Amino acid dipepetide frequency for Pseudomonas phage vB_PaeP_130_113

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.494AlaAla: 13.494 ± 1.473
1.071AlaCys: 1.071 ± 0.304
5.569AlaAsp: 5.569 ± 0.607
8.282AlaGlu: 8.282 ± 0.859
4.141AlaPhe: 4.141 ± 0.474
10.281AlaGly: 10.281 ± 1.184
1.856AlaHis: 1.856 ± 0.385
3.855AlaIle: 3.855 ± 0.621
5.926AlaLys: 5.926 ± 0.969
11.566AlaLeu: 11.566 ± 1.041
3.427AlaMet: 3.427 ± 0.485
2.785AlaAsn: 2.785 ± 0.611
4.569AlaPro: 4.569 ± 0.811
5.783AlaGln: 5.783 ± 0.75
5.283AlaArg: 5.283 ± 0.644
4.141AlaSer: 4.141 ± 0.594
6.569AlaThr: 6.569 ± 0.647
8.282AlaVal: 8.282 ± 0.987
1.285AlaTrp: 1.285 ± 0.201
2.713AlaTyr: 2.713 ± 0.582
0.0AlaXaa: 0.0 ± 0.0
Cys
1.214CysAla: 1.214 ± 0.329
0.143CysCys: 0.143 ± 0.131
0.571CysAsp: 0.571 ± 0.212
0.571CysGlu: 0.571 ± 0.175
0.286CysPhe: 0.286 ± 0.138
1.071CysGly: 1.071 ± 0.386
0.428CysHis: 0.428 ± 0.2
0.571CysIle: 0.571 ± 0.33
0.357CysLys: 0.357 ± 0.177
1.285CysLeu: 1.285 ± 0.401
0.357CysMet: 0.357 ± 0.173
0.214CysAsn: 0.214 ± 0.13
0.357CysPro: 0.357 ± 0.154
0.928CysGln: 0.928 ± 0.318
0.571CysArg: 0.571 ± 0.277
0.428CysSer: 0.428 ± 0.202
0.643CysThr: 0.643 ± 0.214
0.428CysVal: 0.428 ± 0.189
0.143CysTrp: 0.143 ± 0.152
0.5CysTyr: 0.5 ± 0.231
0.0CysXaa: 0.0 ± 0.0
Asp
6.354AspAla: 6.354 ± 0.562
0.357AspCys: 0.357 ± 0.146
2.856AspAsp: 2.856 ± 0.402
4.498AspGlu: 4.498 ± 0.536
1.856AspPhe: 1.856 ± 0.408
4.998AspGly: 4.998 ± 0.684
1.0AspHis: 1.0 ± 0.253
3.356AspIle: 3.356 ± 0.34
2.356AspLys: 2.356 ± 0.476
5.212AspLeu: 5.212 ± 0.456
1.642AspMet: 1.642 ± 0.292
1.928AspAsn: 1.928 ± 0.376
3.713AspPro: 3.713 ± 0.448
1.928AspGln: 1.928 ± 0.431
3.855AspArg: 3.855 ± 0.517
2.999AspSer: 2.999 ± 0.368
3.855AspThr: 3.855 ± 0.577
3.427AspVal: 3.427 ± 0.557
0.928AspTrp: 0.928 ± 0.186
1.856AspTyr: 1.856 ± 0.412
0.0AspXaa: 0.0 ± 0.0
Glu
8.711GluAla: 8.711 ± 0.957
0.286GluCys: 0.286 ± 0.149
2.927GluAsp: 2.927 ± 0.445
3.855GluGlu: 3.855 ± 0.542
2.142GluPhe: 2.142 ± 0.346
4.355GluGly: 4.355 ± 0.556
1.642GluHis: 1.642 ± 0.288
2.713GluIle: 2.713 ± 0.47
1.928GluLys: 1.928 ± 0.437
5.997GluLeu: 5.997 ± 0.557
2.213GluMet: 2.213 ± 0.366
1.785GluAsn: 1.785 ± 0.342
1.142GluPro: 1.142 ± 0.329
3.213GluGln: 3.213 ± 0.474
3.998GluArg: 3.998 ± 0.62
2.499GluSer: 2.499 ± 0.499
2.213GluThr: 2.213 ± 0.37
5.141GluVal: 5.141 ± 0.626
0.857GluTrp: 0.857 ± 0.204
2.213GluTyr: 2.213 ± 0.424
0.0GluXaa: 0.0 ± 0.0
Phe
2.57PheAla: 2.57 ± 0.412
0.428PheCys: 0.428 ± 0.16
2.57PheAsp: 2.57 ± 0.43
2.071PheGlu: 2.071 ± 0.379
1.142PhePhe: 1.142 ± 0.258
1.714PheGly: 1.714 ± 0.331
0.714PheHis: 0.714 ± 0.185
1.428PheIle: 1.428 ± 0.25
1.785PheLys: 1.785 ± 0.279
2.57PheLeu: 2.57 ± 0.411
0.928PheMet: 0.928 ± 0.235
1.642PheAsn: 1.642 ± 0.313
2.285PhePro: 2.285 ± 0.363
1.499PheGln: 1.499 ± 0.248
2.499PheArg: 2.499 ± 0.416
2.428PheSer: 2.428 ± 0.503
1.214PheThr: 1.214 ± 0.272
1.785PheVal: 1.785 ± 0.285
0.428PheTrp: 0.428 ± 0.164
0.785PheTyr: 0.785 ± 0.239
0.0PheXaa: 0.0 ± 0.0
Gly
7.425GlyAla: 7.425 ± 0.85
1.071GlyCys: 1.071 ± 0.28
4.141GlyAsp: 4.141 ± 0.414
3.927GlyGlu: 3.927 ± 0.546
3.142GlyPhe: 3.142 ± 0.505
5.569GlyGly: 5.569 ± 0.639
1.0GlyHis: 1.0 ± 0.221
4.141GlyIle: 4.141 ± 0.477
4.07GlyLys: 4.07 ± 0.556
7.14GlyLeu: 7.14 ± 0.757
2.785GlyMet: 2.785 ± 0.405
1.928GlyAsn: 1.928 ± 0.401
2.428GlyPro: 2.428 ± 0.388
3.57GlyGln: 3.57 ± 0.499
6.212GlyArg: 6.212 ± 0.68
4.355GlySer: 4.355 ± 0.444
5.64GlyThr: 5.64 ± 0.576
6.212GlyVal: 6.212 ± 0.717
1.785GlyTrp: 1.785 ± 0.42
2.57GlyTyr: 2.57 ± 0.445
0.0GlyXaa: 0.0 ± 0.0
His
1.357HisAla: 1.357 ± 0.401
0.286HisCys: 0.286 ± 0.144
1.071HisAsp: 1.071 ± 0.241
1.642HisGlu: 1.642 ± 0.384
0.5HisPhe: 0.5 ± 0.222
1.071HisGly: 1.071 ± 0.273
0.5HisHis: 0.5 ± 0.2
0.785HisIle: 0.785 ± 0.32
1.0HisLys: 1.0 ± 0.35
2.213HisLeu: 2.213 ± 0.429
0.571HisMet: 0.571 ± 0.233
0.857HisAsn: 0.857 ± 0.196
0.785HisPro: 0.785 ± 0.26
0.928HisGln: 0.928 ± 0.226
1.856HisArg: 1.856 ± 0.441
0.928HisSer: 0.928 ± 0.298
1.214HisThr: 1.214 ± 0.268
1.999HisVal: 1.999 ± 0.405
0.428HisTrp: 0.428 ± 0.152
0.571HisTyr: 0.571 ± 0.218
0.0HisXaa: 0.0 ± 0.0
Ile
4.998IleAla: 4.998 ± 0.691
0.428IleCys: 0.428 ± 0.185
3.499IleAsp: 3.499 ± 0.628
2.856IleGlu: 2.856 ± 0.372
1.142IlePhe: 1.142 ± 0.304
2.071IleGly: 2.071 ± 0.373
1.285IleHis: 1.285 ± 0.29
1.642IleIle: 1.642 ± 0.389
2.642IleLys: 2.642 ± 0.475
2.642IleLeu: 2.642 ± 0.59
1.285IleMet: 1.285 ± 0.302
1.928IleAsn: 1.928 ± 0.26
2.499IlePro: 2.499 ± 0.378
1.856IleGln: 1.856 ± 0.322
3.142IleArg: 3.142 ± 0.497
1.499IleSer: 1.499 ± 0.359
2.285IleThr: 2.285 ± 0.453
3.142IleVal: 3.142 ± 0.505
0.357IleTrp: 0.357 ± 0.16
1.0IleTyr: 1.0 ± 0.264
0.0IleXaa: 0.0 ± 0.0
Lys
6.069LysAla: 6.069 ± 0.755
0.214LysCys: 0.214 ± 0.121
2.927LysAsp: 2.927 ± 0.524
2.142LysGlu: 2.142 ± 0.429
1.642LysPhe: 1.642 ± 0.284
4.569LysGly: 4.569 ± 0.591
0.785LysHis: 0.785 ± 0.292
1.071LysIle: 1.071 ± 0.317
1.785LysLys: 1.785 ± 0.468
4.07LysLeu: 4.07 ± 0.712
1.856LysMet: 1.856 ± 0.333
1.0LysAsn: 1.0 ± 0.307
2.285LysPro: 2.285 ± 0.362
2.642LysGln: 2.642 ± 0.431
2.927LysArg: 2.927 ± 0.479
1.928LysSer: 1.928 ± 0.433
1.928LysThr: 1.928 ± 0.353
3.427LysVal: 3.427 ± 0.503
0.571LysTrp: 0.571 ± 0.202
1.071LysTyr: 1.071 ± 0.286
0.0LysXaa: 0.0 ± 0.0
Leu
10.567LeuAla: 10.567 ± 0.911
1.642LeuCys: 1.642 ± 0.551
6.854LeuAsp: 6.854 ± 0.717
5.212LeuGlu: 5.212 ± 0.661
1.714LeuPhe: 1.714 ± 0.388
7.711LeuGly: 7.711 ± 0.761
2.713LeuHis: 2.713 ± 0.469
3.784LeuIle: 3.784 ± 0.488
3.284LeuLys: 3.284 ± 0.386
7.497LeuLeu: 7.497 ± 0.722
2.142LeuMet: 2.142 ± 0.388
3.641LeuAsn: 3.641 ± 0.546
4.712LeuPro: 4.712 ± 0.674
3.356LeuGln: 3.356 ± 0.434
6.926LeuArg: 6.926 ± 0.675
5.069LeuSer: 5.069 ± 0.608
5.212LeuThr: 5.212 ± 0.61
4.926LeuVal: 4.926 ± 0.628
1.571LeuTrp: 1.571 ± 0.28
3.427LeuTyr: 3.427 ± 0.538
0.0LeuXaa: 0.0 ± 0.0
Met
3.998MetAla: 3.998 ± 0.517
0.0MetCys: 0.0 ± 0.0
2.285MetAsp: 2.285 ± 0.289
1.428MetGlu: 1.428 ± 0.306
0.643MetPhe: 0.643 ± 0.255
2.142MetGly: 2.142 ± 0.331
0.785MetHis: 0.785 ± 0.275
0.571MetIle: 0.571 ± 0.199
1.142MetLys: 1.142 ± 0.326
2.785MetLeu: 2.785 ± 0.461
0.928MetMet: 0.928 ± 0.315
1.214MetAsn: 1.214 ± 0.358
1.428MetPro: 1.428 ± 0.365
1.571MetGln: 1.571 ± 0.44
1.499MetArg: 1.499 ± 0.302
2.356MetSer: 2.356 ± 0.435
2.927MetThr: 2.927 ± 0.338
0.928MetVal: 0.928 ± 0.232
0.286MetTrp: 0.286 ± 0.122
0.714MetTyr: 0.714 ± 0.195
0.0MetXaa: 0.0 ± 0.0
Asn
3.57AsnAla: 3.57 ± 0.539
0.071AsnCys: 0.071 ± 0.077
1.357AsnAsp: 1.357 ± 0.297
2.071AsnGlu: 2.071 ± 0.281
1.0AsnPhe: 1.0 ± 0.272
2.499AsnGly: 2.499 ± 0.39
0.571AsnHis: 0.571 ± 0.185
1.142AsnIle: 1.142 ± 0.339
1.999AsnLys: 1.999 ± 0.352
3.713AsnLeu: 3.713 ± 0.561
0.785AsnMet: 0.785 ± 0.193
1.285AsnAsn: 1.285 ± 0.358
2.142AsnPro: 2.142 ± 0.348
1.571AsnGln: 1.571 ± 0.415
1.928AsnArg: 1.928 ± 0.33
1.357AsnSer: 1.357 ± 0.408
2.213AsnThr: 2.213 ± 0.39
3.641AsnVal: 3.641 ± 0.682
1.285AsnTrp: 1.285 ± 0.354
1.357AsnTyr: 1.357 ± 0.316
0.0AsnXaa: 0.0 ± 0.0
Pro
4.926ProAla: 4.926 ± 0.91
0.5ProCys: 0.5 ± 0.198
1.856ProAsp: 1.856 ± 0.45
3.855ProGlu: 3.855 ± 0.492
1.357ProPhe: 1.357 ± 0.29
4.355ProGly: 4.355 ± 0.662
0.785ProHis: 0.785 ± 0.24
1.571ProIle: 1.571 ± 0.311
2.57ProLys: 2.57 ± 0.342
4.641ProLeu: 4.641 ± 0.715
0.643ProMet: 0.643 ± 0.177
2.071ProAsn: 2.071 ± 0.45
1.714ProPro: 1.714 ± 0.623
1.642ProGln: 1.642 ± 0.645
2.785ProArg: 2.785 ± 0.533
2.785ProSer: 2.785 ± 0.436
2.856ProThr: 2.856 ± 0.461
3.07ProVal: 3.07 ± 0.665
1.142ProTrp: 1.142 ± 0.311
1.428ProTyr: 1.428 ± 0.307
0.0ProXaa: 0.0 ± 0.0
Gln
6.997GlnAla: 6.997 ± 1.02
0.643GlnCys: 0.643 ± 0.211
2.142GlnAsp: 2.142 ± 0.317
2.713GlnGlu: 2.713 ± 0.492
1.499GlnPhe: 1.499 ± 0.377
4.07GlnGly: 4.07 ± 0.425
0.785GlnHis: 0.785 ± 0.245
2.142GlnIle: 2.142 ± 0.312
1.142GlnLys: 1.142 ± 0.214
3.713GlnLeu: 3.713 ± 0.601
1.0GlnMet: 1.0 ± 0.226
1.357GlnAsn: 1.357 ± 0.263
1.999GlnPro: 1.999 ± 0.718
2.642GlnGln: 2.642 ± 0.486
3.213GlnArg: 3.213 ± 0.501
1.928GlnSer: 1.928 ± 0.384
1.714GlnThr: 1.714 ± 0.335
3.499GlnVal: 3.499 ± 0.554
0.857GlnTrp: 0.857 ± 0.269
1.928GlnTyr: 1.928 ± 0.347
0.0GlnXaa: 0.0 ± 0.0
Arg
6.64ArgAla: 6.64 ± 0.994
0.785ArgCys: 0.785 ± 0.273
4.784ArgAsp: 4.784 ± 0.475
3.784ArgGlu: 3.784 ± 0.556
2.999ArgPhe: 2.999 ± 0.564
4.569ArgGly: 4.569 ± 0.482
1.071ArgHis: 1.071 ± 0.273
3.213ArgIle: 3.213 ± 0.53
3.284ArgLys: 3.284 ± 0.625
5.712ArgLeu: 5.712 ± 0.564
2.285ArgMet: 2.285 ± 0.434
3.356ArgAsn: 3.356 ± 0.481
2.927ArgPro: 2.927 ± 0.514
2.785ArgGln: 2.785 ± 0.379
6.069ArgArg: 6.069 ± 0.657
4.07ArgSer: 4.07 ± 0.618
3.284ArgThr: 3.284 ± 0.45
4.141ArgVal: 4.141 ± 0.58
1.642ArgTrp: 1.642 ± 0.325
1.999ArgTyr: 1.999 ± 0.402
0.0ArgXaa: 0.0 ± 0.0
Ser
4.998SerAla: 4.998 ± 0.535
0.714SerCys: 0.714 ± 0.285
2.999SerAsp: 2.999 ± 0.334
3.142SerGlu: 3.142 ± 0.45
1.357SerPhe: 1.357 ± 0.268
4.712SerGly: 4.712 ± 0.544
0.643SerHis: 0.643 ± 0.251
2.356SerIle: 2.356 ± 0.523
2.57SerLys: 2.57 ± 0.353
5.212SerLeu: 5.212 ± 0.63
1.571SerMet: 1.571 ± 0.255
1.642SerAsn: 1.642 ± 0.314
2.142SerPro: 2.142 ± 0.332
2.213SerGln: 2.213 ± 0.396
4.427SerArg: 4.427 ± 0.668
1.642SerSer: 1.642 ± 0.446
2.213SerThr: 2.213 ± 0.493
3.142SerVal: 3.142 ± 0.456
0.643SerTrp: 0.643 ± 0.187
1.642SerTyr: 1.642 ± 0.331
0.0SerXaa: 0.0 ± 0.0
Thr
6.783ThrAla: 6.783 ± 0.776
0.857ThrCys: 0.857 ± 0.234
3.284ThrAsp: 3.284 ± 0.549
2.071ThrGlu: 2.071 ± 0.395
1.999ThrPhe: 1.999 ± 0.362
4.284ThrGly: 4.284 ± 0.517
1.571ThrHis: 1.571 ± 0.292
3.213ThrIle: 3.213 ± 0.402
2.642ThrLys: 2.642 ± 0.435
4.284ThrLeu: 4.284 ± 0.461
1.142ThrMet: 1.142 ± 0.337
1.856ThrAsn: 1.856 ± 0.371
3.284ThrPro: 3.284 ± 0.453
2.499ThrGln: 2.499 ± 0.417
2.499ThrArg: 2.499 ± 0.448
3.356ThrSer: 3.356 ± 0.477
2.57ThrThr: 2.57 ± 0.451
2.927ThrVal: 2.927 ± 0.52
1.214ThrTrp: 1.214 ± 0.27
1.999ThrTyr: 1.999 ± 0.302
0.0ThrXaa: 0.0 ± 0.0
Val
6.783ValAla: 6.783 ± 0.647
1.071ValCys: 1.071 ± 0.247
4.784ValAsp: 4.784 ± 0.622
3.499ValGlu: 3.499 ± 0.534
2.356ValPhe: 2.356 ± 0.368
5.64ValGly: 5.64 ± 0.812
1.428ValHis: 1.428 ± 0.425
2.713ValIle: 2.713 ± 0.509
2.713ValLys: 2.713 ± 0.432
6.711ValLeu: 6.711 ± 0.646
2.713ValMet: 2.713 ± 0.533
2.428ValAsn: 2.428 ± 0.313
3.213ValPro: 3.213 ± 0.789
3.142ValGln: 3.142 ± 0.516
5.64ValArg: 5.64 ± 0.63
2.57ValSer: 2.57 ± 0.437
2.999ValThr: 2.999 ± 0.537
5.355ValVal: 5.355 ± 0.746
0.5ValTrp: 0.5 ± 0.183
2.142ValTyr: 2.142 ± 0.462
0.0ValXaa: 0.0 ± 0.0
Trp
1.285TrpAla: 1.285 ± 0.293
0.357TrpCys: 0.357 ± 0.147
1.142TrpAsp: 1.142 ± 0.317
0.571TrpGlu: 0.571 ± 0.191
0.714TrpPhe: 0.714 ± 0.247
0.928TrpGly: 0.928 ± 0.3
0.143TrpHis: 0.143 ± 0.098
0.714TrpIle: 0.714 ± 0.31
0.643TrpLys: 0.643 ± 0.195
1.856TrpLeu: 1.856 ± 0.422
0.5TrpMet: 0.5 ± 0.184
1.285TrpAsn: 1.285 ± 0.3
0.857TrpPro: 0.857 ± 0.272
0.714TrpGln: 0.714 ± 0.258
1.499TrpArg: 1.499 ± 0.329
1.285TrpSer: 1.285 ± 0.304
0.643TrpThr: 0.643 ± 0.177
0.857TrpVal: 0.857 ± 0.27
0.214TrpTrp: 0.214 ± 0.162
0.785TrpTyr: 0.785 ± 0.251
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.142TyrAla: 2.142 ± 0.464
0.143TyrCys: 0.143 ± 0.096
1.357TyrAsp: 1.357 ± 0.355
1.642TyrGlu: 1.642 ± 0.263
0.857TyrPhe: 0.857 ± 0.249
2.499TyrGly: 2.499 ± 0.363
0.857TyrHis: 0.857 ± 0.224
1.214TyrIle: 1.214 ± 0.303
1.142TyrLys: 1.142 ± 0.337
3.142TyrLeu: 3.142 ± 0.437
0.785TyrMet: 0.785 ± 0.241
1.357TyrAsn: 1.357 ± 0.295
2.071TyrPro: 2.071 ± 0.396
1.499TyrGln: 1.499 ± 0.306
2.57TyrArg: 2.57 ± 0.371
2.356TyrSer: 2.356 ± 0.381
2.142TyrThr: 2.142 ± 0.349
2.071TyrVal: 2.071 ± 0.381
0.857TyrTrp: 0.857 ± 0.2
0.5TyrTyr: 0.5 ± 0.293
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 62 proteins (14007 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski