Amino acid dipepetide frequency for Osedax symbiont Rs1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.19AlaAla: 9.19 ± 0.11	0.986AlaCys: 0.986 ± 0.034	5.066AlaAsp: 5.066 ± 0.078	5.636AlaGlu: 5.636 ± 0.076	3.122AlaPhe: 3.122 ± 0.058	6.173AlaGly: 6.173 ± 0.077	1.55AlaHis: 1.55 ± 0.035	6.631AlaIle: 6.631 ± 0.074	5.474AlaLys: 5.474 ± 0.075	9.85AlaLeu: 9.85 ± 0.104	2.413AlaMet: 2.413 ± 0.054	3.688AlaAsn: 3.688 ± 0.06	2.675AlaPro: 2.675 ± 0.057	4.177AlaGln: 4.177 ± 0.066	3.601AlaArg: 3.601 ± 0.061	5.685AlaSer: 5.685 ± 0.073	4.664AlaThr: 4.664 ± 0.066	6.349AlaVal: 6.349 ± 0.081	0.886AlaTrp: 0.886 ± 0.028	2.206AlaTyr: 2.206 ± 0.045	0.008AlaXaa: 0.008 ± 0.003
Cys	1.012CysAla: 1.012 ± 0.03	0.193CysCys: 0.193 ± 0.013	0.63CysAsp: 0.63 ± 0.023	0.579CysGlu: 0.579 ± 0.022	0.532CysPhe: 0.532 ± 0.02	0.844CysGly: 0.844 ± 0.027	0.331CysHis: 0.331 ± 0.02	0.767CysIle: 0.767 ± 0.027	0.546CysLys: 0.546 ± 0.021	1.131CysLeu: 1.131 ± 0.03	0.219CysMet: 0.219 ± 0.014	0.368CysAsn: 0.368 ± 0.018	0.451CysPro: 0.451 ± 0.021	0.538CysGln: 0.538 ± 0.022	0.532CysArg: 0.532 ± 0.022	0.773CysSer: 0.773 ± 0.025	0.562CysThr: 0.562 ± 0.024	0.614CysVal: 0.614 ± 0.024	0.172CysTrp: 0.172 ± 0.011	0.414CysTyr: 0.414 ± 0.019	0.001CysXaa: 0.001 ± 0.001
Asp	4.048AspAla: 4.048 ± 0.07	0.597AspCys: 0.597 ± 0.023	2.817AspAsp: 2.817 ± 0.083	2.898AspGlu: 2.898 ± 0.056	2.482AspPhe: 2.482 ± 0.047	3.201AspGly: 3.201 ± 0.09	1.111AspHis: 1.111 ± 0.031	4.114AspIle: 4.114 ± 0.054	3.104AspLys: 3.104 ± 0.061	5.561AspLeu: 5.561 ± 0.068	1.274AspMet: 1.274 ± 0.037	2.272AspAsn: 2.272 ± 0.056	2.142AspPro: 2.142 ± 0.049	2.667AspGln: 2.667 ± 0.05	2.319AspArg: 2.319 ± 0.05	3.625AspSer: 3.625 ± 0.059	2.473AspThr: 2.473 ± 0.064	3.22AspVal: 3.22 ± 0.06	0.78AspTrp: 0.78 ± 0.024	1.89AspTyr: 1.89 ± 0.043	0.002AspXaa: 0.002 ± 0.001
Glu	4.25GluAla: 4.25 ± 0.062	0.469GluCys: 0.469 ± 0.021	2.324GluAsp: 2.324 ± 0.049	2.876GluGlu: 2.876 ± 0.06	2.228GluPhe: 2.228 ± 0.042	3.008GluGly: 3.008 ± 0.053	1.429GluHis: 1.429 ± 0.037	4.206GluIle: 4.206 ± 0.062	3.58GluLys: 3.58 ± 0.064	6.494GluLeu: 6.494 ± 0.073	1.459GluMet: 1.459 ± 0.037	2.56GluAsn: 2.56 ± 0.046	1.729GluPro: 1.729 ± 0.037	3.846GluGln: 3.846 ± 0.061	2.855GluArg: 2.855 ± 0.056	3.321GluSer: 3.321 ± 0.061	2.534GluThr: 2.534 ± 0.048	3.621GluVal: 3.621 ± 0.056	0.505GluTrp: 0.505 ± 0.022	1.676GluTyr: 1.676 ± 0.037	0.002GluXaa: 0.002 ± 0.001
Phe	3.518PheAla: 3.518 ± 0.06	0.584PheCys: 0.584 ± 0.019	2.487PheAsp: 2.487 ± 0.053	2.195PheGlu: 2.195 ± 0.046	1.838PhePhe: 1.838 ± 0.041	2.778PheGly: 2.778 ± 0.056	0.792PheHis: 0.792 ± 0.027	3.082PheIle: 3.082 ± 0.053	2.404PheLys: 2.404 ± 0.045	3.52PheLeu: 3.52 ± 0.057	1.01PheMet: 1.01 ± 0.032	2.101PheAsn: 2.101 ± 0.042	1.315PhePro: 1.315 ± 0.033	1.415PheGln: 1.415 ± 0.035	1.399PheArg: 1.399 ± 0.037	3.749PheSer: 3.749 ± 0.058	2.233PheThr: 2.233 ± 0.043	2.586PheVal: 2.586 ± 0.05	0.454PheTrp: 0.454 ± 0.021	1.357PheTyr: 1.357 ± 0.035	0.003PheXaa: 0.003 ± 0.002
Gly	5.362GlyAla: 5.362 ± 0.072	0.944GlyCys: 0.944 ± 0.027	3.423GlyAsp: 3.423 ± 0.073	3.616GlyGlu: 3.616 ± 0.061	3.103GlyPhe: 3.103 ± 0.05	4.525GlyGly: 4.525 ± 0.091	1.394GlyHis: 1.394 ± 0.035	4.57GlyIle: 4.57 ± 0.068	3.783GlyLys: 3.783 ± 0.058	6.759GlyLeu: 6.759 ± 0.079	1.856GlyMet: 1.856 ± 0.048	2.475GlyAsn: 2.475 ± 0.071	1.679GlyPro: 1.679 ± 0.039	2.544GlyGln: 2.544 ± 0.054	2.976GlyArg: 2.976 ± 0.058	4.284GlySer: 4.284 ± 0.076	3.105GlyThr: 3.105 ± 0.063	4.791GlyVal: 4.791 ± 0.071	0.815GlyTrp: 0.815 ± 0.027	2.335GlyTyr: 2.335 ± 0.045	0.004GlyXaa: 0.004 ± 0.002
His	1.524HisAla: 1.524 ± 0.035	0.45HisCys: 0.45 ± 0.019	0.919HisAsp: 0.919 ± 0.028	0.852HisGlu: 0.852 ± 0.029	1.029HisPhe: 1.029 ± 0.034	1.324HisGly: 1.324 ± 0.035	0.659HisHis: 0.659 ± 0.025	1.494HisIle: 1.494 ± 0.034	1.063HisLys: 1.063 ± 0.03	2.382HisLeu: 2.382 ± 0.049	0.497HisMet: 0.497 ± 0.021	0.918HisAsn: 0.918 ± 0.026	1.11HisPro: 1.11 ± 0.033	1.272HisGln: 1.272 ± 0.037	1.189HisArg: 1.189 ± 0.032	1.764HisSer: 1.764 ± 0.038	0.982HisThr: 0.982 ± 0.027	1.003HisVal: 1.003 ± 0.027	0.369HisTrp: 0.369 ± 0.018	0.824HisTyr: 0.824 ± 0.025	0.002HisXaa: 0.002 ± 0.002
Ile	7.306IleAla: 7.306 ± 0.096	0.873IleCys: 0.873 ± 0.029	4.789IleAsp: 4.789 ± 0.067	4.86IleGlu: 4.86 ± 0.071	2.816IlePhe: 2.816 ± 0.059	4.899IleGly: 4.899 ± 0.068	1.262IleHis: 1.262 ± 0.033	4.892IleIle: 4.892 ± 0.082	4.144IleLys: 4.144 ± 0.068	6.462IleLeu: 6.462 ± 0.084	1.411IleMet: 1.411 ± 0.037	3.602IleAsn: 3.602 ± 0.051	2.72IlePro: 2.72 ± 0.051	2.586IleGln: 2.586 ± 0.044	2.843IleArg: 2.843 ± 0.048	5.82IleSer: 5.82 ± 0.075	3.937IleThr: 3.937 ± 0.07	4.409IleVal: 4.409 ± 0.064	0.644IleTrp: 0.644 ± 0.023	1.99IleTyr: 1.99 ± 0.043	0.002IleXaa: 0.002 ± 0.001
Lys	4.586LysAla: 4.586 ± 0.078	0.394LysCys: 0.394 ± 0.018	2.475LysAsp: 2.475 ± 0.053	2.877LysGlu: 2.877 ± 0.054	1.887LysPhe: 1.887 ± 0.045	3.186LysGly: 3.186 ± 0.052	1.199LysHis: 1.199 ± 0.034	4.568LysIle: 4.568 ± 0.058	3.858LysLys: 3.858 ± 0.068	6.132LysLeu: 6.132 ± 0.078	1.567LysMet: 1.567 ± 0.039	2.753LysAsn: 2.753 ± 0.054	2.082LysPro: 2.082 ± 0.041	2.856LysGln: 2.856 ± 0.057	2.687LysArg: 2.687 ± 0.054	3.958LysSer: 3.958 ± 0.064	3.085LysThr: 3.085 ± 0.055	3.899LysVal: 3.899 ± 0.054	0.526LysTrp: 0.526 ± 0.022	1.676LysTyr: 1.676 ± 0.04	0.004LysXaa: 0.004 ± 0.002
Leu	11.033LeuAla: 11.033 ± 0.11	1.186LeuCys: 1.186 ± 0.036	5.793LeuAsp: 5.793 ± 0.066	5.815LeuGlu: 5.815 ± 0.068	4.142LeuPhe: 4.142 ± 0.064	6.563LeuGly: 6.563 ± 0.09	2.345LeuHis: 2.345 ± 0.041	7.456LeuIle: 7.456 ± 0.092	6.17LeuLys: 6.17 ± 0.084	11.886LeuLeu: 11.886 ± 0.148	2.652LeuMet: 2.652 ± 0.042	4.948LeuAsn: 4.948 ± 0.065	4.429LeuPro: 4.429 ± 0.067	5.005LeuGln: 5.005 ± 0.091	4.482LeuArg: 4.482 ± 0.06	8.428LeuSer: 8.428 ± 0.101	5.612LeuThr: 5.612 ± 0.075	6.73LeuVal: 6.73 ± 0.087	1.045LeuTrp: 1.045 ± 0.032	2.718LeuTyr: 2.718 ± 0.047	0.002LeuXaa: 0.002 ± 0.001
Met	2.303MetAla: 2.303 ± 0.05	0.211MetCys: 0.211 ± 0.011	1.137MetAsp: 1.137 ± 0.031	1.068MetGlu: 1.068 ± 0.032	0.911MetPhe: 0.911 ± 0.032	1.629MetGly: 1.629 ± 0.038	0.585MetHis: 0.585 ± 0.026	1.698MetIle: 1.698 ± 0.038	1.275MetLys: 1.275 ± 0.034	2.936MetLeu: 2.936 ± 0.051	0.687MetMet: 0.687 ± 0.026	0.968MetAsn: 0.968 ± 0.027	1.155MetPro: 1.155 ± 0.033	1.443MetGln: 1.443 ± 0.036	1.212MetArg: 1.212 ± 0.035	1.973MetSer: 1.973 ± 0.04	1.408MetThr: 1.408 ± 0.033	1.544MetVal: 1.544 ± 0.041	0.187MetTrp: 0.187 ± 0.013	0.478MetTyr: 0.478 ± 0.021	0.001MetXaa: 0.001 ± 0.001
Asn	3.305AsnAla: 3.305 ± 0.054	0.514AsnCys: 0.514 ± 0.023	2.052AsnAsp: 2.052 ± 0.066	1.748AsnGlu: 1.748 ± 0.037	1.775AsnPhe: 1.775 ± 0.042	2.58AsnGly: 2.58 ± 0.056	0.944AsnHis: 0.944 ± 0.027	3.688AsnIle: 3.688 ± 0.061	2.392AsnLys: 2.392 ± 0.048	4.436AsnLeu: 4.436 ± 0.06	0.976AsnMet: 0.976 ± 0.03	2.09AsnAsn: 2.09 ± 0.05	1.932AsnPro: 1.932 ± 0.04	2.346AsnGln: 2.346 ± 0.044	2.09AsnArg: 2.09 ± 0.048	3.252AsnSer: 3.252 ± 0.055	2.366AsnThr: 2.366 ± 0.048	2.371AsnVal: 2.371 ± 0.048	0.611AsnTrp: 0.611 ± 0.024	1.471AsnTyr: 1.471 ± 0.041	0.002AsnXaa: 0.002 ± 0.001
Pro	3.225ProAla: 3.225 ± 0.05	0.348ProCys: 0.348 ± 0.018	2.004ProAsp: 2.004 ± 0.044	2.505ProGlu: 2.505 ± 0.047	1.605ProPhe: 1.605 ± 0.039	2.169ProGly: 2.169 ± 0.048	0.781ProHis: 0.781 ± 0.026	2.657ProIle: 2.657 ± 0.047	2.0ProLys: 2.0 ± 0.044	4.177ProLeu: 4.177 ± 0.059	0.897ProMet: 0.897 ± 0.027	1.467ProAsn: 1.467 ± 0.031	1.089ProPro: 1.089 ± 0.031	1.628ProGln: 1.628 ± 0.038	1.256ProArg: 1.256 ± 0.037	2.6ProSer: 2.6 ± 0.051	1.878ProThr: 1.878 ± 0.047	2.765ProVal: 2.765 ± 0.053	0.478ProTrp: 0.478 ± 0.018	1.087ProTyr: 1.087 ± 0.031	0.003ProXaa: 0.003 ± 0.002
Gln	4.539GlnAla: 4.539 ± 0.072	0.469GlnCys: 0.469 ± 0.019	1.972GlnAsp: 1.972 ± 0.041	2.117GlnGlu: 2.117 ± 0.052	1.779GlnPhe: 1.779 ± 0.036	3.05GlnGly: 3.05 ± 0.052	1.394GlnHis: 1.394 ± 0.037	3.086GlnIle: 3.086 ± 0.051	2.434GlnLys: 2.434 ± 0.043	6.36GlnLeu: 6.36 ± 0.099	1.159GlnMet: 1.159 ± 0.036	1.667GlnAsn: 1.667 ± 0.042	1.819GlnPro: 1.819 ± 0.043	4.151GlnGln: 4.151 ± 0.081	2.732GlnArg: 2.732 ± 0.044	3.122GlnSer: 3.122 ± 0.054	2.081GlnThr: 2.081 ± 0.04	3.339GlnVal: 3.339 ± 0.041	0.748GlnTrp: 0.748 ± 0.029	1.408GlnTyr: 1.408 ± 0.039	0.004GlnXaa: 0.004 ± 0.002
Arg	3.761ArgAla: 3.761 ± 0.069	0.498ArgCys: 0.498 ± 0.023	2.253ArgAsp: 2.253 ± 0.047	2.809ArgGlu: 2.809 ± 0.058	1.884ArgPhe: 1.884 ± 0.037	2.687ArgGly: 2.687 ± 0.049	1.039ArgHis: 1.039 ± 0.031	3.179ArgIle: 3.179 ± 0.049	2.618ArgLys: 2.618 ± 0.052	4.702ArgLeu: 4.702 ± 0.073	1.134ArgMet: 1.134 ± 0.033	1.795ArgAsn: 1.795 ± 0.043	1.529ArgPro: 1.529 ± 0.036	2.506ArgGln: 2.506 ± 0.047	2.294ArgArg: 2.294 ± 0.047	2.888ArgSer: 2.888 ± 0.056	2.026ArgThr: 2.026 ± 0.049	2.806ArgVal: 2.806 ± 0.053	0.625ArgTrp: 0.625 ± 0.024	1.557ArgTyr: 1.557 ± 0.036	0.003ArgXaa: 0.003 ± 0.002
Ser	6.719SerAla: 6.719 ± 0.087	0.734SerCys: 0.734 ± 0.024	3.594SerAsp: 3.594 ± 0.061	3.916SerGlu: 3.916 ± 0.064	3.045SerPhe: 3.045 ± 0.057	5.233SerGly: 5.233 ± 0.075	1.505SerHis: 1.505 ± 0.034	5.313SerIle: 5.313 ± 0.075	3.687SerLys: 3.687 ± 0.054	7.755SerLeu: 7.755 ± 0.094	1.809SerMet: 1.809 ± 0.037	2.959SerAsn: 2.959 ± 0.058	2.394SerPro: 2.394 ± 0.051	3.079SerGln: 3.079 ± 0.049	3.068SerArg: 3.068 ± 0.055	5.147SerSer: 5.147 ± 0.081	3.816SerThr: 3.816 ± 0.073	4.659SerVal: 4.659 ± 0.072	0.797SerTrp: 0.797 ± 0.028	2.297SerTyr: 2.297 ± 0.045	0.002SerXaa: 0.002 ± 0.001
Thr	5.154ThrAla: 5.154 ± 0.08	0.451ThrCys: 0.451 ± 0.018	2.96ThrAsp: 2.96 ± 0.071	3.075ThrGlu: 3.075 ± 0.059	1.882ThrPhe: 1.882 ± 0.042	3.909ThrGly: 3.909 ± 0.067	1.057ThrHis: 1.057 ± 0.032	3.359ThrIle: 3.359 ± 0.057	2.399ThrLys: 2.399 ± 0.043	5.761ThrLeu: 5.761 ± 0.077	1.115ThrMet: 1.115 ± 0.033	2.06ThrAsn: 2.06 ± 0.046	2.343ThrPro: 2.343 ± 0.059	2.071ThrGln: 2.071 ± 0.041	1.934ThrArg: 1.934 ± 0.037	3.434ThrSer: 3.434 ± 0.061	2.779ThrThr: 2.779 ± 0.05	3.559ThrVal: 3.559 ± 0.064	0.568ThrTrp: 0.568 ± 0.022	1.22ThrTyr: 1.22 ± 0.032	0.005ThrXaa: 0.005 ± 0.002
Val	6.171ValAla: 6.171 ± 0.081	0.703ValCys: 0.703 ± 0.026	3.86ValAsp: 3.86 ± 0.064	3.883ValGlu: 3.883 ± 0.056	2.808ValPhe: 2.808 ± 0.052	4.098ValGly: 4.098 ± 0.064	1.191ValHis: 1.191 ± 0.033	4.95ValIle: 4.95 ± 0.068	3.373ValLys: 3.373 ± 0.055	6.858ValLeu: 6.858 ± 0.084	1.748ValMet: 1.748 ± 0.041	2.765ValAsn: 2.765 ± 0.048	2.26ValPro: 2.26 ± 0.049	2.362ValGln: 2.362 ± 0.048	2.745ValArg: 2.745 ± 0.049	4.743ValSer: 4.743 ± 0.065	3.668ValThr: 3.668 ± 0.062	4.777ValVal: 4.777 ± 0.073	0.64ValTrp: 0.64 ± 0.023	1.662ValTyr: 1.662 ± 0.036	0.003ValXaa: 0.003 ± 0.002
Trp	0.719TrpAla: 0.719 ± 0.026	0.164TrpCys: 0.164 ± 0.011	0.551TrpAsp: 0.551 ± 0.021	0.43TrpGlu: 0.43 ± 0.017	0.525TrpPhe: 0.525 ± 0.021	0.712TrpGly: 0.712 ± 0.028	0.305TrpHis: 0.305 ± 0.016	0.655TrpIle: 0.655 ± 0.026	0.505TrpLys: 0.505 ± 0.019	1.733TrpLeu: 1.733 ± 0.046	0.308TrpMet: 0.308 ± 0.016	0.373TrpAsn: 0.373 ± 0.018	0.483TrpPro: 0.483 ± 0.023	0.945TrpGln: 0.945 ± 0.033	0.676TrpArg: 0.676 ± 0.026	0.768TrpSer: 0.768 ± 0.034	0.412TrpThr: 0.412 ± 0.021	0.692TrpVal: 0.692 ± 0.023	0.154TrpTrp: 0.154 ± 0.011	0.334TrpTyr: 0.334 ± 0.016	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.298TyrAla: 2.298 ± 0.048	0.438TyrCys: 0.438 ± 0.02	1.491TyrAsp: 1.491 ± 0.034	1.215TyrGlu: 1.215 ± 0.033	1.421TyrPhe: 1.421 ± 0.04	1.776TyrGly: 1.776 ± 0.043	0.754TyrHis: 0.754 ± 0.026	1.901TyrIle: 1.901 ± 0.04	1.448TyrLys: 1.448 ± 0.035	3.538TyrLeu: 3.538 ± 0.058	0.613TyrMet: 0.613 ± 0.025	1.107TyrAsn: 1.107 ± 0.037	1.281TyrPro: 1.281 ± 0.036	1.989TyrGln: 1.989 ± 0.043	1.705TyrArg: 1.705 ± 0.041	2.189TyrSer: 2.189 ± 0.046	1.469TyrThr: 1.469 ± 0.038	1.529TyrVal: 1.529 ± 0.04	0.442TyrTrp: 0.442 ± 0.021	1.034TyrTyr: 1.034 ± 0.035	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.007XaaAla: 0.007 ± 0.002	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.003XaaGlu: 0.003 ± 0.002	0.003XaaPhe: 0.003 ± 0.002	0.002XaaGly: 0.002 ± 0.001	0.002XaaHis: 0.002 ± 0.001	0.002XaaIle: 0.002 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.006XaaLeu: 0.006 ± 0.003	0.001XaaMet: 0.001 ± 0.001	0.003XaaAsn: 0.003 ± 0.001	0.002XaaPro: 0.002 ± 0.001	0.002XaaGln: 0.002 ± 0.002	0.001XaaArg: 0.001 ± 0.001	0.006XaaSer: 0.006 ± 0.002	0.007XaaThr: 0.007 ± 0.002	0.005XaaVal: 0.005 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.001	0.021XaaXaa: 0.021 ± 0.009

Statistics based on 4383 proteins (1210298 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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