa: 0.001 ± 0.001
Lys	2.126LysAla: 2.126 ± 0.062	0.055LysCys: 0.055 ± 0.008	1.14LysAsp: 1.14 ± 0.046	0.744LysGlu: 0.744 ± 0.032	0.489LysPhe: 0.489 ± 0.021	1.478LysGly: 1.478 ± 0.044	0.437LysHis: 0.437 ± 0.022	0.809LysIle: 0.809 ± 0.029	0.679LysLys: 0.679 ± 0.032	1.569LysLeu: 1.569 ± 0.041	0.339LysMet: 0.339 ± 0.016	0.499LysAsn: 0.499 ± 0.023	1.05LysPro: 1.05 ± 0.033	0.752LysGln: 0.752 ± 0.027	1.303LysArg: 1.303 ± 0.042	1.128LysSer: 1.128 ± 0.035	1.31LysThr: 1.31 ± 0.04	1.555LysVal: 1.555 ± 0.043	0.235LysTrp: 0.235 ± 0.016	0.432LysTyr: 0.432 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	13.209LeuAla: 13.209 ± 0.141	0.406LeuCys: 0.406 ± 0.02	6.754LeuAsp: 6.754 ± 0.098	4.664LeuGlu: 4.664 ± 0.084	2.661LeuPhe: 2.661 ± 0.056	9.23LeuGly: 9.23 ± 0.109	1.865LeuHis: 1.865 ± 0.043	3.277LeuIle: 3.277 ± 0.077	1.351LeuLys: 1.351 ± 0.041	8.967LeuLeu: 8.967 ± 0.134	1.4LeuMet: 1.4 ± 0.036	1.445LeuAsn: 1.445 ± 0.04	5.31LeuPro: 5.31 ± 0.089	2.49LeuGln: 2.49 ± 0.049	7.071LeuArg: 7.071 ± 0.094	5.028LeuSer: 5.028 ± 0.074	6.107LeuThr: 6.107 ± 0.083	10.31LeuVal: 10.31 ± 0.127	1.159LeuTrp: 1.159 ± 0.035	1.448LeuTyr: 1.448 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.014MetAla: 2.014 ± 0.05	0.075MetCys: 0.075 ± 0.008	0.916MetAsp: 0.916 ± 0.031	0.572MetGlu: 0.572 ± 0.026	0.522MetPhe: 0.522 ± 0.024	1.226MetGly: 1.226 ± 0.037	0.427MetHis: 0.427 ± 0.02	0.754MetIle: 0.754 ± 0.024	0.31MetLys: 0.31 ± 0.017	1.85MetLeu: 1.85 ± 0.042	0.277MetMet: 0.277 ± 0.017	0.402MetAsn: 0.402 ± 0.017	1.138MetPro: 1.138 ± 0.03	0.55MetGln: 0.55 ± 0.02	1.364MetArg: 1.364 ± 0.04	1.409MetSer: 1.409 ± 0.038	1.794MetThr: 1.794 ± 0.04	1.387MetVal: 1.387 ± 0.039	0.219MetTrp: 0.219 ± 0.014	0.258MetTyr: 0.258 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.496AsnAla: 2.496 ± 0.052	0.102AsnCys: 0.102 ± 0.011	1.248AsnAsp: 1.248 ± 0.038	0.828AsnGlu: 0.828 ± 0.03	0.533AsnPhe: 0.533 ± 0.024	2.064AsnGly: 2.064 ± 0.055	0.385AsnHis: 0.385 ± 0.019	0.709AsnIle: 0.709 ± 0.03	0.375AsnLys: 0.375 ± 0.019	1.654AsnLeu: 1.654 ± 0.045	0.288AsnMet: 0.288 ± 0.018	0.419AsnAsn: 0.419 ± 0.021	1.359AsnPro: 1.359 ± 0.036	0.533AsnGln: 0.533 ± 0.021	1.207AsnArg: 1.207 ± 0.037	0.947AsnSer: 0.947 ± 0.034	1.263AsnThr: 1.263 ± 0.042	1.642AsnVal: 1.642 ± 0.043	0.293AsnTrp: 0.293 ± 0.018	0.444AsnTyr: 0.444 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.166ProAla: 7.166 ± 0.109	0.171ProCys: 0.171 ± 0.013	4.269ProAsp: 4.269 ± 0.075	3.313ProGlu: 3.313 ± 0.066	1.722ProPhe: 1.722 ± 0.035	5.258ProGly: 5.258 ± 0.078	0.988ProHis: 0.988 ± 0.032	2.043ProIle: 2.043 ± 0.05	1.087ProLys: 1.087 ± 0.035	4.426ProLeu: 4.426 ± 0.073	0.949ProMet: 0.949 ± 0.031	1.077ProAsn: 1.077 ± 0.031	2.043ProPro: 2.043 ± 0.063	1.331ProGln: 1.331 ± 0.044	3.237ProArg: 3.237 ± 0.069	3.72ProSer: 3.72 ± 0.063	4.107ProThr: 4.107 ± 0.07	5.289ProVal: 5.289 ± 0.083	0.842ProTrp: 0.842 ± 0.029	0.994ProTyr: 0.994 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.366GlnAla: 3.366 ± 0.066	0.098GlnCys: 0.098 ± 0.009	1.592GlnAsp: 1.592 ± 0.033	1.185GlnGlu: 1.185 ± 0.032	0.902GlnPhe: 0.902 ± 0.031	2.04GlnGly: 2.04 ± 0.05	0.729GlnHis: 0.729 ± 0.031	1.334GlnIle: 1.334 ± 0.035	0.64GlnLys: 0.64 ± 0.023	2.836GlnLeu: 2.836 ± 0.056	0.452GlnMet: 0.452 ± 0.022	0.64GlnAsn: 0.64 ± 0.026	1.541GlnPro: 1.541 ± 0.053	1.318GlnGln: 1.318 ± 0.056	2.267GlnArg: 2.267 ± 0.05	1.602GlnSer: 1.602 ± 0.041	1.663GlnThr: 1.663 ± 0.051	2.396GlnVal: 2.396 ± 0.046	0.406GlnTrp: 0.406 ± 0.018	0.693GlnTyr: 0.693 ± 0.031	0.001GlnXaa: 0.001 ± 0.001
Arg	9.167ArgAla: 9.167 ± 0.109	0.272ArgCys: 0.272 ± 0.017	4.266ArgAsp: 4.266 ± 0.067	3.615ArgGlu: 3.615 ± 0.076	2.448ArgPhe: 2.448 ± 0.049	5.409ArgGly: 5.409 ± 0.076	1.536ArgHis: 1.536 ± 0.038	3.6ArgIle: 3.6 ± 0.054	1.252ArgLys: 1.252 ± 0.038	6.674ArgLeu: 6.674 ± 0.094	1.701ArgMet: 1.701 ± 0.045	1.398ArgAsn: 1.398 ± 0.034	3.958ArgPro: 3.958 ± 0.072	2.05ArgGln: 2.05 ± 0.041	6.572ArgArg: 6.572 ± 0.106	4.767ArgSer: 4.767 ± 0.072	5.021ArgThr: 5.021 ± 0.073	6.299ArgVal: 6.299 ± 0.094	1.25ArgTrp: 1.25 ± 0.036	1.497ArgTyr: 1.497 ± 0.037	0.003ArgXaa: 0.003 ± 0.003
Ser	7.904SerAla: 7.904 ± 0.112	0.282SerCys: 0.282 ± 0.018	3.776SerAsp: 3.776 ± 0.068	2.413SerGlu: 2.413 ± 0.053	1.928SerPhe: 1.928 ± 0.043	6.634SerGly: 6.634 ± 0.112	0.971SerHis: 0.971 ± 0.028	2.717SerIle: 2.717 ± 0.06	1.161SerLys: 1.161 ± 0.034	5.052SerLeu: 5.052 ± 0.071	1.207SerMet: 1.207 ± 0.035	1.192SerAsn: 1.192 ± 0.036	2.933SerPro: 2.933 ± 0.054	1.395SerGln: 1.395 ± 0.037	3.708SerArg: 3.708 ± 0.063	4.066SerSer: 4.066 ± 0.086	4.608SerThr: 4.608 ± 0.084	5.431SerVal: 5.431 ± 0.079	0.972SerTrp: 0.972 ± 0.034	1.148SerTyr: 1.148 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	9.248ThrAla: 9.248 ± 0.14	0.318ThrCys: 0.318 ± 0.02	4.343ThrAsp: 4.343 ± 0.074	2.921ThrGlu: 2.921 ± 0.049	2.025ThrPhe: 2.025 ± 0.05	6.706ThrGly: 6.706 ± 0.115	1.136ThrHis: 1.136 ± 0.028	3.2ThrIle: 3.2 ± 0.064	1.393ThrLys: 1.393 ± 0.045	6.086ThrLeu: 6.086 ± 0.079	1.171ThrMet: 1.171 ± 0.035	1.45ThrAsn: 1.45 ± 0.045	4.349ThrPro: 4.349 ± 0.077	1.495ThrGln: 1.495 ± 0.05	3.979ThrArg: 3.979 ± 0.064	4.314ThrSer: 4.314 ± 0.079	5.577ThrThr: 5.577 ± 0.124	7.089ThrVal: 7.089 ± 0.149	1.03ThrTrp: 1.03 ± 0.035	1.31ThrTyr: 1.31 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	12.488ValAla: 12.488 ± 0.128	0.46ValCys: 0.46 ± 0.021	6.632ValAsp: 6.632 ± 0.082	4.801ValGlu: 4.801 ± 0.092	3.087ValPhe: 3.087 ± 0.054	8.369ValGly: 8.369 ± 0.102	1.894ValHis: 1.894 ± 0.041	3.993ValIle: 3.993 ± 0.069	1.459ValLys: 1.459 ± 0.045	10.175ValLeu: 10.175 ± 0.127	1.457ValMet: 1.457 ± 0.034	1.628ValAsn: 1.628 ± 0.04	5.358ValPro: 5.358 ± 0.083	2.489ValGln: 2.489 ± 0.054	6.764ValArg: 6.764 ± 0.088	5.378ValSer: 5.378 ± 0.07	6.606ValThr: 6.606 ± 0.127	11.067ValVal: 11.067 ± 0.145	1.135ValTrp: 1.135 ± 0.034	1.496ValTyr: 1.496 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.479TrpAla: 1.479 ± 0.038	0.108TrpCys: 0.108 ± 0.011	0.824TrpAsp: 0.824 ± 0.031	0.56TrpGlu: 0.56 ± 0.024	0.623TrpPhe: 0.623 ± 0.027	1.074TrpGly: 1.074 ± 0.037	0.311TrpHis: 0.311 ± 0.016	0.687TrpIle: 0.687 ± 0.027	0.313TrpLys: 0.313 ± 0.02	1.551TrpLeu: 1.551 ± 0.04	0.305TrpMet: 0.305 ± 0.018	0.439TrpAsn: 0.439 ± 0.02	0.66TrpPro: 0.66 ± 0.024	0.561TrpGln: 0.561 ± 0.025	1.196TrpArg: 1.196 ± 0.032	1.122TrpSer: 1.122 ± 0.039	1.076TrpThr: 1.076 ± 0.037	1.113TrpVal: 1.113 ± 0.033	0.342TrpTrp: 0.342 ± 0.018	0.282TrpTyr: 0.282 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.174TyrAla: 2.174 ± 0.046	0.106TyrCys: 0.106 ± 0.01	1.317TyrAsp: 1.317 ± 0.033	0.977TyrGlu: 0.977 ± 0.032	0.636TyrPhe: 0.636 ± 0.026	1.886TyrGly: 1.886 ± 0.053	0.283TyrHis: 0.283 ± 0.016	0.568TyrIle: 0.568 ± 0.026	0.333TyrLys: 0.333 ± 0.019	1.86TyrLeu: 1.86 ± 0.049	0.248TyrMet: 0.248 ± 0.015	0.405TyrAsn: 0.405 ± 0.021	0.94TyrPro: 0.94 ± 0.029	0.551TyrGln: 0.551 ± 0.023	1.482TyrArg: 1.482 ± 0.038	1.088TyrSer: 1.088 ± 0.038	1.193TyrThr: 1.193 ± 0.048	1.589TyrVal: 1.589 ± 0.038	0.296TyrTrp: 0.296 ± 0.019	0.421TyrTyr: 0.421 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.004XaaArg: 0.004 ± 0.003	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 3343 proteins (1097335 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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